今年9月2日，诺华与Arrowhead就siRNA疗法ARO-SNCA达成一项2亿美元首付款以及后续高达20亿美元潜在里程碑付款的 BD交易。次日，诺华与舶望制药再次就4款siRNA药物达成超52亿美元BD交易。接连2笔累计超70亿美元的BD交易向市场 释放出强烈信号，也让投资者将目光聚焦于近年来越来越亮眼的小核酸领域。 实际上，早在今年5月，全球基因编辑巨头CRISPR Therapeutics斥资8.95亿美元(约合人民币65亿元)与国内创新药企靖因药 业达成重磅合作，携手推进siRNA创新疗法的开发。这也是中国小核酸领域第三起BD出海交易。也正是因此BD履历在 前，让靖因药业的港股IPO备受关注。 智通财经APP了解到，9月28日，靖因药业正式向港交所递交招股书，高盛、海通国际、HSBC为其联席保荐人。 siRNA疗法赛道已成下一个"香饽饽" 据弗若斯特沙利文报告，2024年全球siRNA疗法市场规模达24亿美元，预计至2040年将增长至503亿美元，复合年增长率为 20.9%。其中，其中获批上市的有22款(包含撤市的产品)，包括7款siRNA药物、13款ASO药物和2款适配体。与此同时，全 球在研的小 ...

今年9月2日，诺华与Arrowhead就siRNA疗法ARO-SNCA达成一项2亿美元首付款以及后续高达20亿美元潜在里程碑付款的 BD交易。次日，诺华与舶望制药再次就4款siRNA药物达成超52亿美元BD交易。接连2笔累计超70亿美元的BD交易向市场 释放出强烈信号，也让投资者将目光聚焦于近年来越来越亮眼的小核酸领域。 实际上，早在今年5月，全球基因编辑巨头CRISPR Therapeutics斥资8.95亿美元(约合人民币65亿元)与国内创新药企靖因药 业达成重磅合作，携手推进siRNA创新疗法的开发。这也是中国小核酸领域第三起BD出海交易。也正是因此BD履历在 前，让靖因药业的港股IPO备受关注。 智通财经APP了解到，9月28日，靖因药业正式向港交所递交招股书，高盛、海通国际、HSBC为其联席保荐人。 siRNA疗法赛道已成下一个"香饽饽" 据弗若斯特沙利文报告，2024年全球siRNA疗法市场规模达24亿美元，预计至2040年将增长至503亿美元，复合年增长率为 20.9%。其中，其中获批上市的有22款(包含撤市的产品)，包括7款siRNA药物、13款ASO药物和2款适配体。与此同时，全 球在研的小 ...

Investment Rating - The report maintains a "Buy" rating for the company [6] Core Viewpoints - The company achieved a significant reduction in losses, with a total revenue of CNY 129.47 million in 2024, representing a year-on-year increase of 13.32%. The net loss attributable to shareholders was CNY 201.38 million, a reduction of CNY 127.58 million compared to the previous year [1][3] - The company is focusing on expanding the indications for its product Aikening, with new clinical trials approved for maintenance therapy and immune reconstitution failure, addressing a significant unmet clinical need in the HIV treatment space [2] - The company is actively exploring the small nucleic acid field for new drug development, with a candidate drug FB7013 for IgA nephropathy entering the IND-enabling stage and nine patent applications submitted to establish a technological moat [2] - The company is making breakthroughs in high-end generic drugs, with FB4001 expected to be approved in the US by 2025 and FB3002's application accepted for review, enhancing the company's revenue matrix [3] - Revenue forecasts for 2025-2027 are projected at CNY 161 million, CNY 190 million, and CNY 223 million, with year-on-year growth rates of 24.0%, 18.4%, and 17.2% respectively [3] Financial Summary - In 2024, the company reported total revenue of CNY 129.47 million, with a year-on-year growth rate of 13.32%. The net loss attributable to shareholders was CNY 201.38 million, a decrease of 38.8% from the previous year [5] - The projected revenues for 2025, 2026, and 2027 are CNY 161 million, CNY 190 million, and CNY 223 million, with corresponding growth rates of 24.0%, 18.4%, and 17.2% [5][11] - The latest diluted EPS for 2024 is expected to be CNY -0.54, with a projected improvement to CNY -0.49 in 2025 [5][11]

Investment Rating - The report maintains a "Buy" rating for the company [6] Core Insights - The company achieved a significant reduction in losses, with a total revenue of 129.47 million yuan in 2024, representing a year-on-year increase of 13.32% [1] - The net profit attributable to shareholders was a loss of 201.38 million yuan, a reduction in loss by 127.58 million yuan compared to the previous year, attributed to cost reduction and efficiency improvements [1] - The company is focusing on expanding its revenue matrix through its main product, Aikening, and diversified business operations [1][2] Revenue Growth and Business Development - The company is actively promoting Aikening for new indications, with clinical trials for maintenance therapy and immune reconstitution failure approved by the National Medical Products Administration [2] - There is a significant unmet clinical need in the immune reconstitution failure area, with over 200,000 patients in China, indicating potential for future commercialization [2] - The company is exploring new technologies in the small nucleic acid field, with a candidate drug for IgA nephropathy, FB7013, entering the IND-enabling stage [2] High-End Generic Drugs and Future Projections - The company is making breakthroughs in high-end generic drugs, with FB4001 expected to be approved in the US by 2025 and FB3002's application accepted for review [3] - Revenue projections for 2025-2027 are 161 million yuan, 190 million yuan, and 223 million yuan, with year-on-year growth rates of 24.0%, 18.4%, and 17.2% respectively [3][5] - The net profit attributable to shareholders is projected to be -182 million yuan, -120 million yuan, and -176 million yuan for the same period [3][5] Financial Metrics - The company reported a revenue of 114 million yuan in 2023, with a growth rate of 34.8% [5] - The latest diluted EPS is projected to improve from -0.88 yuan in 2023 to -0.49 yuan in 2025 [5] - The company’s total market capitalization is approximately 3,206.39 million yuan, with a closing price of 8.56 yuan as of May 7 [6]