8月19日晚间，华东医药（000963.SZ）如期交出上半年"成绩单"。 创新产品放量 根据华东医药财报，公司业绩呈现"逐季提升"的态势，尤其在第二季度，核心子公司中美华东表现亮眼，营收和净利润增速均跃升至两位数， 这预示着创新药扮演了越来越重要的"发动机"角色。 具体来看，2025年上半年，中美华东实现营业收入73.17亿元（含CSO业务），同比增长9.24%，实现归母净利润15.80亿元，同比增长 14.09%。其中第二季度实现营业收入36.96亿元（含CSO业务），同比增长12.04%，实现归母净利润7.37亿元，同比增长16.34%。 聚焦创新产品商业化情况，华东医药独家商业化科济药业的CAR-T产品赛恺泽®（泽沃基奥仑赛注射液）2025年上半年已完成全国20余省市医 疗机构认证及备案，公司已向合作方科济药业下达111份有效订单，目前已获超百家保险及惠民保项目纳入报销范畴。随着商保覆盖持续深 化，该产品有望延续高速增长态势。 华东医药与荃信生物合作的乌司奴单抗注射液赛乐信2024年11月获批上市，截至2025年6月30日，已开具处方的医院数量超过1200家，新增儿 童斑块状银屑病适应症的补充申请于20 ...

Core Viewpoint - Huadong Medicine reported a steady growth in its financial performance for the first half of 2025, with revenue reaching 21.675 billion yuan, a year-on-year increase of 3.39%, and a net profit of 1.815 billion yuan, up 7.01% [1] Financial Performance - The company achieved a total revenue of 21.675 billion yuan in the first half of 2025, reflecting a 3.39% increase year-on-year [1] - The net profit attributable to shareholders was 1.815 billion yuan, marking a 7.01% growth, while the net profit excluding non-recurring items was 1.762 billion yuan, up 8.40% [1] - A mid-year dividend of 614 million yuan is proposed, representing 33.83% of the net profit for the first half of 2025 [1] Business Growth and Product Commercialization - Huadong Medicine's core subsidiary, Zhongmei Huadong, reported a revenue of 7.317 billion yuan, a 9.24% increase, and a net profit of 1.580 billion yuan, up 14.09% [2] - The innovative product sales and agency service revenue reached 1.084 billion yuan, with a significant growth of 59% [2] - The CAR-T product, Zekai Ze, has expanded its market coverage, with over 20 provinces certified and more than 100 insurance projects included for reimbursement [2] R&D and Innovation - The company invested 1.484 billion yuan in R&D, a 33.75% increase, with direct R&D spending at 1.174 billion yuan, up 54.21% [6] - Huadong Medicine is advancing over 80 innovative drug pipelines, focusing on oncology, endocrinology, and autoimmune diseases [6][7] - The ADC product pipeline is progressing well, with several candidates in clinical trials and receiving orphan drug designation from the FDA [8] Industrial Microbiology and Aesthetic Medicine - The industrial microbiology segment achieved sales of 368 million yuan, a 29% increase, with significant growth in various sub-segments [10] - The aesthetic medicine division has launched multiple products, with strong market reception and ongoing registration efforts for new products [11][12] - The company aims to enhance its global presence and continue driving innovation in both pharmaceutical and aesthetic sectors [12]

