Core Viewpoint - Maiwei Biotech announced that its adalimumab injection 9MW0113 (domestic brand name: Junmaikang®) has received registration approval from the Indonesian Food and Drug Authority (BPOM), marking it as the first adalimumab biosimilar independently developed in China to gain such approval in Indonesia [1] Group 1 - 9MW0113 was co-developed by Maiwei Biotech and Junshi Bioscience [1] - The product has been formally partnered in over ten countries, indicating a strong international collaboration strategy [1] - Registration application documents have been submitted to multiple countries, including Jordan and Peru, showcasing the company's global expansion efforts [1]

Core Viewpoint - The company has decided to extend the implementation deadlines for its fundraising investment projects, specifically the "Innovative Drug R&D Project" to December 2028 and the "Shanghai Junshi Biotech Headquarters and R&D Base Project" to June 2026, without changing the investment content or total amount [1][4][17]. Fundraising Basic Situation - The company was approved to issue 70 million A-shares at a price of RMB 53.95 per share, raising a total of RMB 3,776.5 million. After deducting issuance costs of RMB 31.7 million, the net amount raised was RMB 3,744.8 million, with actual funds received amounting to RMB 3,759.35 million [1][2]. Project Delay Details - The delay in the fundraising projects is based on the company's prudent assessment of the actual progress of the projects, with no changes to the project entities, fundraising purposes, or investment scale [4][17]. - The "Innovative Drug R&D Project" deadline is extended to December 2028 to enhance the efficiency and effectiveness of fund usage, considering the dynamic changes in the innovative drug industry and the company's strategic development [6][9]. - The "Shanghai Junshi Biotech Headquarters and R&D Base Project" deadline is extended to June 2026 due to the complexity of the construction and verification processes, ensuring quality and compliance with regulations [7][8]. Feasibility Analysis of Fundraising Projects - The company possesses excellent drug discovery and development capabilities, covering five major therapeutic areas, and has established a complete technical system for drug development and production [10][12]. - The company has a professional and experienced management and R&D team, with a focus on innovative drug development and a strong emphasis on intellectual property management [13][14]. Impact of Project Delay - The project delay is a cautious decision based on operational needs and actual project conditions, ensuring that it does not adversely affect the company's normal operations or shareholder interests [17][18].

香港交易及結算所有限公司及香港聯合交易所有限公司對本公告的內容概不負責，對其準確性 或完整性亦不發表任何聲明，並明確表示，概不對因本公告全部或任何部分內容而產生或因倚 賴該等內容而引致的任何損失承擔任何責任。 SHANGHAI JUNSHI BIOSCIENCES CO., LTD.* 上海君實生物醫藥科技股份有限公司 調整2022年A股發行所得款項預期使用時間表 謹此提述上海君實生物醫藥科技股份有限公司（「本公司」）於2022年3月7日刊發 的公告及通函（「通函」）、於2022年4月6日刊發的投票結果公告，於2022年6月14 日及2024年5月30日刊發的公告，內容有關2022年12月2日向特定對象發行A股 （「2022年A股發行」）。除文義另有所指外，本公告所用詞彙與通函所界定者具有 相同涵義。 於2025年12月29日，董事會決議調整2022年A股發行所得款項用途中「創新藥研 發項目」及「上海君實生物科技總部及研發基地項目」的未動用所得款項的預期使 用時間表。如本公司2025年中期報告所述，「創新藥研發項目」和「上海君實生物 科技總部及研發基地項目」原定動用預期時間表為2026年12月31日或之前，使 ...

