Japan Equity Research June 20, 2025 Pharmaceutical Sector Data Book – Valuation, Product Sales Trend Biotechnology & Pharmaceuticals/ Medical Technologies & Services Seiji Wakao, Ph.D. AC seiji.wakao@jpmorgan.com (81-3) 6736-8612 | | | | | P/E(x) | | | | | | P/B(x) | | | | | | EV/EBITDA(x) | | | | | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | | | | FY25E | FY26E | FY27E | FY28E | FY29E | FY35E | FY25E | FY26E | FY27E | FY28E | FY29E ...

Financial Data and Key Metrics Changes - The company expects to generate approximately $600 to $700 million in revenue for FY 2025, marking a significant increase from the previous year [5][18] - EBITDA guidance for FY 2025 has been raised to $200 to $280 million, up from $108 million in FY 2024, indicating a substantial growth trajectory [15][18] Business Line Data and Key Metrics Changes - The company has two commercial assets and a total of 28 assets in various stages of development, which is the largest biosimilars program globally [11][12] - The company has launched biosimilars in over 25 countries outside the US, with plans for three major approvals in the next six months [7][8] Market Data and Key Metrics Changes - The biosimilars market is maturing, with only 14 out of 62 biologic drugs that have gone off patent seeing launches, indicating significant growth potential [24][25] - The company targets a total addressable market of $185 billion with its existing pipeline of 28 drugs [27] Company Strategy and Development Direction - The company is focused on ramping up biosimilar launches and integrating R&D operations from its recent acquisition in Sweden [8][9] - The company employs a partnership model, selling through established players in each market, which allows for shared investment and risk [29][30] Management's Comments on Operating Environment and Future Outlook - Management expressed confidence in the biosimilars market's growth, citing a long tail of opportunities due to many biologics still off patent [26][24] - The company anticipates a significant increase in revenue, projecting $1.5 billion by 2028, with product revenues contributing 80-85% of this total [19][20] Other Important Information - The company expects minimal CapEx requirements moving forward, with $60 to $70 million expected in FY 2025 and $25 million annually for the next three years [23] - The company has a favorable tariff position due to its operations in Iceland, which has low tariff rates [64][66] Q&A Session Summary Question: What are the key differentiators for Alvotech? - The company highlighted its close integration between R&D and manufacturing, a custom-built platform, and an exceptional management team as key differentiators [3][4] Question: What is the focus for the next 12-18 months? - The focus will be on executing biosimilar launches, obtaining major approvals, and integrating R&D operations from the recent acquisition [6][8] Question: What led to the raised guidance for 2025? - The raised guidance was due to the acquisition of Xbrain and the potential for partnerships and milestone income from new assets [13][15] Question: How does the company view the biosimilars market? - The company is excited about the biosimilars market, noting significant growth opportunities and a large addressable market [24][27] Question: How does the company structure its partnerships? - The company typically has a 60-40 revenue split in favor of the commercial partner, allowing it to mitigate commercial risks [41][42] Question: What is the impact of the IRA on the biosimilars market? - The IRA may disincentivize smaller players but could benefit larger biosimilar companies like Alvotech [58][59] Question: How does the company view tariffs? - The company expects minimal impact from tariffs due to its low tariff rates and the structure of its contracts with commercial partners [64][66]

Spyre Therapeutics Inc (SYRE) FY Conference June 09, 2025 09:20 AM ET Speaker0 Thank you for joining us. I'm Paul Choi, and I cover biotechnology here at the firm. It's our pleasure to welcome Spire, and we have Cameron here on on stage with us. Maybe to to kick it off, Cameron, can just give us a brief overview of Spire and just sort of the key programs and technologies under pending pending the company? Yeah. Speaker1 Of course. And so and thanks for having us. It's a great event as always. So the backgro ...

Spyre Therapeutics Inc (SYRE) 2025 Conference June 04, 2025 08:10 AM ET Speaker0 Alrighty. Good morning, everyone. Really appreciate you joining us. My name is Akash Jawari. I am a pharma and biotech analyst here at Jefferies and this is day one of our wonderful New York Healthcare Conference. I've got Cameron from Spire. Cameron, why don't I hand it off to you for some brief introductory remarks and then we'll get started with the Q and A. Speaker1 Sounds good. Thanks for having me as always. So the the br ...

Core Insights - The article discusses the investment strategy of GARP (Growth at a Reasonable Price) as a hybrid approach that combines elements of both value and growth investing, particularly in uncertain market conditions [2][3][5]. Investment Strategy - GARP investing prioritizes the PEG (Price/Earnings Growth) ratio, which relates a stock's P/E ratio to its future earnings growth rate, providing a more comprehensive view of a stock's potential [5][6]. - A lower PEG ratio, ideally below 1, indicates both undervaluation and future growth potential, making it attractive for GARP investors [6]. Stock Performance - Several stocks have shown significant success using the GARP strategy, including Takeda Pharmaceutical, Five9, LATAM Airlines, and Mizuho Financial Group [4]. - Takeda Pharmaceutical has a Zacks Rank of 1, a Value Score of A, and a long-term expected growth rate of 35% [11]. - Five9 holds a Zacks Rank of 2, a Value Score of B, and a historical growth rate of 19.3% [13]. - LATAM Airlines also has a Zacks Rank of 1, a Value Score of A, and an expected growth rate of 14.8% [14]. - Mizuho Financial has a Zacks Rank of 2, a Value Score of B, and a long-term expected growth rate of 15.9% [16]. Screening Criteria - Effective GARP investing involves screening for stocks with a PEG ratio less than the industry median, a P/E ratio below the industry median, a Zacks Rank of 1 or 2, a market capitalization greater than $1 billion, and an average 20-day trading volume exceeding 50,000 [8][9].