Investment Rating - The report maintains an "Accumulate" rating for the pharmaceutical and biotechnology sector [5]. Core Viewpoints - The report is optimistic about the domestic substitution of high-end reagents in the upstream life sciences sector, driven by factors such as product quality, emerging demands in oncology and CAR-T therapies, policy support, and the increasing emphasis on supply chain security amid rising global protectionism [2][24]. Summary by Sections Market Review - Over the past two weeks, the pharmaceutical and biotechnology index increased by 1.50%, underperforming the CSI 300 index by 0.06 percentage points and the ChiNext index by 2.80 percentage points, ranking 16th among 31 sub-industries [1][17]. - The Hong Kong Hang Seng Healthcare Index fell by 1.48%, lagging behind the Hang Seng China Enterprises Index by 4.31 percentage points [1][17]. Company Updates - Recent clinical application updates include new undertakings for injectable BG-C9074 by BeiGene and HDM2005 by Huadong Medicine, as well as IND applications for BGB-45035 tablets by BeiGene [27]. - Companies such as Enhua Pharmaceutical and Bide Pharmaceutical are currently in Phase III clinical trials for NH600001 and BL-M07D1, respectively [27]. Investment Recommendations - The report suggests focusing on companies like Titan Technology, Novozymes, Aladdin, Bide Pharmaceutical, Baipusais, and Yiqiao Shenzhou, which are well-positioned to benefit from the domestic substitution trend in high-end life science reagents [2][24]. Financial Forecasts and Valuations - Key company forecasts include: - Hengrui Medicine: EPS of 1.07 in 2025E with a PE of 48, rated as "Accumulate" [4]. - Mindray Medical: EPS of 10.62 in 2025E with a PE of 22, rated as "Buy" [4]. - United Imaging Healthcare: EPS of 2.39 in 2025E with a PE of 59, rated as "Buy" [4]. - Yuyue Medical: EPS of 2.32 in 2025E with a PE of 15, rated as "Buy" [4].

Investment Rating - The report maintains an "Outperform" rating for the pharmaceutical industry as of May 11, 2025 [1]. Core Insights - The A-share innovative drug sector saw a weekly increase of 2.33%, outperforming the CSI 300 index by 0.33 percentage points, while the biopharmaceutical sector rose by 0.75% [2][17]. - In the past six months, the A-share innovative drug sector has cumulatively increased by 5.43%, outperforming the CSI 300 index by 9.13 percentage points, whereas the biopharmaceutical sector has decreased by 10.55% [2][17]. - The Hong Kong innovative drug sector experienced a decline of 2.14%, underperforming the Hang Seng Index by 3.75 percentage points, with a cumulative increase of 22.08% over the past six months [2][20]. - The XBI index in the US fell by 8.59% this week, with a cumulative decline of 22.72% over the past six months [2][23]. Summary by Sections Domestic Key Innovative Drug Progress - In May, one new drug was approved for market launch in China, with no new indications approved [3][41]. Overseas Key Innovative Drug Progress - In May, there were no NDA or BLA approvals in the US, Europe, or Japan for innovative drugs [4][45]. Global Key Innovative Drug Transaction Progress - A total of 12 key transactions occurred globally this week, with one disclosed transaction amounting to 415 million USD between Alchemab Therapeutics and Eli Lilly [5]. Market Performance - The report indicates that 39 stocks in the innovative drug sector rose while 67 fell during the week, with the top gainers being HaiChuang Pharmaceutical-U (22.76%), Changchun High-tech (8.99%), and Zhongsheng Pharmaceutical (8.98%) [2][16]. - The top decliners included Fuhong Hanlin (-12.64%), Connaught-B (-12.40%), and Boan Biotechnology (-11.77%) [2][16]. Clinical Trials and Approvals - In May, there were 23 newly announced clinical trials in China, including 17 in BE/I phase, 4 in II phase, and 2 in III phase [31].