香港交易及結算所有限公司及香港聯合交易所有限公司對本公告之內容概不負責，對其準確性 或完整性亦不發表任何聲明，並明確表示，概不對因本公告全部或任何部分內容而產生或因倚 賴該等內容而引致的任何損失承擔任何責任。 SHANGHAI JUNSHI BIOSCIENCES CO., LTD.* 上海君實生物醫藥科技股份有限公司 （於中華人民共和國註冊成立的股份有限公司） （股份代號：1877） 海外監管公告 本公告乃根據香港聯合交易所有限公司證券上市規則第13.10B條規則作出。 茲載列上海君實生物醫藥科技股份有限公司在上海證券交易所網站刊發之《上海 君實生物醫藥科技股份有限公司關於募集資金投資項目延期的公告》、《國泰海通 證券股份有限公司關於上海君實生物醫藥科技股份有限公司募集資金投資項目延 期的核查意見》，僅供參閱。 承董事會命 上海君實生物醫藥科技股份有限公司 熊俊先生 主席 中國，上海，2025年12月29日 於本公告日期，本公司董事會包括執行董事熊俊先生、李寧博士、鄒建軍博士、 李聰先生、張卓兵先生、姚盛博士、王剛博士及李鑫博士；非執行董事湯毅先 生；以及獨立非執行董事張淳先生、馮曉源博士、酈仲賢先生、魯琨 ...

Core Viewpoint - Junshi Biosciences is positioned as a comprehensive innovative pharmaceutical company with capabilities spanning drug discovery, clinical research, large-scale production, and commercialization, aiming for a global footprint while being rooted in China [2] Group 1: Company Overview - Junshi Biosciences was established on December 27, 2012, and went public on July 15, 2020, focusing on the research and commercialization of monoclonal antibody drugs and other therapeutic proteins [7] - The company's main revenue sources include drug sales (90.67%), technology licensing and royalties (8.74%), and technical services (0.59%) [7] - As of September 30, 2023, Junshi Biosciences reported a revenue of 1.806 billion yuan, a year-on-year increase of 42.06%, while the net profit attributable to shareholders was -596 million yuan, reflecting a year-on-year growth of 35.72% [8] Group 2: Product Pipeline and Innovations - The company has developed a robust product pipeline, including its core product, Toripalimab, which is the first domestically approved PD-1 monoclonal antibody in China, with 11 approved indications and one supplemental NDA under review [2] - Toripalimab is also the first innovative biopharmaceutical developed and produced in China to receive FDA approval, with approvals in multiple regions including the U.S., EU, and Australia [2] - Junshi Biosciences is advancing its self-developed Tifcemalimab, the world's first anti-BTLA monoclonal antibody entering clinical development, with two Phase III registration trials ongoing [2] Group 3: Collaborations and Future Developments - On October 27, 2023, Junshi Biosciences announced collaborations with several institutions, including Peking University and the Chinese Academy of Sciences, to develop a monkeypox recombinant protein vaccine [3] - The company’s subsidiary, JunTuo Biologics, is involved in the preclinical development of vaccines for monkeypox and Zika virus, indicating a focus on expanding its vaccine pipeline [3]

Group 1 - The top three companies with the highest short positions are Vanke Enterprises (02202), COSCO Shipping Holdings (01919), and Heng Rui Medicine (01276), with short ratios of 18.48%, 16.79%, and 15.54% respectively [1][2] - The companies with the largest absolute increase in short positions are CATL (03750), Lens Technology (06613), and UBTECH Robotics (09880), which increased by 2.35%, 2.34%, and 1.29% respectively [1][2] - The companies with the largest absolute decrease in short positions are Changfei Optical Fiber (06869), Mao Ge Ping (01318), and Meilan Airport (00357), which decreased by -1.26%, -0.68%, and -0.67% respectively [1][2] Group 2 - The latest short ratio for Vanke Enterprises (02202) is 18.48%, down from 19.04% previously [3] - The latest short ratio for COSCO Shipping Holdings (01919) is 16.79%, down from 16.79% previously [2] - The latest short ratio for Heng Rui Medicine (01276) is 15.54%, up from 3919.30 million shares to 4011.67 million shares [2]

