Core Viewpoint - The article discusses the performance and business operations of Haiprui, a leading multinational pharmaceutical company, highlighting its revenue structure and market dynamics, particularly in relation to the depreciation of the Chinese yuan and its impact on overseas revenue [2][3]. Company Overview - Haiprui was established in 1998 in Shenzhen and operates with A+H dual financing platforms, focusing on the heparin industry chain, biopharmaceutical CDMO, and innovative drug development [2]. - The company’s main business revenue composition includes: formulations (56.55%), heparin sodium and low molecular weight heparin raw materials (20.25%), CDMO (19.58%), and others (3.63%) [7]. - As of March 31, 2025, Haiprui reported a revenue of 1.394 billion yuan, a year-on-year increase of 1.53%, and a net profit attributable to shareholders of 157 million yuan, up 1.00% year-on-year [7]. Financial Performance - Haiprui's overseas revenue accounts for 93.04% of its total revenue, benefiting from the depreciation of the yuan [3]. - The company has distributed a total of 4.21 billion yuan in dividends since its A-share listing, with 514 million yuan distributed over the past three years [8]. Market Dynamics - The stock experienced a decline of 1.40% on July 31, with a trading volume of 152 million yuan and a turnover rate of 0.91%, resulting in a total market capitalization of 19.647 billion yuan [1]. - The stock's average trading cost is 11.28 yuan, with recent buying activity observed, although the buying pressure is not strong [6]. - The stock is currently trading between resistance at 13.88 yuan and support at 12.41 yuan, indicating potential for range trading [6]. Institutional Holdings - As of March 31, 2025, Haiprui's top ten circulating shareholders include Hong Kong Central Clearing Limited and Innovation Drug, with increases in their holdings compared to the previous period [8].

本文源自：金融界 作者：行情君 海普瑞AH溢价达122.85%，位居AH股溢价率第17位。当日收盘，海普瑞A股报13.58元，跌幅0.15%，H 股报6.66港元，下跌2.63%。 资料显示，深圳市海普瑞药业集团股份有限公司于1998年成立于深圳,是拥有A+H双融资平台的领先跨 国制药企业,主要业务覆盖肝素全产业链、生物大分子CDMO和创新药物的投资、开发及商业化。公司 的三大板块业务相互协同,以临床未满足需求为驱动,致力于为全球患者提供高质量的安全有效药物和服 务,护佑健康。 *注：AH股是指同时在A股和港股上市的公司，溢价（A/H）越大，说明H股相比A股越便宜。 7月30日，上证指数涨0.17%，收报3615.72点，恒生指数跌1.36%，收报25176.93点。 ...

Core Viewpoint - As of July 18, 160 stocks reached their 52-week highs, with notable performances from China New Economy Investment (00080), Aoyuan Group Equity (02905), and Zhong An Holdings Group (08462) showing high growth rates of 288.89%, 55.28%, and 50.00% respectively [1][2]. Summary by Category 52-Week High Performers - China New Economy Investment (00080) closed at 0.440, with a peak price of 0.700, achieving a growth rate of 288.89% [2]. - Aoyuan Group Equity (02905) closed at 0.218, with a peak price of 0.250, achieving a growth rate of 55.28% [2]. - Zhong An Holdings Group (08462) closed at 0.221, with a peak price of 0.228, achieving a growth rate of 50.00% [2]. - Other notable performers include Hualian International (00969) with a growth rate of 40.13% and Zhongke Bio (01237) with a growth rate of 37.25% [2]. Additional High Performers - Wanma Holdings (06928) closed at 0.550 with a growth rate of 30.43% [2]. - Lepu Biopharma-B (02157) closed at 7.940 with a growth rate of 24.54% [2]. - Other stocks with significant growth include ZhiJianYueDong (06860) at 17.14% and China Jindian Group (08281) at 17.12% [2]. 52-Week Low Performers - The document also lists stocks that reached their 52-week lows, with XI Ernan CO-U (09311) showing a decline of 16.10% [6]. - Other notable declines include XI Ernan CO (07311) at -12.62% and Haotian International Construction Investment (01341) at -5.70% [6].

