Financial Performance - The company's operating revenue for Q1 2025 was CNY 1,394,250,050.21, representing a 1.53% increase compared to CNY 1,373,251,921.93 in the same period last year[8] - Net profit attributable to shareholders for Q1 2025 was CNY 156,590,188.54, a 1.00% increase from CNY 155,040,262.39 year-on-year[8] - The net profit after deducting non-recurring gains and losses increased by 20.27% to CNY 188,891,082.26 from CNY 157,052,354.18 in the previous year[8] - The total operating profit for the current period is 178,980,342.21, a decrease of 9.4% from 196,847,737.66 in the previous period[34] - Net profit for the current period is 156,169,189.45, showing a slight increase of 1.0% compared to 154,597,836.94 in the previous period[34] - The company's net profit margin improved, with net profit for the period showing a significant recovery compared to the previous period, although specific figures were not disclosed[33] Cash Flow - The net cash flow from operating activities decreased by 38.21% to CNY 544,031,931.35, down from CNY 880,453,882.15 in the same period last year[8] - The cash flow from operating activities is 544,031,931.35, down 38.3% from 880,453,882.15 in the previous period[39] - The net cash flow from investing activities saw a significant decline of 297.07%, resulting in a negative cash flow of ¥257,551,999.87, mainly due to increased purchases of financial products[19] - The cash flow from investment activities shows a net outflow of 257,551,999.87, compared to a net inflow of 130,688,287.99 in the previous period[40] - The net cash flow from financing activities increased by 103.37% to ¥22,602,544.83, as the amounts borrowed and repaid remained relatively stable compared to the previous year[19] - Net cash flow from financing activities was $22,602,544.83, a significant improvement from a negative $670,833,066.44 in the previous period[41] Assets and Liabilities - Total assets at the end of the reporting period were CNY 17,545,801,889.02, reflecting a 1.17% increase from CNY 17,343,523,964.97 at the end of the previous year[8] - Total liabilities increased to CNY 5,205,766,284.88 from CNY 5,141,403,413.17, reflecting an increase of approximately 1.2%[31] - The equity attributable to shareholders increased by 1.14% to CNY 12,287,013,002.74 from CNY 12,148,672,778.24 year-on-year[8] Shareholder Information - The total number of ordinary shareholders at the end of the reporting period was 28,367, with the largest shareholder, Shenzhen Lerun Technology Co., Ltd., holding 32.31% of shares[22] - The top ten shareholders collectively hold significant stakes, with the second-largest shareholder, Xiamen Jintian Soil Investment Partnership, holding 27.81%[22] - The largest shareholder, Shenzhen Lerun Technology Co., Ltd., has a total of 474,029,899 shares, while the second-largest holds 408,041,280 shares[23] - The company has not reported any changes in the participation of the top ten shareholders in margin trading or securities lending activities compared to the previous period[24] - There are no preferred shareholders or related changes reported in the current period[24] Investment and Expenses - The company reported a significant increase in investment income, rising by 132.79% to CNY 20,292,064.76 from a loss of CNY 61,890,173.43 in the previous year[17] - Research and development expenses were CNY 39,993,799.57, up from CNY 35,294,968.25, indicating an increase of about 19.2%[33] - The company experienced a 190.08% decrease in financial expenses, resulting in a gain of CNY 56,508,230.69 due to foreign exchange gains[17] - The deferred income increased by 65.95% to CNY 45,279,690.29, primarily due to government subsidies received during the reporting period[15] - The company reported a substantial increase in asset disposal income, which rose by 4404.34% to CNY 1,288,820.50 from CNY 28,612.85 in the previous year[17] Inventory and Receivables - Accounts receivable increased to CNY 1,382,358,370.19 from CNY 1,178,554,557.22, showing