Core Viewpoint - Huaxi Biological asserts that claims exempt from scientific verification are inherently pseudoscientific, emphasizing the necessity of measurable and verifiable scientific methods in the industry [1][2]. Group 1: Huaxi Biological's Position - Huaxi Biological argues that the absence of standardized testing methods does not negate the existence of scientific methods for validation, using their product "Runbaiyan" as an example of verifiable testing results for recombinant collagen [2][5]. - The company highlights the use of High-Performance Liquid Chromatography-High-Resolution Mass Spectrometry (HPLC-HRMS) as a reliable method to accurately measure recombinant collagen content, claiming it effectively avoids complex matrix interference [5][12]. Group 2: Response from Juzhi Biological - Juzhi Biological acknowledged the limitations of their existing quality standards and testing methods in a statement, indicating a need for continuous optimization to meet industry advancements [6][9]. - The company plans to collaborate with research institutions to enhance the qualitative and quantitative detection methods for recombinant collagen in cosmetics, aiming for greater transparency and industry standardization [9][10]. Group 3: Testing Method Controversy - The debate over testing methods arose when beauty blogger Dazui Doctor (Hao Yu) questioned the recombinant collagen content in a product, using a high-precision HPLC amino acid quantification method, which Juzhi Biological claimed was not included in industry standards [10][11]. - Experts noted that both HPLC amino acid quantification and HPLC-HRMS methods have their unique applications and challenges, particularly in detecting low concentrations of collagen in complex cosmetic formulations [12][13].

Core Viewpoint - The ongoing debate between two major companies regarding the restructuring of collagen detection methods highlights the industry's need for standardized testing protocols and the challenges posed by varying product quality in the market [1][4][6]. Group 1: Company Actions and Statements - Huaxi Biological published an article asserting the need for industry standards based on testing results, revealing that their product "Runbaiyan" was tested for collagen content using advanced HPLC-HRMS technology, yielding a result of 0.60 mg/g (0.06%) for type III collagen [2][3]. - Huaxi Biological emphasized that their testing method effectively eliminates matrix interference and ensures accurate detection of recombinant collagen, addressing concerns about the reliability of their results [2][3]. - Juzhi Biological acknowledged the limitations of their existing quality standards and testing methods, stating the need for continuous optimization to meet industry advancements and consumer expectations [5][6]. Group 2: Industry Implications - The debate over collagen measurement methods has been ongoing since May, with Huaxi Biological criticizing misleading conclusions from industry reports and calling for a unified testing standard [4][6]. - Juzhi Biological has committed to collaborating with research institutions to enhance detection methods and to gradually disclose key technical parameters and quality control data to foster industry development and transparency [5]. - The lack of a unified detection method has been described as a strategy to evade scrutiny, highlighting the industry's regulatory challenges and the necessity for verifiable solutions [6].

Core Viewpoint - The article discusses the ongoing dispute between Huaxi Biological and Juzhi Biological regarding the measurement and standards of recombinant collagen products, emphasizing the importance of scientific validation and the need for reliable testing methods [1][5][7]. Group 1: Huaxi Biological's Position - Huaxi Biological published an article asserting that claims without scientific testing are pseudoscience, specifically targeting the lack of unified testing methods for recombinant collagen [1][7]. - The company argues that if the actual content of recombinant collagen cannot be accurately measured, then claims about its presence or efficacy become unverifiable, thus lacking scientific credibility [7][8]. - Huaxi Biological emphasizes the need for collaborative efforts to explore the limitations of current testing methods and to develop more precise standards, rather than evading verification [7][8]. Group 2: Juzhi Biological's Response - Juzhi Biological acknowledged the limitations of its existing quality standards and testing methods in a statement, indicating a need for continuous optimization to meet industry advancements [5][6]. - The company defended its testing methods by referencing national standards, claiming that the methods used by critics were not validated and therefore produced inaccurate results [6][8]. Group 3: The Role of "Big Mouth Doctor" - The influencer "Big Mouth Doctor" (Hao Yu) has been involved in the dispute, previously criticizing Juzhi Biological for alleged false claims regarding recombinant collagen content [1][6]. - Despite being silenced on social media, "Big Mouth Doctor" published an article aligning with Huaxi Biological's views on the standards of scientific validation, quoting philosophers on the nature of science [9][12]. - There are speculations about a potential conflict of interest between "Big Mouth Doctor" and Huaxi Biological due to their financial connections, suggesting that the dispute may have underlying commercial motivations [12].