证券研究报告 创新药黄金赛道梳理之PD-1（PD-L1）/VEGF双抗 生物医药行业强于大市（维持） 平安证券研究所生物医药团队 分析师： 叶寅投资咨询资格编号:S1060514100001邮箱：YEYIN757@PINGAN.COM.CN 倪亦道投资咨询资格编号:S1060518070001邮箱：NIYIDAO242@PINGAN.COM.CN 韩盟盟投资咨询资格编号:S1060519060002邮箱：HANMENGMENG005@PINGAN.COM.CN 裴晓鹏投资咨询资格编号:S1060523090002邮箱：PEIXIAOPENG719@PINGAN.COM.CN 何敏秀投资咨询资格编号:S1060524030001邮箱：HEMINXIU894@PINGAN.COM.CN 王钰畅投资咨询资格编号:S1060524090001邮箱：WANGYUCHANG804@PINGAN.COM.CN 曹艳凯投资咨询资格编号:S1060524120001邮箱：CAOYANKAI947@PINGAN.COM.CN 张梦鸽投资咨询资格编号:S1060525070003邮箱：ZHANGMENGGE752@PINGAN.C ...

其 他 研 究 沪深300 及创业板指数近1年走势 数据来源：聚源 -20% 0% 20% 40% 60% 80% 2024-08 2024-12 2025-04 沪深300 创业板指 昨日涨跌幅前五行业 | 行业名称 | 涨跌幅(%) | | --- | --- | | 电子 | 4.818 | | 通信 | 3.772 | | 计算机 | 3.504 | | 非银金融 | 2.761 | | 国防军工 | 2.286 | | 数据来源：聚源 | | 昨日涨跌幅后五行业 | 行业名称 | 涨跌幅(%) | | --- | --- | | 银行 | -0.297 | | 纺织服饰 | -0.198 | | 煤炭 | -0.147 | | 石油石化 | -0.146 | | 钢铁 | -0.108 | 数据来源：聚源 开源晨会 0825 ——晨会纪要 晨会纪要 2025 年 08 月 25 日 吴梦迪（分析师） wumengdi@kysec.cn 证书编号：S0790521070001 观点精粹 总量视角 【宏观经济】新型政策性金融工具即将落地——宏观周报-20250824 【宏观经济】美联储 9 月降息共识或 ...

医药生物 2025 年 08 月 24 日 投资评级：看好（维持） 行业走势图 数据来源：聚源 -12% 0% 12% 24% 36% 48% 2024-08 2024-12 2025-04 医药生物 沪深300 相关研究报告 《国谈药品初审名单公布，关注相关 公司的投资机会 — 行 业 周 报 》 -2025.8.17 《二代 IO 升级迭代，PD-1/VEGF 三抗 加速推进—行业周报》-2025.8.10 《设备更新政策持续深化，医疗设备 招采稳步复苏—行业周报》-2025.8.3 关注 PD-(L)1/VEGF 双抗海内外临床进展 ——行业周报 | 余汝意（分析师） | 余克清（分析师） | 聂媛媛（联系人） | | --- | --- | --- | | yuruyi@kysec.cn | yukeqing@kysec.cn | nieyuanyuan@kysc.cn | | 证书编号：S0790523070002 | 证书编号：S0790525010002 | 证书编号：S0790124050002 | PD-(L)1/VEGF 双抗赛道第一梯队海外临床加速开展 依沃西单抗（康方生物/Summit ...

