机构：中信建投证券 研究员：贺菊颖/袁清慧/王云鹏 金斯瑞是被低估的生命科学与基因治疗龙头。我们预计金斯瑞有望迎来估值重估，合理市值为654亿港 币，62%上涨空间。①生命科学板块随着创新药投融资回暖，蛋白业务第二增长极日益壮大，将逐步看 到业绩加速回暖；②蓬勃生物抗体业务逐步回暖，稀缺的兼具激活T细胞和猴交叉能力的CD3 vhh具备 对外授权潜力；③传奇生物重磅产品Carvykti2026年有望读出一线临床数据，继续巩固其在多发性骨髓 瘤中的优势领先地位。 传奇生物：海外商业化持续推进，期待26年Carvykti一线数据读出。Carvykti长期生存显著领先，CR具 有优势，神经毒性可控，已经成为NCCN指南中的MM推荐疗法，是目前爬坡最快的CAR-T产品。随着 产能逐渐落地，有望加速放量。 此外，期待2026年Carvykti一线数据读出，继续巩固其在MM领域的疗效地位。 盈利预测：预计2025-2027年公司总收入分别为9.5亿美元、8.1亿美元、9.7亿美元，对应增速分别为 60%、-15%、20%；经调整归母净利润分别为1.6亿美元、1.5亿美元、3.2亿美元。 投资建议：公司各业务板块估值方式差异 ...

Johnson & Johnson Today JNJ Johnson & Johnson $179.10 +0.17 (+0.09%) 52-Week Range $140.68 ▼ $181.16 Dividend Yield 2.90% P/E Ratio 19.15 Price Target $176.29 Add to Watchlist Johnson & Johnson's NYSE: JNJ stock chart is sending a clear signal that contrasts sharply with the persistent hum of repetitive negative headlines. While news cycles continue to circle long-running legal battles, the company's market performance paints a picture of investor confidence, with its stock climbing over 23% year- to-date. ...

Core Insights - The company achieved a revenue of $519 million in H1 2025, representing an 81.9% increase, with a gross profit of approximately $320 million, up 140.1%, and an adjusted net profit of about $178 million, a significant increase of 509.6% [1] - The core business segments are showing a rapid recovery, particularly in life sciences services and products, which generated approximately $248 million in revenue, a growth of 11.3% [1] - The biopharmaceutical development (CDMO) segment saw a remarkable revenue increase of approximately $247 million, up 511.1%, primarily due to a substantial rise in licensing revenue [1][2] Revenue and Profit Analysis - The adjusted operating profit for life sciences services and products was approximately $46.35 million, a slight decrease of 3.2%, attributed to increased marketing transformation and R&D investments [1] - The industrial synthetic biology products generated revenue of $2.83 million, an increase of 8.4%, with an adjusted gross profit of about $11.4 million, up 3.6% [2] Project and Product Development - In H1 2025, the company secured 20 new CDMO projects for antibody protein drugs, with over 50% coming from global clients, and added 9 new IND approvals, totaling 56 [2] - The company continues to expand its NME portfolio, with over 30 antibody assets available for external licensing [2] Future Outlook - Revenue projections for 2025 to 2027 are estimated at $927 million, $803 million, and $905 million, reflecting year-on-year growth rates of 56.0%, -13.4%, and 12.6% respectively [2] - The biopharmaceutical CDMO segment is expected to return to an upward trajectory, with licensing revenue contributing positively to performance [2]