a rise of about 17.3%[28] - Inventory decreased to CNY 4,952,734,323.44 from CNY 5,393,947,174.38, a decline of approximately 8.2%[28] Cash and Equivalents - The company's cash and cash equivalents at the end of the period were CNY 2,000,842,827.21, up from CNY 1,689,041,495.34 at the beginning of the period, indicating a growth of approximately 18.4%[28] - The ending balance of cash and cash equivalents was $1,740,464,878.53, down from $2,108,383,601.96 in the prior period[41] - The net increase in cash and cash equivalents was $318,638,044.68, slightly lower than $342,738,890.08 in the previous period[41] Other Financial Metrics - The total comprehensive income for the current period is 137,915,052.34, a decrease of 8.1% from 150,135,056.48 in the previous period[36] - Basic and diluted earnings per share for the current period are both 0.1067, an increase from 0.1057 in the previous period[36] - The company recorded a foreign exchange loss of 47,399,165.67 in other comprehensive income, contrasting with a gain of 3,002,651.97 in the previous period[35] - The company received cash from sales of goods and services totaling 1,327,258,705.88, down 11.1% from 1,493,180,137.55 in the previous period[39] - The company reported a decrease in cash received from other operating activities to 47,510,298.94, down from 97,379,140.23 in the previous period[39] - The company’s net impairment loss on assets decreased significantly to 44,094.91 from 33,754,398.03 in the previous period[34] Audit and Reliability - The first quarter report was not audited, indicating potential limitations in financial reliability[42]

一、主要会计数据和财务指标 三、分红送配方案情况 | 报告期指标 | 2025年一季报 | 2024年一季报 | 本年比上年增减(%) | 2023年一季报 | | --- | --- | --- | --- | --- | | 基本每股收益（元） | 0.1067 | 0.1057 | 0.95 | 0.0453 | | 每股净资产（元） | 8.37 | 8.22 | 1.82 | 8.43 | | 每股公积金(元) | 4 | 4.33 | -7.62 | 3.99 | | 每股未分配利润(元) | 2.86 | 2.41 | 18.67 | 2.99 | | 每股经营现金流(元) | - | - | - | - | | 营业收入(亿元) | 13.94 | 13.73 | 1.53 | 13.01 | | 净利润(亿元) | 1.57 | 1.55 | 1.29 | 0.67 | | 净资产收益率(%) | 1.28 | 1.29 | -0.78 | 0.54 | 本次公司不分配不转赠。 数据四舍五入，查看更多财务数据>> 二、前10名无限售条件股东持股情况 前十大流通股东累计持有： 125360.0 ...

Revenue and Profit - The company's revenue for Q1 2025 was ¥1,394,250,050.21, representing a year-over-year increase of 1.53% compared to ¥1,373,251,921.93 in the same period last year[5]. - Net profit attributable to shareholders was ¥156,590,188.54, a slight increase of 1.00% from ¥155,040,262.39 in the previous year[5]. - The net profit after deducting non-recurring gains and losses increased by 20.27% to ¥188,891,082.26 from ¥157,052,354.18 year-over-year[5]. - Total operating revenue for the current period reached ¥1,394,250,050.21, an increase of 1.4% compared to ¥1,373,251,921.93 in the previous period[23]. - Net profit for the current period was ¥156,169,189.45, slightly higher than ¥154,597,836.94 from the previous period, indicating a growth of about 1%[24]. - Earnings per share (EPS) for the current period was ¥0.1067, compared to ¥0.1057 in the previous period, showing an increase of 0.9%[25]. Cash Flow - The net cash flow from operating activities decreased significantly by 38.21% to ¥544,031,931.35 from ¥880,453,882.15 in the same period last year[5]. - Cash inflow from operating activities totaled ¥1,501,965,061.54, a decrease from ¥1,664,646,503.27 in the previous period, representing a decline of approximately 9.7%[26]. - The net cash flow from operating activities was $544,031,931.35, a decrease of 38.2% compared to $880,453,882.15 in the previous period[27]. - Total cash outflow from operating activities amounted to $957,933,130.19, up from $784,192,621.12, indicating a 22.1% increase[27]. - Cash inflow from investment activities totaled $605,376,122.24, compared to $441,112,963.21, reflecting a 37.3% increase[27]. - The net cash flow from investment activities was -$257,551,999.87, a decline from $130,688,287.99 in the previous period[27]. - Cash inflow from financing activities was $750,396,287.53, down from $835,834,333.10, representing