Core Viewpoint - The article discusses the revival of electrochemistry in synthetic chemistry, highlighting its potential in enzyme applications and the challenges faced in utilizing electrochemistry to unlock new catalytic modes for enzymes [2]. Group 1: Research Findings - A research team from Nanjing University published a paper in Nature on May 28, 2025, demonstrating a new catalytic function of ThDP-dependent enzymes through the integration of electrocatalysis and enzyme catalysis, achieving dynamic kinetic oxidation of aldehydes to chiral carboxylic acids [2]. - The study reported a robust electroenzymatic method for the efficient synthesis of ten (S)-arylpropionic acid anti-inflammatory drugs, such as ibuprofen and naproxen, with enantiomeric selectivity reaching 99% ee and enzyme loading as low as 0.05 mol% [4]. - Mechanistic studies revealed that the electroenzyme plays multiple roles in precise substrate recognition, accelerating racemization, and facilitating electron transfer events for kinetic matching [5]. Group 2: Recent Publications - The research team has published three papers in Nature over the past two years, including a study on December 18, 2023, that developed a dual catalytic system combining ThDP-dependent enzymes and photocatalysis, significantly expanding enzyme catalytic functions and providing new strategies for chiral precision control in chemical fields [7]. - Another publication on November 22, 2024, introduced a synergistic photobiocatalysis system for enantioselective triple radical sorting, overcoming the limitations of natural enzymes that typically catalyze only 1-2 substrates, thus empowering green biomanufacturing [10].