Core Viewpoint - Aging significantly increases the risk of cancer and profoundly affects the immune system, leading to impaired immune responses to chronic and acute infections, as well as a higher susceptibility to autoimmune diseases [2]. Group 1: Research Findings - A study published by researchers at the Moffitt Cancer Center indicates that lymphoma accelerates T cell and tissue aging [3][4]. - The research shows that lymphoma induces transcriptional, epigenetic, and phenotypic changes in young T cells, which are also reflected in older T cells [8]. - Aging T cells exhibit strong resistance to changes induced by lymphoma, while lymphoma itself accelerates aging in young T cells and tissues [9]. Group 2: Immune System Changes - Aging leads to numerous changes in the immune system, including an imbalance of inflammatory cytokines and chemokines, a shift in hematopoietic stem cells towards monocyte generation, and a reduction in lymphocyte populations [6]. - Tumors escape immune surveillance by creating various pressures, such as an acidic environment that damages CD8+ T cells while promoting the expansion of regulatory T cells (Tregs) [7]. - The study highlights that lymphoma drives age-related inflammation and alters protein and iron homeostasis in T cells [9].