Core Viewpoint - The study reveals a mechanism of liver-breast metabolic communication that drives cancer progression, particularly highlighting the role of exosomes derived from non-alcoholic fatty liver disease (NAFLD) in promoting breast cancer development [9]. Group 1: Research Findings - Exosomes from fatty liver induce the release of free fatty acids in breast adipocytes, thereby promoting breast cancer progression [3][10]. - The study establishes a correlation between NAFLD and increased breast cancer risk in atypical hyperplasia individuals, as well as poor prognosis in breast cancer patients [4]. - The accumulation of fatty liver-derived exosomes in adipocytes contributes to the formation of a pro-tumor microenvironment in the breast [4]. Group 2: Mechanisms Involved - The targeting of adipocytes by exosomes is mediated by the interaction between ErbB4 and Nrg4 [4][10]. - TRMT10C in the exosomes is transferred to mitochondria, leading to m1A modification of mitochondrial mRNA, which suppresses the translation of ND5 and ND6, resulting in increased reactive oxygen species (ROS) levels and accelerated tumor progression [4][10]. Group 3: Prognostic Indicators - Plasma ErbB4-positive exosomes are identified as an independent prognostic indicator for breast cancer patients with NAFLD [5].

Group 1 - Exosomes are nano-sized vesicles (30-150 nanometers) that act as "messengers" between cells, playing a crucial role in maintaining cellular vitality through precise information transfer and efficient material exchange [1][2] - Exosomes have a lipid bilayer structure that protects their internal bioactive substances, which include proteins, mRNA, miRNA, and small molecules essential for cellular functions [2][3] Group 2 - Exosomes can be derived from three main sources: human, animal, and plant, each with distinct functional characteristics and application scenarios [3] - Human-derived exosomes are natural carriers that facilitate cellular cooperation and metabolic regulation [3] - Animal-derived exosomes, found in colostrum and stem cells, enhance human cell vitality and require safety assessments before use [3] - Plant-derived exosomes, sourced from soybeans, grapes, and other plants, are cost-effective and free from animal components, making them suitable for skincare and food additives [3] Group 3 - Exosomes play an irreplaceable role in cellular cooperation and vitality maintenance by enabling precise intercellular communication, efficient material exchange, and dynamic regulation of cellular vitality [4] - They facilitate accurate signaling between cells, ensuring synchronized operations within cellular groups [4] - Exosomes act as efficient transporters for essential nutrients and repair materials, accelerating cell renewal [4] - They regulate cellular vitality by activating metabolic pathways based on the cell's needs [4] Group 4 - The research field is exploring the application value of exosomes, such as enhancing skin cell vitality in skincare products and optimizing stem cell exosome delivery systems using AI technology [5] - Exosomes are expected to become a core technological carrier for next-generation cellular health management and functional product development, offering new possibilities for human health [5]

Core Viewpoint - The recent regulatory movement in the pharmaceutical sector, particularly the classification of exosomes as advanced therapy medicinal products (ATMP), has significant implications for the beauty industry, especially in the development of skincare products utilizing exosomes [3][5][31]. Regulatory Developments - In July 2023, the National Medical Products Administration (NMPA) released guidelines that clarify the classification of cell therapy products, officially categorizing exosomes as drugs [3][5]. - This regulatory clarity resolves previous ambiguities regarding the status of stem cells and exosomes, which are now recognized as pharmaceutical products [5][31]. Industry Trends - Over 17 beauty-related companies, including major players like L'Oréal and Estée Lauder, are actively exploring the potential of exosomes in skincare, indicating a growing trend towards innovative beauty solutions [5][17]. - Exosomes are gaining attention for their unique properties, such as promoting skin rejuvenation and anti-aging effects, which are increasingly being recognized in the beauty industry [9][13]. Scientific Background - Exosomes are small vesicles secreted by cells, containing proteins and nucleic acids, and are involved in intercellular communication [7][8]. - The scientific foundation for exosome research has been bolstered by Nobel Prize-winning discoveries related to cell communication and gene regulation [8][9]. Market Potential - The market for exosome-related skincare products is expanding, with significant sales growth observed on platforms like Douyin, where sales reached 1.646 billion yuan in the first half of 2025, marking a year-on-year increase of 359.8% [25][27]. - The average price of exosome-related skincare products on Douyin was 371.46 yuan, indicating a premium positioning in the market [25]. Challenges Ahead - Despite the promising potential, the beauty industry faces challenges related to regulatory compliance, as current regulations in China do not recognize exosomes as valid cosmetic ingredients [29][30]. - There is also a need for clearer technical standards and clinical evidence to support the efficacy and safety of exosome-based products [32][33].

