超额配售选择权行使前，康乐卫士募集资金总额为29,400.00万元，扣除发行费用2,737.59万元(不含增值 税)后，募集资金净额为26,662.41万元。公司募集资金净额比原计划少3,337.59万元。2023年2月28日公 司招股书显示，康乐卫士拟募集资金30,000.00万元，用于HPV疫苗研发项目、昆明生产基地代建回购项 目。 康乐卫士发行费用总额为2,737.59万元(超额配售选择权行使前)；3,008.02万元(若超额配售选择权全额行 使后)，其中中信证券、国信证券获得承销保荐费1,902.83万元(超额配售选择权行使前)；2,173.25万元 (超额配售选择权全额行使后)。 中国经济网北京9月22日讯康乐卫士(833575.BJ)今日股价截至收盘报14.71元，跌幅6.9%。目前该股处于 破发状态。 康乐卫士于2023年3月15日在北交所上市，发行价为42.00元，该股上市首日开盘破发，截至收盘报35.52 元，跌幅15.43%。 康乐卫士在北交所发行数量7,000,000股(不含超额配售选择权)；8,050,000股(全额行使超额配售选择权 后)，保荐机构(主承销商)为中信证券股份有限公司， ...

Core Viewpoint - The Trump administration's health officials plan to present claims linking COVID-19 vaccines to 25 child deaths to a key vaccine advisory committee, impacting biotech stocks negatively [1] Group 1: Impact on Biotech Stocks - Following the news, U.S. biotech stocks experienced significant declines, with BioNTech down 7.26%, Pfizer down 3.98%, Moderna down 7.40%, and Novavax down 3.62% [1] - Citigroup highlighted the volatility risk for biotech companies due to the news, emphasizing the robust research supporting COVID-19 vaccines and billions of doses administered [1] Group 2: Company Ratings by Citigroup - **BioNTech**: Rated "Buy" with a target price of $140, but considered "high risk" due to typical volatility in biotech stocks and uncertainties in clinical trials [3] - **Moderna**: Rated "Neutral" with a target price of $30, also deemed "high risk" with potential down risks related to market stability and product effectiveness [4] - **Novavax**: Rated "Sell" with a target price of $6, facing risks but with potential upside if the COVID-19 vaccine market recovers unexpectedly [5] - **Pfizer**: Target price set at $26, with both upside and downside risks related to new drug sales and competitive pressures [6]

Market Overview - The U.S. stock market showed mixed results, with the Nasdaq closing at a record high, supported by Microsoft, while investors focused on the upcoming Federal Reserve policy meeting, where a rate cut is widely expected due to a slowing job market [2] - The Dow Jones Industrial Average fell by 273.78 points, or 0.59%, to 45,834.22 points, while the Nasdaq rose by 0.44% to 22,141.10 points, and the S&P 500 dipped by 0.05% to 6,584.29 points [2] - The Dow gained 0.95% for the week, the Nasdaq increased by 2.03%, and the S&P 500 rose by 1.59%, marking the best weekly performance for the S&P 500 since early August [2] Individual Stocks - Tesla surged by 7.4%, while Microsoft rose by 1.8%, Apple by 1.7%, and Meta by 0.6%. Nvidia and Google saw minor increases, while Amazon fell by 0.8% and Oracle dropped by 5.1% [2][6] - Microsoft avoided potential high antitrust fines from the EU by offering a discounted Office product without Teams components and reached a non-binding agreement with OpenAI [5] - Warner Bros Discovery's stock increased by nearly 17% amid reports of a potential acquisition offer from Paramount Skydance [6] Economic Indicators - The University of Michigan's consumer confidence index fell to 55.4 in September, the lowest since May, down from 58.2 in August, indicating rising concerns about the economy [4] - The 10-year U.S. Treasury yield rose by 3.3 basis points to 4.06%, while the 2-year yield increased by 1.2 basis points to 3.56% [3] Inflation and Federal Reserve Expectations - Recent inflation reports have reinforced expectations for a Federal Reserve rate cut, with traders fully pricing in a 25 basis point cut next week [5] - The CME FedWatch Tool indicates a 7.5% probability for a 50 basis point cut, with expectations for a total of 75 basis points in cuts this year and an additional 50-75 basis points in the next 12 months [5]

