不仅如此，为更好支持科技企业，当地政府还推出了模型券、贴息券、技改券等六项服务工具，以"陪伴式服务"为科创企业提供全周期金 融支撑。 深圳市南山区副区长 蔡淡宏：我们以5亿元种子基金、百亿级引导基金撬动超1400亿元社会资本；央地联动方面，我们联合人民银行构 建"央行政策工具+地方服务网络"机制，推出"千亿计划"、南山"信易贷"平台等，助力了6263家次企业获贷超1000亿元，让金融"活水"直达科 创一线。 央视网消息：信贷投向是经济发展的"风向标"，资金流向折射产业变迁。今年前10个月，我国新增人民币贷款近15万亿元，这些"真金白 银"投向了哪些领域？透过数据我们发现，今年以来科技型中小企业贷款、绿色贷款增速均高于全部贷款增速，金融资源正加速流向科技创 新、绿色发展、旅游消费等关键领域。 天津这家专注基因工程领域基础材料研发的企业，目前正全力攻关一项核心技术。针对企业研发阶段的大额资金需求，人民银行天津市分 行推出45项具体举措，推动金融服务精准对接技术研发、成果转化等关键环节需求。凭借过硬的研发实力，企业顺利通过评分获得1300万元信 贷资金。 不仅仅是研发阶段，科创企业在早期都需要资金支持。但记者在采访 ...

Core Insights - The flow of credit is a key indicator of economic development, with nearly 15 trillion RMB in new loans issued in China in the first ten months of the year, indicating a shift towards technology innovation, green development, and tourism consumption [1] Group 1: Credit Allocation Trends - Loans to technology-oriented small and medium-sized enterprises (SMEs) and green loans have grown faster than the overall loan growth rate, reflecting a strategic allocation of financial resources towards critical sectors [1] - The People's Bank of China has introduced 45 specific measures to address the funding needs of enterprises in the research and development phase, facilitating precise financial services for technology development and results transformation [3] Group 2: Innovative Financial Solutions - Shenzhen has implemented an innovative approach allowing banks to provide long-term low-cost loans to technology companies while sharing in the excess equity appreciation post-growth, addressing the risk concerns of financial institutions [3] - A small electronic components company in Shenzhen benefited from a 15 million RMB long-term pure credit loan, highlighting the confidence of financial institutions in the high growth potential of such enterprises [5] - Local governments have introduced various support tools, including model vouchers, interest subsidies, and technology transformation vouchers, to provide comprehensive financial support for technology enterprises [5]

Core Viewpoint - The company is utilizing temporarily idle raised funds for cash management to enhance fund efficiency and increase returns for the company and its shareholders [2][3][7]. Summary by Sections Cash Management Overview - The purpose of the investment is to improve fund utilization efficiency without affecting the construction of fundraising projects and normal operations [3]. - The amount of idle raised funds used for cash management is 120 million RMB [2][3]. - The source of funds is temporarily idle raised funds from a previous fundraising effort, which totaled approximately 446.99 million RMB, netting about 444.45 million RMB after expenses [4]. Investment Method - The cash management product purchased is a structured deposit with a principal protection and minimum return feature, ensuring high safety and liquidity [5][6]. - The investment does not alter the intended use of the raised funds and does not harm shareholder interests [5]. Review Procedures - The board of directors and supervisory board approved the cash management proposal on December 18, 2024, with no objections from the independent financial advisor [5][6]. Impact on the Company - The cash management initiative is expected to enhance fund efficiency and profitability, benefiting both the company and its shareholders [7]. - The financial reporting will reflect changes in "trading financial assets," "cash and cash equivalents," "financial expenses," "fair value changes," and "investment income" due to this cash management [7].

Core Insights - The rapid development and widespread application of genome editing technology in the life sciences provide strong technical support for basic research and application development [1] - A new programmable chromosome editing technology developed by a team from the Institute of Genetics and Developmental Biology of the Chinese Academy of Sciences allows for precise manipulation of DNA at the kilobase to megabase level in plants and animals, significantly enhancing the scale and capability of eukaryotic genome manipulation [1] Group 1 - The new technology enables multi-gene stacking editing and manipulation of genomic structural variations, opening new pathways for crop trait improvement and genetic disease treatment [1] - This technology is expected to promote the development of new breeding strategies, such as manipulating genetic linkage and regulating recombination frequency for fertility control, as well as eliminating linkage drag to fully exploit the breeding potential of superior alleles in wild germplasm [1] - Reviewers have evaluated this work as a significant breakthrough in the field of genetic engineering, with enormous application potential in breeding and gene therapy [1]

Core Viewpoint - The research team from the Chinese Academy of Sciences has developed a novel programmable chromosome-level large segment DNA manipulation technology, PCE, which enables precise editing of DNA at the kilobase to megabase level in eukaryotic genomes, representing a significant breakthrough in the field of genetic engineering [1][2]. Group 1: Technology Development - The new method addresses the core challenge of precise manipulation of large segments of DNA, which existing tools struggle with in terms of efficiency, scale, precision, and diversity [2]. - The research team has created two programmable chromosome editing systems, PCE and RePCE, which allow for precise and seamless manipulation of ultra-large segments of DNA [2][3]. - Three key technological innovations have been achieved to enhance the capabilities of large segment DNA editing, including the development of a high-throughput recombination site modification platform, optimization of Cre recombinase using artificial intelligence, and the creation of a "no trace editing strategy" called Re-pegRNA [3]. Group 2: Applications and Implications - The new technology has the potential to revolutionize crop trait improvement and genetic disease treatment by enabling the manipulation of genomic structural variations [4][6]. - In traditional breeding, desirable traits are often linked with undesirable genes, but the breakthrough in large segment DNA editing could lead to new breeding strategies that eliminate these undesirable traits while enhancing beneficial ones [4]. - The technology has already been successfully applied to create a rice variety with a precise inversion of 315 kilobases that is resistant to herbicides [5]. - In the field of genetic disease treatment, this technology may provide new therapeutic approaches for diseases caused by chromosomal abnormalities and accelerate the construction of artificial chromosomes, which is crucial for synthetic biology and other emerging fields [6].