Investment Rating - The report maintains a "Strong Outperform" rating for the pharmaceutical sector, indicating a positive outlook compared to the broader market indices [2][4]. Core Insights - The pharmaceutical sector continues to adjust and has underperformed the CSI 300 index, with a weekly decline of 0.84% compared to the index's increase of 1.23% [2]. - The report highlights the recent performance of various sectors, noting that the pharmaceutical sector ranks last among 31 sectors [2]. - The report emphasizes the potential of the brain-computer interface (BCI) industry, supported by recent government policies aimed at fostering innovation and development [2]. - The efficacy of Eli Lilly's oral weight loss drug, Orforglipron, was below market expectations, which opens opportunities for Chinese innovative weight loss drugs in the global market [2]. Summary by Sections Market Performance - The SW Pharmaceutical Index decreased by 0.84% this week, ranking 31 out of 31 sectors, while the CSI 300 index rose by 1.23% [2]. - The report notes that sectors such as defense, non-ferrous metals, and machinery outperformed the pharmaceutical sector [2]. Brain-Computer Interface (BCI) Development - A joint policy from seven government departments aims to promote the BCI industry, targeting breakthroughs in key technologies by 2027 and establishing a competitive industry ecosystem by 2030 [2]. - Companies actively involved in BCI technology development, such as Ruimaite and Chengyitong, are highlighted as potential investment opportunities [2]. Weight Loss Drug Market - Eli Lilly's Orforglipron showed a weight loss of 12.4% after 72 weeks, which is significantly lower than the 17.4% weight loss from a competitor's product [2]. - The report suggests that this underperformance may provide a competitive edge for Chinese companies developing similar drugs, with several already in late-stage clinical trials [2]. Investment Strategy - The report recommends focusing on core sectors with potential for business development (BD) and international expansion, particularly in ADC and PD-1 dual antibodies [2]. - It suggests monitoring high-growth companies in the CXO sector and medical devices, as well as those involved in BCI and AI in healthcare [2].

Summary of Key Points from the Conference Call Industry Overview - **Industry**: China Healthcare - **Key Indices Performance**: HSHCI/HSHKBIO indices rose by 0.2% and 0.1% respectively from August 4 to August 8, 2025. SW Healthcare A/H indices moved -0.8% and +2.5%, ranking 31st and 20th among A/H-share sectors [1][1][1]. Company Insights - **Saint Bella**: Initiated coverage with a Buy rating due to its strong position in postpartum care and long-term family care potential, which may be overlooked [1][1][1]. - **Wuxi Bio**: Upgraded to Buy as it is well-positioned as a biologics CDMO amid therapy upgrades from chemotherapy to antibody-drug conjugates (ADC) and from monoclonal to bi/multi-specific candidates [1][1][1]. Subsector Performance - **Medtech**: Outperformed in A shares with a +2.7% increase, likely due to sectoral rotation within healthcare [1][1][1]. - **Biologics**: Outperformed in H shares with a +6.3% increase, primarily driven by small-cap biotechs [1][1][1]. Notable Company Performances - **Innovent**: Reported H125 product sales exceeding RMB 5.2 billion, up more than 35% year-over-year, surpassing estimates of RMB 5.1 billion [3][3][3]. - **3SBio**: Issued new shares to Pfizer worth HK$7.85 million, equating to 1.28% of its total post-IPO equity [3][3][3]. - **Huadong**: Released phase II trial results for HDM1002, showing weight reduction of -4.63%, -6.08%, and -2.88% in different dosage groups after 12 weeks [3][3][3]. Regulatory Developments - **Generics GPO**: The National Joint Procurement Office started demand reporting for the 11th round of national centralized drug procurement, allowing reporting by product name or brand for the first time [2][2][2]. - **Biosimilar VBP**: Initiated by the Anhui Provincial Pharmaceutical Procurement Center for eight monoclonal antibodies [2][2][2]. Investment Recommendations - **Top Picks**: Include Innovent, 3SBio, Wuxi Apptec, and United Imaging among others [1][1][1]. - **Medtech Focus**: Added United Imaging to top picks while retaining Weigao [1][1][1]. Risks and Challenges - **Healthcare Industry Risks**: Include potential price cuts from GPO programs, intensified competition, lower-than-expected innovative drug prices for NRDLs, slower consumption recovery, stricter regulations, and geopolitical tensions impacting operations [35][35][35]. Additional Insights - **Funding Trends**: Biopharma funding in July 2025 showed a year-over-year increase of 133% and a month-over-month increase of 34% [8][8][8]. - **Clinical Trials**: The number of registered clinical trials in China has been on an upward trend, indicating a robust pipeline for future drug development [22][22][22]. This summary encapsulates the key points from the conference call, highlighting the performance of companies within the China healthcare sector, regulatory changes, investment recommendations, and potential risks.