a decrease of 10.2%[27]. - The net cash flow from financing activities was $22,602,544.83, a significant improvement from -$670,833,066.44 in the previous period[27]. - The total cash and cash equivalents at the end of the period were $1,740,464,878.53, down from $2,108,383,601.96[27]. - The cash and cash equivalents increased by $318,638,044.68 during the period, compared to an increase of $342,738,890.08 in the previous period[27]. Assets and Liabilities - Total assets at the end of the reporting period were ¥17,545,801,889.02, reflecting a 1.17% increase from ¥17,343,523,964.97 at the end of the previous year[5]. - The company's total liabilities amounted to ¥5,205,766,284.88, compared to ¥5,141,403,413.17 in the previous period, reflecting an increase of about 1.25%[21]. - Total equity attributable to shareholders reached ¥12,287,013,002.74, up from ¥12,148,672,778.24, marking an increase of approximately 1.14%[21]. - Total current assets amount to 9,873,944,183.93 RMB, an increase from 9,621,274,306.15 RMB at the beginning of the period[19]. - Total assets amount to 17,545,801,889.02 RMB, compared to 17,343,523,964.97 RMB at the beginning of the period[20]. Shareholder Information - Total number of common shareholders at the end of the reporting period is 28,367[16]. - The largest shareholder, Shenzhen Lerun Technology Co., Ltd., holds 32.31% of shares, totaling 474,029,899 shares[16]. - The second-largest shareholder, Xiamen Jintian Investment Partnership, holds 27.81%, totaling 408,041,280 shares[16]. Other Financial Metrics - The company's basic earnings per share (EPS) was ¥0.1067, up 0.95% from ¥0.1057 in the same period last year[5]. - The weighted average return on equity (ROE) slightly decreased to 1.28% from 1.29% year-over-year[5]. - The company reported a decrease in financial expenses, with a net financial cost of -¥56,508,230.69 compared to ¥62,732,180.93 in the previous period[24]. - The company experienced a decrease in comprehensive income, totaling ¥137,915,052.34 compared to ¥150,135,056.48 in the previous period, a decline of about 8%[25]. - The company reported a significant increase in deferred income by 65.95% to ¥45,279,690.29 due to government subsidies received during the reporting period[11]. - Deferred income increased to ¥45,279,690.29 from ¥27,284,974.87, indicating a significant rise of approximately 65.9%[21]. - The company has a total of 366,727,264.95 RMB in long-term equity investments[20]. - The company’s goodwill stands at 2,353,689,028.00 RMB, a slight decrease from 2,357,033,547.26 RMB[20]. - Inventory decreased to 4,952,734,323.44 RMB from 5,393,947,174.38 RMB[20]. - Short-term borrowings are reported at 1,819,531,746.74 RMB, slightly down from 1,838,944,224.03 RMB[20]. - The company paid $225,883,127.82 to employees, an increase from $182,063,990.65 in the previous period[27]. - The company reported a total tax payment of $71,329,471.04, up from $61,136,636.42, indicating a 19.8% increase[27].

证券代码：002399 证券简称：海普瑞 公告编号：2025-021 根据外部市场环境结合公司全球业务发展的需求，经公司于2025年4月24日 召开的第六届董事会第十五次会议审议通过，决定对原增资方案进行调整，将原 增资金额1.05亿美元调整为3,192万美元，其余内容不变。 调整后的增资金额在公司董事会决策权限内，无需提交股东大会审议批准。 上述调整增资方案的事项不构成关联交易，亦不构成《上市公司重大资产重组管 理办法》规定的重大资产重组。 一、增资标的的基本情况 （一）多普乐 关于向全资子公司天道医药（香港）有限公司增资 的进展公告 本公司及董事会全体成员保证信息披露的内容真实、准确、完整，没有虚假 记载、误导性陈述或重大遗漏。 重要内容提示 经深圳市海普瑞药业集团股份有限公司（以下简称"公司"或"海普瑞"） 于2021年12月10日召开的第五届董事会第十五次会议审议通过，公司决定使用H 股募集资金1.05亿美元以逐层增资的方式向全资子公司天道医药（香港）有限公 司（以下简称"香港天道"）增资，用于欧盟及其他全球市场拓展销售及营销网 络以及基础设施的建设。具体增资路径为海普瑞向其全资子公司深圳市多普乐实 ...

深圳市海普瑞药业集团股份有限公司（以下简称"公司"）的全资孙公司深圳 市天道医药有限公司（以下简称"天道医药"）近期收到南非卫生产品管理局（South African Health Products Regulatory Authority）签发的依诺肝素钠注射液批准通知。 现将相关情况公告如下： （五）适应症： （六）许可有效期：五年 证券代码： 002399 证券简称：海普瑞 公告编号：2025-024 深圳市海普瑞药业集团股份有限公司 关于依诺肝素钠注射液获得南非药品注册批件的公告 本公司及董事会全体成员保证信息披露的内容真实、准确、完整，没有虚假记 载、误导性陈述或重大遗漏。 一、基本情况 《证券时报》《证券日报》《中国证券报》《上海证券报》和巨潮资讯网 （www.cninfo.com.cn）为公司指定信息披露媒体，公司所有信息均以在上述指定媒 体刊登的信息为准。公司将严格按照有关法律法规的规定和要求，认真履行信息披 露义务，及时做好信息披露工作。 公司郑重提请投资者注意：投资者应充分了解股票市场风险及公司定期报告 中披露的风险因素，审慎决策、理性投资。 特此公告 深圳市海普瑞药业集团股份有限公司 二 ...

