亿万富豪们正将巨额资金投入一度被视为学术边缘领域的长寿产业，押注于可能彻底改变人类生命体验 的科学突破。 根据《华尔街日报》对PitchBook数据、上市公司声明及监管文件的分析，在过去二十五年间，全球顶 级富豪已向长寿领域投入超过50亿美元；其中包括PayPal联合创始人Peter Thiel、OpenAI首席执行官 Sam Altman、科技投资人Yuri Milner及Marc Andreessen等。 与此相对应，过去十年间，长寿公司的平均融资额增长了20%以上，今年已达到近4300万美元。这波投 资热潮中，最引人注目的动态包括Sam Altman向致力于细胞重编程的Retro Biosciences投入1.8亿美元， 以及Altos Labs在成立之初便筹集了创纪录的30亿美元。 尽管该领域存在如Unity Biotechnology退市解散等高失败风险，但丝毫未动摇投资者们追逐科学前沿的 决心。他们正通过真金白银的下注，决定着资金和科研力量的流向。 巨头扎堆，投资网络浮现 硅谷的投资生态催生了一个紧密相连的长寿产业投资网络。在这个圈层中，人脉和过往的合作关系成为 催化新投资的关键。 Peter T ...

逆转衰老，这个人类永恒的课题，终于迎来了令人振奋的突破性进展！ 巴克衰老研究所的研究人员首次通过严谨的随机、安慰剂对照临床试验证明，一种现有的医疗手段——治疗性血浆置换（TPE），能够显著逆转健康成年 人的生物学年龄，三个月的治疗后，生物学年龄平均年轻 2.61 岁！为人类对抗衰老带来了全新的希望。 该研究以：Multi-Omics Analysis Reveals Biomarkers That Contribute to Biological Age Rejuvenation in Response to Single-Blinded Randomized Placebo- Controlled Therapeutic Plasma Exchange 为题，发表在了 Aging Cell 期刊。 这项由巴克衰老研究所和抗衰老公司 Global Apheresis 的科学家们领导的临床研究，招募了 44 名 50 岁以上的健康志愿者，以评估治疗性血浆置换 （TPE）方案对 50 岁以上健康成年人的安全性以及对生物年龄的影响，他们被随机分为 4 组： 该研究的主要目标是评估长期 TPE 治疗的安全性以及生物钟 ...

Core Insights - The article discusses a significant breakthrough in anti-aging research, demonstrating that Therapeutic Plasma Exchange (TPE) can effectively reverse biological age in healthy adults by an average of 2.61 years after three months of treatment [2][10]. Study Overview - The study, led by scientists from the Buck Institute for Research on Aging and Global Apheresis, involved 44 healthy volunteers aged 50 and above, assessing the safety and impact of TPE on biological age [5]. - Participants were divided into four groups with varying treatment frequencies and a placebo control group [5]. Methodology - TPE is designed to replace harmful aging-related molecules in the blood, such as inflammatory factors and senescent cell secretions [6]. - The process includes blood collection, plasma separation, plasma replacement with sterile fluids, and reinfusion of the treated blood [11]. Results - The study found that TPE is safe, with only two participants experiencing adverse events leading to treatment interruption [10]. - The most effective treatment was TPE combined with intravenous immunoglobulin (IVIG), which improved immune function and reduced chronic inflammation [10][14]. - Participants receiving TPE every two weeks showed the most significant biological age reduction, while those treated monthly also experienced benefits, albeit to a lesser extent [13]. Mechanisms of Action - TPE significantly improved age-related immune system decline and regulated immune cell composition towards a younger state [14]. - The therapy also reduced aging-promoting proteins and "rebooted" aging signal networks, affecting multiple aging-related signaling pathways [18]. Implications - This research marks a major advancement in aging studies, providing scientific evidence that biological aging can be measured, intervened, and potentially reversed [17]. - The findings suggest the potential for TPE to be used not only for disease treatment but also for health aging and preventive interventions [19]. - The study lays the groundwork for personalized anti-aging strategies based on individual biological markers [19].