伴随着药审改革红利持续释放，在国内工程师红利、丰富临床资源和支持性政策多方支持下，国产创新 药产业正从"追赶"的1.0时代迈向"超越"的2.0时代。数据显示，近年来，在ADC、双/多抗、细胞与基因 治疗等热门技术类型中，中国创新药公司启动的药物临床数量明显增加，中国企业研发项目的数量占比 已超过50%，成为全球研发的主力军。在此背景下，富国基金旗下的聚焦港股医药核心资产的恒生生物 科技ETF富国（基金代码：159132），拟于12月19日结束募集。 本次产品发行的成功，恰逢中国生物医药产业发展的关键机遇期。一方面，"十四五"以来国产创新药研 发成果显著，同时创新药支付体系正从医保单轨制迈向"医保+商保"双轨制新阶段，为行业长期发展打 开了更广阔的市场空间；另一方面，港股医药板块首个股指期货——恒生生物科技指数期货已上市交 易，进一步提升了相关资产的流动性与策略丰富性。往后看，恒生生物科技ETF富国（基金代码： 159132）有望成为投资者高效布局港股医药投资机遇的有力工具。 免责声明：以上内容为本网站转自其他媒体，相关信息仅为传递更多信息之目的，不代表本网观点，亦 不代表本网站赞同其观点或证实其内容的真实性。 ...

Group 1 - The Penghua Hang Seng Biotechnology ETF (159130) will be launched from November 10 to November 14, 2025, with a maximum initial fundraising scale of 2 billion yuan [1] - The fund will be managed by Penghua Fund, with Lin Song and Zhang Yuxiang as the fund managers [1] - The performance benchmark for the fund is the Hang Seng Biotechnology Index return (adjusted for exchange rates) [1]

Core Viewpoint - The Hang Seng Biotechnology Index experienced a decline of 2.9%, reaching a new low not seen in over three months [1] Group 1 - The biotechnology sector is facing significant downward pressure as indicated by the recent performance of the Hang Seng Biotechnology Index [1]

1. Report Industry Investment Rating No information about the report industry investment rating is provided in the content. 2. Report's Core Viewpoints - The Hang Seng Biotech Index (HSHKBIO) consists of 50 constituent stocks with notable investment scarcity, and foreign investors hold strong pricing power, influencing the AH premium. The index is affected by factors such as U.S. bond yields, credit spreads, and market liquidity [9][11]. - The index shows different correlations and trends with various factors, including a negative correlation with U.S. Treasury yields, a similar trend with Moutai Basket and Ning Portfolio, a closer alignment with A - share healthcare indices, and better performance when credit spreads widen [101][114][126]. - The trading behavior of foreign capital impacts the AH premium from aspects such as substitution, risk appetite, sentiment, and market liquidity [179][188]. 3. Summary According to the Table of Contents 3.1 Introduction - **Three Major Healthcare Sector Indices in Hong Kong Stocks**: There are three major industry indices in the Hong Kong healthcare sector: the HS Healthcare Index (68 constituents), the HS Biotechnology Index (50 constituents), and the HS Innovative Drug Index (37 constituents). The first two have high long - term correlation, and the Biotech Index can more effectively track the leading Hong Kong healthcare stocks due to its quarterly rebalancing [21][25]. - **Focus on Drugs and Medical Devices**: Hong Kong pharmaceutical stocks have scarcity as many innovative biotech companies are listed there before the STAR Market. The Biotech Index focuses on innovative drugs, medical devices, and CXO, different from A - share listed pharmaceutical enterprises [26][33]. - **The Low Proportion of AH Shares**: By April 2025, 13 AH shares in the index accounted for 17% - 20% of the index weight. Except for WuXi AppTec, the AH premium of other AH shares is generally around 1.5 - 2.0, and it may climb above 2.0 during market declines [38][42]. 3.2 Pricing Power - **Capital Structure**: Foreign and Hong Kong capital hold a dominant position (61% - 80%) in the Hang Seng Biotech Index. Since 2023, foreign capital has been reducing holdings, leading to a passive increase in the proportion of Southbound Stock Connect. By the end of March 2025, domestic and Chinese - funded institutions' investment proportion rose to 30% [51][55]. - **Proportion of Foreign Capital's Holdings**: Foreign capital holds controlling stakes in most individual stocks in the Hong Kong pharmaceutical sector, mainly from Europe and the United States. In 2024, U.S. - based foreign capital rapidly reduced its holdings, and some equity was transferred to the Qatar Investment Authority [60][64]. - **Belonging of Pricing Power**: From 2021 to 2025, foreign institutional investors had strong pricing power over pharmaceutical stocks, with more than half of the individual stocks showing a correlation coefficient exceeding 0.5 between their stock prices and the proportion of foreign holdings. Based on foreign ownership fluctuations for market timing has a long - term alpha effect [75][86]. 3.3 Sector Rotations - **The Index is Negatively Correltated with the U.S. Treasury Yield**: The HS Biotech Index has a significant negative correlation (- 0.84) with the 10 - year U.S. Treasury yield. Since 2024, its correlation with long - term Chinese bond yields has strengthened [95][101]. - **The Index Moves in Tandem with Moutai Basket and Ning Portofolio**: The Hang Seng Biotech Index, Moutai Basket, and Ning Portfolio are all dominated by foreign capital, tied to U.S. Treasury yields. They peaked simultaneously in 2021, with different maximum drawdowns [108][114]. - **The Index Tracks A - Share Healthcare Indices More Closely**: The HS Biotech Index shows stronger alignment with A - share healthcare indices and has diverged from U.S. biotech indices since 2024. After 2024, its trajectory is mainly driven by China's economic expectations [120][126]. - **The Index Paradoxically Outperforms When Credit Spreads Widen**: Credit spreads typically expand during macro - economic deterioration or industry profit headwinds. Widening spreads imply a higher probability of interest - rate cuts, boosting biotech valuations [133][139]. - **Hang Seng Sector Rotation Signals**: When the 10 - year U.S. Treasury yield declines, the elasticity of Hong Kong's major broad - based indices is Biotech > HSTECH > HSI; in the interest - rate hike cycle, HSI and HSTECH have stronger excess returns. When the 10 - year CGB yield rises, it is suitable to overweight the Biotech Index [147][158]. 3.4 AH Premium - **AH Premium Rate: Negatively Correlated with the Index**: The average AH premium of 13 AH shares from September 2022 to March 2025 has a high negative correlation (- 0.90) with the index, which may be due to the high elasticity of biopharmaceutical stocks and the significant influence of foreign capital transactions [165][166]. - **AH Premium: The Trading Behavior of Foreign Capital**: The trading behavior of foreign capital affects the AH premium from four aspects: substitution (long - term deviation in AH premium after the launch of the Mainland - Hong Kong Stock Connect), risk appetite (higher U.S. Treasury yields lead to a higher AH premium), sentiment (negative correlation between warrant PCR ratio and AH premium), and market liquidity (lower Hong Kong stock liquidity leads to a higher AH premium) [174][179][188].