香港交易及結算所有限公司及香港聯合交易所有限公司對本公告的內容概不負責， 對其準確性或完整性亦不發表任何聲明，並明確表示，概不對因本公告全部或任 何部分內容而產生或因倚賴該等內容而引致的任何損失承擔任何責任。 1. 收入約為人民幣5,258.9百萬元（二零二三年：約人民幣5,431.0百萬元）； 2. 毛利約為人民幣1,739.3百萬元（二零二三年：約人民幣940.9百萬元）；毛利 率約為33.1%（二零二三年：約17.3%）； 3. 製劑業務銷售收入約為人民幣2,986.1百萬元（二零二三年：約人民幣2,979.0 百萬元）；毛利率約為31.8%（二零二三年：約43.1%）； 4. API業務銷售收入約為人民幣1,065.7百萬元（二零二三年：約人民幣1,307.3 百萬元）；毛利率約為38.6%（二零二三年：約-42.8%）； 5. CDMO業務銷售收入約為人民幣1,033.8百萬元（二零二三年：約人民幣 967.0百萬元）；毛利率約為32.9%（二零二三年：約22.0%）； 6. 母公司權益擁有人應佔溢利約為人民幣646.7百萬元（二零二三年：母公司 權益擁有人應佔虧損約為人民幣783.3百萬元）；及 ...

Financial Performance - For Q3 2024, the company's operating revenue was RMB 1,231,523,140.11, a decrease of 8.80% compared to the same period last year[4] - The net profit attributable to shareholders was RMB 116,430,360.57, representing a significant increase of 487.43% year-on-year[4] - The net profit attributable to shareholders after deducting non-recurring gains and losses was RMB 99,358,854.26, up 1,631.43% from the previous year[4] - The company reported a basic earnings per share of RMB 0.0794, an increase of 488.15% compared to the same period last year[4] - Net profit rose by 449.08% to ¥779,059,287.68, reflecting the overall improvement in operating profit[10] - Basic and diluted earnings per share for the current period were both RMB 0.5317, compared to RMB 0.0976 in the previous period, marking an increase of approximately 444.43%[23] - The total comprehensive income for the current period was RMB 713,437,124.04, compared to RMB 242,978,158.09 in the previous period, indicating a growth of approximately 194.00%[23] Cash Flow - The cash flow from operating activities for the year-to-date was RMB 1,792,139,231.56, an increase of 865.91% compared to the same period last year[4] - Cash flow from operating activities improved significantly, with a net increase of 865.91% to ¥1,792,139,231.56, driven by higher cash receipts from sales[11] - Operating cash flow for the current period is RMB 1,792,139,231.56, compared to a negative cash flow of RMB -233,988,970.92 in the previous period, indicating a significant recovery[25] - Cash received from sales of goods and services decreased to RMB 4,299,443,691.71 from RMB 4,603,550,675.54, a decline of approximately 6.6%[25] - Cash paid for purchasing goods and services significantly decreased to RMB 1,477,390,948.62 from RMB 3,633,091,884.41, a reduction of about 59.3%[25] - Cash inflow from investment activities decreased to RMB 1,515,558,196.54 from RMB 2,301,332,024.93, reflecting a decline of approximately 34%[26] - Net cash flow from financing activities shows a significant outflow of RMB -1,345,954,669.90, worsening from RMB -672,098,505.03 in the previous period[26] - The total cash and cash equivalents at the end of the period increased to RMB 1,995,479,199.24, up from RMB 1,757,779,083.22 in the previous period[27] Assets and Liabilities - The total assets at the end of the reporting period were RMB 18,121,417,326.69, a decrease of 5.63% from the end of the previous year[4] - Total non-current assets decreased to RMB 7,749,434,630.32, down 9.93% from RMB 8,599,510,606.98 at the beginning of the period[18] - Total liabilities decreased to RMB 5,906,888,588.09, down 18.11% from RMB 7,215,037,414.42 at the beginning of the period[20] - The total equity attributable to shareholders increased to RMB 12,140,384,965.66, reflecting a growth of 1.91% year-on-year[4] - The total equity attributable to shareholders increased to RMB 12,140,384,965.66, up 1.91% from RMB 11,913,149,195.32 at the beginning of the period[20] Investments - The company experienced a 102.03% increase in trading financial assets, totaling RMB 836,795,932.21, primarily due to increased investments in financial products[8] - Long-term equity investments decreased by 50.58% to RMB 496,236,843.73, mainly due to the disposal of shares in HighTide Therapeutics, Inc.[8] - Investment income increased by 251.52% to ¥416,440,156.93, primarily from the disposal of equity and fund investments[9] - The company reported an investment income of RMB 416,440,156.93, a turnaround from a loss of RMB 274,834,971.73 in the previous period[21] Shareholder Information - The total number of ordinary shareholders at the end of the reporting period was 27,499, with the top ten shareholders holding significant stakes[12] - Shenzhen Lerun Technology Co., Ltd. held 32.31% of shares, while Xiamen Jintian Tuti Investment Partnership held 27.81%[12] - The company has a strong shareholder base, with the top three shareholders collectively owning over 75% of the shares[12] Expenses - Sales expenses decreased by 30.26% to ¥280,983,594.46 due to reduced marketing costs[9] - Research and development expenses decreased to RMB 129,976,981.05 from RMB 152,223,825.20, a reduction of about 14.58%[21] - The company’s tax expenses increased to RMB 108,143,486.10 from RMB 39,289,379.06, reflecting an increase of approximately 175.00%[22] Other Information - The company reported a significant increase in non-operating income due to government subsidies amounting to RMB 5,108,928.12 for Q3 2024[5] - The company experienced a foreign exchange loss of RMB 60,898,382.20, contrasting with a gain of RMB 103,834,456.09 in the previous period[23] - The impact of exchange rate changes on cash and cash equivalents was a positive RMB 9,871,785.63, compared to RMB 31,821,093.12 in the previous period[27] - The company did not undergo an audit for the third quarter report[28]