Group 1: Coal Industry Insights - In July 2025, coal supply showed a marginal decrease, with cumulative production from January to July reaching 2.779 billion tons, a year-on-year increase of 3.8%, but the growth rate is declining. In July alone, production was 381 million tons, down 3.8% year-on-year and 9.52% month-on-month [6][5]. - Demand for coal in the first seven months of 2025 was supported by manufacturing and infrastructure, with fixed asset investment increasing by 1.6% year-on-year. However, real estate investment fell by 12.0% [6]. - Coal prices entered a rebound phase in July, with coking coal showing resilience. The average price of Shanxi mixed 5500 thermal coal has decreased since the beginning of 2025, while the average price of coking coal at Jingtang Port has also declined [6][5]. - The report suggests that the market's pricing in July was "beyond expectations," indicating a potential shift in policy that could lead to inflationary pressures. The expectation of price increases has led to a significant rise in coal stock prices [6][5]. - The report anticipates that the low point for coal prices this year may have already occurred, with prices unlikely to fall back in the second half of the year [6]. Group 2: Biopharmaceutical Industry Insights - The report highlights the potential of next-generation immuno-oncology (IO) therapies for non-small cell lung cancer (NSCLC), particularly those combining PD-1/L1 monoclonal antibodies with VEGF inhibitors, IL-2 agonists, and antibody-drug conjugates (ADCs) [8]. - Clinical data shows that PD-1/VEGF dual antibodies have achieved significant progression-free survival (PFS) and overall survival (OS) benefits in first-line NSCLC treatments, outperforming traditional therapies [8]. - The report notes that the PD-1/IL-2α-bias dual antibody fusion protein has shown promising OS benefits in IO-treated NSCLC patients, indicating a strong potential for these innovative therapies in overcoming immune resistance [8]. Group 3: Company-Specific Insights on Beite Technology - Beite Technology reported a revenue of 1.113 billion yuan for the first half of 2025, a year-on-year increase of 14.71%, with a net profit of 55 million yuan, up 45.14% [9]. - The company’s main business segments showed steady growth, particularly in the air conditioning compressor sector, which grew by 42.13% year-on-year [9]. - Beite Technology is expanding its production capacity for planetary roller screws, which is expected to contribute to its second growth curve, alongside ongoing construction projects in Jiangsu and Thailand [9].

Investment Rating - The report maintains an investment rating of "B" for the biopharmaceutical industry, indicating that it is expected to outperform the market [1][3]. Core Insights - The report highlights that tumor immunotherapy (IO) is a cornerstone treatment for non-small cell lung cancer (NSCLC), with next-generation IO therapies based on PD-1/L1 monoclonal antibodies showing promise when combined with VEGF, IL-2, ADC, and CTLA-4 to overcome immune resistance and improve survival rates [3][4]. - PD-1/VEGF dual antibodies have demonstrated significant clinical benefits in first-line progression-free survival (PFS) and overall survival (OS) settings, while PD-L1 ADCs offer new options for immune-resistant cases [3][4]. - The report notes that the combination of PD-1/VEGF dual antibodies with chemotherapy has outperformed PD-1 monoclonal antibodies combined with chemotherapy in clinical trials [3][4]. Summary by Sections Tumor Immunotherapy Developments - The report discusses the efficacy of various ADC drugs in NSCLC, including TROP2, EGFR×HER3, and PD-L1 ADCs, which have shown outstanding results [3]. - PD-1/VEGF dual antibodies have reached PFS endpoints in clinical trials for squamous NSCLC, with an overall response rate (ORR) of 71.4% and a median duration of response (mDOR) of 12.7 months [4]. Clinical Trial Results - In first-line PD-L1 positive NSCLC, the ORR for the 707 single-agent treatment was 70.8%, while the combination with chemotherapy yielded an ORR of 58.3% for non-squamous and 81.3% for squamous NSCLC [4]. - The report also highlights the significant OS benefits observed with the PD-1/IL-2α-bias dual antibody fusion protein IBI363 in previously treated squamous NSCLC, achieving a median OS of 15.3 months [5]. Emerging Therapies - The PD-L1 ADC HLX43 has shown an ORR of 31.9% in CPI-treated NSCLC, with a notable 47.4% ORR in the EGFR wild-type non-squamous NSCLC subgroup [6]. - The report emphasizes the potential of the PD-1/VEGF/CTLA-4 triple antibody CS2009, which has demonstrated anti-tumor activity in early clinical trials [6].

