Core Insights - Johnson & Johnson's MedTech segment achieved a 5.4% year-over-year growth in operational sales, reaching approximately $33.8 billion in 2025 [1] - The Innovative Medicine segment also saw growth, with a 5.3% increase in operational sales, totaling around $60.4 billion [2] - The company anticipates overall worldwide operational sales growth of 5.7% to 6.2%, potentially exceeding the $100 billion mark [6] MedTech Segment Performance - The growth in the MedTech segment was primarily driven by electrophysiology products, Abiomed in the Cardiovascular area, and wound closure products in General Surgery [4] - Abiomed reported an operational growth of 18% in Q4, while Shockwave achieved a 23% growth [4] - Johnson & Johnson completed the acquisition of Shockwave in May 2024, which is expected to enhance annual sales to at least $1 billion [5] Future Outlook - Both the Shockwave and Carvykti platforms surpassed $1 billion in annual sales for the first time, increasing the total number of platforms generating at least that much revenue to 28 [6] - The company is positioned to become the only healthcare company with over $100 billion in revenue, attributed to its diverse strengths in both Innovative Medicine and MedTech [7]

Financial Data and Key Metrics Changes - In Q4 2025, worldwide sales reached $24.6 billion, a 7.1% increase despite a 650 basis point headwind from Stelara [17] - For the full year 2025, worldwide sales were $94.2 billion, reflecting a 5.3% increase, with U.S. growth at 6.9% and international growth at 3.4% [18] - Net earnings for Q4 were $5.1 billion, with diluted earnings per share at $2.10, compared to $1.41 a year ago [18] - Full year 2025 net earnings were $26.8 billion, with diluted earnings per share at $11.03, significantly up from $5.79 the previous year [19] Business Line Data and Key Metrics Changes - Innovative Medicine reported Q4 sales of $15.8 billion, a 7.9% increase, with notable growth in oncology and immunology [20] - In oncology, Darzalex grew 24.1%, while Carvykti achieved sales of $555 million with a growth of 63.2% [20] - Immunology saw Tremfya grow 65.4%, while Stelara declined 48.6% due to biosimilar competition [21] - MedTech sales for the year were $34 billion, with operational growth of 5.4%, driven by cardiovascular and surgical segments [13] Market Data and Key Metrics Changes - U.S. sales growth was 7.5% in Q4, while international sales grew by 6.6% [17] - The cardiovascular segment delivered 15% operational sales growth, with Abiomed and Shockwave showing strong performance [13] - Surgical vision grew 10.8%, driven by new product innovations and demand for premium intraocular lenses [24] Company Strategy and Development Direction - The company plans to separate its orthopedics business by mid-2027, focusing on high-growth areas [30] - Investments of over $32 billion in R&D and M&A were made in 2025, including acquisitions of Intra-Cellular Therapies and HALDA Therapeutics [6] - The company aims for double-digit growth by the end of the decade, supported by a strong portfolio and pipeline [5] Management's Comments on Operating Environment and Future Outlook - Management expressed confidence in achieving faster growth in 2026 compared to 2025, with a line of sight to double-digit growth [6] - The company anticipates operational sales growth in 2026 to be between 5.7% and 6.7%, with a midpoint of $100 billion [31] - Management highlighted the strength of their portfolio and pipeline as key drivers for future growth [41] Other Important Information - The company ended 2025 with approximately $20 billion in cash and marketable securities, and $48 billion in debt [30] - A net interest expense of $300 million to $400 million is expected for 2026 [33] - The effective tax rate is projected to be between 17.5% and 18.5% for 2026 [34] Q&A Session Summary Question: Overview of growth prospects and key levers for double-digit growth - Management highlighted the strength of the portfolio and pipeline, focusing on oncology, immunology, and MedTech as key growth areas [40][41] Question: MedTech market dynamics and growth expectations - Management does not expect the loss of ACA subsidies to materially impact MedTech performance, with a focus on clinical capacity driving growth [48] Question: Margin progression and relationship to top-line growth - Management indicated that margin improvements will align with sales growth, with expectations for at least 50 basis points of improvement in 2026 [55] Question: Vision care market health and performance - Management noted strong underlying demand in the contact lens category, with robust growth driven by new product launches [58][59]