Financial Performance - Revenue for the six months ended June 30, 2024, was RMB 2,828,657, representing a 4.5% increase from RMB 2,706,246 in the same period of 2023[7]. - Gross profit for the same period was RMB 999,274, with a gross profit margin of 35.3%, slightly down from 35.4% in 2023[7]. - Profit attributable to equity holders of the parent surged to RMB 663,684, a significant increase of 438.1% compared to RMB 123,349 in 2023[7]. - The Group achieved sales revenue of RMB 2,828.7 million, a year-on-year increase of 4.5% compared to RMB 2,706.2 million in the same period last year[12]. - Gross profit for the Group was RMB 999.3 million, representing a 4.2% increase from RMB 959.0 million year-on-year, with a gross profit margin of 35.3%[12]. - Profit before tax increased significantly to RMB 767.6 million, compared to RMB 167.7 million in the prior year, marking a growth of 357.5%[103]. - Profit for the period reached RMB 662.8 million, up from RMB 122.4 million, reflecting a year-over-year increase of 441.5%[103]. - Basic earnings per share attributable to ordinary equity holders of the parent was RMB 0.45, compared to RMB 0.08 in the same period last year[103]. Cash Flow and Liquidity - Cash and cash equivalents rose to RMB 2,202,718, reflecting a 24.8% increase from RMB 1,765,645 in the previous year[7]. - Net cash flows generated from operating activities amounted to RMB 1,294,842, a recovery from a cash outflow of RMB (542,752) in 2023[7]. - The Group achieved a net operating cash inflow of RMB 1,294.8 million during the Reporting Period, representing an increase of 338.6% year-on-year[11]. - The Group's operating cash flow net inflow was RMB 1,294.8 million, a year-on-year increase of 338.6%[13]. - The net increase in cash and cash equivalents for the first half of 2024 was RMB 426,081, compared to RMB 84,888 in the same period last year[120]. - The Group's liquidity remains strong, with primary funding sourced from ordinary business operations[54]. Market and Strategic Initiatives - The company is focusing on expanding its market presence and enhancing its product portfolio through new product development and technology advancements[7]. - Future outlook includes strategic initiatives aimed at increasing operational efficiency and market share in the pharmaceutical sector[7]. - The company is exploring potential mergers and acquisitions to bolster its growth strategy and enhance competitive positioning[7]. - The Group actively strengthened its commercial and operational capabilities in the United States and Europe to enhance global market share[11]. - The Group is advancing the commercialization of Fozaprepitant in the U.S. to create new revenue sources[22]. - The Group's investment strategy was adjusted to focus more on core business development, optimizing asset portfolio and rate of return[11]. Research and Development - Continued investment in research and development is prioritized to drive innovation and meet evolving market demands[7]. - Research and development costs for the period were RMB 81,041,000, down 15% from RMB 95,362,000 in the previous year[162]. Shareholder and Corporate Governance - The Board resolved not to declare interim dividends for the six months ended June 30, 2024, consistent with the same period last year, which also had no dividends declared[72]. - The Company has complied with all applicable code provisions in the Corporate Governance Code during the reporting period[90]. - The Company is committed to high standards of corporate governance as per the Corporate Governance Code[90]. Assets and Liabilities - The asset-liability ratio improved to 34.3%, down from 37.6% in the previous year[7]. - The Group's total assets amounted to approximately RMB 18,573.5 million, down from RMB 19,203.4 million as of December 31, 2023[62]. - The Group's total amount of other borrowings increased to RMB 750.0 million as of June 30, 2024, from RMB 556.0 million as of December 31, 2023[71]. - The Group's short-term loans were approximately RMB 2,992.8 million as of June 30, 2024, down from RMB 3,624.6 million as of December 31, 2023[59]. Sales