撰文丨王聪 编辑丨王多鱼 排版丨水成文 巨噬细胞 及其与 间充质干细胞 的相互作用，被认为是骨愈合、协调炎症和组织再生的关键因素。之前的研究发现，巨 噬细胞会影响间充质干细胞的分化、迁移和归巢功能。值得注意的是， 巨噬细胞 和 间充质干细胞 共享一个微环境 （包括细胞因子、趋化因子、转录因子和调控骨愈合的信号分子） ，这表明它们之间存在信号交流。然而，介导两者之 间信号传递的机制尚不明确。 迁移体 （ M igrasome） 是清华大学 俞立 教授团队于 2015 年首次发现的一种 参与细胞间通讯的特化细胞器 ——这 是一种 大的膜包被结构，其中包含了数量不等的小囊泡，形似打开的石榴，其形成依赖于细胞迁移，并因此得名。 最近的研究发现， 巨噬细胞 也会产生迁移体。鉴于巨噬细胞影响间充质干细胞的归巢以及间充质干细胞介导的成骨分 化，那么，巨噬细胞来源的迁移体是否能够通过影响巨噬细胞与骨间充质干细胞之间的相互作用，参与骨折的愈合？ 2025 年 11 月 17 日， 新疆医科大学骨科中心脊柱微创与精准骨科 赵文 / 杨毅 团队 （ 张思宇 、 阿不都热西提·库 提彼丁 为论文共同第一作者） 在 Cell 子刊 C ...

Core Viewpoint - The establishment of the Xiamen University-Guyu Biomedicine Joint Research Center and the launch of the human-like exosome HME represent a significant breakthrough in the application of exosomes in the beauty industry, potentially overcoming the challenges of industrialization and safety [3][4][5]. Group 1: Understanding Exosomes - Exosomes are small vesicles that facilitate intercellular communication by delivering proteins and nucleic acids, playing a crucial role in regulating metabolism and cellular repair [5][6]. - The decline in the function of exosomes with aging highlights their importance in anti-aging treatments, as they are essential for maintaining healthy cellular communication [6][8]. Group 2: Challenges in Application - Current market offerings primarily feature plant-derived exosomes, which are less effective due to structural differences with human cells, while human-derived exosomes face regulatory challenges and safety concerns [8][10]. - The classification of exosomes as Advanced Therapy Medicinal Products (ATMP) by the Chinese National Medical Products Administration indicates a clearer direction for research and application in the industry [8][10]. Group 3: Breakthrough of HME - The human-like exosome HME is not a simple extraction from natural exosomes but a product of reverse engineering and optimization, addressing safety, efficiency, and industrialization challenges [10][12]. - HME mimics the structure and active components of human-derived exosomes, allowing for better cellular recognition and uptake, thus enhancing delivery efficiency [12][13]. Group 4: Advantages of HME - HME directly regulates target genes and signaling pathways, significantly shortening the action mechanism compared to traditional anti-aging ingredients [16]. - The incorporation of targeting peptides in HME allows for precise delivery to key skin cells responsible for regeneration, improving utilization compared to conventional treatments [16][17]. - HME can be stored at room temperature, overcoming the stability issues associated with natural exosomes, thus facilitating large-scale production [17][18]. Group 5: Research and Development Strategy - The collaboration with Xiamen University enhances Guyu's research capabilities, shifting focus from application optimization to foundational research in anti-aging [22][23]. - The development of rare ginsenoside CK for anti-aging drug research reflects a strategic move to strengthen the brand's capabilities in raw material selection and efficacy validation [23][24]. Group 6: Future Directions - The introduction of HME signifies a transition towards gene-level research in skincare, aiming to directly influence cellular functions and reverse aging processes [25][26]. - Guyu's approach aligns with the broader goals of life sciences, positioning the brand uniquely in the competitive landscape of global beauty technology [25][26].