Core Viewpoint - Exosomes, small vesicles released by living cells, are recognized as a promising area in biomedicine, with applications in disease diagnosis, cell therapy, drug delivery, and regenerative medicine. The regulatory inclusion of extracellular vesicles (EVs) as advanced therapy medicinal products (ATMPs) marks a significant step towards their industrial application, although challenges remain in technology, standards, and interdisciplinary collaboration [2]. Group 1: Exosome Overview - Exosomes are tiny vesicles with a diameter of 30-150 nm, serving as messengers for intercellular communication and signal transmission. They contain various bioactive substances, including proteins, functional DNA fragments, mRNAs, and miRNAs [2]. - The National Medical Products Administration (NMPA) in China has recognized EVs as part of the ATMP category, indicating a move towards regulatory standardization in the development of exosome-related products [2]. Group 2: Challenges in the Industry - The exosome industry faces three main challenges: the need for breakthroughs in key technologies, the establishment of industry standards, and the enhancement of interdisciplinary collaborative innovation [2]. Group 3: Upcoming Event - An online seminar titled "First Exosome Innovation Technology and Application Progress" will be held on August 12, 2025, organized by Instrument Information Network, focusing on advancements in exosome extraction, characterization, and applications in disease diagnosis and treatment [3][5]. - The seminar will feature various sessions, including topics on standardization, single-molecule characterization, clinical applications, and innovative detection methods related to exosomes [6].

Core Viewpoint - The article highlights the ongoing developments in the field of skin repair and aesthetic medicine, particularly focusing on the integration of exosomes and hydrogels as innovative solutions for skin tissue regeneration and precise repair [1][6]. Group 1: Event Overview - The event titled "2025 Third China Plastic Surgery Innovation and Transformation Competition" is currently open for registration, featuring various sessions on medical aesthetics and innovation in medical devices [1]. - The event will include a special sharing session by Dr. Chen Junge from Beihang University, focusing on the basic mechanisms of skin injury repair and material system design [2][6]. - The event is organized by the Ba Da Chu Plastic Surgery Medical Concept Verification Center, which is the first professional platform in China dedicated to the transformation of plastic surgery technology achievements [5]. Group 2: Key Topics and Discussions - The agenda includes a presentation on "Exosomes and Smart Hydrogels: From Delivery Systems to Skin Regeneration," emphasizing the role of exosomes in skin regeneration and the design logic of hydrogels as delivery systems [4][6]. - Discussions will cover the pathways and technical challenges of exosomes in skin regeneration, the design keys and application differences of hydrogels in delivery systems, and the differentiation of product paths for skin medical and aesthetic applications [10]. - The event aims to explore how basic research can transition into industrial transformation, identifying key links and the layout logic of entrepreneurial teams in the skin repair sector [10].

Group 1 - The report highlights that the exosome industry is in its early stages of industrialization, with significant growth potential anticipated in the coming years [3][8][9] - Exosomes, which are nano-sized vesicles involved in intercellular communication, play crucial roles in tumor progression, immune regulation, and metastasis, with applications in early cancer detection and treatment guidance [3][8] - The global exosome market is projected to grow from USD 112.25 million in 2022 to approximately USD 1.5 billion by 2030, reflecting a compound annual growth rate (CAGR) of 32.75%, with around 30% of applications in oncology and 50% of revenue generated by biopharmaceutical companies [3][8] Group 2 - The report notes that there are currently at least 46 companies in China engaged in exosome research and development, focusing on areas such as separation, purification, detection, new drug development, delivery, and diagnostics [3][8] - The industrialization of exosomes is still in its nascent phase, with only a few products available in the disease diagnosis sector, while drug delivery applications remain in early development without any products on the market [9] - The report emphasizes that the lack of a clear competitive landscape presents substantial opportunities for new entrants in the exosome industry [9]

Core Viewpoint - The study reveals that exosomes derived from macrophage-derived foam cells in atherosclerotic plaques exacerbate ischemic white matter injury and vascular cognitive impairment by transmitting metabolic defects to microglia [2][5][10]. Group 1: Research Findings - Atherosclerosis (AS) is identified as an independent risk factor for vascular cognitive impairment (VCI), with unclear mechanisms [2]. - The research team discovered that exosomes in the circulation of AS patients worsen ischemic white matter injury and VCI [5]. - Foam cells produce exosomes that target microglia in the central nervous system, transmitting oxidative stress imbalance and metabolic defects through the miR-101-3p-Nrf2-Slc2a1 signaling axis [5][7]. Group 2: Potential Therapeutic Targets - The study confirms that inhibiting miR-101-3p or activating Nrf2 can counteract the effects of atherosclerotic exosomes and improve vascular cognitive impairment [6][7]. - The findings suggest a long-distance connection between peripheral macrophages and microglia, providing new insights and potential therapeutic targets for atherosclerosis-induced vascular cognitive impairment [3][10].