and Revenue Breakdown - For the six months ended June 30, 2024, the total revenue from external customers was RMB 2,828,657,000, with segment revenues of RMB 1,453,516,000 from finished dose pharmaceutical products, RMB 747,599,000 from API, RMB 560,378,000 from CDMO, and RMB 67,164,000 from others[133]. - The finished dose pharmaceutical products segment reported a profit of RMB 454,738,000, while the API segment reported RMB 461,857,000, and the CDMO segment reported RMB 174,560,000[133]. - Revenue from external customers in the United States was RMB 580,353,000, representing an increase from RMB 535,379,000 in the previous period[137]. Employee and Operational Metrics - As of June 30, 2024, the Group had 1,928 employees, with total staff costs approximately RMB 282.6 million, down from RMB 360.5 million in the same period last year[72]. - The Group's credit period with customers generally ranges from one to three months, emphasizing the importance of timely collections[195]. Foreign Exchange and Financial Management - Unrealized foreign exchange losses during the Reporting Period amounted to RMB 31.9 million, with the Group planning to use financial market tools to mitigate foreign exchange risks[53]. - The company recognized a foreign exchange loss of RMB 12,134,000 for the six months ended June 30, 2024, compared to a gain of RMB 126,847,000 for the same period in 2023[158].

Financial Performance - For the six months ended June 30, 2024, the company recorded revenue of RMB 2,828,657 thousand, representing a 4.5% increase from RMB 2,706,246 thousand in the same period of 2023[2] - Gross profit for the same period was RMB 999,274 thousand, up 4.2% from RMB 958,958 thousand year-on-year, with a gross margin of 35.3%[2] - The profit attributable to equity holders of the parent company surged to RMB 663,684 thousand, a significant increase of 438.1% compared to RMB 123,349 thousand in the prior year[2] - The company reported a total comprehensive income of RMB 708,332 thousand for the period, compared to RMB 230,198 thousand in the previous year[4] - The basic and diluted earnings per share for the period were RMB 0.45, compared to RMB 0.08 in the same period of 2023[3] - The company achieved a sales revenue of RMB 2,828.7 million, a year-on-year increase of 4.5% compared to RMB 2,706.2 million in the previous year[10] - Gross profit was RMB 999.3 million, up 4.2% from RMB 959.0 million year-on-year, with a gross margin of 35.3%[10] - The net profit attributable to shareholders was RMB 663.7 million, significantly higher than RMB 123.3 million in the previous year[10] Cash Flow and Financial Position - Cash and cash equivalents increased by 24.8% to RMB 2,202,718 thousand from RMB 1,765,645 thousand as of June 30, 2023[2] - The net cash flow from operating activities was RMB 1,294,842 thousand, a turnaround from a cash outflow of RMB 542,752 thousand in the same period last year[2] - Total assets decreased to RMB 18,573,510 thousand from RMB 19,203,417 thousand as of December 31, 2023[6] - Current liabilities decreased to RMB 4,479,909 thousand from RMB 4,986,182 thousand as of December 31, 2023[6] - The company's net assets increased to RMB 12,209,423 thousand from RMB 11,988,377 thousand as of December 31, 2023[6] - Financing costs decreased by RMB 41.7 million to RMB 84.5 million, a reduction of 33.0% year-on-year, primarily due to the repayment of maturing bonds and a decrease in net borrowings[30] - Total assets as of June 30, 2024, were approximately RMB 18,573.5 million, with total liabilities of approximately RMB 6,364.1 million, resulting in a debt-to-asset ratio of about 34.3%[38] Market and Sales Performance - The heparin value chain business generated sales revenue of RMB 2,245.3 million, slightly down from RMB 2,289.5 million in the previous year[11] - The company's formulation sales remained stable at RMB 1,453.5 million, down from RMB 1,547.3 million, with a gross margin of 34.0%[11] - The group signed a distribution agreement with Chengdu Tianqing Pharmaceutical Co., Ltd. for the commercialization of Fosaprepitant in the U.S., leveraging its self-operated sales network[15] - The group's sales revenue in the U.S. market increased significantly, driven by both self-operated and agency sales, with a focus on promoting the sales of enoxaparin sodium and standard heparin products[12] - The non-European and American overseas markets saw significant sales growth, with sales volume doubling during the reporting period, and the group actively expanding into new markets[12] - The group continues to strengthen its market presence in China, achieving double-digit sales growth despite price restrictions from national procurement platforms[12] Research and Development - The company is developing