Investment Rating - The report maintains a rating of "B" for the biopharmaceutical industry, indicating expected volatility greater than the benchmark index [1]. Core Insights - The biopharmaceutical industry has shown significant market performance over the past year, with innovative drug developments, particularly in the area of ADCs (Antibody-Drug Conjugates) for lung cancer treatment [1]. - PD-1/L1 combined with ADCs is expected to overcome resistance and improve overall response rates (ORR), with promising results from various clinical trials [3][4]. - The report highlights specific drugs such as sac-TMT, HLX43, and SYS6010, which have demonstrated significant efficacy and tolerability in treating NSCLC and SCLC [3][5]. Summary by Sections Market Performance - The biopharmaceutical industry has outperformed the market, driven by advancements in innovative therapies [1]. Clinical Trials and Efficacy - In first-line treatment for non-squamous NSCLC, sac-TMT combined with PD-L1 showed an ORR of 59.3% and a median progression-free survival (mPFS) of 15.0 months, compared to 9-10 months for chemotherapy combined with PD-1 [4]. - In second-line EGFR wild-type NSCLC, the ORR for the drug iza-bren was 50.0%, while SYS6010 achieved an ORR of 88.9% in previously treated EGFR-mutant NSCLC [5]. Drug Tolerability - The report notes that the common grade 3 or higher treatment-related adverse events (TRAE) for the mentioned drugs were primarily hematological toxicities, with specific rates of treatment discontinuation due to TRAE being 2.4% for iza-bren [3][5].

Investment Rating - The report maintains a positive outlook on the pharmaceutical industry, rating it as "Overweight" [4][25]. Core Insights - The pharmaceutical sector saw a weekly increase of 1.2%, outperforming the Shanghai Composite Index, which rose by 0.6% [4][5]. - The Ministry of Industry and Information Technology, along with six other departments, issued a plan for the digital transformation of the pharmaceutical industry, aiming for significant advancements by 2027 and full coverage by 2030 [4][12]. - A head-to-head clinical trial showed that the dual antibody drug Ivoris combined with chemotherapy outperformed Tislelizumab in treating advanced squamous non-small cell lung cancer [4][13]. - The FDA approved the PD-1 monoclonal antibody for use in treating recurrent or metastatic non-keratinizing nasopharyngeal carcinoma [4][14]. - New clinical data from SYS6010, an EGFR ADC, demonstrated promising safety and efficacy in treating advanced solid tumors [4][16]. Market Performance - The overall valuation of the pharmaceutical sector is at 24.9 times PE (2025E), ranking fifth among 31 primary industries [4][11]. - The performance of various sub-sectors includes: - Raw materials (+4.7%) - Chemical preparations (+2.3%) - Traditional Chinese medicine (-0.5%) - Blood products (-3.3%) - Vaccines (-3.8%) [4][7]. Key Events - The digital transformation plan aims to integrate AI into the pharmaceutical industry, enhancing competitiveness and quality management across the entire supply chain [4][12]. - The report suggests focusing on companies with existing AI applications in diagnostics, devices, services, and pharmaceuticals [4].