Core Viewpoint - The article discusses the effectiveness and timeline of the weight loss drug Semaglutide (Ozempic, Wegovy), highlighting that users can expect to see significant weight loss results within a few months of starting the treatment [2][4]. Summary by Sections Effectiveness of Semaglutide - Users of Semaglutide can expect to lose between 5% to 20% of their body weight within a year, depending on their initial weight [4]. - A study published in 2022 indicated that overweight or obese individuals lost an average of 5.9% of their weight after three months and 10.9% after six months of using Semaglutide [4]. Timeline of Effects - Initial absorption of Semaglutide occurs within 1-2 hours after subcutaneous injection [10]. - Peak concentration in the bloodstream is reached within 24-48 hours, where the drug actively binds to GLP-1 receptors [11]. - Noticeable effects, such as reduced appetite and improved blood sugar regulation, may begin within 1-2 weeks [12]. - Steady-state levels of the drug are achieved after 4-5 weeks, leading to more pronounced appetite suppression and accelerated weight loss [13]. Factors Influencing Effectiveness - **Metabolism**: Conditions like fatty liver, diabetes, and high blood sugar can complicate weight loss efforts and may delay the initial effects of Semaglutide [14]. - **Age**: Metabolism slows with age, potentially affecting the drug's efficacy, especially in individuals over 60 [15]. - **Gender**: Research suggests that women may experience better weight loss results with Semaglutide compared to men, possibly due to differences in body fat composition and insulin resistance [17]. - **Concurrent Medications**: Certain medications, such as chemotherapy drugs and steroids, can lead to weight gain, potentially diminishing the effectiveness of Semaglutide [18]. - **Treatment Plan and Dosage**: Higher doses of Semaglutide may lead to more noticeable effects and side effects, but the optimal dosage should be determined in consultation with a healthcare provider [19]. - **Genetics**: Individual genetic factors can influence the response to Semaglutide, leading to variability in effectiveness among users [20]. - **Lifestyle Factors**: Combining Semaglutide with lifestyle changes, such as exercise and a balanced diet, enhances weight loss outcomes [21].

Core Viewpoint - The article discusses the rising trend of weight loss among celebrities and entrepreneurs, highlighting the effectiveness of GLP-1 medications like Semaglutide and Tirzepatide in achieving significant weight loss results [2][15][31]. Group 1: Celebrity Weight Loss Stories - Yan Rujing lost 55 pounds (approximately 24.9 kg) over six months, starting from a weight of 196 pounds (approximately 89 kg) with a body fat percentage of 48.6% and a BMI of 40.27, indicating severe obesity [4][6]. - Lamei Yang achieved a weight loss of 20 pounds (approximately 9.1 kg) in just one month during the filming of "Sisters Who Make Waves," through an intense training regimen of 8 hours daily [7][11]. - Ma Weiwei lost 20 pounds (approximately 9.1 kg) in 45 days, adopting a low-carb diet and rigorous exercise, while also managing her mental health challenges related to depression [12][14]. Group 2: GLP-1 Medications Effectiveness - Semaglutide has shown an average weight loss of 15% in obese patients, significantly outperforming previous weight loss medications that typically resulted in a 5%-10% reduction [26][30]. - In clinical trials, Semaglutide demonstrated that over one-third of participants lost more than 20% of their body weight, while the placebo group only lost 2.4% [28]. - Tirzepatide has also proven effective, with studies showing an average weight loss of 15.4% to 22.9% in patients, significantly reducing the risk of diabetes progression [31][34].

Core Viewpoint - The article discusses the rising trend of weight loss among celebrities and public figures, highlighting the role of GLP-1 medications like Semaglutide and Tirzepatide in achieving significant weight loss results, with average reductions of 15% and 20% respectively. The impact of social media on public perception and awareness of weight loss is also emphasized [3][20][26]. Group 1: Celebrity Weight Loss Stories - Chinese singer and actress Chui Nalisah lost 70 pounds due to health concerns, specifically severe fatty liver disease, and emphasizes the importance of health over aesthetics [3][7]. - Elon Musk reported a weight loss of 30 pounds (approximately 27.2 pounds) using Semaglutide [8]. - Oscar winner Whoopi Goldberg shared her experience of using Tirzepatide to manage her weight after gaining due to steroid treatment [10]. - Grammy winner Kelly Clarkson attributed her slim figure to Semaglutide, alongside a high-protein diet and exercise [12]. - Jon Gosselin lost 32 pounds in two months after using Semaglutide, expressing regret for not starting earlier [14]. - Jeremy Clarkson began using Semaglutide after hearing positive feedback from others about its appetite-suppressing effects [16]. - Influencer Shannon Natalia lost approximately 20 kilograms with the help of Semaglutide while battling lipedema [18]. Group 2: Efficacy of Semaglutide - The STEP series of studies demonstrated that Semaglutide leads to an average weight loss of 15% in obese patients, significantly outperforming previous weight loss medications [20][25]. - In the STEP 1 study, participants lost an average of 14.9%, with over one-third losing more than 20% of their body weight [22]. - The STEP 2 study showed a 10.6% average weight reduction in patients with type 2 diabetes, with improvements in cardiovascular risk factors and quality of life [22]. - The STEP 3 study indicated a 16% weight loss when combined with behavioral therapy, compared to 5.7% in the placebo group [22]. - The STEP 4 study found that continuous use of Semaglutide resulted in an 18.2% weight loss over time [23]. - The STEP 7 study, focusing on a Chinese population, reported a 12.1% average weight loss with Semaglutide [23]. Group 3: Efficacy of Tirzepatide - The SURMOUNT-1 study showed that Tirzepatide significantly reduced weight in prediabetic patients, with average weight losses of 15.4% to 22.9% depending on dosage [26][28]. - The SURMOUNT-2 study confirmed a 15.7% average weight loss in type 2 diabetes patients using higher doses of Tirzepatide [28]. - The SURMOUNT-3 trial reported a weight loss of up to 26.6% after 72 weeks of treatment [30]. - The SURMOUNT-5 trial indicated that Tirzepatide outperformed Semaglutide, with participants losing an average of 50.3 pounds (22.8 kg) compared to 33.1 pounds (15.0 kg) for Semaglutide [30].