近日，深圳市海普瑞药业集团股份有限公司（以下简称"海普瑞"或"公司"） 自主研发的创新候选药物注射用 H1710（以下简称"H1710"）I 期临床试验已完 成首例受试者入组及首次给药。现将相关情况公告如下： 一、 注射用 H1710 的基本情况 证券代码： 002399 证券简称：海普瑞 公告编号：2025-028 深圳市海普瑞药业集团股份有限公司 关于H1710完成I期临床试验首例受试者入组 及首次给药的公告 本公司及董事会全体成员保证信息披露的内容真实、准确、完整，没有虚假记 载、误导性陈述或重大遗漏。 深圳市海普瑞药业集团股份有限公司 董事会 注射用H1710是一种低抗凝活性的肝素衍生物，是海普瑞自主研发的高效高选 择性的乙酰肝素酶（HPA）抑制剂。乙酰肝素酶在多种恶性肿瘤中高表达，并且与 肿瘤的生长和转移密切相关。H1710通过抑制乙酰肝素酶的活性和表达，展现出抗 肿瘤作用。H1710作为靶向乙酰肝素酶的全新化合物，具有更为合理的链长和独特 的柔性结构，是一种高效、高选择性的乙酰肝素酶抑制剂。 二、 临床试验的相关情况 公司于2025年2月获得国家药品监督管理局核准签发的《药物临床试验批准通 知书》 ...

Core Viewpoint - The company has completed the enrollment and first dosing of the first subject in the Phase I clinical trial for its innovative candidate drug H1710, which is a low anticoagulant activity heparin derivative and a highly selective HPA inhibitor [1] Group 1 - The clinical trial for H1710 is an open-label, dose-escalation Phase I study [1] - The trial aims to evaluate the safety, tolerability, and preliminary anti-tumor activity of H1710 in patients with advanced solid tumors [1] - Approximately 36 patients are expected to be enrolled in the trial [1]

Core Viewpoint - The report outlines the management of the 2024 bond issuance by Shenzhen Hepalink Pharmaceutical Group Co., Ltd, detailing the bond's approval, issuance, financial performance, and compliance with regulations [1][2][5]. Section 1: Bond Overview - The bond, named "22 Hepalink," was approved on March 16, 2022, with a total issuance scale of 500 million yuan, and it was listed on the Shenzhen Stock Exchange on April 11, 2022 [2][3]. - The bond includes options for interest rate selection, issuer redemption, and investor repurchase [2][3]. Section 2: Management of Bond Issuance - The bond trustee, Guotou Securities, is responsible for monitoring the issuer's credit status, fund usage, and repayment of principal and interest [5]. - No bondholder meetings were held during the reporting period [5]. Section 3: Issuer's Business and Financial Status - Shenzhen Hepalink is a leading multinational pharmaceutical company with a registered capital of 1,467.30 million yuan, focusing on the heparin industry chain and CDMO services [6]. - For the first nine months of 2023, the company reported a gross margin of 33.04% and a net profit of 714.69 million yuan [6]. Section 4: Financial Data - As of September 30, 2023, total assets were 201.21 billion yuan, a decrease from the previous year, while total liabilities were 76.22 billion yuan, also down from the previous year [7]. - The net profit for the first nine months of 2023 was 141.89 million yuan, compared to 714.69 million yuan for the entire previous year [7]. - The cash flow from operating activities was negative at -233.99 million yuan, while cash flow from investing activities was positive at 1.31 billion yuan [7]. Section 5: Fund Usage and Disclosure - The bond's proceeds were used to repay the principal of the "19 Hepalink" bond, in line with the bond issuance agreement [8][9]. - The total amount raised after deducting underwriting fees was 496 million yuan [8]. Section 6: Debt Repayment and Guarantees - The bond was fully repaid on April 1, 2024, with no delays in principal or interest payments [10][11]. - The bond is backed by an unconditional and irrevocable guarantee from Shenzhen High-tech Investment and Financing Guarantee Co., Ltd, which has maintained a stable financial condition [10][11]. Section 7: Credit Rating - The issuer's long-term credit rating is AA+, and the bond's credit rating is AAA, with a stable outlook as of May 25, 2023 [12].

