导读： 有什么能比做蛋白纯化时一次轻松拿到满意的实验结果更美好的人生呢？如果有，就是再搭配一 杯咖啡，（ 文末送咖啡 ） 特别提示 因 微信调整，点击顶部"仪器信息网" → 右上方"…" → 设为" ★ "星标，否则很可能无法看到我 们的推送。 熬了一个通宵， 做蛋白抗体纯化的小D已经处在崩溃边缘 …… 话说回来，看到这种实验结果，情绪稳定的太乙真人也得崩溃。 懂的都懂 ，开盲盒式的纯化工作， 杂带多 到怀疑人生、 纯度低 的达不到预期、 得率低 的像 玩"蛋白消失术"，同样的条件纯化 结果全看"蛋白心情" ，一步没优化好久 满盘皆输 …… 还有，无尽的夜班、有毒试剂、每一步的拍照记录，纯化5小时，记录2小时…… 这种槽你还想要吐多久？ 用上 AmMa g™ Qua t ro 1 3 0 0的隔壁实验室老王 ，早就在茶水间轻松的 边喝咖啡边等实验结 果 了 。 羡慕老王，成为老王 ，请往下读： 01 AmMag™ Quat ro 1300是啥？ 蛋白纯化，手动操作繁琐、半自动流程相对复杂、花费时间巨大、各环节重复进行、科研项目 进度拖慢…… AmMa g™ Qu a tr o 1 3 0 0是 金斯瑞针对蛋白 ...

Core Viewpoint - Beijing has launched an action plan for the innovation and development of high-end scientific instruments, aiming to enhance independent innovation capabilities and cultivate leading enterprises by 2027, establishing a "1+3" industrial pattern and creating a technology source and industrial cluster [1][2]. Summary by Sections Action Plan Goals - By 2027, Beijing aims to improve its independent innovation capabilities in high-end scientific instruments, developing over 50 complete products and breaking through more than 30 key components. The plan also includes establishing recognized technical standards and attracting top scientists and engineers [3]. Industrial Cluster Development - The plan targets the cultivation of approximately 2 leading enterprises with annual revenues exceeding 3 billion yuan, over 30 enterprises with revenues exceeding 100 million yuan, more than 80 specialized and innovative enterprises, and over 200 national high-tech enterprises. The focus is on creating a collaborative "1+3" industrial pattern in Huairou, Haidian, Changping, and the Beijing Economic-Technological Development Area [3]. Ecosystem Improvement - The action plan emphasizes the establishment of service platforms for precision processing, verification, and pilot testing, along with the development of typical instrument libraries and specialized software. The goal is to enhance the self-control level of the industrial and supply chains and improve the international competitiveness of the high-end scientific instrument industry [3].

Core Viewpoint - Feina Electron Microscope has localized manufacturing in Guangzhou, maintaining its original performance and providing desktop scanning electron microscopes and solutions to support domestic demand [1][2]. Group 1: Localization and Product Offering - Feina Electron Microscope has introduced part of its scanning electron microscope production line to China, achieving localized manufacturing in its Guangzhou factory [1]. - The domestic model of Feina Electron Microscope retains the original resolution and performance, offering optimal desktop scanning electron microscope solutions to customers [1]. Group 2: Company Background and Services - Founded in 2012 in Shanghai, Feina Electron Microscope (Fina Scientific Instruments (Shanghai) Co., Ltd.) provides a range of desktop scanning electron microscopes for universities, enterprises, and research institutions [1]. - The product line includes various models such as the desktop Schottky thermal field emission scanning electron microscope, CeB6 filament XL series intelligent desktop scanning electron microscope, and the fully automatic particle and foreign matter detection scanning electron microscope [1]. - Feina Electron Microscope also offers technical support and testing services related to desktop scanning electron microscopes, with testing and after-sales service centers established in Shanghai, Beijing, Guangzhou, and Chengdu, serving over 2000 users in China [2].

导读： 2024年，哪些企业凭借战略韧性实现逆势增长？哪些企业在结构性挑战中艰难突围？未来的市场机遇又将锚定何方？ 特别提示 微信机制调整，点击顶部"仪器信息网" → 右上方"…" → 设为 ★ 星标，否则很可能无法看到我们的推送。 随着2 0 2 4年年报季的落幕，众多国内科学仪器行业相关上市公司也陆续交出了过去一年的业绩"成绩单"。 回首2 0 2 4，在大环境持续承压，国际形势复杂多变，竞争愈演愈烈的背景下，企业利润空间不断收窄，运营成本节节攀升，下调预期、重组架 构、降薪裁员已成行业普遍现象；但另一方面，大规模设备更新重启增长"引擎"，国产仪器在政策、标准、出海之间寻找新的增长点；与此同 时，越来越多的企业选择潜心练内功，优化产品结构，全力提升产品品质与服务水平。 复杂多变的大环境进一步加剧了行业分化态势： 哪些企业凭借战略韧性实现逆势增长？哪些企业在结构性挑战中艰难突围？未来的市场机遇又 将锚定何方？ 为更好地了解分析和研究这些企业的经营策略和业务模式，仪器信息网特别制作" 2 0 2 4年国内上市仪器公司营收TOP排行榜"， 对4 6家上市企业的财报进行了全面盘点和分析，旨在为行业人士提供有价值的 ...

