Core Viewpoint - The article discusses the implementation of a free HPV vaccination program for girls aged 13 and above in Shanghai, highlighting the rising incidence of cervical cancer in China and the importance of early vaccination for effective prevention [3][6]. Group 1: HPV Vaccination Program - The Shanghai CDC announced that community health service centers are now providing free HPV vaccinations for girls who are 13 years old and born after November 10, 2011, allowing them to receive two doses of the bivalent HPV vaccine [3][6]. - The national HPV vaccination program, effective from November 10, 2025, aims to provide free vaccinations to the specified age group, based on considerations of protection effectiveness, cost-effectiveness, and operational feasibility [6]. - Evidence indicates that completing the HPV vaccination series before the first sexual intercourse yields the best preventive effects, with antibody levels in girls aged 9-14 being more than double those in individuals over 15, providing protection for at least 10 years [6]. Group 2: Vaccine Procurement and Availability - The Chinese government procurement website announced that two domestic bivalent HPV vaccines from Wantai Biological Pharmacy and Watson Biotech were selected for the national immunization program, with a unit price of 27.5 yuan per dose and a total budget of approximately 254 million yuan [6][7]. - The free HPV vaccines available in Shanghai are also from Wantai Biological and Watson Biotech, and it is recommended to use the same manufacturer's vaccine for both doses [7]. - The Shanghai CDC continues to offer non-immunization program HPV vaccines for women aged 9-45 and men aged 9-26, who can self-schedule and pay for these vaccines [8].

Core Points - The National Health Commission and other departments have decided to include the HPV vaccine in the national immunization program, providing free vaccinations for girls born after November 10, 2011, who are at least 13 years old [1][2] - The incidence and mortality rates of cervical cancer in China are on the rise, with a trend towards younger ages for onset, highlighting the importance of HPV vaccination in disease prevention [1] - The notification outlines requirements for effective organization, preparation, and implementation of the vaccination program [1][2] Preparation and Implementation - Local authorities are required to assess the number of eligible girls and their previous vaccination status, set up vaccination sites, train staff, and adapt immunization information systems [1] - The industrial and information technology departments are tasked with ensuring that production companies prepare raw materials and production schedules in advance [2] - The China CDC will organize procurement in accordance with regulations, and localities must standardize vaccination practices and monitor adverse reactions [2] Risk Management and Organizational Support - The drug regulatory department is responsible for supervising vaccine quality throughout production, storage, and transportation [2] - Local CDCs and vaccination units must manage vaccine registration and documentation effectively [2] - Financial departments are expected to ensure funding is available, while the China CDC will develop technical plans and provide guidance and training to localities [2]