PresentationLadies and gentlemen, thank you very much for joining us today for Q&A session of AGC's Life Science business. I am Tamaki from PR and IR. It is my pleasure to serve you as [ EMC ]. Let me introduce the speaker of the day, our Senior Executive Officer and President of Life Science Company, Tadashi Murano.First off, we would like to have Murano-san give you an outline of our Life Science business, followed by questions and answers. The materials to be used have been uploaded through our website. ...

Core Viewpoint - The company has successfully obtained the Drug Registration Certificate for its trivalent influenza virus split vaccine, marking a significant achievement in its commitment to dual-driven technology and market strategies [1] Group 1: Product Development - The trivalent influenza vaccine was developed by the company's wholly-owned subsidiary, Anhui Zhifei Longkema Biological Pharmaceutical Co., Ltd [1] - This vaccine adds to the company's existing portfolio, which includes a quadrivalent influenza vaccine already approved for market and other vaccines in various stages of clinical trials and approval [1] Group 2: Market Strategy - The successful registration of the trivalent influenza vaccine demonstrates the company's innovative research and development capabilities [1] - The company aims to enhance its comprehensive competitiveness and promote sustainable and steady growth by offering a diverse range of high-quality products to meet public health needs [1]

Core Viewpoint - The company, Zhifei Biological Products (300122.SZ), has successfully obtained a drug registration certificate for its trivalent influenza virus split vaccine from the National Medical Products Administration, showcasing its innovation and research capabilities [1] Group 1: Product Development - The trivalent influenza vaccine is developed by the company's wholly-owned subsidiary, Anhui Zhifei Longkema Biological Pharmaceutical Co., Ltd [1] - This achievement reflects the company's commitment to a dual-driven strategy of "technology & market," laying a solid foundation for further market expansion [1] Group 2: Product Portfolio - The newly registered trivalent influenza vaccine complements the company's existing product lineup, which includes a quadrivalent influenza virus split vaccine already approved for market, a quadrivalent/trivalent influenza vaccine (for children) currently under review, and a quadrivalent influenza vaccine (ZFA02 adjuvant) in Phase I/II clinical trials [1] - The comprehensive range of influenza vaccines covers all age groups and enhances the variety of products offered by the company [1] Group 3: Strategic Goals - The company aims to provide more high-quality products to meet public health needs, strengthen its overall competitiveness, and promote sustainable and steady development [1]

Group 1 - The core point of the article is that Zhifei Biological has recently obtained a patent for a method to detect quality differences in immune adjuvants, which may enhance its product offerings and competitive edge in the biopharmaceutical industry [1] - Zhifei Biological's revenue composition for the year 2024 is heavily reliant on biological products, accounting for 99.14% of total revenue, indicating a strong focus on this segment [2] - As of the latest report, Zhifei Biological has a market capitalization of 49.7 billion yuan, reflecting its significant position in the market [3]

Core Viewpoint - The company Zhifei Biological's subsidiary has received a drug registration certificate for its influenza virus split vaccine, which is aimed at individuals aged 32 and above to prevent infections caused by the influenza virus [1] Group 1: Product Development - The newly approved trivalent influenza vaccine is one of the main products for influenza prevention both domestically and internationally [1] - The company has a diverse range of influenza vaccine products, including an already approved quadrivalent influenza virus split vaccine and a trivalent influenza virus split vaccine that is currently in clinical trials [1] Group 2: Market Position - The vaccine series covers all age groups, indicating a comprehensive approach to influenza prevention [1] - The company is expanding its product offerings with various types of influenza vaccines, enhancing its market presence [1]

Core Points - Shanghai Junshi Biosciences Co., Ltd. announced a stock option incentive plan for 2025, proposing to grant a total of 25.965871 million rights [1] - The initial grant consists of 25.15 million options, accounting for 96.86% of the total, with Chairman Xiong Jun receiving 8 million options, representing 30.81% of the total options granted [1] - A total of 234 other incentive recipients will receive 17.15 million options, which is 66.05% of the total [1] - The reserved portion of the incentive plan is 815,871 options, making up 3.14% of the total [1] - The plan complies with relevant regulations, and the incentive recipients do not include independent directors, supervisors, or senior executives [1] - The reserved incentive recipients will be determined and disclosed within 12 months [1]