国泰海通证券股份有限公司 关于上海君实生物医药科技股份有限公司 募集资金投资项目延期的核查意见 国泰海通证券股份有限公司（以下简称"国泰海通"或"保荐人"）作为上 海君实生物医药科技股份有限公司（以下简称"君实生物"、"公司"或"发行人"） 2022 年度向特定对象发行 A 股股票的保荐人，根据《证券发行上市保荐业务管 理办法》《上市公司募集资金监管规则》《上海证券交易所科创板股票上市规则》 《上海证券交易所科创板上市公司自律监管指引第 1 号——规范运作》等有关法 律法规和规范性文件的要求，就君实生物募集资金投资项目延期的事项进行了审 慎核查，并发表如下核查意见: 一、募集资金基本情况 根据中国证券监督管理委员会出具的《关于同意上海君实生物医药科技股份 有限公司向特定对象发行股票注册的批复》（证监许可〔2022〕2616 号），公司获 准向特定对象发行人民币普通股 7,000.00 万股，每股发行价格为人民币 53.95 元， 募集资金总额为人民币 3,776,500,000.00 元；扣除各项发行费用合计人民币 31,697,205.06 元（不含增值税）后，实际募集资金净额为人民币 3,744,802, ...

证券代码：688180 证券简称：君实生物 公告编号：临 2025-077 上海君实生物医药科技股份有限公司 关于募集资金投资项目延期的公告 本公司董事会及全体董事保证本公告内容不存在任何虚假记载、误导性陈 述或者重大遗漏，并对其内容的真实性、准确性和完整性依法承担法律责任。 上海君实生物医药科技股份有限公司（以下简称"公司"）于 2025 年 12 月 29 日召开第四届董事会第十六次会议，审议通过了《关于募集资金投资项目延 期的议案》，同意将公司 2022 年度向特定对象发行 A 股股票募集资金投资项目 （以下简称"募投项目"）之"创新药研发项目"的项目实施期限延期至 2028 年 12 月及"上海君实生物科技总部及研发基地项目"的项目实施期限延期至 2026 年 6 月。本次募投项目延期仅涉及项目进度的变化，未改变募投项目的投 资内容、投资总额、实施主体等，不会对募投项目的实施造成实质性影响。保荐 人国泰海通证券股份有限公司（以下简称"保荐人"）对本事项出具了明确的核 查意见，本事项无需提交公司股东会审议。现将相关情况公告如下： 一、募集资金基本情况 根据中国证券监督管理委员会出具的《关于同意上海君实生 ...

Core Insights - JD Health and Junshi Biosciences have established a strategic partnership to enhance ecological services for oral mucositis care in cancer patients [1][2] - The collaboration aims to integrate JD Health's resources in medical services and instant retail to create a comprehensive ecosystem for oral care [1][3] Group 1: Partnership Details - The partnership focuses on a core model of "professional medical services + compliant supply + instant accessibility" [1] - The newly launched oral mucosal liquid dressing, Su Shu®, is exclusively available on JD Health, providing a full-chain solution for oral health [1][2] Group 2: Clinical Context - Clinical data indicates that 20%-40% of patients undergoing chemotherapy experience oral mucositis, with over 80% of radiotherapy patients suffering from moderate to severe pain [2] - Oral mucositis significantly impacts patients' quality of life and can lead to treatment delays, increased costs, and heightened psychological burdens [2] Group 3: Product and Service Integration - JD Health leverages its online consultation, pharmaceutical retail, and rapid delivery capabilities to create a three-in-one service system for cancer patients [1][3] - The collaboration addresses key pain points in care, such as the difficulty in obtaining compliant devices and the lack of professional guidance [1][3] Group 4: Strategic Implications - Junshi Biosciences aims to focus on comprehensive health management for cancer patients, with Su Shu® representing a strategic shift towards integrated health management [2][3] - The partnership exemplifies the integration of medical and retail resources in specialized healthcare scenarios, setting a benchmark in the medical device sector [3]

Group 1 - The company, Junshi Biosciences (01877), has received a registration notice from the China Interbank Market Dealers Association for its technology innovation bonds [1] - The registered amount for the medium-term notes is set at 2 billion RMB, with a validity period of two years from the date of the notice [1] - Shanghai Bank (601229) will act as the lead underwriter for this bond issuance [1]