闻乐 发自 凹非寺 量子位 | 公众号 QbitAI 熬夜会变傻有了进一步科学依据！ 缺乏休息后白天容易走神的生理机制找到了：正在被"洗脑"。 麻省理工学院的一项新研究揭示了此时大脑内部的变化。研究发现，当 注意力短暂缺失时，一波脑脊液（CSF，可以理解成大脑里的清洁 液）会从大脑流出 。 而这个"洗脑"过程通常在睡眠时发生，用于清理日间积累的废物。在睡眠不足的人身上，这个夜间睡觉时限定的活动，则会在白天清醒时启动 ——而代价是 注意力严重受损 。 该研究已经登上了Nature子刊。 这项研究引起了网友们广泛讨论，有人提到：白天小睡完就会变得非常精神，可能是因为在这个时间里洗完脑了。 △ 绿色是血液氧合信号，紫色是脑脊液信号 醒来之后，周期不见了，脑脊液就没办法大量冲进大脑，完成有效的清洗。 不过，熬夜变傻真不是吓唬人，实际上，在此之前就已经有了科学依据。 夜间睡眠是最佳洗脑时间 2019年，波士顿大学的研究团队在 Science 期刊发表了一项突破性成果，首次通过功能性磁共振成像与脑电图同步监测，清晰捕捉到了人类 睡眠时的大脑清洗全过程。 大脑内会出现大周期血氧水平依赖信号波动。红色的血液会大规模、周期性地 ...

Core Viewpoint - The study conducted by researchers at the University of Rhode Island indicates that microplastics and nanoplastics, which are prevalent in the environment, can accumulate in the brain and potentially lead to cognitive decline and symptoms similar to Alzheimer's disease, particularly in individuals carrying genetic risk factors like the APOE4 gene [1][5]. Group 1: Research Findings - Microplastics can penetrate various human body systems, including the brain, and may cross the blood-brain barrier, which typically protects the brain from harmful substances [1][2]. - The study involved genetically modified mice carrying the APOE4 gene, which is a significant risk factor for Alzheimer's disease, showing that these mice are approximately 3.5 times more likely to develop the disease compared to those with the APOE3 gene variant [1][2]. - The research demonstrated that exposure to microplastics led to behavioral changes in mice, such as increased exploration in open areas and impaired recognition of new objects, indicating cognitive decline [3][4]. Group 2: Implications and Future Research - The findings raise concerns about the widespread exposure to microplastics as environmental toxins and highlight the need for further research into their health impacts [5]. - The study encourages stricter regulations on microplastics, with the U.S. House of Representatives proposing the Microplastics Safety Act to investigate the effects of microplastics on human health, particularly in vulnerable populations [5]. - The researcher emphasizes the necessity for increased funding and research on the health impacts of microplastics, noting that observed trends in mice align with real-world observations [5].