Investment Rating - The report maintains a rating of "Buy" for the pharmaceutical and biotechnology industry [1]. Core Insights - GLP-1 drugs have emerged as leading products, with recommendations to focus on companies such as BoRui Pharmaceutical, Innovent Biologics, and Federated Pharmaceutical [1][15]. - The global GIP-1 market shows significant potential, with Q1 2025 sales surpassing PD-1 antibodies. The WHO is developing guidelines for the use of GLP-1 in adult obesity, expected to be released in August-September 2025 [1][15]. - The report highlights a shift in R&D trends from single-target to multi-target drugs, with a focus on oral formulations and both peptide and small molecule drugs [1][16]. Summary by Sections Industry Performance - The A-share pharmaceutical index has increased by 1.0% this week and 1.2% year-to-date, underperforming the CSI 300 by 1.0% and outperforming by 3.4% respectively [9]. - The H-share biotechnology index has decreased by 4% this week but increased by 27% year-to-date, outperforming the Hang Seng Technology Index by 19% and 29% respectively [9]. GLP-1 Drug Market - Sales of semaglutide reached 78.64 billion USD in Q1 2025, surpassing Keytruda's 72.05 billion USD [15]. - The WHO is expected to finalize guidelines for GLP-1 RA use in obesity treatment by late 2025, which could significantly boost sales [15]. R&D Trends - The report notes a transition from single-target to multi-target drug development, with multi-target drugs showing superior clinical efficacy [16][17]. - Clinical data indicates that semaglutide and dual-target drugs like tirzepatide are leading in weight loss efficacy, with ongoing trials for multi-target drugs showing promising results [17]. Investment Recommendations - The report ranks preferred sub-sectors as follows: innovative drugs > CXO > traditional Chinese medicine > medical devices > pharmacies > pharmaceutical commerce [10]. - Specific stock recommendations include BoRui Pharmaceutical, Innovent Biologics, Federated Pharmaceutical, and others based on growth potential and valuation metrics [10].

Market Overview - The Hang Seng Index closed at 21,973 points, down 7 points, with a trading range of only 255 points, indicating a lack of direction in the market[1] - The market turnover was approximately HKD 163.8 billion, the lowest since February 4[1] - Net inflow from the Hong Kong Stock Connect was HKD 2.12 billion[1] Sector Performance - Major banks and some consumer brands showed strong performance, with four major banks rising between 0.7% and 2.8%[1] - Stocks like Mixue Group and Pop Mart surged between 4.1% and 12.0%, reaching new highs since their listings[1] - Yao Cai Securities saw a significant increase of 81.9% to HKD 5.55, following Ant Group's acquisition[1] Economic Indicators - The upcoming release of China's PMI data and the U.S. GDP for Q1 is expected to increase market volatility[1] - New home sales in 30 major cities fell by 23.3% year-on-year, indicating a continued decline in the real estate market[3] Valuation and Strategy - The current PE ratio of the Hang Seng Index is approximately 9.7 times, suggesting limited downside but requiring effective internal policies for upward movement[2] - Key focus areas for investment include AI infrastructure, consumer demand, and high-dividend state-owned enterprises[2] Coal Market Insights - Yancoal Australia reported a 12.8% year-on-year decline in average coal prices to AUD 157 per ton, influenced by strong market supply[7] - The company’s coal production increased by 8.0% to 9.5 million tons, but sales only rose by 1.2% due to inventory rebuilding[6] Risk Factors - Potential risks include production delays, fluctuations in electricity and steel market demand, and geopolitical uncertainties[11]