12月15日，华东医药（000963）股份有限公司(以下简称"华东医药"或公司)全资子公司杭州中美华东制 药有限公司(以下简称"中美华东")宣布，其研发的创新多肽类人GLP-1(胰高血糖素样肽-1)受体和GIP受 体(葡萄糖依赖性促胰岛素多肽)的双靶点长效激动剂HDM1005注射液在体重管理适应症中国II期临床试 验中取得了积极结果，展现了公司在代谢疾病领域强大的研发实力。 此外，公司另一款自主研发的ADC创新药注射用HDM2012的胃癌和胃食管交界癌、胰腺癌两项适应症 获得美国食品药品监督管理局(以下简称"美国FDA")孤儿药资格认定(Orphan Drug Designation,ODD)， 证明了其ADC研发创新性获国际认可。 这两大进度这标志着华东医药在新药研发的国际化与前沿探索方面实现了重要跨越，不仅体现了公司以 科研为基础理念的成功实践，更彰显了其在新靶点探索和研发布局上的前瞻性，为华东医药在创新领域 的持续领先奠定了坚实基础。 强效减重临床数据惊艳，创新产品获孤儿药认定 公开资料显示，HDM1005注射液是由中美华东研发并拥有全球知识产权的1类化学新药，为多肽类人 GLP-1受体和GIP受体的双 ...

Core Insights - AbbVie reported global net revenue of ELAHERE at $508 million for the first three quarters of 2025, with $453 million coming from the U.S. market [2] - Huadong Medicine announced that ELAHERE's packaging version for the Chinese market was officially commercialized earlier this month, with the first prescription issued nationwide [2] - ELAHERE has achieved sales revenue exceeding 45 million yuan in the Greater China region from January to September 2025 [2]

Core Viewpoint - The article highlights the successful leadership of Lv Liang at Huadong Medicine, emphasizing the company's strategic shift towards innovative drugs and its impressive market performance, including a significant increase in market value and a robust pipeline of new products [4][6][13]. Group 1: Leadership and Company Strategy - Lv Liang has been re-elected as chairman and appointed as CEO, marking his third term in leadership [2][3]. - Under his management, Huadong Medicine has transitioned from a generics-focused company to one that emphasizes innovative drug development, particularly in oncology, endocrinology, and autoimmune diseases [3][6]. - The company has a pipeline of over 80 innovative drug projects, with 50 being self-developed [9]. Group 2: Financial Performance - As of July 17, Huadong Medicine's market capitalization reached 77 billion, reflecting a 28% increase since the beginning of the year [4]. - The company reported a projected net profit of 3.5 billion for 2024, representing a year-on-year growth of over 20%, primarily driven by innovative drugs [13]. - Research and development expenses have increased, reaching approximately 1.43 billion in 2024, up 12.19% from the previous year [19]. Group 3: Product Development and Approvals - Huadong Medicine has received multiple approvals for innovative products, including a first-in-class drug for recurrent pericarditis and a treatment for moderate to severe plaque psoriasis [11][12]. - The company is advancing its innovative drug pipeline with significant projects in late-stage clinical trials, including oral GLP-1 receptor agonists and a three-target product for fatty liver disease [24]. Group 4: Market Expansion and Diversification - Huadong Medicine operates across four major sectors: pharmaceutical manufacturing, pharmaceutical commerce, medical aesthetics, and industrial microbiology, with a focus on accelerating innovation and international collaboration [29][30]. - The medical aesthetics segment has seen substantial growth, with 40 high-end products launched, generating approximately 2.3 billion in revenue [33]. - The company is also exploring new fields such as synthetic biology and industrial microbiology, indicating a commitment to diversifying its product offerings [35].

Group 1 - Company announced the research results of three GLP-1 innovative drugs at the 2025 ADA conference, with HDM1005 selected for oral presentation and HDM1002-102 and semaglutide injection results displayed as posters [1][2] - HDM1005 is a dual-target long-acting agonist for GLP-1 and GIP, with a Phase I study showing significant weight loss and metabolic improvements in participants [3][4] - HDM1002, an oral non-peptide GLP-1 receptor agonist, demonstrated good safety and weight loss effects in a Phase 1b study, with further clinical development planned [4] Group 2 - Semaglutide injection's Phase III study involved 494 type 2 diabetes patients, showing comparable efficacy to Novo Nordisk's treatment, with lower adverse event rates [5] - Company has a robust pipeline with 133 projects under development, focusing on endocrine, autoimmune, and oncology fields, with significant R&D investment [5][6] - In the endocrine sector, the company is developing a diverse range of GLP-1 products, including HDM1005 and HDM1002, with ongoing clinical trials [6] Group 3 - In oncology, the company aims to establish a leading drug development platform, with over 30 innovative drug candidates, including ADCs and small molecules [7][8] - The first ADC project, HDM2005, received orphan drug designation from the FDA, with ongoing clinical trials for various cancer indications [8] - The company has a comprehensive pipeline in the autoimmune field, with over 20 products in development, targeting various conditions [9] Group 4 - The company ranked 41st in the "2025 Global Pharmaceutical Companies Top 50" list, marking a significant recognition of its competitive strength [1][10] - The successful presentation of GLP-1 drugs at the ADA conference highlights the company's advancements in metabolic disease treatment [10] - The company continues to focus on innovation and research to provide better solutions for global patients [10]