| 证券简称： | 海普瑞 | 证券代码： | 002399 | | --- | --- | --- | --- | | 债券简称： | 22 海普瑞 | 债券代码： | 149870 | 深圳市海普瑞药业集团股份有限公司 公司债券 2024 年度受托管理事务报告 发行人 住所：深圳市南山区松坪山郎山路 21 号 债券受托管理人 住所：深圳市福田区福田街道福华一路 119 号安信金融大厦 二〇二五年六月 重要声明 本报告根据《公司债券发行与交易管理办法》《公司债券受托管理人执业 行为准则》等相关规定的要求以及《深圳市海普瑞药业集团股份有限公司 2022 年面向专业投资者公开发行公司债券募集说明书》、《深圳市海普瑞药业集团 股份有限公司 2022 年公开发行公司债券债券受托管理协议》（以下简称"受托 管理协议"）的约定，以相关公开披露信息和深圳市海普瑞药业集团股份有限公 司（以下简称"发行人"或"公司"）提供的资料为依据，由国投证券股份有限公 司（以下简称"国投证券"或"受托管理人"）编制。国投证券编制本报告的内容 及信息均来源于发行人提供的资料、说明以及其他已公开披露的信息。 本报告不构成对投资者进行或不进行 ...

证券代码： 002399 证券简称：海普瑞 公告编号： 2025-027 深圳市海普瑞药业集团股份有限公司 2024年年度权益分派实施公告 本公司及董事会全体成员保证信息披露的内容真实、准确、完整，没有虚假 记载、误导性陈述或重大遗漏。 深圳市海普瑞药业集团股份有限公司（以下简称"公司"）2024年年度权益 分派方案已获2025年5月22日召开的公司2024年年度股东大会审议通过，现将权益 分派事宜公告如下： 一、股东大会审议通过利润分配方案情况 1、公司股东大会审议通过的利润分配方案具体内容 公司2024年年度利润分配方案为：以公司总股本1,467,296,204股（其中含A股 1,247,201,704股，H股220,094,500股）为基数，向全体股东每10股派发现金红利人 民币2.50元（含税），不送红股，不以资本公积金转增股本，剩余利润作为未分配 利润留存。 2、自利润分配方案披露至实施期间，公司股本总额未发生变化。 H股股东：权益分派的详细安排请见公司披露于香港联合交易所网站 www.hkexnews.hk的相关公告。 三、分红派息日期 本次A股权益分派股权登记日为：2025年7月4日，除权除息日 ...

证券代码： 002399 证券简称：海普瑞 公告编号：2025-026 深圳市海普瑞药业集团股份有限公司 关于依诺肝素钠注射液获得EMA新增生产商批准的公告 本公司及董事会全体成员保证信息披露的内容真实、准确、完整，没有虚假记 载、误导性陈述或重大遗漏。 深圳市海普瑞药业集团股份有限公司（以下简称"海普瑞"或"公司"）近日 收到欧洲药品管理局（以下简称"EMA"）签发的关于依诺肝素钠注射液新增成 品制造商的批准通知。现将相关情况公告如下： 一、药品相关情况 （一）通用名称：依诺肝素钠 （二）商品名：Inhixa 三、风险提示 本次坪山制剂生产场地的获批对公司现阶段业绩暂不会产生重大影响。由于 医药行业的特点，药品的生产和销售可能受到政策法规调整、市场环境变化等不确 定因素的影响。敬请广大投资者谨慎决策，注意投资风险。 （六）生产场地地址：中国深圳市坪山区坑梓街道荣田路 1 号 （七）批准文号：EMA/VR/0000262543 二、对公司的影响 海普瑞坪山园区新建预灌封制剂生产线项目于2022年正式启动，首期新建三 条预灌封生产线设计产能为3.3亿支/年，按照中国、欧美药品法规标准设计建造， 用于生产依诺肝素 ...

Core Viewpoint - The company received approval from the European Medicines Agency (EMA) for a new manufacturer of Enoxaparin Sodium Injection, enhancing its production capacity and market competitiveness [1] Group 1: Approval Details - The approved product is Enoxaparin Sodium Injection, marketed under the name Inhixa [1] - The injection comes in various specifications: 20mg/0.2ml, 40mg/0.4ml, 60mg/0.6ml, 80mg/0.8ml, 100mg/1ml, 120mg/0.8ml, and 150mg/1ml [1] - The new manufacturer is Shenzhen Hepalink Pharmaceutical Group Co., Ltd., located at No. 1 Rongtian Road, Kengzi Street, Pingshan District, Shenzhen, China [1] Group 2: Strategic Implications - The approval will support the company's strategy for internationalization of its formulations [1] - It will provide sufficient production capacity to enhance the company's competitiveness in the market [1]