10月9日的"立法突破"与市场震动 美国当地时间 2025 年 10 月 9 日，美国参议院以多数票表决通过 2026 财年《国防授权法案》 （NDAA），这一每年必过的"国家优先级法案"中，悄然夹带了新版《生物安全法案》（S.A.3841）作 为附案。 这则消息迅速引发全球生物医药产业震荡——与 2024 年"胎死腹中"的 1.0 版本不同，此次法案通过"搭 车"国防预算的方式规避了参议院高门槛，距离最终生效仅差众议院表决与特朗普签字两道程序。 考虑到《国防授权法案》的"必过"属性及特朗普政府对对华科技限制的一贯立场，外界普遍认为该法案 落地概率已接近百分之百，中国生物医药产业正面临新一轮政策围堵的现实挑战。 法案核心内容解读：从"夭折"到"破局"的演变逻辑 法案发展历程与立法路径： 1. 版本迭代 1.0 版本（2024 年）：2024 年 5 月，美国众议院推出 H.R.833 法案（《生物安全法案》），点名中国基 因测序公司与制药业龙头 CRO，要求联邦机构及其合作伙伴不得采购其产品或服务；同年 9 月，众议 院以 306 票同意、81 票反对通过该法案，但因参议院流程门槛高（需 60 票同意讨论）且 ...

Group 1 - Pharmaceutical stocks continue to decline, with CRO sector leading the drop, including significant declines in Junshi Biosciences (down 7.98%), Kanglong Chemical (down 6.3%), Kelaiying (down 5.69%), and Tigermed (down 3.48%) [1] - Recent market trends in the pharmaceutical sector are attributed to several factors, including a deal between the Trump administration and Pfizer to lower drug prices in the U.S., which is seen as a reconciliation signal between U.S. pharmaceutical companies and the government [1] - The U.S. Senate's consideration of a bill to prohibit certain Chinese biotech companies from receiving federal funding has led to a significant pullback in the CXO sector [1] Group 2 - Recent tensions in U.S.-China trade relations have escalated, with a renewed tariff war expected; however, the pharmaceutical market is not overly concerned as the industry has shown resilience since the first tariff war in April [2] - The innovative drug and CXO sectors have outperformed other sub-industries, driven by China's rising independent innovation and ongoing overseas business development, which are less affected by tariffs [2] - The CXO sector benefits from strong upstream and downstream relationships and a service pricing model that allows companies to pass on tariff pressures relatively freely [2]

Group 1 - Pharmaceutical stocks continued to decline, with CRO sector leading the drop, including significant declines in companies like Junshi Biosciences (-7.98%), Kanglong Chemical (-6.3%), and others [1] - Recent market trends in the pharmaceutical sector are attributed to several factors, including a deal between the Trump administration and Pfizer to lower drug prices in the U.S., which is seen as a reconciliation signal between U.S. pharmaceutical companies and the government [1] - The U.S. Senate's consideration of a bill to prohibit certain Chinese biotech companies from receiving federal funding has led to a significant pullback in the CXO sector [1] Group 2 - Tensions in U.S.-China trade relations have escalated, with renewed tariff battles expected; however, the pharmaceutical market is not overly concerned as the industry has shown resilience [2] - The innovative drug and CXO sectors have performed exceptionally well since the first tariff battle in April, driven by China's rising independent innovation and ongoing overseas business development [2] - The CXO sector's strong business model allows companies to transfer tariff pressures relatively freely due to strong upstream and downstream relationships [2]

Investment Rating - The industry rating is "stronger than the market" indicating that the overall return of the industry is expected to exceed the market benchmark index by more than 5% in the next 6 months [6][75]. Core Insights - The report analyzes the impact of the "Biological Safety Act" on the CXO industry and concludes that the BD policies will not have a substantial effect on the innovative drug sector [4][28]. - The CXO companies have shown resilience, with stock prices recovering and reaching new highs despite the changes in the Biological Safety Act [4][17]. - The report emphasizes the advantages of China's innovative drug industry, including talent resources, research efficiency, and cost-effectiveness, which are expected to mitigate the impact of external policies [4][28]. Summary by Sections Market Review - During the week of September 8-12, 2025, the CITIC Pharmaceutical Index fell by 0.3%, underperforming the CSI 300 Index by 1.7 percentage points, ranking 28th among CITIC's primary industry classifications [3][30]. - Year-to-date, the CITIC Pharmaceutical and Biotechnology Index has risen by 27.8%, outperforming the CSI 300 Index by 12.9 percentage points, ranking 8th among CITIC's industry classifications [3][30]. - The top five performing stocks for the week included: Zhend Medical (+41.3%), Haooubo (+28%), Jimin Medical (+25.9%), Kangwei Century (+23.2%), and Ao Jing Medical (+20.5%) [3][44]. Impact of the Biological Safety Act - The report details the evolution of the Biological Safety Act since December 30, 2023, noting that the stock price reactions of representative CXO companies have become desensitized over time, with current prices surpassing levels from December 29, 2023 [4][17]. - The performance of CXO companies in the U.S. market has remained strong, with significant growth in orders and revenue despite the act's implications [24][28]. Investment Focus - The report suggests focusing on three main areas in the innovative drug and its supply chain: companies with revenue and commercialization capabilities, potential BD opportunities based on technological trends, and exploring cutting-edge technologies such as gene therapy and CAR-T [5][28]. - The medical device sector is also highlighted as a key area for investment, with expectations of a policy turning point and improving fundamentals [5][28]. Stock Recommendations - The report recommends a focus on specific stocks including Kangfang Biotech, Baiji Shenzhou, Xinda Biotech, Enhua Pharmaceutical, and others for the upcoming month [5][12].

Investment Rating - The investment rating for the industry is maintained at "Buy" [3] Core Insights - The report highlights a recovery process for the CXO sector, driven by a rebound in global healthcare investment and the potential of AI in drug development [6][9][10] - The FDA has granted priority review status to a potential "first-in-class" small molecule for cancer treatment, indicating significant advancements in the pharmaceutical pipeline [3][43] Market Performance Review - The Shanghai Composite Index closed at 3379.11, up 0.97%, while the Shenzhen 300 Index rose by 1.00% [1] - The pharmaceutical industry index increased by 0.96%, ranking 8th among 31 primary industry indices [1] - Weekly performance of various segments within the pharmaceutical industry showed mixed results, with traditional Chinese medicine down by 2.30% and medical services up by 6.87% [1] CXO Recovery Process - Global healthcare investment is showing signs of recovery, with 2024 global pharmaceutical investment amounting to $57.747 billion, a slight decline of 1% year-on-year, significantly narrowing from a 34% drop in 2023 [7][22] - Domestic investment in the pharmaceutical sector for 2024 is projected at 517.97 billion yuan, also reflecting a narrowing decline [7][22] - The failure of the 2024 Biodefense Act to pass is expected to alleviate valuation pressures on CXO companies [8][28] AI Empowerment in Drug Development - The rise of artificial intelligence is transforming drug development, addressing challenges such as long development cycles and high costs [9][29] - Companies that achieve breakthroughs in AI applications within the CXO sector are likely to gain competitive advantages in future drug development [9][29] Industry News - The RuiPath pathology model, developed by Huawei and Ruijin Hospital, aims to enhance diagnostic accuracy and efficiency in pathology [2][43] - Chimerix's dordaviprone has received FDA priority review, marking a significant milestone for potential cancer therapies [3][43]