Core Viewpoint - A new mRNA vaccine platform developed by researchers at Yale University aims to significantly enhance immune responses and expand the application potential of mRNA vaccines in various disease prevention and treatment [1][2]. Group 1: Vaccine Technology - The new technology, named "Molecular Vaccine Platform" (MVP), addresses the issue of antigen exposure by adding a "cellular GPS" module to mRNA-encoded proteins, guiding them efficiently to the cell surface [1][2]. - The "cellular GPS" module consists of natural membrane protein elements, including signal peptides and transmembrane anchors, which ensure stable expression of proteins on the cell membrane [2]. Group 2: Experimental Results - Laboratory tests on various pathogens, including monkeypox, human papillomavirus (HPV), and varicella-zoster virus, demonstrated stronger antigen expression, higher antibody levels, and more active T-cell responses [2]. Group 3: Future Applications - Researchers are working to expand this technology to broader disease areas, including cancer, AIDS, and autoimmune diseases, aiming to transition mRNA technology from infectious disease prevention to comprehensive medical applications [2][3]. - The MVP technology is expected to accelerate the development of new vaccines, reduce research and development costs and timelines, and elevate vaccine technology to new heights [3].

Group 1 - European stock markets declined, with wind energy-related stocks leading the drop after Orsted A/S's project in the U.S. was halted [1] - The Stoxx Europe 600 index closed down 0.4%, while the UK market was closed for a holiday [1] - The French CAC 40 index fell 1.6%, with notable declines in major companies such as BNP Paribas down 3.5%, AXA SA down 3.8%, and Engie SA down 2.4% [1] Group 2 - Orsted's stock plummeted 19% to a record low, making it the worst performer in the index, following the halt of its nearly completed offshore wind project by the Trump administration [1] - Vestas Wind Systems A/S, a wind turbine manufacturer, also saw a decline of 3.5% [1] Group 3 - Keurig Dr Pepper Inc. agreed to acquire JDE Peet's NV for €15.7 billion, resulting in a 17% surge in JDE Peet's stock price [1] - Valneva SE experienced a 22% drop after its vaccine for mosquito-borne diseases was halted in the U.S. due to adverse reactions in elderly patients [1]

值得一提的是，三叶草生物-B是首批通过港交所18A规则上市的生物科技公司之一，曾引入高瓴、淡马 锡等知名机构作为基石投资者。公司依托自主研发的Trimer-Tag平台，该技术通过模拟人体胶原蛋白三 聚体结构，可将任意病毒抗原稳定为类天然三聚体形态，已验证适用于新冠、RSV等多种疫苗开发。 三叶草生物-B(02197)盘中涨近12%，近一个月股价累计涨幅逾2倍。截至发稿，涨10%，报0.88港元， 成交额1029.42万港元。 消息面上，三叶草生物-B拟于8月26日举行董事会会议考虑及批准中期业绩。据悉，三叶草生物-B是一 家专注于呼吸道疫苗研发的生物科技公司，其核心技术平台和产品管线在行业内具有显著差异化。公司 此前宣布，一项评估SCB-1022(RSV+hMPV)及SCB1033(RSV+hMPV+PIV3)呼吸道联合疫苗候选产品的I 期临床试验已完成首批受试者入组。该等疫苗候选产品开发的融合前稳定的F(PreF)三聚体亚单位疫苗 抗原基于三叶草生物的蛋白质三聚体化疫苗技术平台。 ...

Core Viewpoint - Three Leaf Clover Biotech-B (02197) has seen a significant stock price increase, with a nearly 12% rise during trading and over a 200% increase in the past month, indicating strong market interest and potential investor confidence [1] Company Overview - Three Leaf Clover Biotech-B is a biotechnology company focused on the development of respiratory vaccines, with a differentiated core technology platform and product pipeline in the industry [1] - The company is one of the first biotech firms to list under the Hong Kong Stock Exchange's 18A rules, attracting notable institutional investors such as Hillhouse Capital and Temasek as cornerstone investors [1] Clinical Development - The company has completed the enrollment of the first batch of subjects in Phase I clinical trials for its respiratory combination vaccine candidates SCB-1022 (RSV+hMPV) and SCB-1033 (RSV+hMPV+PIV3) [1] - The vaccine candidates utilize a stabilized PreF trimer subunit vaccine antigen based on the company's proprietary protein trimerization vaccine technology platform [1] Technology Platform - The Trimer-Tag™ platform developed by the company mimics the structure of human collagen trimer, allowing for the stabilization of any viral antigen into a natural trimeric form, which has been validated for the development of vaccines against various viruses, including COVID-19 and RSV [1]

