包括抑郁症、焦虑症在内的中枢神经系统治疗领域是本集团长期布局的核心战略领域之一。围绕该领 域，集团已形成一系列具有差异化优势的产品组合，涵盖精神分裂症、双相障碍、阿尔茨海默病等多种 疾病。除了若欣林®，产品组合还包括：在美国获批上市的Erzofri®(棕榈酸帕利哌酮缓释混悬注射 液)、Rykindo® (利培酮缓释微球注射剂)，在欧洲多国、日本、中国获批上市的利斯的明透皮贴剂(2 次/W)等。同时，集团积极布局下一代创新药的研发，另有包括VMAT2/ Sigma-1R双靶点新药 LY03015、5-HT2A R/5-HT2C R双靶点新药LY03017、TAAR1/5 HT2C R双靶点新药LY03020、 NET/DAT/GABAA R三靶点新药LY03021等多个1类创新药处于临床阶段。 临床应用中，选择性5-羟色胺再摄取抑制剂(SSRIs)、5-羟色胺和去甲肾上腺素再摄取抑制剂(SNRIs)被 广泛用于焦虑谱系障碍的治疗，也是目前治疗广泛性焦虑障碍的一线药物。然而，该两类药物的疗效仍 有限。荟萃分析显示， SSRIs/SNRIs整体有效率为67.7%，缓解率仅为39.7%;此外，该两类药物通常伴 有脂代 ...

这一发现对于理解自身免疫疾病具有重要意义。研究团队表示，诸如1型糖尿病、红斑狼疮和多发 性硬化症等疾病往往需要外部触发因素，而压力可能正是其中之一。 科技日报北京12月4日电 （记者张佳欣）美国哈佛大学研究团队在最新一期《细胞》杂志上发表研 究成果，揭示了压力导致脱发的双重机制，这可能为理解自身免疫疾病提供新线索。 团队进一步通过电子显微成像发现第二重机制，即被去甲肾上腺素破坏的毛囊"看起来就像被倒上 了盐酸一样"坏死。深入观察发现，在去甲肾上腺素释放之后，人体会把发炎或坏死组织视为外来入侵 者。这反过来又会触发一连串免疫反应，激活自身反应性的CD8+T细胞，这些细胞在错误判断下攻击 毛囊，使脱发可能反复发生，并产生持久影响。 研究显示，压力导致脱发的第一重是"即时脱发"机制，这是一种来自交感神经系统的即时反应。人 体面对压力时，会触发天然的"战或逃"机制，释放大量去甲肾上腺素。这种神经递质在浓度过高时，会 杀死毛囊中高度增殖的细胞。但由于毛囊干细胞未受损，毛发通常可再生，因此这种脱发多为暂时性 的。 ...

Core Insights - A new study from MIT provides scientific evidence that lack of sleep can impair attention due to a physiological mechanism where cerebrospinal fluid (CSF) is involved in "cleaning" the brain during sleep, which is disrupted when sleep is insufficient [2][18] Group 1: Research Findings - The study reveals that during moments of attention lapses, a wave of cerebrospinal fluid flows out of the brain, a process typically occurring during sleep to clear waste accumulated during the day [2][18] - Insufficient sleep leads to the activation of this cleaning process during waking hours, resulting in significant attention deficits [18][21] - The research involved 26 healthy volunteers who underwent attention tests under both sufficient and insufficient sleep conditions, showing that sleep-deprived individuals had longer reaction times and sometimes failed to respond altogether [19][21] Group 2: Mechanism of Action - The study indicates that during deep sleep, a synchronized activity of neurons allows for a significant withdrawal of blood, creating space for cerebrospinal fluid to enter and cleanse the brain [15][26] - In contrast, when awake, the active state of neurons prevents this cleaning process, leading to a buildup of waste and forcing the brain to initiate a similar cleaning mechanism while awake, which detracts from attention resources [26][27] - The research suggests that there may be a central switch in the brain that regulates attention and the flow of cerebrospinal fluid, potentially influenced by norepinephrine [29]

Core Viewpoint - The article highlights the significant contributions of Professor Danyang in the field of sleep research and her recent affiliation with Shenzhen Medical Academy, where she will establish a Sleep and Consciousness Laboratory [1][4]. Group 1: Professor Danyang's Background - Professor Danyang graduated from Peking University with a degree in Physics and later pursued a PhD in Biology at Columbia University, followed by postdoctoral research at Rockefeller University and Harvard Medical School [4]. - She has been a faculty member at the University of California, Berkeley since 1997, focusing on the neural circuits that control sleep and the functions of the prefrontal cortex [4][21]. Group 2: Recent Research Contributions - On December 8, 2023, Professor Danyang's team published a study in Cell, revealing that frontal cortical ignition, related to consciousness awareness, is strongly suppressed during NREM sleep in mice due to cholinergic modulation [7][10]. - On January 18, 2024, a study published in Nature Neuroscience demonstrated that microglia can promote sleep through calcium-dependent modulation of norepinephrine transmission, suggesting a protective role for microglia in brain health [12][13]. - On January 17, 2025, a study in Science Advances explored how activation of locus coeruleus noradrenergic neurons rapidly increases homeostatic sleep pressure, indicating a mechanism for sleep regulation [15][17]. Group 3: Implications for Sleep Research - The findings from Professor Danyang's research suggest that understanding the mechanisms of sleep regulation could have implications for addressing sleep disruptions associated with neurodegenerative diseases like Alzheimer's [13]. - The research emphasizes the importance of microglial function in maintaining sleep and brain homeostasis, potentially offering insights into therapeutic strategies for sleep-related disorders [13]. - The studies collectively indicate that the functional fatigue of locus coeruleus neurons may lead to increased sleep pressure, providing a new perspective on the relationship between wakefulness and sleep [17].