以下文章来源于赛业生物订阅号 ，作者小赛 赛业生物订阅号 . 分享生命科学领域的前沿资讯、解读行业动态、讲解实用的学科知识、实验方法和技巧。 国自然 （NSFC） 的资助方向是学科发展的晴雨表。2026年申报在即，洞察热点趋势对于课题设计至关重 要。基于对历年资助项目与前沿发表的综合分析，我们猜测，以下几个热点领域，在新的一年将继续保持高 热度和高竞争力。 ➢ 核心机制类： 免疫调控 （巨噬细胞极化、中性粒细胞、T细胞耗竭） 、线粒体功能与稳态、新型细胞死 亡 （铁死亡、焦亡） 、代谢重编程 （糖酵解、乳酸化） 、蛋白质翻译后修饰 （泛素化、SUMO化、组蛋 白修饰） ； ➢前沿交叉类： 表观转录组学 （RNA修饰，如m6A、m7G） 、细胞间通讯 （外泌体） 、宿 主-微生物互作 （肠道菌群） 、干细胞与再生医学； ➢关键技术类： 单细胞与空间多组学、类器官与疾病模型、人工智能/机器学习驱动的靶点发现与数据分析 这些方向并非孤立存在，例如铁死亡不仅是一种程序性细胞死亡机制，更与免疫代谢、蛋白质修饰网络和 RNA表观调控紧密相连；外泌体则作为载体，跨界调控着肿瘤免疫与神经疾病中的细胞命运……因此， 从单 一热 ...

Core Insights - The study highlights the role of M2 macrophage-derived migrasomes in enhancing fracture healing through the coordination of CXCL12/CXCR4 signaling and neutrophil-MMP-9/MSC-EphB2 pathways, providing a promising strategy for tissue engineering in fracture repair [3][7]. Group 1: Mechanisms of Action - M2 macrophage-derived migrasomes are found to be rich in CXCL12, which activates the CXCL12/CXCR4 signaling axis to promote the migration of mesenchymal stem cells (MSCs) [6]. - The study reveals that M2-migra regulates the expression of neutrophil-derived MMP-9, enhancing the expression of EphB2 receptors on MSCs, thereby promoting osteogenic differentiation and fracture healing [6][9]. - Compared to M2-exosomes, M2-migra exhibits superior MSC homing capabilities through a dual mechanism involving CXCL12/CXCR4 recruitment and neutrophil-MMP-9/MSC-EphB2 induced osteogenic differentiation [7][9]. Group 2: Experimental Findings - The research team isolated migrasomes and exosomes from polarized M2 and M1 macrophages and co-cultured them with MSCs to assess their effects on MSC migration [5]. - An injectable thermosensitive hydrogel was developed to first release migrasomes to recruit MSCs, followed by the delivery of BMP-2 to enhance osteogenic activity, resulting in accelerated bone healing in mouse models [9][10]. - The study suggests a new paradigm of using immune cell-derived vesicles as programmable delivery vehicles for recruiting and guiding endogenous repair cells, applicable not only for fracture healing but potentially for other tissue regeneration [9].

Core Viewpoint - The establishment of the Xiamen University-Guyu Biomedicine Joint Research Center and the launch of the human-like exosome HME represent a significant breakthrough in the application of exosomes in the beauty industry, potentially overcoming the challenges of industrialization and safety [3][4][5]. Group 1: Understanding Exosomes - Exosomes are small vesicles that facilitate intercellular communication by delivering proteins and nucleic acids, playing a crucial role in regulating metabolism and cellular repair [5][6]. - The decline in the function of exosomes with aging highlights their importance in anti-aging treatments, as they are essential for maintaining healthy cellular communication [6][8]. Group 2: Challenges in Application - Current market offerings primarily feature plant-derived exosomes, which are less effective due to structural differences with human cells, while human-derived exosomes face regulatory challenges and safety concerns [8][10]. - The classification of exosomes as Advanced Therapy Medicinal Products (ATMP) by the Chinese National Medical Products Administration indicates a clearer direction for research and application in the industry [8][10]. Group 3: Breakthrough of HME - The human-like exosome HME is not a simple extraction from natural exosomes but a product of reverse engineering and optimization, addressing safety, efficiency, and industrialization challenges [10][12]. - HME mimics the structure and active components of human-derived exosomes, allowing for better cellular recognition and uptake, thus enhancing delivery efficiency [12][13]. Group 4: Advantages of HME - HME directly regulates target genes and signaling pathways, significantly shortening the action mechanism compared to traditional anti-aging ingredients [16]. - The incorporation of targeting peptides in HME allows for precise delivery to key skin cells responsible for regeneration, improving utilization compared to conventional treatments [16][17]. - HME can be stored at room temperature, overcoming the stability issues associated with natural exosomes, thus facilitating large-scale production [17][18]. Group 5: Research and Development Strategy - The collaboration with Xiamen University enhances Guyu's research capabilities, shifting focus from application optimization to foundational research in anti-aging [22][23]. - The development of rare ginsenoside CK for anti-aging drug research reflects a strategic move to strengthen the brand's capabilities in raw material selection and efficacy validation [23][24]. Group 6: Future Directions - The introduction of HME signifies a transition towards gene-level research in skincare, aiming to directly influence cellular functions and reverse aging processes [25][26]. - Guyu's approach aligns with the broader goals of life sciences, positioning the brand uniquely in the competitive landscape of global beauty technology [25][26].