香港交易及結算所有限公司及香港聯合交易所有限公司對本公告的內容概不負責，對其準確性 或完整性亦不發表任何聲明，並明確表示概不就因本公告全部或任何部分內容而產生或因依賴 該等內容而引致的任何損失承擔任何責任。 Cryofocus Medtech (Shanghai) Co., Ltd. 哮喘冷凍消融系統獲得美國食品監督管理局授予的突破性醫療器械認證 本公告乃由康灃生物科技（上海）股份有限公司（「本公司」，連同其附屬公司統稱 為「本集團」）自願作出，以告知本公司股東及潛在投資者有關本集團業務的最新 進展。 本公司欣然宣佈，於2025年7月24日，本集團的哮喘冷凍消融系統（「哮喘冷凍消 融系統」），本集團的呼吸介入產品之一，由冷凍治療設備及氣道冷凍消融導管組 成，已獲得美國食品及藥物管理局授予的突破性醫療器械認證。 哮喘冷凍消融系統為用於治療中度及重度哮喘的自主研發冷凍消融系統。在手術 過程中，哮喘冷凍消融系統通過冷凍消融破壞肺部迷走神經，減少過度活化乙醯 膽鹼的釋放（其為哮喘病因），並減少黏液分泌，從而達到治療哮喘的效果。 本公司無法保證哮喘冷凍消融系統的未來前景。本公司股東及潛在投資者於買賣 本公司證券時務請審 ...

Group 1 - The core viewpoint of the articles emphasizes the chronic nature of asthma as an airway inflammatory disease that requires ongoing management and treatment to prevent acute attacks and long-term complications [2][4][6] - The importance of adhering to prescribed inhalation therapies, particularly the combination of inhaled corticosteroids (ICS) and long-acting beta-agonists (LABA), is highlighted as essential for controlling inflammation and alleviating symptoms [3][4] - A significant portion of asthma patients in China, approximately 55%-70%, are not effectively managing their condition, indicating a substantial unmet medical need [3] Group 2 - Severe asthma patients, constituting about 5% of the asthma population in China, face higher risks of complications and economic burdens due to frequent acute episodes and hospitalizations [5] - Innovative therapies, particularly biologics, are emerging as effective treatments for severe asthma, targeting specific inflammatory pathways and reducing reliance on corticosteroids [5][6] - The recent update to the bronchial asthma prevention and treatment guidelines introduces the concept of "clinical cure," offering hope for better management and quality of life for severe asthma patients [6]

Group 1 - Asthma is a common chronic respiratory disease characterized by airway inflammation, which can occur at any age and leads to symptoms such as wheezing, chest tightness, shortness of breath, and coughing [2] - The inflammation associated with asthma causes long-term damage to the airways, resulting in structural changes such as airway smooth muscle contraction [2] - Misdiagnosis of asthma is common due to overlapping symptoms with other conditions, particularly chronic cough and chest tightness, which may require further examination for accurate diagnosis [2] Group 2 - Allergic rhinitis can increase the risk of developing asthma, as inflammation may spread from the upper airways to the bronchial tubes if not well-controlled [3] - Individuals with allergic conditions should monitor their respiratory symptoms closely and seek medical evaluation for early diagnosis and treatment [3] Group 3 - Although asthma cannot be cured, most patients can manage their condition effectively through proper medication and treatment protocols, allowing them to breathe freely [4] - Treatment options include both pharmacological and non-pharmacological approaches, with inhaled corticosteroids being the first-line maintenance therapy [4] - New targeted biological therapies are emerging, offering improved treatment options by addressing immune abnormalities associated with asthma [4] Group 4 - Standardized management and long-term care are crucial for asthma patients to control their condition and improve their quality of life [5] - Public awareness of standardized diagnosis and treatment can facilitate early detection and intervention, potentially preventing the progression to chronic obstructive pulmonary disease [5] - Enhanced communication between patients and healthcare providers is essential for improving treatment adherence and patient confidence in managing their condition [5]

Group 1 - The global asthma patient population exceeds 358 million, with projections to surpass 400 million this year; in China, the number of patients exceeds 45 million, including 15 million children [1] - Common triggers for asthma in children include dust mites, pet dander, certain foods, vigorous exercise, and emotional factors such as crying or laughing [1] - Asthma is characterized by bronchial spasms leading to breathing difficulties, with an increasing number of cases attributed to allergies and viral respiratory infections [1] Group 2 - Inhalation therapy is a classic treatment method for asthma, tailored to the patient's age and condition, with a gradual reduction in medication [2] - Other treatment options include traditional Chinese medicine, dietary adjustments, and acupuncture, which can help improve symptoms and reduce asthma attack risks [2] - Parents are advised to seek medical attention promptly during acute asthma attacks, as prolonged hypoxia can damage vital organs [2]