Core Viewpoint - The "14th Five-Year Plan" marks a milestone in China's technological development, emphasizing the importance of large scientific facilities in driving innovation and addressing fundamental scientific challenges [1][5]. Group 1: Investment in Scientific Infrastructure - Large scientific facilities are crucial for national innovation, requiring significant investment and long-term commitment [3]. - China's R&D investment is projected to exceed 3.6 trillion yuan in 2024, reflecting a steady increase in technological innovation capabilities [5]. Group 2: Core Competencies of Large Scientific Facilities - **Competency 1: Addressing Fundamental Scientific Questions** Large scientific facilities represent the pinnacle of engineering technology, essential for exploring unknowns and tackling fundamental scientific issues, such as those addressed by the Tianyan and Jiangmen neutrino experiments [7]. - **Competency 2: Catalyzing Disruptive Technological Breakthroughs** These facilities serve as sources of original innovation, enabling significant advancements in materials science and reducing the development cycle and costs of new materials, particularly in critical areas like semiconductors and renewable energy [8][9]. - **Competency 3: Enhancing Public Health** Large scientific facilities are directly linked to public health, facilitating the development of targeted therapies for diseases like cancer and Alzheimer's through advanced techniques such as protein structure analysis and proton therapy [11][13]. Group 3: Broader Implications - Investment in large scientific facilities not only enhances national technological competitiveness but also contributes to the well-being and sustainable development of humanity, making it a vital area for future investment [13].