Core Viewpoint - The pharmaceutical sector in China is experiencing significant growth, driven by favorable government policies and increasing international market share, with a notable rise in innovative drug development and exports [1][2]. Group 1: Market Performance - On May 23, 2025, pharmaceutical stocks collectively surged, with sectors like Helicobacter pylori, AI healthcare concepts, and weight-loss drugs rising over 2% [1]. - Hai Chen Pharmaceutical's stock hit a 20% limit up within three minutes of opening, reaching a new high in two and a half years [1]. - Heng Rui Pharmaceutical officially listed on the Hong Kong stock market, with its stock price increasing by approximately 30% post-opening, raising about 9.9 billion HKD through an IPO of 224.5 million shares, marking the largest IPO in the Hong Kong pharmaceutical sector in five years [1]. Group 2: Export and Innovation - In Q1 2025, China's pharmaceutical and healthcare product exports reached 26.632 billion USD, a year-on-year increase of 4.39%, while imports decreased by 4.42% to 20.456 billion USD, indicating a domestic industry upgrade and import substitution effect [1][2]. - The United States remains the largest single market for Chinese pharmaceutical exports, with exports amounting to 4.639 billion USD, a 9.6% increase, primarily driven by raw materials and disposable medical supplies [2]. - By the end of 2024, the number of active innovative drugs developed by Chinese companies reached 3,575, ranking first globally, with domestic products accounting for 42% of newly approved innovative drugs, up from less than 10% in 2015 [2]. Group 3: Future Outlook - Analysts predict that 2025 will be a pivotal year for the pharmaceutical industry in China, marking the beginning of significant revenue growth, profitability for many companies, and an extended valuation cycle due to improvements in payment systems [2].

Core Viewpoint - The stock of Berry Genomics has reached its daily limit, with other companies in the sector such as Celgen, Chuangyi Huikang, Tigermed, Anbiping, Meinian Health, and BGI also experiencing gains. This surge is linked to the announcement from Insilico Medicine's CEO, Alex Zhavoronkov, regarding the potential market entry of the first drugs entirely conceived by artificial intelligence by 2030 [1] Group 1 - Berry Genomics has hit the daily trading limit, indicating strong market interest and investor confidence [1] - Other companies in the healthcare and biotechnology sector, including Celgen, Chuangyi Huikang, Tigermed, Anbiping, Meinian Health, and BGI, have also seen their stock prices rise in response to the news [1] - Insilico Medicine's CEO has projected that the first AI-conceived drugs could be available by 2030, highlighting the growing role of artificial intelligence in drug development [1]

Summary of Key Points Core Viewpoint - The announcement details a significant change in shareholding for Chengdu Berry Genomics Technology Co., Ltd. (referred to as "the Company") due to forced execution of shares by the controlling shareholder Gao Yang and his associate Hou Ying, resulting in a reduction of their holdings without affecting the company's control or operational stability [1][2]. Shareholding Changes - Gao Yang's shares decreased by 5,580,549 shares, representing a 1.58% reduction in total shareholding [1]. - Hou Ying's shares decreased by 1,135,661 shares, accounting for 0.32% of total shareholding [1]. - The total reduction in shareholding for both Gao Yang and Hou Ying amounts to 6,716,210 shares, which is 1.90% of the total share capital [1]. Execution Details - The forced execution of shares occurred due to a stock pledge default, with the shares being sold through centralized bidding by Guoxin Securities from August 1, 2024, to October 31, 2024, and again on May 20, 2025 [1]. - The execution process did not lead to a change in the company's control, nor did it have a significant adverse impact on the company's production, financial status, or governance structure [2].

证券代码：000710 证券简称：贝瑞基因 公告编号：2025-027 成都市贝瑞和康基因技术股份有限公司 关于持股5%以上股东权益变动触及1%整数倍的公告 本公司及董事会全体成员保证信息披露的内容真实、准确、完整，没有虚假 记载、误导性陈述或重大遗漏。 控股股东高扬先生及一致行动人侯颖女士保证向本公司提供的信息内容真 实、准确、完整，没有虚假记载、误导性陈述或重大遗漏。 本公司及董事会全体成员保证公告内容与信息披露义务人提供的信息一致。 成都市贝瑞和康基因技术股份有限公司董事会 一、本次股份变动情况 | 股份种类（A 股、B 股 | | | | | --- | --- | --- | --- | | 等） | 减少股数（股） 减少比例（%） | | | | A 股 | 高扬 5,580,549 1.58 | | | | A 股 | 侯颖 1,135,661 0.32 | | | | 合 计 | 6,716,210 1.90 | | | | 本次权益变动方式 | 通过证券交易所的集中交易（司法强制执行） | | ☑ | | （可多选） | 通过证券交易所的大宗交易 | □ | | | | 其他（司法拍卖） ☑ ...