Investment Rating - The report maintains a "Buy" rating for the company, indicating an expected investment return that will outperform the market benchmark by over 20% in the next 6-12 months [6][11]. Core Insights - The company achieved a revenue of $519 million in the first half of 2025, representing an increase of 81.9%. The gross profit was approximately $320 million, up 140.1%, and the adjusted net profit was about $178 million, reflecting a significant increase of 509.6%. The net loss was reduced to $24.5 million compared to a net loss of $216 million in the same period of 2024 [1][6]. Summary by Sections Financial Performance - In H1 2025, the life sciences services and products generated approximately $248 million in revenue, a growth of 11.3%, with an adjusted gross profit of $126 million, up 5.3%. The adjusted operating profit was about $46.35 million, down 3.2% [2]. - The CDMO segment reported revenue of approximately $247 million, a remarkable increase of 511.1%, with an adjusted operating profit of $150 million, compared to a loss of $18.88 million in H1 2024. This growth was driven by significant licensing revenue and double-digit growth in regular income [2]. - The company secured 20 new CDMO projects for antibody protein drugs, with over 50% from global clients, and 30 new CDMO projects in CGT, including one CAR-T project [2]. Revenue and Profit Forecast - The company forecasts revenues of $927 million, $803 million, and $905 million for 2025, 2026, and 2027, respectively, with growth rates of 56.0%, -13.4%, and 12.6% [3][4]. - The adjusted net profit is expected to be $84 million in 2025, with a significant recovery projected in subsequent years [4]. Key Financial Metrics - The company reported a gross margin of 48.8% in 2023, expected to rise to 56.8% in 2025, and a projected return on equity (ROE) of 1.9% in 2025, improving to 6.4% by 2027 [10]. - The earnings per share (EPS) is projected to be $0.04 in 2025, with a price-to-earnings (P/E) ratio of 472.05 [4][10].

证 券 研 究 报 告 行业周报 医药行业周报 全球GLP-1市场稳定扩容，关注国内企 业的授权机会 投资评级： 报告日期： 推荐 （维持 ） 2025年08月17日 分析师：胡博新 SAC编号：S1050522120002 分析师：吴景欢 SAC编号：S1050523070004 医 药 行 业 观 点 1. 东升西落，出海将是长期趋势 根据医药魔方数据，2025年上半年，全球医药交易数量达456笔，同比增长32%；首付款总额达118亿美元，同比激增 136%；交易总金额高达1304亿美元，同比增长58%。全球交易数量与金额均呈现显著上升态势。其中，涉及中国的交易 贡献了近50%的总金额和超过30%的交易数量。无论交易金额和总数，中国企业在全球创新药中价值得到进一步认可。中 国的研发效率优势正逐步显现，而且工程师数量和临床资源优势叠加。展望未来十年，中国的效率优势还将持续扩大，中 国企业参与的创新药交易预计超过全球的50%以上。根据wind数据，医药生物行业最近1月涨幅为11.07%，跑赢沪深300指 数6.51个百分点，截止8月15日，医药生物行业指数当期PE（TTM）39.94倍；高于5年历史平均估值3 ...

Group 1: Lexin Group (乐信集团) - The company is experiencing a continuous improvement in profitability, with a significant year-on-year net profit growth of 126% in Q2 2025, reaching 511 million yuan, and a quarter-on-quarter increase of 19% [1][2] - The improvement in profitability is primarily attributed to a decrease in provisioning expenses and an increase in revenue, with the net take rate reaching 1.92%, up 34 basis points quarter-on-quarter [2] - The company maintains a buy rating with a target price of $11.80, indicating a potential upside of 73.5% from the current price of $6.80 [1][2] Group 2: Legend Biotech (传奇生物) - The company reported adjusted earnings in Q2 2025, with Carvykti sales reaching $439 million, marking a 19% year-on-year and 136% quarter-on-quarter increase, setting a new record for CAR-T therapy sales in a single quarter [8][9] - Despite a net loss of $125 million, the company achieved adjusted net profit of $10 million after excluding non-operating items, indicating a turnaround from previous losses [8] - The target price has been raised to $74, reflecting a potential upside of 100% from the current price of $37 [8][9] Group 3: Rui Pu Lan Jun (瑞浦兰钧) - The company experienced a 25% revenue growth in the first half of 2025, with sales of lithium battery products doubling year-on-year to 32.4 GWh [10][11] - Gross margin improved significantly, rising by 5.9 percentage points to 8.5%, while net loss decreased by 85% to 65.32 million yuan [10] - The target price has been adjusted to 15.46 HKD, indicating a potential upside of 33.8% from the current price of 11.55 HKD [10][11] Group 4: Battery Industry - In July 2025, the growth rate of battery installations slowed, with a total of 55.9 GWh installed, reflecting a year-on-year increase of 34.3% but a month-on-month decrease of 4% [14][15] - Battery exports remained robust, with July exports reaching 23.2 GWh, a year-on-year increase of 35.4%, despite a month-on-month decline of 4.7% [15] - The supply-demand balance is expected to support lithium prices, especially with the suspension of operations at a key lithium mine [15]

