闻乐 发自 凹非寺 量子位 | 公众号 QbitAI 熬夜会变傻有了进一步科学依据！ 缺乏休息后白天容易走神的生理机制找到了：正在被"洗脑"。 麻省理工学院的一项新研究揭示了此时大脑内部的变化。研究发现，当 注意力短暂缺失时，一波脑脊液（CSF，可以理解成大脑里的清洁 液）会从大脑流出 。 而这个"洗脑"过程通常在睡眠时发生，用于清理日间积累的废物。在睡眠不足的人身上，这个夜间睡觉时限定的活动，则会在白天清醒时启动 ——而代价是 注意力严重受损 。 该研究已经登上了Nature子刊。 这项研究引起了网友们广泛讨论，有人提到：白天小睡完就会变得非常精神，可能是因为在这个时间里洗完脑了。 △ 绿色是血液氧合信号，紫色是脑脊液信号 醒来之后，周期不见了，脑脊液就没办法大量冲进大脑，完成有效的清洗。 不过，熬夜变傻真不是吓唬人，实际上，在此之前就已经有了科学依据。 夜间睡眠是最佳洗脑时间 2019年，波士顿大学的研究团队在 Science 期刊发表了一项突破性成果，首次通过功能性磁共振成像与脑电图同步监测，清晰捕捉到了人类 睡眠时的大脑清洗全过程。 大脑内会出现大周期血氧水平依赖信号波动。红色的血液会大规模、周期性地 ...

Core Viewpoint - The article highlights the significant contributions of Professor Danyang in the field of sleep research and her recent affiliation with Shenzhen Medical Academy, where she will establish a Sleep and Consciousness Laboratory [1][4]. Group 1: Professor Danyang's Background - Professor Danyang graduated from Peking University with a degree in Physics and later pursued a PhD in Biology at Columbia University, followed by postdoctoral research at Rockefeller University and Harvard Medical School [4]. - She has been a faculty member at the University of California, Berkeley since 1997, focusing on the neural circuits that control sleep and the functions of the prefrontal cortex [4][21]. Group 2: Recent Research Contributions - On December 8, 2023, Professor Danyang's team published a study in Cell, revealing that frontal cortical ignition, related to consciousness awareness, is strongly suppressed during NREM sleep in mice due to cholinergic modulation [7][10]. - On January 18, 2024, a study published in Nature Neuroscience demonstrated that microglia can promote sleep through calcium-dependent modulation of norepinephrine transmission, suggesting a protective role for microglia in brain health [12][13]. - On January 17, 2025, a study in Science Advances explored how activation of locus coeruleus noradrenergic neurons rapidly increases homeostatic sleep pressure, indicating a mechanism for sleep regulation [15][17]. Group 3: Implications for Sleep Research - The findings from Professor Danyang's research suggest that understanding the mechanisms of sleep regulation could have implications for addressing sleep disruptions associated with neurodegenerative diseases like Alzheimer's [13]. - The research emphasizes the importance of microglial function in maintaining sleep and brain homeostasis, potentially offering insights into therapeutic strategies for sleep-related disorders [13]. - The studies collectively indicate that the functional fatigue of locus coeruleus neurons may lead to increased sleep pressure, providing a new perspective on the relationship between wakefulness and sleep [17].