Core Viewpoint - Southeast University has announced multiple government procurement intentions for laboratory instruments, with a total budget of 121 million yuan, indicating significant investment in research and development capabilities [1][2]. Summary by Sections Procurement Intentions - Southeast University has released intentions for 37 items of laboratory equipment, with a total budget of 121 million yuan, expected to be procured between May and June 2025 [2][3]. Equipment Details - The procurement includes various advanced instruments such as: - Film stress measurement instruments with a budget of 3.02 million yuan [4]. - Scanning electrochemical microscopes with a budget of 3.4 million yuan [4]. - Mercury probe testers with a budget of 3.4 million yuan [4]. - Fourier infrared spectrometers with a budget of 2.3 million yuan [4]. - 12-inch probe stations with a budget of 4.5 million yuan [4]. - Ultrasonic microscopes with a budget of 1.75 million yuan [4]. Specific Equipment Functions - The film stress measurement instrument will measure stress in films with a range of 1 MPa to 7.8 GPa and an accuracy of less than 1% [4]. - The scanning electrochemical microscope will provide insights into metal plating mechanisms with a scanning precision better than 1 nm [4]. - The mercury probe tester will allow for non-destructive testing of electrical properties in films, with a maximum voltage of 250V [4]. Additional Equipment - Other notable equipment includes: - High-throughput automated liquid handling workstations with a budget of 1.6 million yuan [6]. - High-resolution live cell imaging workstations with a budget of 2 million yuan [6]. - Environmental simulation experimental devices with a budget of 25 million yuan [6]. Conclusion - The procurement intentions reflect Southeast University's commitment to enhancing its research capabilities through significant investments in advanced laboratory instruments, which may present opportunities for suppliers in the scientific equipment sector [1][2].

Core Viewpoint - Waters Corporation launched the Xevo TQ Absolute XR mass spectrometer at ASMS 2025, featuring StepWave XR technology that enhances sensitivity and contamination resistance, aiding in PFAS detection and compliance with environmental regulations while optimizing energy consumption and space utilization [1][2]. Innovation Technology Highlights - StepWave XR ion guide technology offers 6 times the performance robustness compared to the previous Xevo TQ Absolute, with a continuous analysis duration increase of 6 times, successfully validated through 12,000 pesticide samples in fish feed, and improved contamination resistance [4][5]. - The instrument significantly reduces downtime, with customer evidence showing over 20,000 plasma sample injections maintaining reproducibility [5]. - Designed specifically for PFAS and genotoxic impurities, the quantification capability for negatively ionized compounds has been enhanced [5]. Environmental/Green Efficient Laboratory Solutions - Energy consumption and nitrogen usage have been reduced by 50%, with heat emissions also decreased by 50% [6]. - The compact design reduces the footprint by 50% [6]. Core Application Scenarios - PFAS Detection: The system is ready for quantitative analysis, meeting the latest EPA regulatory requirements [7]. - Pharmaceutical Quantitative Analysis: Achieves ultra-high sensitivity analysis of trace drug molecules in complex matrices, accelerating new drug development [7]. - High-Throughput Scenarios: Supports pharmaceutical companies, CROs, and government laboratories, with a 30% increase in daily sample throughput, validated by Synexa with over 20,000 injections [7]. - User Feedback: The Scientific Director of Synexa Life Sciences highlighted the Xevo TQ Absolute XR's reproducibility and accuracy in addressing emerging bioanalytical challenges, having completed over 20,000 plasma sample analyses in conjunction with the ACQUITY™ Premier UPLC™ system [7].

Core Viewpoint - The article highlights the launch of the ZenoTOF 8600 system by SCIEX, which sets a new benchmark in high-resolution mass spectrometry, enhancing both qualitative and quantitative capabilities for complex sample analysis [3][4]. Group 1: Product Features - The ZenoTOF 8600 system significantly improves ion generation and transmission efficiency, achieving a tenfold increase in sensitivity compared to previous models [4]. - It incorporates advanced technologies such as the OptiFlow Pro ion source, DJet ion introduction, and dual-frequency QJet ion guide [4]. - The ZT Scan DIA 2.0 mode enhances data-independent acquisition capabilities, allowing for faster scanning and broader mass range, facilitating precise identification and quantification in multi-omics research [7][9]. Group 2: Data Processing and Software - The new SCIEX OS 4.0 software improves operational efficiency through automated processes and accelerated computations, setting new standards for analysis accuracy and precision [10]. - Collaboration with the open-source mass spectrometry data analysis platform MS-DIAL enhances small molecule identification and quantification capabilities, optimizing data analysis for ZT Scan DIA [11]. - The latest PEAKS 13 software supports various data types and improves processing workflows, enhancing protein identification and post-translational modification analysis [11]. Group 3: Industry Impact - The advancements introduced by the ZenoTOF 8600 system are expected to have a profound impact on the multi-omics field, with positive feedback from customers indicating that new data and insights will drive significant research outcomes [13].