Investment Rating - The report maintains an "Overweight" rating for the pharmaceutical and biotechnology industry [4]. Core Insights - In the first half of 2025, several CXO companies are expected to see year-on-year improvements in performance, suggesting potential investment opportunities [2][21]. - The pressure from the US interest rate hike cycle on new drug financing is gradually easing, leading to a recovery in overseas new drug development demand, which is beneficial for Chinese companies [2][21]. - The report highlights the resilience of gross margins for leading companies in the CXO sector, indicating a positive trend in external CDMO orders [2][21]. Summary by Sections Market Review - Last week, the A-share pharmaceutical and biotechnology index rose by 1.82%, outperforming the CSI 300 index by 1.00 percentage points but underperforming the ChiNext index by 0.39 percentage points, ranking 16th among 31 sub-industries [1][13]. - The Hong Kong Hang Seng Healthcare Index increased by 0.05%, lagging behind the Hang Seng China Enterprises Index by 0.96 percentage points [1][13]. Company Performance Expectations - WuXi AppTec, a leading CXO company, expects to achieve approximately CNY 20.799 billion in revenue for the first half of 2025, a year-on-year increase of about 20.64%, with adjusted net profit expected to be around CNY 6.315 billion, up 44.43% year-on-year [19][21]. - Other companies like Boteng Co. and Aopumai also forecast revenue growth of 15%-20% and 23.25% respectively for the same period [19][20]. Investment Strategy - The report suggests a focus on three payment channels within the pharmaceutical industry: hospital payments, out-of-pocket payments, and overseas payments, with recommendations for companies like Heng Rui Pharmaceutical, Mindray Medical, and Yuyue Medical [2][21]. R&D Progress - Recent updates indicate that several companies are advancing in their clinical trials, with notable progress from companies like Baiyao and Huadong Medicine [25][26]. Financial Metrics - The pharmaceutical manufacturing industry reported a cumulative revenue of CNY 994.79 billion from January to May 2025, reflecting a year-on-year decline of 1.40% [52].

Core Viewpoint - Tirzepatide, a drug by Eli Lilly, has shown impressive sales growth and market penetration, significantly impacting the company's stock performance since its approval in May 2022, with a stock price increase of 180% [1][16]. Group 1: Sales Performance and Market Position - Tirzepatide achieved a combined revenue of $5 billion in Q1 2025, accounting for 39% of Eli Lilly's total revenue, with a year-on-year growth rate exceeding 100% [1][12]. - As of Q1 2025, Eli Lilly's total prescription volume in the U.S. for GLP-1 receptor agonists reached 53.3%, surpassing its main competitor, Novo Nordisk [3][5]. - The rapid growth in prescription volume for tirzepatide is attributed to higher patient acceptance and superior efficacy compared to semaglutide [5][10]. Group 2: Clinical Efficacy and Competitive Advantage - In head-to-head clinical trials, tirzepatide demonstrated superior weight loss results compared to semaglutide, with an average weight loss of 20.2% versus 13.7% [8][9]. - The trial results support tirzepatide's position as a more effective treatment option, which is expected to sustain its sales growth [6][10]. Group 3: Market Dynamics and Future Challenges - The demand for GLP-1 drugs has surged, leading to supply shortages for semaglutide, which has allowed tirzepatide to capture excess demand [11][12]. - The competitive landscape is intensifying, with 179 GLP-1 drug candidates in clinical stages from 45 companies, indicating potential future sales pressure for both semaglutide and tirzepatide [12][14]. - Patent expirations for semaglutide in key markets like China and India in 2026 may lead to significant price reductions for generic versions, impacting tirzepatide's market position [14][15]. Group 4: Investment Opportunities - Tirzepatide's success has stimulated investment interest across the GLP-1 supply chain, with various companies advancing their own GLP-1 drug candidates [16][17]. - Notable companies in the GLP-1 space include Hengrui Medicine, which has multiple candidates in clinical trials, and other firms like East China Pharmaceutical and Innovent Biologics that are also progressing rapidly [17].

