英国利物浦大学科学家领衔的国际团队研制出一种名为Novltex的新型抗生素。测试表明，该抗生素对 多种致命超级细菌展现出持续抑制性，标志着对抗抗生素耐药性的努力取得重要进展。相关成果发表于 新一期《药物化学杂志》。 抗生素耐药性被列为人类面临的十大健康威胁之一，每年导致近500万人死亡。世界卫生组织发布的一 份急需新型抗生素的"优先病原体"名单，其中包括耐甲氧西林金黄色葡萄球菌和粪肠球菌。Novltex对 这两种细菌均表现出强效且快速的杀灭作用。 与传统抗生素不同，Novltex以脂质Ⅱ为靶点。脂质Ⅱ是细菌细胞壁的重要组成部分，不易发生突变。 这意味着Novltex可提供持久的耐药保护，有望应对现代医学中的一大难题。 团队此前曾开发出泰斯巴汀的简化合成版本。泰斯巴汀是从土壤细菌中分离出的一种环肽类抗生素，对 多种耐药菌具有显著活性。在此基础上，他们构建并测试了一个合成泰斯巴汀库，优化了多项关键性 能。 在最新研究中，受泰斯巴汀和另一种抗生素克洛维菌素启发，团队开发出新型抗生素Novltex。Novltex 避免了昂贵原料的使用，可用于构建大量候选分子以供优化，并靶向不易突变的脂质Ⅱ。这种高效、耐 用与可量产特 ...

Core Viewpoint - The company reported a decline in revenue for the first half of 2025, but a significant increase in net profit, indicating strong operational efficiency despite market challenges [4]. Group 1: Financial Performance - In H1 2025, the company achieved revenue of 4.32 billion yuan, a year-on-year decrease of 1.9%, while net profit attributable to shareholders reached 673 million yuan, a year-on-year increase of 113.5% [4]. - In Q2 2025, the company recorded revenue of 2.07 billion yuan, down 4.1% year-on-year and 8.3% quarter-on-quarter, with net profit of 264 million yuan, up 28.5% year-on-year but down 35.4% quarter-on-quarter [4]. Group 2: Product Pricing and Market Conditions - Vitamin prices remained high, contributing to a significant year-on-year increase in Q2 performance, despite a quarter-on-quarter decline [5]. - In Q2 2025, the average market price for domestic Vitamin A was 75 yuan/kg (down 14% year-on-year, down 38% quarter-on-quarter), Vitamin E was 107 yuan/kg (up 53% year-on-year, down 21% quarter-on-quarter), and biotin was 33.5 yuan/kg (down 7% year-on-year, down 3% quarter-on-quarter) [5]. Group 3: Research and Development Initiatives - The company has been increasing its investment in R&D, with expenditures of 749 million yuan in 2024 and 314 million yuan in H1 2025 [6]. - New product approvals include the injectable Daptomycin and the successful completion of facility inspections by the FDA, indicating a robust pipeline for future growth in the pharmaceutical sector [6]. - The company is actively expanding its pharmaceutical business through new product development and regulatory approvals, enhancing future profitability [6].