2025.06. 27 本文字数：1364，阅读时长大约3分钟 作者 | 第一财经 林志吟 从此次实验结果来看，聚谱成像技术的腺瘤检出率为38.29%，明显高于白光内镜的腺瘤检出率 （30.46%）且具有统计学差异；在次要结局指标上，聚谱成像技术的息肉检出率、无蒂锯齿状病变检出 率与进展期腺瘤检出率分别为56.29%、3.14%、6.57%，高于白光内镜的检出率（按顺序分别为： 47.99%、1.15%、3.16%），且息肉检出率、进展期腺瘤检出率均具有统计学差异。 该项目也是国内首次针对国产聚谱成像技术的大规模多中心研究，历时近一年，纳入覆盖全国各区域的 698例患者，采用了随机对照设计，旨在通过聚谱成像技术（SFI）和传统的白光内镜对息肉、无蒂锯齿 状病变及进展期腺瘤的检出率，对比两项技术在早癌临床筛查中的效果。 结直肠癌的发生发展大多遵循"腺瘤—癌 " 序列，约90%的结直肠癌是由腺瘤恶变而来，早期切除可使5 年生存率提升至90%以上。因此，要提高结直肠镜的生存率，需要提高早期结直肠癌患者腺瘤检出率 （ADR）。 当前，在内窥镜光学技术中，使用最广的是白光内窥镜，后者是利用可见光波段的白光成像，虽然可以 ...

Core Viewpoint - The study led by Shanghai Jiao Tong University Affiliated Renji Hospital demonstrates that the novel spectral imaging technology significantly improves the detection rate of colorectal adenomas compared to traditional white light endoscopy, addressing the challenge of missed diagnoses in flat lesions [1][4]. Group 1: Colorectal Cancer Context - Colorectal cancer is the second most prevalent and the fourth leading cause of cancer-related deaths in China [1]. - Approximately 90% of colorectal cancers arise from adenomas, and early removal can increase the five-year survival rate to over 90% [3]. Group 2: Study Overview - The multi-center randomized controlled trial involved over 698 patients across various regions in China, comparing the adenoma detection rates (ADR) of spectral imaging technology (SFI) and traditional white light endoscopy [1][4]. - The study is the first large-scale investigation of domestic spectral imaging technology in China, lasting nearly one year [1]. Group 3: Results of the Study - The adenoma detection rate for spectral imaging technology was 38.29%, significantly higher than the 30.46% rate for white light endoscopy, with statistical significance [4]. - Secondary outcomes showed that the polyp detection rate, flat serrated lesions detection rate, and advanced adenoma detection rate for spectral imaging were 56.29%, 3.14%, and 6.57%, respectively, all higher than the corresponding rates for white light endoscopy [4]. Group 4: Technological Advantages - Spectral imaging technology enhances the contrast between lesions and normal mucosa, making it easier to identify flat lesions and flat serrated lesions that are often missed with white light endoscopy [4]. - The technology is designed to be user-friendly, allowing for easy switching between imaging modes without the need for dye application, thus reducing the reliance on clinical experience [5].