证券代码：000710 证券简称：贝瑞基因 公告编号：2025-026 成都市贝瑞和康基因技术股份有限公司 2024年年度股东大会决议公告 本公司及董事会全体成员保证信息披露的内容真实、准确、完整，没有虚假记 载、误导性陈述或重大遗漏。 一、会议召开情况 1、会议时间： （1）现场会议召开时间：2025年5月20日（星期二）14:30 6、本次股东大会符合有关法律、行政法规、部门规章、规范性文件、深圳证券 交易所业务规则和公司章程等的规定。 7、股东出席会议情况 本次出席现场会议的股东2人，代表股份45,773,798股，占公司有表决权股份总 数的12.9480%。 （2）网络投票时间：其中，通过深圳证券交易所交易系统进行网络投票的具体 时间为2025年5月20日9:15—9:25、9:30—11:30、13:00—15:00； 通过深圳证券交易所互联网投票系统投票的具体时间为：2025年5月20日9:15— 15:00。 2、会议地点：北京市昌平区生命园路4号院5号楼公司6层会议室 3、会议召开方式： 本次股东大会采用现场表决与网络投票相结合的方式。本公司通过深圳证券交 易所交易系统和互联网投票系统（htt ...

之法律意见书 致：成都市贝瑞和康基因技术股份有限公司 北京市金杜律师事务所（以下简称本所）接受成都市贝瑞和康基因技术股份 有限公司（以下简称公司）委托，根据《中华人民共和国证券法》（以下简称《证 券法》）、《中华人民共和国公司法》（以下简称《公司法》）、中国证券监督 管理委员会《上市公司股东会规则》（以下简称《股东会规则》）等中华人民共 和国境内（以下简称中国境内，为本法律意见书之目的，不包括中国香港特别行 政区、中国澳门特别行政区和中国台湾地区）现行有效的法律、行政法规、规章 和规范性文件和现行有效的公司章程有关规定，指派律师现场出席了公司于 2025 年 5 月 20 日召开的 2024 年年度股东大会（以下简称本次股东大会），并 就本次股东大会相关事项出具本法律意见书。 为出具本法律意见书，本所律师审查了公司提供的以下文件，包括但不限于： 1. 经公司 2023 年年度股东大会审议通过的《成都市贝瑞和康基因技术股份 有限公司章程》（以下简称《公司章程》）； 北京市金杜律师事务所 关于成都市贝瑞和康基因技术股份有限公司 2024 年年度股东大会 2. 公司 2025 年 4 月 25 日刊登于《中国证券报 ...

Core Viewpoint - The forced liquidation of shares held by the controlling shareholder, Gao Yang, due to a default in a stock pledge repurchase agreement, raises concerns about the financial stability of Berry Genomics and its declining stock price [1][2][5] Group 1: Shareholder Actions and Impacts - Gao Yang, the founder and chairman of Berry Genomics, has had 3,535,214 shares (1% of total shares) ordered for forced liquidation due to a default on a stock pledge with Guosen Securities [1] - All shares held by Gao Yang (9.05% of total shares) are currently under judicial freeze, indicating significant financial distress [3] - The forced execution of shares is part of a broader trend where both Gao Yang and his associate, Hou Ying, have seen their shares subjected to judicial auction due to ongoing financial difficulties [4] Group 2: Financial Performance - Berry Genomics has experienced a continuous decline in revenue and has reported losses for four consecutive years, totaling approximately 9.85 billion yuan [5] - The company's revenue figures from 2021 to 2024 are approximately 14.22 billion yuan, 13.68 billion yuan, 11.51 billion yuan, and 10.78 billion yuan, respectively, with net profits turning negative starting in 2021 [5] - The decline in performance is attributed to market demand changes and increased competition, leading to significant asset impairment provisions [5] Group 3: Stock Performance - The stock price of Berry Genomics has plummeted from a peak of 98 yuan per share in July 2020 to below 10 yuan per share in 2023, reflecting a severe loss of investor confidence [2] - As of May 19, the stock closed at 13.40 yuan per share, down 5.57% [5]

