Summary of Alpha Molecular Technology Conference Call Company Overview - **Company**: Alpha Molecular Technology - **Focus**: AI drug development targeting GPCR (G protein-coupled receptors) - **Funding**: Completed 150 million RMB financing - **Pipeline**: Four research pipelines, with the autoimmune pipeline progressing the fastest, currently in Phase I clinical trials, expected to complete EA clinical trials by 2026 [2][6][21] Industry Insights - **GPCR Target Potential**: GPCR targets have significant development potential, with GLP-1 drugs like Semaglutide and Tirzepatide projected to generate sales of $175 billion and $11.5 billion respectively by 2024 [2][7] - **Market Position**: Alpha Molecular Technology holds a first-mover advantage in the GPCR field, having achieved high prediction accuracy in the 2021 Global GPCR Drug Competition, surpassing Google’s AlphaFold 2 [2][7] Key Developments - **Clinical Trials**: The drug AM001 (mast cell receptor modulator) has entered the EA stage, with all EB experiments expected to be completed by the end of 2027. Indications include atopic dermatitis, chronic urticaria, and IBD (inflammatory bowel disease) [2][10][12] - **Safety Profile**: The design of autoimmune pipeline drugs emphasizes safety, showing promising results in healthy human data and animal studies, indicating potential to become a first-in-class (FIC) drug [11][12] Strategic Plans - **Business Development (BD)**: Alpha plans to engage in BD transactions after validating healthy human data, particularly for popular targets like GLP-1, potentially entering the IND enabling stage [3][17] - **IPO Prospects**: The company anticipates a significant opportunity for an IPO within five years, contingent on clinical progress [3][23] Team and Expertise - **Founders**: The founding team, led by Dr. Yuan Shuguang and Academician Hostogo, brings extensive experience in GPCR research and AI, with Dr. Yuan having over 16 years in the field [4][8] - **Collaborations**: The company collaborates with NVIDIA for hardware support and has participated in their startup acceleration program [9][26] Research and Development - **Pipeline Logic**: The four pipelines cover metabolic weight loss and cancer pain relief, with two targeting weight loss through non-GLP-1 and GLP-1/GIP2/GCGR pathways [15][16] - **Data Utilization**: Alpha utilizes external data to enhance its AI platform, improving drug development efficiency [18][19] Financial Overview - **Valuation**: The latest financing round valued the company at approximately 500 million RMB, with funds primarily allocated to clinical trials for the autoimmune pipeline [21] Future Directions - **Long-term Goals**: The company aims to evolve from a startup to a firm deeply engaged in GPCR target research, with plans to advance more pipelines into clinical trials and potentially launch new drugs [27]

Core Insights - The collaboration between Four Seasons Medicine (00460.HK) and Abalone Bio focuses on developing innovative treatments for obesity by targeting metabolic GPCRs to enhance energy expenditure while maintaining or increasing muscle mass [1][2] Group 1: Collaboration Details - The agreement allows both companies to leverage their strengths: Abalone will provide its core technology in GPCR antibody discovery, while Four Seasons Medicine will contribute its research in metabolic diseases and established business framework in Greater China [2] - This partnership marks a transition from a capital investment to a business execution level, reinforcing Four Seasons Medicine's innovative positioning in the weight loss sector [2] Group 2: Technical and Market Context - GPCRs are a complex family of membrane proteins, and developing agonistic antibodies for them has been a recognized challenge in the pharmaceutical industry [1] - Abalone's unique functional antibody screening technology and AI capabilities position it well to tackle the regulatory challenges associated with GPCRs, enhancing the potential for successful drug development [1]

Core Insights - The collaboration between Four环医药 and AbaloneBio aims to develop innovative obesity treatment drugs by targeting metabolic-related GPCRs to enhance energy expenditure while maintaining or increasing muscle mass [1][2] - The partnership is based on complementary strengths, with Abalone providing its core technology in GPCR antibody discovery and Four环医药 contributing its research and industrial resources in metabolic diseases [2] Group 1 - Four环医药 has signed a formal collaboration agreement with AbaloneBio to advance the research and development of next-generation obesity treatments [1] - The project focuses on overcoming the limitations of current weight loss therapies to meet unmet clinical needs in the global obesity treatment market [1] - GPCRs are a challenging target for drug development due to their complex structural requirements, and Abalone's unique functional antibody screening technology aims to address these challenges [1] Group 2 - The collaboration follows Four环医药's strategic investment in Abalone earlier this year, marking a transition from capital investment to business execution [2] - This partnership is expected to enhance Four环医药's innovative positioning in the weight loss sector and accelerate the development of new weight loss and muscle gain therapies [2] - The collaboration also represents a significant step in Four环医药's ongoing strategy to deepen its involvement in the GPCR target area, building on previous investments in related companies [2]

Core Viewpoint - The collaboration between Four环医药 and AbaloneBio aims to develop innovative obesity treatment drugs by targeting metabolic-related GPCRs, addressing current limitations in weight loss therapies and meeting unmet clinical needs globally [1][2] Group 1: Collaboration Details - Four环医药 has signed a cooperation agreement with AbaloneBio to jointly advance the research and development of next-generation obesity treatments [1] - The project focuses on enhancing energy expenditure safely and effectively while maintaining or increasing muscle mass [1] - AbaloneBio will provide its core technology and platform support in GPCR antibody discovery, while Four环医药 will contribute its research and industrial resources in metabolic diseases [2] Group 2: Strategic Importance - The partnership extends from a previous strategic investment in Abalone, marking a shift from capital involvement to operational execution [2] - This collaboration strengthens Four环医药's innovative positioning in the weight loss sector and accelerates the development of new weight loss and muscle gain therapies [2] - The partnership is also a significant step in deepening Four环医药's focus on GPCR targets, building on prior investments in companies like DJS Antibodies, which has been recognized for its GPCR-targeted antibody development [2]

香港交易及結算所有限公司及香港聯合交易所有限公司對本公告之內容概不 負 責，對 其 準 確 性 或 完 整 性 亦 不 發 表 任 何 聲 明，並 明 確 表 示，概 不 就 因 本 公 告 全部或任何部份內容而產生或因倚賴該等內容而引致之任何損失承擔任何責 任。 Sihuan Pharmaceutical Holdings Group Ltd. 四環醫藥控股集團有限公司 （於百慕達註冊成立的有限公司） （股份代號：0460） – 1 – GPCRs屬 於 龐 大 且 動 態 的 膜 蛋 白 家 族，其 活 性 調 控 對 結 構 變 化 的 精 準 度 要 求 極 高，因 此，針 對 此 類 受 體 的 啟 動 型 抗 體 研 發，長 期 以 來 為 製 藥 行 業 公 認 的 技 術 難 點。Abalone憑 藉 其 獨 有 的 功 能 性 抗 體 篩 選 技 術 平 台，專 注 於 攻 克 難 成 藥 膜 蛋 白（尤 其GPCRs）的 調 控 難 題，具 備 大 規 模 量 測 抗 體 功 能 活 性 數 據 的 能 力，並 可 依 托 人 工 智 慧 技 術，開 展 啟 動 型 抗 體 的 發 現 與 ...