Investment Rating - The report maintains an "Overweight" rating for the pharmaceutical and biotechnology industry [1] Core Insights - The upcoming World Conference on Lung Cancer (WCLC) is expected to showcase significant advancements in innovative drugs, generating new business development expectations [1] - The A-share pharmaceutical index has increased by 3% this week and 25% year-to-date, outperforming the CSI 300 by 0.7% and 18.2% respectively [4][9] - The report highlights the strong performance of the pharmaceutical sector, particularly in innovative drugs, research services, and CXO [10][11] Industry Trends - The WCLC will take place from September 6 to September 9, 2025, in Barcelona, featuring over 1,500 presentations, with a significant number from Chinese researchers [17][18] - Chinese innovation is prominently represented, with over 400 submissions, indicating a shift towards the commercialization of innovative drugs [18][19] Stock Performance - Notable stock performances include a 69% increase for Sainuo Medical and a 94% increase for Paig Biological in the H-share market [4][9] - The report provides a detailed overview of stock performance, highlighting both top gainers and losers in the pharmaceutical sector [9][13] Recommendations - The report suggests a focus on specific sub-sectors, ranking them as follows: innovative drugs > research services > CXO > traditional Chinese medicine > medical devices > pharmacies [10] - Specific stock recommendations include companies like Bory Pharmaceutical, Singlera Genomics, and Innovent Biologics based on various therapeutic angles [11][12]

Investment Rating - The report maintains an "Accumulate" rating for the pharmaceutical and biotechnology industry [6] Core Views - The report emphasizes that the second wave of innovation in pharmaceuticals is just beginning, with a focus on disruptive technologies and a potential bull market driven by innovative drugs [2][12][13] - The PD-1 Plus pipeline is highlighted as a significant trend, with various companies actively developing dual-target and triple-target drugs [17][21] Summary by Sections Recent Performance - The pharmaceutical index increased by 3.08% during the week of August 11-15, underperforming the ChiNext index but outperforming the CSI 300 index [11] - The market showed strong momentum, particularly in innovative drugs, with significant movements in both large-cap and small-cap stocks [12] Future Outlook - The report suggests a continued optimistic view on innovative drugs, with a focus on overseas major drugs and small-cap technology revolutions as key investment themes [13] - Specific strategies include balancing investments in new technologies like brain-computer interfaces and AI in medicine while continuing to explore innovative drugs [13] Investment Strategy - The report outlines a detailed investment strategy focusing on innovative drugs, including major overseas players and small-cap technology companies [14] - Key companies mentioned include: - Overseas Major Drugs: Innovent Biologics, 3SBio, and others [14] - Small-Cap Technology Revolution: Junshi Biosciences, Zai Lab, and others [14] - New Technologies: Companies involved in brain-computer interfaces and AI in healthcare [16] PD-1 Plus Pipeline - The PD-1/VEGF dual antibodies are identified as critical in the current research landscape, with several companies like CanSino Biologics and 3SBio making significant advancements [17][18] - The report highlights the competitive landscape and the potential for new therapies to emerge from ongoing clinical trials [19][20] Market Trends - The report notes that the innovation drug index has outperformed the pharmaceutical index and the CSI 300 index since the beginning of 2025, indicating a strong market trend towards innovative pharmaceuticals [47][48]

Investment Rating - The investment rating for the pharmaceutical industry is "Positive" (maintained) [4] Core Viewpoints - The report highlights the acceleration of IO tri-antibody therapies entering clinical stages, with significant potential, particularly focusing on Shanghai Yizhong [3][19] - The pharmaceutical index rose by 3.08% from August 11 to August 15, outperforming the CSI 300 index by 0.7% [5] - The report emphasizes the importance of innovative drugs as a clear industry trend, suggesting a focus on companies with strong business development catalysts in the second half of the year [5][29] Summary by Sections Market Performance - The pharmaceutical market showed a positive trend with 279 stocks rising and 200 falling during the week, with notable gains from companies like Sino Medical (+69.13%) and Innovative Medical (+51.53%) [5][30] - The report indicates that the pharmaceutical index has outperformed the CSI 300 index year-to-date by 18.22% [29] Investment Opportunities - The report suggests focusing on innovative drugs, particularly those with low valuation and potential for marginal improvement, including companies like WuXi AppTec, Tigermed, and others [5][29] - It also highlights the increasing importance of tri-antibody therapies in cancer immunotherapy, recommending attention to specific candidates like Shanghai Yizhong's YXC-001 [19][22] Industry Trends - The report notes that the domestic innovative pharmaceutical industry has reached a scale, with traditional companies like Hengrui Medicine and Hansoh Pharmaceutical successfully transitioning to innovation [29][50] - The aging population is driving demand for chronic disease treatments, which is expected to grow steadily [29][50] - The report emphasizes the potential of AI in the pharmaceutical sector, suggesting it could unlock new growth opportunities [29][50] Suggested Focus Areas - The report recommends focusing on innovative drugs and devices, manufacturing overseas, and addressing the needs of an aging population [50][51] - Specific companies to watch include Hengrui Medicine, Shanghai Yizhong, and others in the innovative drug space [52]