Core Viewpoint - The announcement highlights that a significant shareholder of Berry Genomics, Gao Yang, is subject to judicial enforcement regarding the forced liquidation of a portion of his shares due to a breach of contract with Guoxin Securities [1][2]. Group 1: Shareholder and Legal Actions - Gao Yang, the controlling shareholder of Berry Genomics, holds 31,988,723 shares, accounting for 9.05% of the total share capital [1]. - The Chengdu Financial Court has ordered the forced liquidation of 3,535,214 shares held by Gao Yang due to a breach of a stock pledge repurchase agreement with Guoxin Securities [1][2]. - The enforcement action is based on a legally effective arbitration ruling from the Shenzhen International Arbitration Court [1]. Group 2: Financial Performance - Berry Genomics reported net profits attributable to shareholders of -117 million yuan in 2021, -249 million yuan in 2022, -427 million yuan in 2023, and -192 million yuan in 2024 [3]. - The company's operating revenue for 2024 is 1,078 million yuan, a decrease of 6.36% from 2023, which had revenue of 1,151 million yuan [4]. - The net profit attributable to shareholders for 2024 improved by 54.96% compared to 2023, indicating a reduction in losses [4].

成都市贝瑞和康基因技术股份有限公司 关于持股5%以上股东所持部分股份被司法强制执行的提示性公告 证券代码：000710 证券简称：贝瑞基因 公告编号：2025-025 股东高扬先生保证向本公司提供的信息内容真实、准确、完整，没有虚假 记载、误导性陈述或重大遗漏。 公司及董事会全体成员保证公告内容与信息披露义务人提供的信息一致。 特别提示： 1、高扬先生持有成都市贝瑞和康基因技术股份有限公司（以下简称"公司"或 "贝瑞基因"）股份 31,988,723 股（占公司总股本比例为 9.05%），为公司控股股 东。现因高扬先生在国信证券股份有限公司（以下简称"国信证券"）开展的股票质 押回购业务发生违约，成渝金融法院裁定强制变现被执行人高扬先生持有的 3,535,214 股"贝瑞基因"股票。 2、公司目前生产经营情况正常，该事项未对公司的生产经营及财务状况产生重 大不利影响，未对公司治理结构产生重大不利影响。 公司于近日收到股东高扬先生通知，其于近日收到成渝金融法院作出的(2024) 渝 87 执 4703 号之三《执行裁定书》，裁定强制变现被执行人高扬先生持有的 3,535,214 股"贝瑞基因"股票。现将有关情况 ...

资金面上看，今日基因测序概念板块获主力资金净流入4.22亿元，其中，33股获主力资金净流入，10股 主力资金净流入超千万元，净流入资金居首的是贝瑞基因，今日主力资金净流入1.38亿元，净流入资金 居前的还有东方海洋、华大基因、美年健康等，主力资金分别净流入1.31亿元、1.26亿元、3326.88万 元。 截至5月13日收盘，基因测序概念上涨1.23%，位居概念板块涨幅第10，板块内，39股上涨，贝瑞基 因、东方海洋等涨停，华大基因、迪安诊断、华大智造等涨幅居前，分别上涨14.55%、8.27%、 6.89%。跌幅居前的有新芝生物、谱尼测试、茂莱光学等，分别下跌1.66%、1.62%、1.61%。 今日涨跌幅居前的概念板块 | 概念 | 今日涨跌幅（%） | 概念 | 今日涨跌幅（%） | | --- | --- | --- | --- | | 中韩自贸区 | 3.03 | 中船系 | -3.40 | | 航运概念 | 2.51 | 国产航母 | -2.37 | | 硅能源 | 2.30 | 军工信息化 | -2.16 | | 环氧丙烷 | 1.95 | 太赫兹 | -2.14 | | 阿尔茨海默概念 | 1 ...