Core Viewpoint - The article emphasizes the importance of standardization in the surface analysis technology sector, highlighting its role in driving high-quality development and responding to national policy directives from the 2025 National Two Sessions [1][2]. Group 1: Event Overview - The "12th Surface Analysis Technology Application Forum and National Standard Promotion Conference" will be held online on June 4-5, 2025, focusing on the theme of "AI+Science" [1][4]. - The event aims to gather industry experts to discuss the integration of AI in surface analysis technology, enhancing theoretical and practical levels, and promoting national standards [2][4]. Group 2: Conference Agenda - The conference will feature various sessions, including topics such as intelligent bioanalysis, AI-enabled material science research paradigms, and advancements in surface analysis technologies [5][6]. - Notable speakers include academicians and experts from prestigious institutions, discussing cutting-edge research and applications in surface analysis [7][8][9]. Group 3: Supporting Organizations - The event is supported by several organizations, including the Chinese Society for Analysis and Testing, and various academic and research institutions [4][6].

Core Viewpoint - Thermo Fisher Scientific launched two innovative mass spectrometers, Orbitrap Astral Zoom and Orbitrap Excedion Pro, at ASMS 2025, aimed at advancing research in complex biological processes and major diseases such as Alzheimer's and cancer, thereby enhancing precision medicine and biopharmaceutical development [1][2]. Group 1: Orbitrap Astral Zoom Highlights - The Orbitrap Astral Zoom features a 35% increase in scanning speed, facilitating rapid data collection [4]. - It offers a 40% improvement in throughput, supporting large-scale sample screening [4]. - The system enhances multi-detection capabilities by 50%, enabling multidimensional analysis in a single experiment [4]. - Applications include deep proteomics analysis and trace biomarker discovery [4]. Group 2: Orbitrap Excedion Pro Highlights - The Orbitrap Excedion Pro integrates next-generation Orbitrap technology with complementary fragmentation techniques, providing breakthrough solutions for analyzing complex biomolecules [7]. - It accelerates biopharmaceutical development by enabling in-depth analysis of monoclonal antibodies and other biological therapeutics [7]. - Enhanced sensitivity, dynamic range, and reliability allow for simultaneous high-quality data on proteins and post-translational modifications [9]. - The system supports research in cardiovascular diseases, neuroscience, and oncology [7]. Group 3: Overall Impact and Ecosystem - Both instruments strengthen Thermo Fisher's "end-to-end" research ecosystem, which includes reagents, imaging systems, and advanced mass spectrometry workflows [7]. - They provide robust support for proteomics, biopharmaceutical characterization, and translational medicine, focusing on disease mechanism research and target validation [7].

Core Viewpoint - The article highlights the significant innovations introduced by Bruker at the ASMS 2025 conference, particularly the launch of the timsOmni™, timsMetabo™, and proteoElute™ systems, which are expected to advance research in proteomics and metabolomics significantly [1][2][3]. Group A: timsOmni™ Mass Spectrometry System - The timsOmni™ system is a revolutionary mass spectrometry platform designed for in-depth analysis of biomolecular structures, particularly in the fields of scientific research, drug development, clinical studies, and biopharmaceutical quality control [3]. - It features a multi-modal eXd capture technology that allows precise electronic energy control, ion accumulation, and adjustable reaction times, supporting various fragmentation methods for comprehensive structural information [3][5]. - The system is particularly adept at identifying low-abundance protein variants associated with diseases such as cancer and neurodegenerative disorders, enhancing the understanding of protein function and pathology [5][7]. Group B: OmniScape™ Software - OmniScape™ is a new generation protein sequencing analysis software that supports data analysis from the timsOmni™ system, offering advanced algorithms for complex spectrum deconvolution and protein identification [5][9]. - It transforms complex eXd fragmentation spectra into biologically relevant information, facilitating the study of functional proteomics [5][9]. Group C: timsMetabo™ Mass Spectrometry System - The timsMetabo™ system is a high-performance 4D mass spectrometry instrument that enhances small molecule analysis and integrates seamlessly with high-sensitivity proteomics [10][12]. - It introduces the "MoRE" scanning mode, which significantly improves sensitivity, separation capability, and annotation reliability for metabolomics studies [12][14]. - The system generates unique digital metabolomic profiles for each sample, enhancing the reliability of analysis results and supporting AI applications in metabolomics [14]. Group D: proteoElute™ Nanoflow Liquid Chromatography System - The proteoElute™ system is designed to provide sensitive and robust solutions for proteomics, particularly in analyzing protein variants and complex biological samples [15][16]. - It features the TwinScape™ technology for real-time system monitoring and proactive maintenance, ensuring reliable performance even with low sample volumes [16]. - The new PepSep® Advanced chromatography column enhances peak shape and resolution, improving peptide and protein identification rates by approximately 20% and 10%, respectively [17].