Investment Rating - The report maintains a "Buy" rating for the company, Legend Biotech (LEGN US), with a target price raised to $74.00, indicating a potential upside of 100% from the current price of $37.00 [2][12]. Core Insights - The company achieved adjusted profitability in Q2 2025, driven by strong sales growth of Carvykti, with sales reaching $439 million, marking a year-over-year increase of 19% and a sequential increase of 136% [6]. - The report highlights optimistic sales expectations for Carvykti due to capacity expansion, improved production efficiency, and accelerated demand from the community healthcare market [2][6]. - The company is projected to reach operational breakeven by the end of 2025 and net profit breakeven in 2026 [6]. Financial Performance - Revenue forecasts for 2025, 2026, and 2027 have been adjusted upwards by 1-6%, reflecting a more optimistic outlook for Carvykti sales driven by new capacity and market penetration [6][7]. - The projected revenues for 2025, 2026, and 2027 are $1,016 million, $1,436 million, and $1,811 million respectively, with gross profit margins improving to 62.4%, 64.3%, and 66.8% [13][14]. - The company reported a net loss of $127.5 million in Q2 2025, but adjusted net profit was achieved after excluding non-operating items [6][13]. Market Position and Growth Potential - The report emphasizes that the current stock price is significantly undervalued, and the company is well-positioned for growth with a projected peak sales potential of $6.9 billion for Carvykti [6][7]. - The expansion of production capacity in the U.S. and Belgium is expected to enhance annual sales potential to over $4 billion [6]. - The report notes that the number of authorized treatment centers in the U.S. has increased to 123, improving community accessibility for Carvykti [6].

Investment Rating - The report maintains a "Recommended" rating for the pharmaceutical industry [1] Core Insights - The global pharmaceutical transaction volume reached 456 deals in the first half of 2025, a 32% year-on-year increase, with total upfront payments soaring to $11.8 billion, up 136% year-on-year, and total transaction value hitting $130.4 billion, a 58% increase year-on-year. Chinese companies contributed nearly 50% of the total transaction value and over 30% of the transaction volume, indicating a growing recognition of their value in global innovative drugs [3] - The report highlights a strategic opportunity for Chinese companies in the weight loss sector, with significant clinical data and collaborations emerging. For instance, the oral GLP-1 molecule Orforglipron showed a weight reduction of 11% compared to the placebo group, providing a competitive edge for domestic firms [4] - Chinese innovative drug companies are leading breakthroughs in CAR-T technology, with significant sales figures reported. For example, the collaboration between Legend Biotech and Johnson & Johnson for Carvykti is expected to exceed $2 billion in annual sales [5] - The CXO industry is anticipated to gradually recover, with a notable increase in license-out transactions and funding for biotech companies, indicating a positive trend in order recovery [6] - The report emphasizes the continuous iteration and updates in TCE technology, with promising clinical data emerging from various trials, showcasing the potential for significant advancements in the field [7] Summary by Sections 1. Pharmaceutical Market Tracking - The pharmaceutical industry underperformed the CSI 300 index by 2.07 percentage points in the last week, ranking 31st among 31 primary industry indices [19] - In the past month, the pharmaceutical industry outperformed the CSI 300 index by 8.23 percentage points, ranking 3rd among the primary industry indices [25] 2. Pharmaceutical Sector Trends and Valuation - The pharmaceutical and biotechnology sector's index has a current PE (TTM) of 38.77, above the 5-year historical average of 31.9 [45] 3. Recent Research Achievements - The report includes various deep-dive studies on the pharmaceutical industry, highlighting trends in supply and demand, as well as the growth of specific sectors such as blood products and inhalation formulations [51] 4. Recent Industry Policies and News - Recent policies from the National Healthcare Security Administration aim to support the high-quality development of innovative drugs, including increased funding and support for clinical applications [54] - Notable industry news includes the approval of innovative treatments by major pharmaceutical companies, indicating a robust pipeline and ongoing advancements in the sector [56]