Group 1: Market Recognition and Performance - Chinese innovative drug assets are increasingly recognized globally, capturing a larger share of the global innovative drug licensing market [2] - In the first half of this year, Chinese A/H share listed innovative drug companies saw stock prices rise by 78%, significantly outperforming the healthcare sector and U.S. peers [2] - Chinese innovative drug licensing accounted for 27% of global transaction volume and 32% of global transaction value year-to-date [2] Group 2: IPO Trends and Market Dynamics - Multiple "10x stocks" have emerged in the Hong Kong pharmaceutical sector this year, with companies like Deqi Medicine and Hengrui Medicine seeing significant stock price increases [4][5] - At least 40 biopharmaceutical companies are currently waiting to go public in Hong Kong, indicating strong market interest [6] - The capital market's positive sentiment has led to several companies engaging in refinancing, with notable transactions from companies like Innovent Biologics and I-Mab [6] Group 3: Global Contribution and Challenges - One-third of the global clinical pipeline for innovative drugs comes from China, with Chinese companies capturing approximately 32% of global licensing transactions [7] - Despite the growth, only 10 out of 307 new drugs approved by the U.S. FDA since 2019 originated from China, highlighting the low global market share of Chinese innovative drugs [12] - Challenges remain, including the need for more robust clinical trial data and the impact of geopolitical factors on market access [13] Group 4: Focus Areas and Future Outlook - Oncology remains a primary focus for Chinese innovative drugs, accounting for over 60% of licensing transactions in the past three years [13] - The cardiovascular and metabolic (CVM) drug sectors are seeing increased interest, particularly in GLP-1 drugs, which are becoming a focal point for multinational companies [14] - The future success of Chinese GLP-1 drugs in global markets may depend on strategic partnerships with multinational corporations for licensing and distribution [14]

Group 1 - China's innovative drug assets are increasingly recognized globally, capturing a larger share of the global innovative drug licensing market, with 27% of global transaction volume and 32% of transaction value in 2023 [1] - Despite the growth, only 10 out of 307 new drugs approved by the FDA since 2019 are from China, representing less than 3% [1][11] - The market capitalization of Chinese pharmaceutical and biotech companies is significantly lower than their US counterparts, with only 14% of the total market cap of US listed companies [7] Group 2 - The Hong Kong stock market has seen multiple "10x stocks" in the pharmaceutical sector, with companies like Deqi Medicine and Hengrui Medicine experiencing significant price increases [4][5] - The recent IPOs of biopharmaceutical companies in Hong Kong have nearly matched the total for 2023, indicating a strong market interest [5] - A wave of high-profile IPOs is expected in the second half of 2025, driven by improved market conditions and increased liquidity [5][6] Group 3 - The capital market's enthusiasm has led to significant refinancing activities among listed companies, with major transactions from companies like Innovent Biologics and I-Mab [6] - Chinese companies now account for about one-third of the global pipeline of innovative drugs, with a total transaction scale of $48 billion in the first half of 2025 [6] - The trend of increasing licensing agreements with multinational pharmaceutical companies is expected to continue, as many innovative drugs are entering clinical stages [9][10] Group 4 - The focus of Chinese innovative drugs remains on oncology, with over 60% of licensing transactions in the past three years related to cancer treatments [12] - There is a rising interest in cardiovascular and metabolic disease drugs, particularly GLP-1 medications, which are becoming a focal point for multinational companies [12][13] - The global valuation of innovative drugs is undergoing a transformation, with a cautious approach towards high-priced acquisitions of late-stage drugs [10]