Financial Data and Key Metrics Changes - In Q3 2025, worldwide sales reached $24 billion, reflecting a 5.4% increase despite a 640 basis point headwind from Stelara [22][23] - Net earnings were $5.2 billion, with diluted earnings per share of $2.12, compared to $1.11 a year ago, marking a significant increase [22][23] - Adjusted net earnings for the quarter were $6.8 billion, with adjusted diluted earnings per share of $2.00, representing a 15.7% increase compared to Q3 2024 [22][23] Business Line Data and Key Metrics Changes - Innovative Medicine reported worldwide sales of $15.6 billion, increasing by 5.3% despite a 1,070 basis point headwind from Stelara [23][24] - In oncology, Darzalex sales grew by 19.9%, while Carvykti achieved sales of $524 million with an 81.4% growth [24] - Tremfya in Immunology delivered strong growth of 40.1%, while Spravato in neuroscience grew by 60.8% [25][15] - MedTech sales reached $8.4 billion, increasing by 5.6%, driven by strong performance in cardiovascular and vision segments [26][27] Market Data and Key Metrics Changes - U.S. sales growth was 6.2%, while international sales grew by 4.4% [22] - In cardiovascular, operational sales increased by approximately 12%, with Shockwave's technology supporting over 1 million patients [15][16] - Vision segment grew more than 6%, with TECNIS intraocular lenses being the fastest growing in the market [18] Company Strategy and Development Direction - The planned separation of the orthopedics business aims to sharpen focus on high-growth areas and enhance market leadership [19][20] - Johnson & Johnson is committed to investing in six core growth areas: oncology, immunology, neuroscience, cardiovascular surgery, and vision [21] - The company is focused on innovation and expanding its portfolio through strategic acquisitions, such as Intra-Cellular Therapies [19][20] Management's Comments on Operating Environment and Future Outlook - Management expressed confidence in the company's growth trajectory, emphasizing strong performance despite the loss of exclusivity for Stelara [33][34] - The company anticipates continued growth in Innovative Medicine and MedTech, with a focus on high-margin markets [34][40] - Future guidance for 2025 has been increased, projecting operational sales growth of 4.8% to 5.3% [40][41] Other Important Information - The effective tax rate for the quarter was 31.2%, up from 19.3% in the previous year, primarily due to a one-time remeasurement of deferred tax balances [30] - The company plans to invest $55 billion in U.S.-based innovation and manufacturing over the next four years [42][66] Q&A Session Summary Question: Why is the orthopedic spin-out happening now, and will there be similar separations for other divisions? - Management indicated that the orthopedic separation is a strategic move to prioritize breakthrough innovation and focus on high-growth markets [49][50] Question: What are the expectations for margins post-orthopedic spin-out? - Management acknowledged that while initial margin improvements may be modest, they expect stronger growth profiles and margin enhancements over time [56][57] Question: How will capital allocation priorities balance between Innovative Medicine and MedTech? - Management emphasized that capital allocation will focus on significant opportunities within the pipeline, with a strong commitment to both Innovative Medicine and MedTech growth [74][76]

Core Viewpoint - Johnson & Johnson reported strong performance in Q3 2025, driven by a robust portfolio and progress in key therapeutic areas, indicating a new era of growth and innovation [1]. Overall Financial Results - The company does not provide GAAP financial measures on a forward-looking basis due to uncertainties related to legal proceedings and other factors [5]. Regional Sales Results - Specific regional sales results were not detailed in the provided content. Segment Sales Results Innovative Medicine - Worldwide operational sales grew by 5.3%, with net acquisitions and divestitures contributing positively by 1.6% due to CAPLYTA [3]. - Key growth drivers included DARZALEX, CARVYKTI, ERLEADA, and RYBREVANT/LAZCLUZE in Oncology, TREMFYA and SIMPONI/SIMPONI ARIA in Immunology, and SPRAVATO in Neuroscience [3]. - Growth was partially offset by a negative impact of approximately 1,070 basis points from STELARA in Immunology and IMBRUVICA in Oncology [3]. MedTech - Worldwide operational sales increased by 5.6%, with net acquisitions and divestitures negatively impacting growth by 0.1% [4]. - Growth was primarily driven by electrophysiology products, Abiomed, Shockwave in Cardiovascular, wound closure products in General Surgery, and Surgical Vision [4]. Notable Announcements in the Quarter - The company encourages reviewing its disclosures filed with the Securities and Exchange Commission for additional context [7]. Webcast Information - Johnson & Johnson will conduct a conference call with investors to discuss the earnings release, accessible via their website [8]. About Johnson & Johnson - The company emphasizes its commitment to healthcare innovation, aiming to prevent, treat, and cure complex diseases through its expertise in Innovative Medicine and MedTech [9].

Core Insights - Johnson & Johnson's (JNJ) MedTech segment accounts for approximately 36% of total revenues and includes products in orthopedics, surgery, cardiovascular, and vision markets [1] MedTech Segment Performance - Despite challenges in the Asia Pacific markets, particularly China, J&J is shifting its portfolio towards high innovation and high growth markets, especially in Cardiovascular, with sales in this segment increasing by 20% in the first half of 2025 [2] - Second-quarter sales in the MedTech segment improved due to the acquisitions of Abiomed and Shockwave, alongside growth in Surgical Vision and wound closure [3] - The MedTech segment is expected to maintain strong momentum in Cardiovascular, Surgery, and Vision in the third quarter, driven by the adoption of newly launched products [3] Challenges in Asia Pacific - The MedTech business faces headwinds in the Asia Pacific region, particularly in China, where sales are negatively impacted by the volume-based procurement (VBP) program, a government-driven cost containment effort [4][5] - J&J does not anticipate any improvement in its business in the Asia Pacific region for 2025, expecting continued impacts from VBP and competitive pressures affecting sales growth in certain MedTech areas [5] Future Outlook - MedTech sales are projected to be higher in the second half of 2025 compared to the first half, as the business overcomes tougher first-quarter comparisons and new products gain traction [6] - The MedTech unit is estimated to have a compound annual growth rate (CAGR) of around 4.6% over the next three years [6] Competitive Landscape - J&J's MedTech unit faces strong competition from major players such as Medtronic, Abbott, Stryker, and Boston Scientific, each specializing in various medical technologies [7][8] Stock Performance and Valuation - J&J's shares have outperformed the industry year-to-date, rising by 31.9% compared to a 6.4% increase in the industry [9] - The company's shares currently trade at a price/earnings ratio of 16.93, higher than the industry average of 15.70 and above its five-year mean of 15.64 [12] Earnings Estimates - The Zacks Consensus Estimate for 2025 earnings remains at $10.86 per share, while the estimate for 2026 has increased from $11.36 to $11.38 over the past 60 days [13]