记者丨 韩璐 编辑丨陈晓平 420亿杭州老牌药企，董事长顺利连庄。 7月17日，华东医药发布公告，新一届董事会一致同意， 选举吕梁为董事长 ，且聘任其为总经 理，吕本人也身兼战略委员会召集人。 吕梁掌舵的华东医药，以仿制药起家。 上市24年间，其在多数年份净利增长在20%以上， 整体规模超过400亿 。吕于2019年一出任 董事长，即以子公司中美华东为旗舰，全力转向创新药。 吕梁 50岁的吕梁，将开启第三个董事长任期。 作为职业经理人，他担纲一号位6年，成功带领这家传统药企，赶上创新药热潮，6月以来，已 有多款新药获批在美进行试验。 "公司采用自主研发和外部引进相结合的方式。"官方回复《21CBR》记者，其聚焦肿瘤、内分 泌和自身免疫三大核心领域，进行研发布局。 一众利好之下，华东医药市值大涨，截至17日，市值已达770亿元，年初以来上涨约28%。 腾笼换鸟 据首席科学家刘东舟介绍，截至2025年4月，其创新药管线已超80项，其中自研项目50项。 吕梁已手握多款重磅产品。 2024年底，中美华东与ImmunoGen合作的爱拉赫，获批上市，成为全球唯一批准用于治疗铂 类耐药卵巢癌的、靶向FRα的ADC药物。 几 ...

Core Insights - Company East China Pharmaceutical has received FDA approval for its clinical trial application of HDM2012, a novel antibody-drug conjugate targeting MUC-17 for advanced solid tumors [1][2] - HDM2012 is a first-in-class biologic with global intellectual property rights, demonstrating good drug-like properties, safety, and efficacy in preclinical studies [1][2] - The ADC market is projected to grow significantly, with global sales expected to reach $64.7 billion by 2030, reflecting a compound annual growth rate of 30% [2] Company Developments - The clinical trial application for HDM2012 was submitted to the FDA in May 2025 and received approval shortly thereafter, with a similar application accepted in China in June 2025 [2] - East China Pharmaceutical has previously launched other ADC products, including the first-in-class drug Somatuzumab Injection, which received conditional approval in November 2024 [3] - The approval of HDM2012's clinical trial is a significant advancement in the company's R&D process, enhancing its competitiveness in the oncology treatment sector [3]

Core Insights - East China Pharmaceutical (华东医药) has made significant progress in the development of two innovative drugs, HDM2020 and HDM2012, which have received IND approvals in China and the US respectively [1][2][3] Drug Development Progress - HDM2012 is the world's first ADC targeting MUC-17, currently the only ADC in clinical research for this target, showing promising preclinical results for treating MUC-17 positive gastric, colorectal, and pancreatic cancers [2][3] - HDM2020 targets FGFR2b, a potential target associated with aggressive tumors like gastric and breast cancer, and has demonstrated strong anti-tumor activity in preclinical models [3] Clinical Trials and Approvals - HDM2012's clinical trial in China for advanced solid tumors was accepted by the National Medical Products Administration (NMPA) in June 2025 [3] - HDM2020 is the fourth ADC targeting FGFR2b to enter clinical trials, highlighting its clinical significance as recognized in the 2025 CSCO gastric cancer guidelines [3] Strategic R&D Initiatives - The company has built a differentiated product pipeline focusing on endocrine, autoimmune, and oncology therapies, with over 30 innovative oncology drug candidates, including ADCs [4] - Collaborations with companies like ImmunoGen and Heidelberg Pharma aim to strengthen the ADC innovation chain and ecosystem [4] Market Outlook - The global ADC market is projected to grow significantly, with sales expected to reach $64.7 billion by 2030, reflecting a compound annual growth rate of 30% [4] Recent Product Approvals - The ADC drug, Somatuzumab Injection (爱拉赫), received conditional approval in November 2024, with a supplementary application for regular approval submitted in March 2025 [5] - The ovarian cancer drug, Senaparib Capsules (派舒宁), was approved by NMPA in January 2025 [6] Company Vision - The dual approval of HDM2012 and HDM2020 signifies a major breakthrough in target innovation for Chinese pharmaceutical companies, showcasing the company's ambition in innovative R&D and its transition towards becoming a comprehensive innovation leader [7]

