撰文丨王聪 编辑丨王多鱼 排版丨水成文 本周 （8 月 18 日- 8 月 24 日） ，国际顶尖学术期刊 Cell 共上线了 9 篇研究论文，其中 6 篇来自华人学者，这些研究分别是 ， 将 IscB 和 Cas9 转换为 RNA 编辑器、 世界首个维管植物整合细胞图谱、 修饰腺苷的解毒机制、 系统素拮抗肽调控番茄免疫系统的分子机制、 新型通用型 CAR-T 细胞疗法、 生物凝聚体调控神经系统。 将 IscB 和 Cas9 转换为 RNA 编辑器 2025 年 8 月 18 日，耶鲁大学 可爱龙 教授作为通讯作者，在 Cell 期刊发表了题为： Conversion of IscB and Cas9 into RNA-guided RNA- editors 的研究论文 【1】 。 该研究对 Cas9 的祖先 IscB 以及 Cas9 自身进行了工程化改造，删除了其 TID/PID 结构域， 将它们从原本的 RNA 引导的 DNA 编辑器转换为 RNA 引导的 RNA 编辑器 ，并展示其在可变剪切干扰、反式剪接及 RNA 碱基编辑中的应用潜力， 其性能可媲美甚至超越了 Cas13，且更具安全性，为 RNA 疗 ...

Core Viewpoint - The research conducted by Wang Jiawei's team at the Chinese Academy of Sciences has made significant advancements in plant developmental biology by creating a unified cell atlas of vascular plants, which enhances gene discovery and addresses the challenges of gene redundancy in forward genetics [5][6]. Group 1: Research Breakthroughs - The study published in the journal Cell presents the world's first integrated cell atlas of vascular plants, identifying foundational genes for various cell types, thus overcoming bottlenecks in efficient gene discovery [5][6]. - The research team constructed a shoot apex single-cell atlas across six representative species, revealing the foundational gene framework for key plant cell types, significantly improving gene function exploration efficiency [6][7]. Group 2: Methodological Innovations - The team developed an automated cell classification algorithm tool for vascular plant cell types, accelerating the analysis and application of single-cell data [7][10]. - By comparing cross-species single-cell transcriptome maps, the team identified core gene modules for conserved cell types, enabling precise candidate gene screening and avoiding redundancy from random mutations [6][10]. Group 3: New Discoveries - The research identified novel regulatory factors and cell types, including previously unrecognized X8 domain proteins and JULGI-LIKE proteins, which are regulatory factors for phloem development [6][10]. - The study also recognized a new cell type, companion cell-like cells, in ferns and gymnosperms, expanding the understanding of plant cell diversity [6].