Core Viewpoint - The article discusses the implementation of a free HPV vaccination program for girls aged 13 and above in Shanghai, highlighting the rising incidence of cervical cancer in China and the importance of early vaccination for effective prevention [3][6]. Group 1: HPV Vaccination Program - The Shanghai CDC announced that community health service centers are now providing free HPV vaccinations for girls who are 13 years old and born after November 10, 2011, allowing them to receive two doses of the bivalent HPV vaccine [3][6]. - The national HPV vaccination program, effective from November 10, 2025, aims to provide free vaccinations to the specified age group, based on considerations of protection effectiveness, cost-effectiveness, and operational feasibility [6]. - Evidence indicates that completing the HPV vaccination series before the first sexual intercourse yields the best preventive effects, with antibody levels in girls aged 9-14 being more than double those in individuals over 15, providing protection for at least 10 years [6]. Group 2: Vaccine Procurement and Availability - The Chinese government procurement website announced that two domestic bivalent HPV vaccines from Wantai Biological Pharmacy and Watson Biotech were selected for the national immunization program, with a unit price of 27.5 yuan per dose and a total budget of approximately 254 million yuan [6][7]. - The free HPV vaccines available in Shanghai are also from Wantai Biological and Watson Biotech, and it is recommended to use the same manufacturer's vaccine for both doses [7]. - The Shanghai CDC continues to offer non-immunization program HPV vaccines for women aged 9-45 and men aged 9-26, who can self-schedule and pay for these vaccines [8].

Group 1 - The Shanghai CDC announced that community health service centers in Shanghai will provide free HPV vaccinations for girls who are 13 years old and born after November 10, 2011, allowing them to receive two doses of the bivalent HPV vaccine [1] - Cervical cancer is one of the most common malignant tumors in the female reproductive system, with an increasing incidence and younger onset in China. In 2022, there were 151,000 new cases and 56,000 deaths from cervical cancer in the country, equating to one woman diagnosed every four minutes and one death every ten minutes [1] Group 2 - Starting from November 10, 2025, the national immunization program will officially include the HPV vaccine for girls aged 13 and born after November 10, 2011, based on considerations of protection effectiveness, cost-effectiveness, and operational feasibility [4] - Evidence shows that completing the full course of HPV vaccination before the first sexual intercourse provides the best prevention against HPV infection and related diseases, with antibody levels in girls aged 9-14 being more than twice that of those aged 15 and above, and protection lasting at least 10 years [4] - The procurement results for the national immunization program revealed that two domestic bivalent HPV vaccines from Wantai Biological Pharmacy and Watson Biotech were awarded contracts at a unit price of 27.5 yuan per dose, with a total budget of approximately 254 million yuan [4] Group 3 - The Shanghai CDC recommends using the same manufacturer's bivalent HPV vaccine for both doses. If a girl has already received one dose of a non-immunization program HPV vaccine, she should communicate with the vaccination clinic to decide on the second dose [5] - The Shanghai CDC provides various platforms for appointment and information regarding vaccinations, including the "Suishenban" app and the Shanghai CDC WeChat public account [6] - In addition to the HPV vaccines included in the immunization program, Shanghai's vaccination clinics continue to offer non-immunization program HPV vaccines for women aged 9-45 and men aged 9-26 on a self-paid basis [6]

Core Points - China will provide free HPV vaccinations to girls born on or after November 10, 2011, starting from November 10, 2025, marking a significant step in cervical cancer prevention and women's health promotion [1] - The World Health Organization (WHO) has praised this decision as a milestone that will protect millions of women and girls from cervical cancer [1] - The HPV vaccine will be included in the national immunization program, with a focus on girls aged 13, as this age offers optimal protection and cost-effectiveness [2] Group 1 - The HPV vaccination program aims to prevent high-risk HPV infections, significantly reducing cervical cancer incidence, with existing vaccines shown to prevent over 70% of cervical cancer cases [1][2] - The decision to target 13-year-old girls is based on research indicating that vaccination before sexual activity provides stronger protection, with antibody levels in this age group being more than double those in older populations [2] - The vaccination schedule consists of two doses administered six months apart, with a recommendation that the interval should not exceed one year [3] Group 2 - In 2022, China reported approximately 151,000 new cervical cancer cases and 56,000 deaths, accounting for nearly one-fifth of the global total, highlighting the significant burden of cervical cancer in the country [3] - The program is expected to contribute to global efforts to eliminate cervical cancer, with WHO representatives emphasizing its importance [3] - Various departments will collaborate to ensure vaccine supply and safety, including monitoring production and providing necessary medical support during vaccinations [4][5]