Core Viewpoint - Jiangsu Zhonghui Yuantong Biotechnology Co., Ltd. (referred to as "Zhonghui Biotech") has achieved a significant milestone in its research and development by obtaining IND approval for its recombinant respiratory syncytial virus (RSV) vaccine from the National Medical Products Administration (NMPA) in China, which has also received clinical approval from the FDA in the United States, marking the first dual approval for the company [1][5]. Group 1: Company Developments - The RSV vaccine developed by Zhonghui Biotech and its subsidiary, Yihui Biotechnology (Shanghai) Co., Ltd., is designed to prevent lower respiratory tract infections caused by RSV [1][6]. - The vaccine utilizes innovative technology with fully independent intellectual property rights and employs a pre-F antigen sequence that exhibits high stability, allowing for long-term storage at 2-8°C without freeze-drying [7][8]. - The company has established a comprehensive commercial product and R&D pipeline, with its core product, a quadrivalent influenza virus subunit vaccine, already approved and used in over 30 provinces in China [8]. Group 2: Market Potential - The global RSV drug market, including treatment and prevention, is projected to grow from $1.8 billion in 2020 to $12.8 billion by 2030, with a compound annual growth rate (CAGR) of 21.4% [6]. - The high incidence of RSV infections globally is creating a significant market opportunity, especially as there are currently no approved RSV vaccines in the domestic market [6][7]. - The successful IND approval for Zhonghui Biotech's RSV vaccine positions the company to fill a gap in the domestic RSV prevention market, potentially leading to substantial growth and market returns [7][8].

Core Viewpoint - Jiangsu Zhonghui Yuantong Biotechnology Co., Ltd. (referred to as "Zhonghui Bio") has achieved a significant milestone in its research and development by obtaining IND approval for its recombinant respiratory syncytial virus (RSV) vaccine from the National Medical Products Administration (NMPA) in China, marking the first dual approval for clinical trials in both China and the United States for the company [1][5] Company Developments - The RSV vaccine has also received clinical approval from the U.S. Food and Drug Administration (FDA), showcasing the company's research capabilities and marking a key breakthrough in its drug development [1] - The vaccine utilizes innovative technology with fully independent intellectual property rights and has shown promising results in preclinical studies, including the ability to stimulate high-titer neutralizing antibodies against RSV A2 and B strains [7] - The vaccine's pre-F antigen structure exhibits excellent thermal stability, allowing for long-term storage in liquid form at 2-8°C, which optimizes production processes and reduces costs, enhancing product accessibility [7] Market Potential - The global RSV drug market, including treatment and prevention, is projected to grow from $1.8 billion in 2020 to $12.8 billion by 2030, with a compound annual growth rate (CAGR) of 21.4%, indicating a significant market opportunity for Zhonghui Bio's RSV vaccine [6] - The World Health Organization (WHO) has elevated RSV to a global public health intervention priority, further stimulating interest in RSV immunization solutions [6] Financial Performance - Zhonghui Bio's recent IPO on the Hong Kong Stock Exchange received overwhelming market response, with over 190,000 subscriptions and an oversubscription rate exceeding 4,000 times, raising over HKD 200 billion [8] - The company's core product, Huiru Kangxin®, is the first and only approved quadrivalent influenza virus subunit vaccine in China, contributing to projected sales revenue of CNY 260 million in 2024 [8] - The company has a robust pipeline with 11 other vaccines under development, covering various diseases, and has received multiple new drug clinical approvals [8]

Core Viewpoint - The spread of Chikungunya fever in Guangdong has exceeded 7,000 local cases, with limited vaccine development interest from domestic companies due to market uncertainties and high costs associated with vaccine research and development [1][2]. Group 1: Disease Overview - Chikungunya fever is an acute infectious disease caused by the Chikungunya virus, primarily transmitted by Aedes mosquitoes, characterized by fever, joint pain, and rash [1]. - There is currently no specific treatment for Chikungunya fever, and no vaccines are available for use in China [1]. Group 2: Vaccine Development Challenges - Domestic vaccine companies show low enthusiasm for developing a Chikungunya vaccine due to limited market potential, high research and development costs, and the risk of low sales post-development [2]. - The estimated costs for vaccine development phases are approximately 30 million yuan for preclinical and phase I trials, 30 million yuan for phase II, and 50 to 80 million yuan for phase III, with total costs potentially reaching several hundred million yuan depending on disease prevalence [1][2]. Group 3: Market Dynamics - The Chikungunya virus has only one serotype, and while technical routes for vaccine development are feasible, the economic value of developing such a vaccine is considered limited due to the low incidence of cases compared to other common infectious diseases [2]. - Companies are more likely to invest in vaccines with higher return on investment, and significant investment in Chikungunya vaccine development may only occur if there is a clear national strategic reserve demand or limitations on imported vaccines [2]. Group 4: Prevention Measures - Preventive measures against Chikungunya fever focus on mosquito control, including eliminating breeding sites and using repellents, incense, and mosquito nets [3].