Core Insights - The rapid development and widespread application of genome editing technology in the life sciences provide strong technical support for basic research and application development [1] - A new programmable chromosome editing technology developed by a team from the Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, enables precise manipulation of DNA from kilobases to megabases in plants and animals [1] - This technology significantly enhances the scale and capability of manipulating eukaryotic genomes, representing a major breakthrough in the field of genetic engineering [1] Summary by Categories Technology Development - The new technology allows for multi-gene stacking editing and manipulation of genomic structural variations, opening new pathways for crop trait improvement and genetic disease treatment [1] - It is expected to promote the development of new breeding strategies by manipulating genetic linkage and controlling recombination frequency [1] Applications - The technology has the potential to eliminate linkage drag and fully unleash the breeding potential of superior alleles in wild germplasm resources [1] - Reviewers have noted the significant application potential of this work in breeding and gene therapy [1]

Core Insights - The rapid development and widespread application of genome editing technology in the life sciences provide strong technical support for basic research and application development [1] - A new programmable chromosome editing technology developed by a team from the Institute of Genetics and Developmental Biology of the Chinese Academy of Sciences allows for precise manipulation of DNA at the kilobase to megabase level in plants and animals, significantly enhancing the scale and capability of eukaryotic genome manipulation [1] Group 1 - The new technology enables multi-gene stacking editing and manipulation of genomic structural variations, opening new pathways for crop trait improvement and genetic disease treatment [1] - This technology is expected to promote the development of new breeding strategies, such as manipulating genetic linkage and regulating recombination frequency for fertility control, as well as eliminating linkage drag to fully exploit the breeding potential of superior alleles in wild germplasm [1] - Reviewers have evaluated this work as a significant breakthrough in the field of genetic engineering, with enormous application potential in breeding and gene therapy [1]