Core Insights - Johnson & Johnson (JNJ) reported strong second-quarter results, exceeding earnings and sales estimates despite the loss of exclusivity for its drug Stelara [1][2] - The company raised its 2025 sales expectations by approximately $2.0 billion, reflecting robust operational performance and favorable currency impacts [2][3] - JNJ's sales guidance for 2025 was adjusted from $91.0 billion-$91.8 billion to $93.2 billion-$93.4 billion, indicating a growth rate of 5.1%-5.6% compared to the previous expectation of 2.6%-3.6% [3] - Adjusted earnings per share guidance was increased from $10.50-$10.70 to $10.80-$10.90, supported by top-line strength and reduced tariff costs [3] Innovative Medicine Segment - JNJ anticipates higher operational sales growth in the Innovative Medicine segment in the second half of the year, driven by key products like Darzalex, Tremfya, and new drugs such as Carvykti and Tecvayli [4][5] - The impact of Stelara's loss of exclusivity and Medicare Part D redesign is expected to be mitigated by the performance of newly launched products [4] MedTech Segment - The MedTech segment is expected to see growth driven by increased adoption of new products in Cardiovascular, Surgery, and Vision, although challenges in China may persist [5] - Sales in the MedTech segment are projected to be stronger in the second half of the year as the business overcomes tougher comparisons from the first half [5] Market Performance - JNJ's shares have outperformed the industry year-to-date, with a 17.6% increase compared to a 3.3% decline in the industry [8] - The company's stock is currently trading at a price/earnings ratio of 15.0, slightly above the industry average of 14.29 but below its five-year mean of 15.68 [10] Earnings Estimates - The Zacks Consensus Estimate for JNJ's 2025 earnings has increased from $10.62 to $10.86 over the past 30 days, while the estimate for 2026 has risen from $11.0 to $11.36 [11]

Core Investment Strategy - The wide moat strategy focuses on investing in companies with durable competitive advantages that ensure long-term profitability and market leadership, allowing them to withstand economic fluctuations [2][3]. Company Summaries Adobe Inc. (ADBE) - Adobe has integrated AI applications across its products, enhancing user efficiency and introducing tools like Adobe Firefly and Adobe Express for quick editing [7][9]. - The company is diversifying into digital marketing services through its AI-driven cloud platform, enabling personalized marketing experiences [8]. - ADBE has an expected revenue growth rate of 9.5% and earnings growth rate of 12% for the current year, with earnings estimates improving by 0.1% recently [11]. The Walt Disney Co. (DIS) - Disney is experiencing growth in Domestic Parks & Experiences, although international locations face challenges [12]. - The company anticipates double-digit operating income growth in fiscal 2025, with ESPN showing significant viewership growth [13]. - Disney's streaming business has turned profitable, with a second-quarter Direct-to-Consumer operating income of $336 million [14]. - DIS has an expected revenue growth rate of 4.1% and earnings growth rate of 16.3% for the current year, with earnings estimates improving by 0.3% recently [15]. Intuit Inc. (INTU) - Intuit is benefiting from steady revenue growth in its Online Ecosystem and Desktop segments, driven by strong performance in its services [16]. - The company’s generative AI tool, "Intuit Assist," provides personalized financial insights, enhancing user experience across its platforms [17]. - INTU has an expected revenue growth rate of 11.7% and earnings growth rate of 13.7% for the current year, with earnings estimates improving by 4.3% recently [19]. Rollins Inc. (ROL) - Rollins utilizes technology and disciplined acquisitions to enhance operations and customer service, maintaining a strong cash position with zero debt [20]. - The company has made 44 acquisitions in 2024, reflecting its growth strategy and commitment to increasing dividends [20]. - ROL has an expected revenue growth rate of 10.7% and earnings growth rate of 12.1% for the current year, with earnings estimates improving by 0.9% recently [21]. Johnson & Johnson (JNJ) - Johnson & Johnson reported strong earnings, with growth driven by its Innovative Medicine unit and key products [22][23]. - Despite challenges in the MedTech segment, the company expects sales growth to improve in the second half of the year [23]. - JNJ has an expected revenue growth rate of 5.2% and earnings growth rate of 8.8% for the current year, with earnings estimates improving by 0.1% recently [24].