Group 1: Financial Performance - In 2024, the company achieved a revenue growth of 21.24% and a net profit growth of 52.59% compared to 2021, reaching historical highs [2] - The company completed its seventh three-year plan successfully and is now entering the eighth three-year plan with higher goals [14] Group 2: Innovation and R&D - The company has over 80 innovative drug pipelines, with nearly 50 self-developed projects, focusing on oncology, endocrinology, and immunology [3] - In 2024, the company received 4 NDA/BLA approvals and 14 clinical approvals in China and the U.S. [3] - The R&D team consists of over 330 members, with more than 60% holding advanced degrees [3] Group 3: Key Product Developments - The company launched several innovative products, including the first ADC drug for platinum-resistant ovarian cancer and the first biosimilar of ustekinumab in China [2] - The GLP-1 receptor agonist HDM1002 has over 800 participants in clinical trials, showing good safety and efficacy [5][6] - The ADC project HDM2005 for treating advanced malignancies has completed initial dosing stages without dose-limiting toxicity [9] Group 4: AI and Technology Integration - The company established an AI drug design platform, enhancing drug development efficiency through deep integration of AI and traditional methods [10] Group 5: Aesthetic Medicine Sector - The aesthetic medicine division has developed a comprehensive product matrix, covering various treatment methods and achieving significant growth since its inception [12][13] - The company aims to become a leading provider of comprehensive aesthetic solutions globally, with a focus on innovative product launches [12] Group 6: Market Strategy and Future Outlook - The company plans to balance R&D investments with revenue growth, focusing on enhancing project quality and efficiency [15][16] - The domestic aesthetic medicine market is expected to grow, supported by new product launches and increasing consumer demand [19] - The company is optimistic about its industrial microbiology segment, aiming for accelerated development in the next three years [20]

Financial Performance - In 2024, the company achieved a revenue of CNY 41.906 billion, with a foreign sales revenue of CNY 1.095 billion, accounting for 2.61% of total revenue [20] - The pharmaceutical industrial revenue reached CNY 13.811 billion, representing 32.96% of total revenue [13] - The medical beauty business generated CNY 2.326 billion in revenue, with the subsidiary Xinkeli Meixue contributing CNY 1.139 billion [10] Business Development - The company completed its seventh three-year plan, achieving record high revenue and net profit attributable to shareholders [1] - The industrial microbiology business reported a revenue of CNY 711 million, a year-on-year increase of 43.12% [5] - The company is focusing on four strategic directions: xRNA, specialty APIs & intermediates, health & biological materials, and animal health [2] Product Pipeline and Innovation - The company is preparing for the commercial launch of the innovative ADC drug, Ailaha (Somatuzumab), targeting platinum-resistant ovarian cancer [3] - The oral GLP-1 receptor agonist HDM1002 has completed Phase III clinical trials for weight management, with over 800 participants enrolled in earlier phases [4] - The company has 15 new patent authorizations in 2024, including core patents for GLP-1R/GIPR dual-target agonists [6] Market Strategy - The company maintains a global operational layout for its medical beauty business, focusing on high-end markets [2] - The company plans to enhance its market coverage and registration processes to stabilize the performance of its core subsidiary, Sinclair [2] - The company aims to improve the accessibility of its innovative high-priced drugs through diverse payment channels and market penetration strategies [21] Challenges and Responses - The medical beauty sector faces challenges due to macroeconomic slowdowns and declining consumer demand, but is expected to stabilize with new product approvals [30] - The company is actively managing production costs and enhancing operational efficiency to mitigate the impact of drug price negotiations and procurement policies on profit margins [19] - The company is committed to maintaining a cash dividend policy while balancing strategic development and shareholder returns [12]

Financial Performance - In 2024, the company achieved a revenue of CNY 41.906 billion, a year-on-year increase of 3.16% [4] - The net profit attributable to shareholders was CNY 3.512 billion, up 23.72% year-on-year [4] - The net profit after deducting non-recurring gains and losses was CNY 3.352 billion, reflecting a growth of 22.48% [4] - Compared to 2021, revenue and net profit grew by 21.24% and 52.59%, respectively [4] Business Segments Performance Pharmaceutical Industry - The pharmaceutical segment generated a revenue of CNY 13.811 billion, with a year-on-year growth of 13.05% [5] - The net profit for this segment was CNY 2.876 billion, increasing by 29.04% [5] - R&D investment in the pharmaceutical industry reached CNY 2.678 billion, a 16.77% increase [5] Aesthetic Medicine - The domestic aesthetic medicine subsidiary reported a revenue of CNY 1.139 billion, growing by 8.32% [6] - The UK subsidiary, Sinclair, generated approximately CNY 0.967 billion, a decline of 25.81% due to global economic challenges [6] Industrial Microbiology - The industrial microbiology segment achieved a revenue of CNY 0.711 billion, a significant increase of 43.12% [25] - Growth rates for specific areas included 38% for specialty raw materials and intermediates, 20% for xRNA, and 142% for health and biological materials [25] R&D and Product Development - The company has over 80 innovative drug candidates in its pipeline [5] - The oral small molecule GLP-1 receptor agonist HDM1002 has shown promising results in clinical trials, with over 800 participants [17] - The ADC pipeline includes more than 12 projects, with ongoing clinical trials for several candidates [14] Market Strategy and Future Outlook - The company plans to actively participate in medical insurance negotiations for new products [6] - There is a focus on expanding market presence in both domestic and international markets, particularly in the aesthetic medicine sector [26] - The company anticipates a gradual recovery in overseas aesthetic medicine markets [26] Investor Relations and Communication - The annual performance meeting was attended by 381 institutional and individual investors [2] - The chairman emphasized the commitment to high-quality development and strategic goals for the upcoming three-year plan [27]