innovative drug candidates for immune-related diseases, currently in the clinical stage[8] - Oregovomab, a candidate drug for advanced ovarian cancer, is undergoing a mid-term analysis in its Phase III clinical trial, with ongoing patient survival follow-up as per the Data Safety Monitoring Board's recommendations[16] - AR-301, a monoclonal antibody for Staphylococcus aureus pneumonia, did not meet primary endpoints in its global Phase III study, but showed potential benefits in patients over 65 and those with MRSA[17] - RVX-208, a selective BET protein inhibitor, completed its Phase III clinical trial, demonstrating a reduction in major adverse cardiovascular events in high-risk patients, and has received breakthrough therapy designation from the FDA[18] - H1710, a self-developed heparinase inhibitor, is currently in preclinical stage and has shown significant antitumor effects in various tumor models compared to standard treatments[19] Operational Efficiency and Cost Management - The company aims to enhance operational efficiency and cash flow management while controlling operating costs to ensure sustainable development[22] - The company will continue to support the long-term development of its CDMO platforms and strengthen customer channels to increase market penetration[21] - Employee costs totaled approximately RMB 282.6 million for the reporting period, down from RMB 360.5 million in the same period last year, reflecting a decrease of about 22%[77] Corporate Governance and Compliance - The company has adopted the corporate governance code as per the Hong Kong Stock Exchange rules and has complied with all applicable provisions during the reporting period[78] - The board consists of four executive directors and three independent non-executive directors, ensuring that independent directors account for at least one-third of the board[78] - The audit committee has reviewed the unaudited consolidated interim results for the six months ending June 30, 2024, and confirmed compliance with relevant accounting standards and regulations[80] Future Outlook - The company plans to continue expanding its market presence and investing in new product development to drive future growth[56] - The company is exploring new business opportunities and partnerships in Asia and South America to enhance its overseas market coverage[12] - The company anticipates that the overall API sales prices will remain at the bottom level, but demand is expected to gradually recover over time[21]

Financial Performance - Revenue for 2023 was RMB 5,430,974, a decrease of 24.1% compared to RMB 7,151,039 in 2022[23]. - Profit before tax for 2023 was a loss of RMB 928,334, compared to a profit of RMB 829,851 in 2022[23]. - Basic earnings per share for 2023 was a loss of RMB 0.53, down from a profit of RMB 0.50 in 2022[23]. - Operating income for 2023 was RMB 5,431.0 million, a decrease from RMB 7,151.0 million in 2022, reflecting the impact of the post-epidemic era[29]. - Overall gross profit margin decreased by 14.7 percentage points to 17.3% in 2023, down from 32.0% in 2022[29]. - Loss attributable to shareholders on a consolidated basis was RMB 783.3 million in 2023, compared to a profit of RMB 727.4 million in 2022[29]. - Net operating cash inflow was RMB 398.2 million in 2023, a significant recovery from a net outflow of RMB 756.7 million in 2022[29]. - Gross profit for 2023 decreased by RMB 1,349.3 million to RMB 940.9 million, compared to RMB 2,290.2 million in 2022, with a gross profit margin decline of 14.7 percentage points to 17.3%[79]. - Adjusted gross profit for 2023 was approximately RMB 1,796.3 million, with an adjusted gross profit margin of approximately 33.1%, an increase from 32.5% in 2022[80]. - The loss attributable to equity holders was RMB 783.3 million, while the adjusted profit attributable to equity holders was RMB 387.0 million, down from RMB 841.9 million in 2022[51]. Market and Sales Performance - The Group's enoxaparin finished dose pharmaceutical products maintained stable global sales volumes, holding the second-largest market share in Europe[32]. - In the U.S. market, the Group's enoxaparin products received FDA approval and launched in June 2023, actively increasing market share[32]. - The Group secured first place in China's 8th national volume-based procurement, obtaining contracts from five provinces as primary suppliers[32]. - The Group's marketing strategies in Europe led to steady revenue growth in finished dose pharmaceutical products despite global destocking trends[32]. - The Group expanded its market presence in new regions such as Australia and Ecuador, maintaining a solid second position in international non-European and American markets[32]. - The heparin industrial chain business achieved sales