Summary of Key Points from the Conference Call Industry Overview - The conference call focused on the healthcare sector, specifically the developments in diabetes treatment and related biopharmaceuticals in China, particularly in relation to the upcoming ADA'25 conference. Core Insights and Arguments 1. **China's Presence at ADA'25**: Chinese biotech companies are expected to present significant data at ADA'25, including: - Ascletis's ASC30 (oral GLP-1) in Phase 1, showing mild to moderate adverse events (AEs) with no serious adverse events (SAEs) reported [1][2] - Laekna's LAE102 (muscle-preserving drug) in Phase 1, demonstrating dose-dependent increases in serum concentration and no serious AEs [2][3] - Innovent's Mazdutide (GLP-1/GCG) in Phase 3, showing superior results compared to placebo in HbA1c reduction and weight loss [2][3] 2. **Anticipated Outcomes**: There are low expectations for major surprises from Chinese players at ADA'25, as many oral GLP-1 and amylin candidates are still in early stages of development [4]. 3. **Key Data Points**: - **Ascletis's ASC30**: 70.3% of AEs were mild, and 29.7% were moderate, with pharmacokinetic analysis supporting once-daily oral dosing [2]. - **Laekna's LAE102**: No serious AEs or treatment-emergent adverse events (TEAEs) leading to study discontinuation were reported, with increased activin A levels maintained over a 28-day follow-up [2]. - **Innovent's Mazdutide**: At week 24, the mean HbA1c change from baseline was -1.43% for MAZ 4 mg and -2.02% for MAZ 6 mg, with significant proportions of patients achieving HbA1c <7.0% and weight reduction ≥5% [2]. Additional Important Content 1. **Company Valuations and Risks**: - **Eli Lilly & Co**: Price target supported by DCF valuation, with risks including commercial, regulatory, and clinical factors [7]. - **Hengrui**: Price target of Rmb80.0 based on DCF methodology, with risks related to negotiations and market competition [8]. - **Innovent Biologics Inc**: Price target of HK$40.0 derived from DCF methodology, with various operational and regulatory risks [9]. 2. **Development Phases of Key Products**: A detailed table outlines the development phases of various products presented by Chinese companies at ADA'25, including their indications and target mechanisms [6]. 3. **Market Dynamics**: The report highlights the competitive landscape and the potential for intensified market competition as more players enter the diabetes treatment space [8]. This summary encapsulates the critical insights and data points discussed in the conference call, providing a comprehensive overview of the current state and future outlook of the healthcare sector, particularly in diabetes treatment in China.

Core Viewpoint - Company is undergoing an innovative transformation, focusing on chronic diseases, tumors, and immunology, with multiple products entering a harvest phase, maintaining a "buy" rating [1] Group 1: Business Segments - Company covers four major business segments: pharmaceutical manufacturing, pharmaceutical commerce, medical aesthetics, and industrial microbiology, optimizing product structure towards innovation [1] - Pharmaceutical manufacturing revenue is projected to reach 138.1 billion yuan in 2024, reflecting a year-on-year growth of 13.1% [2] - Medical aesthetics revenue is expected to recover gradually as new products are launched, despite a current decline of 4.9% [2] Group 2: Financial Performance - Company forecasts 2024 revenue of 419.1 billion yuan, a year-on-year increase of 3.2%, with a net profit of 35.1 billion yuan, up 23.7% [2] - Expected net profits for 2025, 2026, and 2027 are 40.61 billion yuan, 47.16 billion yuan, and 55.37 billion yuan respectively, with corresponding EPS of 2.32, 2.69, and 3.16 yuan [1] Group 3: Innovation Pipeline - Company is focusing on differentiated layouts in ADC and PROTAC technologies, with several products entering clinical stages [3] - The pipeline includes oral small molecule drugs for diabetes and obesity, with significant milestones expected in 2025 [3] Group 4: Market Sentiment - Recent ratings show 16 out of 17 institutions recommend a "buy" rating, with an average target price of 49.22 yuan [4]

