Nov 25, 2025 12:00 PM Eastern Standard Time This expanded agreement provides Vasomune with increased financial support and the ability to pursue more development opportunities to mitigate pathological vascular leakage. About Vasomune Therapeutics, Inc. Vasomune Therapeutics, Inc. is a private clinical-stage biopharmaceutical company developing the next generation of medicines to boost the body's ability to defend against vascular leak. Founded in 2014, Vasomune has focused on vascular normalization strategi ...

Payrolls at US companies unexpectedly dropped in September, according to ADP Research data released Wednesday: Here’s your Evening Briefing https://t.co/LirPDZibX9 ...

Market Performance - Major U.S. equities indexes recovered from early losses, with the S&P 500 adding 0.3% and the Dow gaining 0.1%, both reaching all-time highs. The Nasdaq climbed 0.4%, finishing just short of its closing record [3] - Shares of renewable energy provider AES surged nearly 17% following reports of a potential acquisition by Global Infrastructure Partners, which could be valued at around $38 billion [4][8] - Pharmaceutical stocks, including Eli Lilly, Biogen, and Regeneron Pharmaceuticals, extended gains after Pfizer became the first major drugmaker to comply with the White House's push to lower medication prices in the U.S. [5][6] Company Developments - Corteva's shares tumbled 9.1% after announcing a plan to split its crop protection and seed businesses into two independent companies, expected to be completed by the second half of 2026 [7][8] - Micron Technology's shares advanced close to 9%, alongside Seagate Technology and Western Digital, due to anticipated demand growth for data storage supporting AI [6] - Gartner's stock fell 4.5% as the government shutdown affected sentiment across the advisory industry, despite the U.S. federal government accounting for less than 5% of its revenue [9] Strategic Moves - Interpublic Group's stock lost 5% after being named the exclusive creative and media partner for Bayer's consumer health business, while also facing pressure from ongoing regulatory approval processes for its merger with Omnicom [10]

Core Insights - Danaher Corporation (NYSE:DHR) is recognized as one of the best diversified stocks to buy, highlighting its significant upside potential according to hedge funds [1] - The company is currently under investigation by Rosen Law Firm for potential breaches of fiduciary duty by its directors and officers, prompting shareholders to consider legal options [2] - Danaher has authorized a new share repurchase program allowing the buyback of up to 35 million shares of common stock with no expiration date, supplementing existing repurchase authorizations [3] - Management may execute share purchases through various methods based on market conditions, and the board has amended bylaws regarding shareholder proposals and director nominations [4] - Operating in the Biotechnology, Life Sciences, and Diagnostics segments, Danaher designs, manufactures, and markets a range of professional, medical, research, and industrial products and services in the U.S. [5]

Core Insights - Morningstar has launched the Morningstar PitchBook U.S. Modern Market Index (Modern Market 100), which tracks the performance of 100 of the largest U.S. companies across public and private markets [2] - The index includes 90 publicly listed firms and 10 large venture capital-backed firms, reflecting the increasing ownership of major companies by private equity [2][4] - Over the past year, the Modern Market Index achieved returns of 28.2%, significantly outperforming the Morningstar U.S. Market Index's 16% return [3] - The index has a substantial technology sector exposure, nearly 50%, compared to about 30% in the U.S. Market Index [3] Index Structure and Methodology - The Modern Market Index allocates 90% of its weighting to the largest public companies by market capitalization and 10% to private firms, mirroring the size of public and private equity markets [4] - The index will be calculated daily, using verified transactions in the secondary market to estimate valuations of venture-backed firms, with data sourced from CapLight and Zanbato [4] - The index will undergo quarterly rebalancing and semi-annual reconstitution, with specific measures in place to account for mergers and acquisitions [6] Exclusions and Limitations - Some large venture-backed firms, such as Waymo, were excluded from the index due to limited trading activity on the secondary market, affecting their liquidity [5]

Project Overview - The project focuses on using deep learning and open AI to aid in archaeological site discovery, specifically in the Amazon rainforest [2][4][10] - The team developed a scalable system (AKOS) integrating open AI to enhance the system's intelligence [1] - The approach involves training classifiers on satellite images and lighter data to classify segments of the Amazon forest, dividing the region into 3x3 km tiles [2] - The team created an interactive website where users can explore potential sites in detail [3] Technical Approach - Deep learning is considered a valuable tool for discovering archaeological sites, especially in the Amazon [10] - GPT models are used as collaborators, assisting in decision-making by providing multiple solutions and discussing their strengths and weaknesses [12] - The team used GPT for summarization, providing detailed descriptions of potential spots to help archaeologists understand why the model chose them [16] Results and Findings - The model successfully identified potential discovery sites, which were confirmed through manual analysis based on archaeological knowledge [3][14] - The deep learning approach is scalable enough to scan the entire Amazon rainforest in a reasonable time [4] - Configuration changes improved the visibility of features, leading to the identification of over 100 potential sites [3] Future Plans - The team intends to make their work public to gather feedback and inspire further research [18] - They plan to improve their approach and share it with a broader community, potentially inspiring applications in other fields [18]

Core Viewpoint - The demand for artificial intelligence skills is surging, leading human resources departments to increase salary levels to attract talent [2][3]. Group 1: Salary Implications - Employers may see an increase of 28% in annual salary expenditures if they include AI skills in job descriptions [2]. - Job postings that list at least one AI or generative AI skill offer an average annual salary that is $18,000 higher than those that do not [2]. - Approximately 51% of AI-related positions are not from the tech industry, up from 44% in 2022 [2]. Group 2: Market Trends - AI skills are becoming increasingly common across nearly all job sectors, not just in technology or IT roles [2]. - The fastest-growing demand for AI skills is seen in roles such as recruiters and HR specialists [2][3]. Group 3: Supply and Demand Dynamics - There is a mismatch between the growing demand for AI-skilled candidates and the stagnant supply of such employees [4]. - The labor market is expected to adapt through skill enhancement and retraining, but this process will take time [4][5]. - There is a lag effect in skill development, as individuals require time to acquire new skills [5].