revenue of RMB4,286.3 million, a decrease from RMB5,884.3 million in 2022[54]. - Finished dose pharmaceutical products sales revenue was RMB2,979.0 million, accounting for 54.9% of total revenue, with a gross profit of RMB1,284.6 million, reflecting a 13.4% increase year-on-year[54]. - The heparin API business reported sales revenue of approximately RMB1,307.3 million, down from RMB2,673.8 million in 2022, accounting for 24.1% of total revenue[57]. - The CDMO business generated sales revenue of approximately RMB967.0 million, a decline from RMB1,084.1 million in 2022, with a gross profit margin decreasing to 22.0%[59]. Challenges and Risks - The CDMO business faced challenges with a revenue decline due to the end of key enzyme orders for mRNA COVID-19 vaccines, but recovery efforts in Q4 helped offset losses[33]. - The external environment remains complex and uncertain, with rising interest rates and tightening credit posing challenges to growth[39]. - The Company experienced a fraudulent incident involving approximately EUR 11.74 million, with about EUR 9.74 million (RMB 74.5 million) fraudulently transferred in 2023[44]. - The significant increase in the cost of sales was attributed to the accounting treatment of including impairment losses on inventory in the cost of sales of APIs[79]. - The company faces risks related to market acceptance of its products, which could adversely impact operations and profitability[194]. - The company’s CDMO business is dependent on customer demand for outsourced biologics, and a reduction in spending could materially affect its financial condition[196]. Strategic Initiatives - The Group plans to enhance its heparin business and increase sales volume and market share in various heparin markets while adjusting marketing strategies based on market dynamics[36]. - The Group will focus on improving internal management systems and risk management, collaborating with external experts to optimize internal control management planning in 2024[36]. - The Group aims to leverage its competitive advantages and capitalize on market opportunities to promote long-term sustainable development and maximize shareholder returns[38]. - The Group plans to optimize resource allocation to improve production capacity and meet future business needs more flexibly[74]. - Hepalink aims to explore new business growth points by collaborating with multinational pharmaceutical companies in Europe and the United States[52]. - The Group plans to actively expand the market size and diversify sales distribution in the API business to achieve market share expansion and solidify its leadership position in the API industry[73]. - Hepalink will increase efforts on market expansion of enoxaparin API and promote sales of high-tech, high-quality, and high-value-added enoxaparin API products for steady revenue growth[73]. Governance and Management - The Group has a strong management team with extensive experience across various pharmaceutical sectors, enhancing its strategic capabilities[97]. - The focus on human resources management is crucial for supporting the Group's operational needs and growth[97]. - The Group's strategic committee includes key members who participate in formulating and implementing business strategies[97]. - The Company is committed to maintaining a comprehensive risk management framework to strengthen internal monitoring and risk management capabilities[74]. - The Group has established a framework to safeguard shareholder interests and enhance corporate value through good governance practices[200]. Shareholder Information - The Group's distributable reserves as of December 31, 2023, were RMB 913 million[118]. - The Board has resolved not to declare a final dividend for the year ended December 31, 2023, compared to RMB 1.0 per ten ordinary shares in 2022[111][113]. - The total beneficial ownership of shares by substantial shareholders indicates a concentration of ownership, with the top three shareholders holding over 100 million shares each[170]. - The report highlights compliance with the Securities and Futures Ordinance regarding the disclosure of interests and short positions in shares[168]. - The company has a significant shareholding structure, with major shareholders including Leren Technology and Jintiantu, which together control over 70% of the shares[170]. Future Outlook - The Chairman expressed a cautiously optimistic outlook for business recovery and financial turnaround, emphasizing the importance of cost control for robust financial performance[37]. - The Company is optimistic about future prospects and will continue to implement its existing strategy while observing market trends[74]. - The Group plans to fully utilize the remaining Net Proceeds on or before November 30, 2025[122].