Group 1: Financial Performance - In 2024, the company achieved a revenue growth of 21.24% and a net profit growth of 52.59% compared to 2021, reaching historical highs [2] - The company completed its seventh three-year plan successfully and is now entering the eighth three-year plan with higher goals [14] Group 2: Innovation and R&D - The company has over 80 innovative drug pipelines, with nearly 50 self-developed projects, focusing on oncology, endocrinology, and immunology [3] - In 2024, the company received 4 NDA/BLA approvals and 14 clinical approvals in China and the U.S. [3] - The R&D team consists of over 330 members, with more than 60% holding advanced degrees [3] Group 3: Key Product Developments - The company launched several innovative products, including the first ADC drug for platinum-resistant ovarian cancer and the first biosimilar of ustekinumab in China [2] - The GLP-1 receptor agonist HDM1002 has over 800 participants in clinical trials, showing good safety and efficacy [5][6] - The ADC project HDM2005 for treating advanced malignancies has completed initial dosing stages without dose-limiting toxicity [9] Group 4: AI and Technology Integration - The company established an AI drug design platform, enhancing drug development efficiency through deep integration of AI and traditional methods [10] Group 5: Aesthetic Medicine Sector - The aesthetic medicine division has developed a comprehensive product matrix, covering various treatment methods and achieving significant growth since its inception [12][13] - The company aims to become a leading provider of comprehensive aesthetic solutions globally, with a focus on innovative product launches [12] Group 6: Market Strategy and Future Outlook - The company plans to balance R&D investments with revenue growth, focusing on enhancing project quality and efficiency [15][16] - The domestic aesthetic medicine market is expected to grow, supported by new product launches and increasing consumer demand [19] - The company is optimistic about its industrial microbiology segment, aiming for accelerated development in the next three years [20]

Financial Performance - In 2024, the company achieved a revenue of CNY 41.906 billion, with a foreign sales revenue of CNY 1.095 billion, accounting for 2.61% of total revenue [20] - The pharmaceutical industrial revenue reached CNY 13.811 billion, representing 32.96% of total revenue [13] - The medical beauty business generated CNY 2.326 billion in revenue, with the subsidiary Xinkeli Meixue contributing CNY 1.139 billion [10] Business Development - The company completed its seventh three-year plan, achieving record high revenue and net profit attributable to shareholders [1] - The industrial microbiology business reported a revenue of CNY 711 million, a year-on-year increase of 43.12% [5] - The company is focusing on four strategic directions: xRNA, specialty APIs & intermediates, health & biological materials, and animal health [2] Product Pipeline and Innovation - The company is preparing for the commercial launch of the innovative ADC drug, Ailaha (Somatuzumab), targeting platinum-resistant ovarian cancer [3] - The oral GLP-1 receptor agonist HDM1002 has completed Phase III clinical trials for weight management, with over 800 participants enrolled in earlier phases [4] - The company has 15 new patent authorizations in 2024, including core patents for GLP-1R/GIPR dual-target agonists [6] Market Strategy - The company maintains a global operational layout for its medical beauty business, focusing on high-end markets [2] - The company plans to enhance its market coverage and registration processes to stabilize the performance of its core subsidiary, Sinclair [2] - The company aims to improve the accessibility of its innovative high-priced drugs through diverse payment channels and market penetration strategies [21] Challenges and Responses - The medical beauty sector faces challenges due to macroeconomic slowdowns and declining consumer demand, but is expected to stabilize with new product approvals [30] - The company is actively managing production costs and enhancing operational efficiency to mitigate the impact of drug price negotiations and procurement policies on profit margins [19] - The company is committed to maintaining a cash dividend policy while balancing strategic development and shareholder returns [12]