在近日召开的"2025阿斯利康中国研发日"期间，阿斯利康全球执行副总裁、生物制药研发负责人贝旭鸿 接受记者采访时表示，阿斯利康今年初宣布在北京投资25亿美元，其中包括在北京建立第六个全球战略 研发中心，并计划建立一个先进的人工智能（AI）和数据科学实验室。主要原因包括：中国已成为全 球创新药物枢纽，且在整个过程中，药物研发和创新势头都非常良好。同时，全球范围内，由中国研发 的药物数量也出现了翻倍的增长，约三分之一的全球授权交易是与中国生物制药企业达成的。 "过去两年，阿斯利康已与14家中国生物技术公司（biotech）签订了15项授权许可交易。"贝旭鸿举例 称，两年前，阿斯利康与诚益生物签订了战略合作协议。诚益生物的候选分子药物AZD5004，是一个 小分子药物，阿斯利康希望通过自身研发和生产平台，能够尽快地开发这款创新的小分子药物。"这款 药物的研发进展良好，目前全球正在进行2B期的临床试验，预计会在今年年底或2026年年初进行公 布。"贝旭鸿说。 贝旭鸿表示："近年来，中国凭借丰富的临床研究资源与不断提升的创新能力，正逐渐成为全球基础研 究和临床开发的关键枢纽，在药物研发中发挥着越来越大的价值。期待未来在 ...

香港交易及結算所有限公司及香港聯合交易所有限公司對本公告的內容概不 負 責，對 其 準 確 性 或 完 整 性 亦 不 發 表 任 何 聲 明，並 明 確 表 示，概 不 對 因 本 公 告 全部或任何部分內容而產生或因倚賴該等內容而引致的任何損失承擔任何責 任。 （股份代號：3309） （於開曼群島註冊成立之有限公司） 自願性公告 最新業務進展 希 瑪 醫 療 控 股 有 限 公 司（「本公司」，連 同 其 附 屬 公 司 統 稱「本集團」）董 事 會（「董 事 會」）欣 然 宣 佈，於2025年9月29日，希 華 醫 藥 有 限 公 司（「希華醫藥」）的 一 間 附 屬公司與Gilead Sciences, Inc.（「Gilead」）及 韓 美 藥 品 工 業 株 式 会 社（「韓 美」）就 病 毒 學領域首款P－糖 蛋 白（「P-gp」）抑 制 劑encequidar（希 華 醫 藥 擁 有 該 款 藥 物 在 韓 國 以 外 的 全 球 獨 家 權 利）訂 立 三 方 全 球 授 權 及 合 作 協 議。 根 據 協 議，希 華 醫 藥 及 韓 美 會 將encequidar在病毒學領域的全球獨家權 ...

Core Viewpoint - Kanghong Pharmaceutical (002773.SZ) is enhancing its gene therapy development by increasing capital in its subsidiary, Chengdu Hongji Biotechnology Co., Ltd. (referred to as "Hongji Bio") to support strategic planning and motivate management teams [1] Group 1: Capital Increase Details - The capital increase amount is 1.54 million yuan, with contributions from three management consulting partnerships: Kangji contributing 460,000 yuan, Kangyin contributing 370,000 yuan, and Kangzhi contributing 710,000 yuan [1] - The company has waived its preferential subscription rights for this capital increase [1] Group 2: Corporate Structure Changes - Hongji Bio has completed the registration of increased capital and changes in shareholding structure, obtaining a new business license from the Chengdu Market Supervision Administration [1] - The company's shareholding in Hongji Bio has decreased from 86.95% to 86.53%, but Hongji Bio remains a controlled subsidiary and is included in the company's consolidated financial statements [1]

Core Viewpoint - Sinopharm's subsidiary Salubris Biotherapeutics has made significant progress with its innovative biologics JK07 and JK06, which are currently undergoing clinical trials for heart failure and solid tumors respectively [1][2][3] Group 1: JK07 Development - JK07 is in a Phase II clinical trial (RENEU-HF) for patients with HFrEF and HFpEF, with all patient enrollments for HFrEF completed and results expected in the first half of 2026 [1] - The trial is randomized, double-blind, placebo-controlled, and aims to assess the safety and efficacy of JK07, with a total of 215 HFrEF patients enrolled [1] - The primary endpoint for the HFrEF cohort is the change in left ventricular ejection fraction after 26 weeks of follow-up [1] Group 2: JK07 in Pulmonary Hypertension - JK07 has received FDA approval for a clinical trial (RENEU-PH) targeting pulmonary hypertension caused by left heart disease, with a Phase IIa study now initiated [2] - The study is an open-label, dose-escalation trial aimed at evaluating the safety, efficacy, and tolerability of JK07 in patients with cpcPH, planning to enroll up to 30 patients [2] - Epidemiological studies indicate that up to 50% of HFrEF or HFpEF patients exhibit varying degrees of pulmonary hypertension, which significantly worsens prognosis [2] Group 3: JK06 Development - JK06 is a selective 5T4-targeting antibody-drug conjugate (ADC) currently undergoing Phase I clinical trials in Europe, with plans for dose expansion studies by the end of the year [3] - Initial data from the Phase I trial is expected to be presented at the ESMO conference in October 2025 [3] - The trial aims to assess the safety, pharmacokinetics, and preliminary efficacy of JK06 in patients with solid tumors expressing the 5T4 protein, with a maximum enrollment of 155 patients [3]