撰文丨王聪 编辑丨王多鱼 排版丨水成文 2026 年 1 月 29 日，著名癌症学家 Douglas Hanahan 在国际顶尖学术期刊 Cell 上发表了关于" 癌症特征 "理论的最新综述 —— Hallmarks of cancer—Then and now, and beyond 。这距离他与 Robert Weinberg 首次提出癌症特征理论已过去了 26 年，当时他们提出的 癌症的六大特征 彻底改变了人们对癌症的理 解。 如今， 这一理论框架已经扩展为 九大特征 ，并加入了 四个理解维度 ，为癌症研究和治疗提供了更为全面的路线图。 癌症特征的演变：从六个到九个 2000 年， Douglas Hanahan 和 Robert Weinberg 在 Cell 期刊发表综述论文， 首次提出了 癌症的六大特征 —— 维持增殖信号 、 失活生长抑制因子 、 抵抗 程序性细胞死亡 、 建立复制永生性 、 诱导或获取血管生成 、 激活侵袭和转移 。 2011 年，他们增加了两大新特征： 解除细胞代谢调控 、 逃逸免疫摧毁 。2022 年， Douglas Hanahan 加入了第九个特征—— 解锁表型可塑性 ...

Group 1: Core Insights - Jiangbei New District in Nanjing has evolved into a national-level innovation hub, recognized for its significant contributions to the biopharmaceutical industry and technology advancements [1][2] - The district is home to over 1,300 biopharmaceutical companies and more than 200 new drugs in development, positioning it as a key player in Jiangsu's biopharmaceutical sector [2][4] - Notable achievements include the first CAR-T drug for cross-border supply by Reindeer Biotech and the first nucleic acid drug ER2001 injection by Aima Biotech, showcasing the district's innovative capabilities [2][3] Group 2: Industry Developments - Jiangbei New District has established itself as a center for integrated circuit industries, hosting hundreds of related companies, including TSMC, and covering the entire supply chain from design to manufacturing [3][4] - The district has seen significant investments in biopharmaceuticals, with funds supporting companies like Vili Biotech, which has 14 innovative drug candidates, and the recent approval of new antiviral drugs [5][6] - The collaboration between Nanjing University and Jiangbei New District aims to foster talent and innovation in biopharmaceuticals, with plans to accommodate over 5,000 students and faculty [4][5] Group 3: Community and Infrastructure - The district is characterized by a high concentration of PhD holders, with over 30% of the local population in the Longshan community holding advanced degrees, contributing to a vibrant innovation ecosystem [6][7] - The establishment of Nanjing North Station as a major transportation hub is expected to enhance connectivity and attract resources, further supporting the district's growth as a technology and innovation center [8][9] - Jiangbei New District is committed to creating a comprehensive ecosystem that integrates education, research, industry, and application in the biopharmaceutical sector [5][6]

Core Insights - Jiangbei New Area in Nanjing has evolved into a national-level innovation hub, particularly in the biopharmaceutical and semiconductor industries, showcasing significant technological advancements and industry breakthroughs [1][2][3]. Biopharmaceutical Industry - Jiangbei New Area is designated as a key area for developing a world-class biopharmaceutical industry cluster, with over 200 new drugs under research and more than 1,300 biopharmaceutical companies [1][2]. - Notable achievements include the first CAR-T drug for cross-border supply by Reindeer Biotech and the first nucleic acid drug ER2001 injection by Aima Biotech, highlighting the area's innovative capabilities [2]. - The area has attracted major pharmaceutical companies, with recent approvals for new drugs such as the anti-flu drug and an antibody drug, indicating a robust pipeline of innovative products [2]. Semiconductor Industry - Jiangbei New Area hosts a significant number of semiconductor companies, including Nanjing University’s collaboration with Nanjing Jiangbei New Area to establish a leading photonic chip production line [3]. - Companies like Chipstar Technology have made strides in high-end chips, with their 7nm chip achieving significant market penetration [3]. - The area is recognized for its comprehensive semiconductor ecosystem, covering all aspects from design to manufacturing [3]. Educational and Research Institutions - The establishment of a technology transfer center in Jiangbei New Area has facilitated collaboration with 78 universities, resulting in numerous projects and a high concentration of talent [4][5]. - Nanjing University and Southeast University are key players in the area, contributing to a rich educational environment that supports innovation and research [4][5]. Innovation Ecosystem - Jiangbei New Area is focused on creating an integrated ecosystem that combines education, research, industry, and application, fostering a collaborative environment for innovation [5]. - The area has seen significant investment from venture capital, supporting the growth of local companies and enhancing the overall innovation landscape [5]. Community and Lifestyle - The demographic profile of Jiangbei New Area shows a high concentration of highly educated individuals, with over 30% of the local population holding advanced degrees [6]. - The community is actively engaged in various cultural and educational activities, contributing to a vibrant lifestyle that attracts young talent [6]. Infrastructure Development - The construction of Nanjing North Station as a major transportation hub is expected to enhance connectivity and attract resources, further supporting the innovation ecosystem in Jiangbei New Area [7]. Conclusion - Jiangbei New Area is positioned as a rising highland in Jiangsu, with a strong focus on biopharmaceuticals and semiconductors, supported by a robust educational framework and community engagement [8].