Core Viewpoint - The research team from the Chinese Academy of Sciences has developed a novel programmable chromosome-level large segment DNA manipulation technology called PCE, which enables precise editing of DNA from thousands to millions of base pairs, representing a significant breakthrough in the field of genetic engineering [2][3]. Group 1: Technological Breakthroughs - The PCE technology addresses the core challenge of precise manipulation of large segment DNA, which has been a limitation of existing tools in terms of efficiency, scale, precision, and diversity [3]. - The research team has created two programmable chromosome editing systems, PCE and RePCE, which allow for precise and seamless manipulation of ultra-large segment DNA [3][5]. - Innovations include a high-throughput recombination site rapid modification platform and an AI-based optimization of Cre recombinase, which enhances editing efficiency by 3.5 times [5]. Group 2: Applications and Implications - The new technology has the potential to revolutionize crop trait improvement and genetic disease treatment by enabling precise genomic structural variations [6]. - In traditional breeding, desirable traits are often linked with undesirable genes; the new method can help decouple these traits, enhancing breeding strategies [6]. - The technology has already been successfully applied to create herbicide-resistant rice with a precise inversion of 315 kilobases [7].

Core Insights - The article discusses a revolutionary breakthrough in genome editing technology, specifically the development of a new programmable chromosome-level DNA manipulation technique called PCE, which enables precise editing of DNA segments ranging from thousands to millions of base pairs [1][2]. Group 1: Technology Development - The research team has developed two programmable chromosome editing systems, PCE and RePCE, which allow for precise manipulation of ultra-large DNA segments, effectively addressing the "scale dilemma" in genome editing [2]. - The team has achieved three key technological innovations to enhance the capabilities of ultra-large DNA precise editing [2][3]. Group 2: Technical Innovations - The first innovation involves changing the "double-gate" system to a "single-channel" system to overcome the reversibility issue of recombination reactions caused by the inherent symmetry of Lox sites, creating a new type of Lox variant that facilitates targeted editing [2]. - The second innovation utilizes artificial intelligence to optimize the Cre recombinase, resulting in a 3.5-fold increase in recombination efficiency, thereby enhancing the overall effectiveness of the editing process [3]. - The third innovation is the development of the Re-pegRNA strategy, which acts like a smart eraser to precisely identify and eliminate residual sites that could interfere with the accuracy of genome editing [3]. Group 3: Applications and Implications - The new ultra-large DNA precise editing method is expected to open new pathways for crop trait improvement and genetic disease treatment by manipulating genomic structural variations [4]. - In traditional breeding, desirable traits are often linked with undesirable genes, but the breakthrough in large segment DNA editing could lead to new breeding strategies that control fertility and eliminate linked burdens, maximizing the breeding potential of wild germplasm resources [4]. - The research team has successfully created a rice variety with a precise inversion of 315 kilobases that is resistant to herbicides, showcasing the practical application of this technology [4].

Core Viewpoint - The article discusses the revolutionary advancements in genome editing technology, particularly focusing on the development of a new programmable chromosome engineering (PCE) system that enables precise manipulation of large DNA segments ranging from kilobases to megabases, which addresses significant challenges in the field of genetic engineering [4][11]. Group 1: Technology Overview - Genome editing technology, exemplified by CRISPR and its derivatives, has made significant strides in precise editing of specific bases and short DNA fragments, but large-scale DNA editing remains a core challenge [3]. - The PCE system developed by the research team allows for efficient and precise manipulation of DNA at the chromosome level, significantly enhancing the capability to edit eukaryotic genomes [4][11]. Group 2: Technical Innovations - The research team addressed three key limitations of the Cre-Lox system, including the inherent symmetry of Lox sites, the difficulty in engineering Cre enzyme activity, and the precision of editing due to residual Lox sites after recombination [6][8]. - Innovations include a high-throughput recombination site modification platform, the development of new Lox variants with reduced recombination activity, and an engineered Cre protein variant that improves recombination efficiency by 3.5 times [6][7]. Group 3: Applications and Implications - The PCE system has successfully achieved various large-scale DNA manipulations, including the integration of an 18.8 kb DNA segment, directional replacement of a 5 kb sequence, and chromosomal inversions and deletions up to 12 Mb [7]. - This technology not only facilitates multi-gene stacking but also opens new pathways for crop trait improvement and genetic disease treatment, potentially transforming breeding strategies and synthetic biology applications [11].

Group 1 - The company held its 19th temporary board meeting on July 9, 2025, via telecommunication, with all 9 attending directors agreeing to waive the notice period due to urgency [1] - The board approved the appointment of Mr. Chen Yiqing as the secretary of the board, with a term lasting until the current board's term ends [1][2] - Mr. Chen Yiqing possesses the necessary qualifications and experience to fulfill the role of board secretary, having obtained the required training certification and meeting legal requirements [2] Group 2 - The company’s subsidiary, Beijing Zhongshan Jinqiao Biotechnology Co., Ltd., plans to donate a total of 3 million yuan, with 2 million yuan to the Peking Union Medical Foundation and 1 million yuan to the Beijing Red Cross Foundation, aimed at supporting public welfare projects [2] - This donation is part of the company's commitment to social responsibility and is expected to enhance its image and social influence [2] - The funds for the donation will come from the company's own resources and will not significantly impact its operational performance or harm the interests of shareholders, particularly minority shareholders [2]