Core Viewpoint - Forrester Research (FORR) has been upgraded to a Zacks Rank 2 (Buy), indicating a positive outlook on its earnings estimates, which is a significant factor influencing stock prices [1][4]. Earnings Estimates and Ratings - The Zacks rating system is based solely on a company's changing earnings picture, tracking the Zacks Consensus Estimate for EPS from sell-side analysts [2]. - The Zacks rating upgrade for Forrester Research reflects an improvement in its earnings outlook, which is expected to lead to increased buying pressure and a rise in stock price [4][6]. Impact of Earnings Estimate Revisions - Changes in a company's future earnings potential, as indicated by earnings estimate revisions, are strongly correlated with near-term stock price movements, particularly due to institutional investors' reliance on these estimates for valuation [5]. - Forrester Research's rising earnings estimates and the subsequent rating upgrade suggest an enhancement in the company's underlying business, likely resulting in higher stock prices as investors respond positively to this trend [6]. Zacks Rank System - The Zacks Rank system classifies stocks into five groups based on earnings estimates, with a strong historical performance, particularly for Zacks Rank 1 stocks, which have averaged a +25% annual return since 1988 [8]. - The upgrade of Forrester Research to a Zacks Rank 2 places it in the top 20% of Zacks-covered stocks, indicating a strong potential for market-beating returns in the near term [10][11]. Current Earnings Estimates for Forrester Research - Forrester Research is projected to earn $1.27 per share for the fiscal year ending December 2025, with no year-over-year change, but the Zacks Consensus Estimate has increased by 1.8% over the past three months [9].

Financial Data and Key Metrics Changes - The company reported normalized FFO of 84¢ per share, representing nearly 8% year-over-year growth [28] - Total same store cash NOI grew by 7%, led by SHOP increasing approximately 14% [29] - The company expects 7% normalized FFO per share growth for 2025 [6][11] Business Line Data and Key Metrics Changes - Senior Housing Operating Portfolio (SHOP) delivered 84¢ of normalized FFO per share in Q1, an increase of approximately 8% [7] - SHOP's same store cash NOI growth was 13.6%, with revenue growth of 7.4% driven by occupancy and rate increases [15] - Outpatient medical and research business reported same store cash NOI growth of 1.3% year-over-year [29] Market Data and Key Metrics Changes - The 80+ population is experiencing its highest growth, with an increase of about half a million people this year and 900,000 annually between 2027 and 2030 [8] - The number of new senior housing units started in Q1 2025 was the lowest on record at only 1,287 units [8] - The company is positioned in markets with over a thousand basis points of expected net absorption in the coming years [9] Company Strategy and Development Direction - The company is focused on delivering superior multiyear growth through internal and external expansion in senior housing [5] - The investment strategy has been increased from $1 billion to $1.5 billion for the year, reflecting a growing pipeline of opportunities [31][26] - The company aims to enhance its portfolio composition through acquisitions, dispositions, and operational improvements [19] Management's Comments on Operating Environment and Future Outlook - Management acknowledges a high degree of macroeconomic uncertainty but believes senior housing remains a top asset class within real estate [87] - The company expects strong demand and occupancy growth, particularly during the key selling season [88] - Management is optimistic about the extended multiyear NOI growth opportunity in senior housing due to favorable demand and supply dynamics [11][88] Other Important Information - The company has improved its credit profile, with a net debt to EBITDA of 5.7 times, representing a 30 basis point improvement from the previous year [32] - The liquidity position is robust, with available liquidity of $3.6 billion as of April 2025 [33] - The company has completed over 250 community redevelopment projects in the past two and a half years [21] Q&A Session Summary Question: Can you provide more details on the dynamics of occupancy and margin expansion? - Management indicated that reaching higher occupancy levels leads to significant margin expansion, with around 50% incremental margin from 80% to 90% occupancy [39] Question: How is the Canadian portfolio performing at high occupancy? - The Canadian portfolio continues to deliver strong NOI growth even at high occupancy levels, demonstrating that occupancy is not the only driver of growth [42] Question: What is the impact of the recent investments on cost per bed? - The cost per bed has increased due to acquiring newer communities in better markets, but the company is still buying below replacement costs [56][60] Question: How are the Brookdale assets expected to perform during the transition? - The Brookdale communities transitioning to new operators are outperforming those remaining in the lease model, and management is optimistic about their future performance [66][71] Question: What are the expectations for pricing power in the upcoming months? - Management expects pricing power to remain strong, with good rent increases anticipated during the key selling season [80] Question: How does the company view the potential changes in NIH funding? - Management believes that any potential changes in NIH funding would have a manageable impact on the research budget due to the strong financial position of their university tenants [113]