Market Overview - The Chinese medicine sector rose by 1.0% on July 29, with Foci Pharmaceutical leading the gains [1] - The Shanghai Composite Index closed at 3609.71, up 0.33%, while the Shenzhen Component Index closed at 11289.41, up 0.64% [1] Top Gainers in Chinese Medicine Sector - Foci Pharmaceutical (002644) closed at 10.69, up 9.98% with a trading volume of 841,300 shares and a turnover of 876 million yuan [1] - Zhongsheng Pharmaceutical (002317) also rose by 9.98% to 19.73, with a trading volume of 1,168,400 shares and a turnover of 2.26 billion yuan [1] - Other notable gainers include: - Zhendong Pharmaceutical (300158) up 6.66% to 7.69 [1] - Huasen Pharmaceutical (002907) up 6.50% to 18.51 [1] - Kangjia Pharmaceutical (600557) up 5.61% to 16.58 [1] Top Losers in Chinese Medicine Sector - Qidi Pharmaceutical (000590) fell by 2.65% to 12.13, with a trading volume of 134,500 shares and a turnover of 163 million yuan [2] - Zhenbaodao (603567) decreased by 2.21% to 12.40, with a trading volume of 182,700 shares and a turnover of 227 million yuan [2] - Other notable losers include: - Yunnan Baiyao (000538) down 1.20% to 55.82 [2] - Kangmei Pharmaceutical (600518) down 0.94% to 2.10 [2] Capital Flow Analysis - The Chinese medicine sector saw a net inflow of 798 million yuan from institutional investors, while retail investors experienced a net outflow of 625 million yuan [2][3] - Notable net inflows from institutional investors include: - Zhongsheng Pharmaceutical (002317) with a net inflow of 308 million yuan [3] - Zhendong Pharmaceutical (300158) with a net inflow of 96.32 million yuan [3] - Conversely, significant net outflows from retail investors were observed in: - Zhongsheng Pharmaceutical (002317) with a net outflow of 98.88 million yuan [3] - Zhendong Pharmaceutical (300158) with a net outflow of 65.62 million yuan [3]

Market Overview - The Shanghai Composite Index rose by 0.12% on July 28, with 15 sectors experiencing gains, led by defense and non-bank financials, which increased by 1.86% and 1.51% respectively. The pharmaceutical and biological sector ranked third in terms of gains [1] - Conversely, the coal and steel sectors saw declines of 2.60% and 1.41% respectively [1] Fund Flow Analysis - The main funds in the two markets experienced a net outflow of 18.575 billion yuan, with 8 sectors seeing net inflows. The electronics sector led with a net inflow of 3.655 billion yuan and a daily increase of 1.10%, followed by the communications sector with a net inflow of 2.848 billion yuan and a daily increase of 1.24% [1] - In contrast, 23 sectors faced net outflows, with the computer sector leading at a net outflow of 6.892 billion yuan, followed by the non-ferrous metals sector with a net outflow of 3.254 billion yuan [1] Pharmaceutical and Biological Sector Performance - The pharmaceutical and biological sector increased by 1.47% with a net inflow of 314 million yuan. Out of 474 stocks in this sector, 265 rose, 9 hit the daily limit up, while 191 fell, with 2 hitting the daily limit down [2] - Notably, 178 stocks in this sector experienced net inflows, with 8 stocks seeing inflows exceeding 100 million yuan. The top stock for net inflow was Heng Rui Medicine, with an inflow of 1.256 billion yuan, followed by Lu Kang Medicine and Zhong Sheng Pharmaceutical with inflows of 181 million yuan and 169 million yuan respectively [2] Top Gainers in Pharmaceutical Sector - The top gainers in the pharmaceutical sector included: - Heng Rui Medicine: +10.00% with a turnover rate of 2.56% and a main fund flow of 1.255 billion yuan - Lu Kang Medicine: +4.30% with a turnover rate of 15.05% and a main fund flow of 181 million yuan - Zhong Sheng Pharmaceutical: +7.88% with a turnover rate of 11.59% and a main fund flow of 169 million yuan [3] Top Losers in Pharmaceutical Sector - The top losers in the pharmaceutical sector included: - Changshan Pharmaceutical: -0.28% with a main fund outflow of 122.818 million yuan - Shenzhou Cell: -1.14% with a main fund outflow of 102.235 million yuan - WuXi AppTec: +3.08% with a main fund outflow of 94.187 million yuan [4]

Investment Rating - The report maintains a "Recommended" investment rating for the pharmaceutical industry [1] Core Views - The innovation environment is continuously improving, leading to an optimistic outlook on innovation premiums. In the first half of 2025, global pharmaceutical transactions reached 456, a 32% year-on-year increase, with total upfront payments soaring to $11.8 billion, a 136% increase. The total transaction value hit $130.4 billion, up 58% year-on-year, with Chinese companies contributing nearly 50% of the total value and over 30% of the transaction count [3] - The CXO sector is expected to gradually recover following a supply-side cleansing post-COVID-19, with a significant increase in License-out transactions and total transaction amounts surpassing previous years [4] - The TCE technology is being continuously iterated and updated, with promising clinical data emerging for TCE-based therapies, indicating a strong market potential [5] - The trend towards more effective and scientific weight loss solutions is evident, with GLP-1 drugs generating over $50 billion in global sales, driving capital interest in the sector [6] - There is a growing focus on autoimmune diseases, with significant clinical data supporting new treatments and collaborations in the field [7] Summary by Sections 1. Pharmaceutical Market Tracking - The pharmaceutical industry outperformed the CSI 300 index by 0.21 percentage points in the last week, with a weekly increase of 1.90% [18] - Over the past month, the industry outperformed the CSI 300 index by 6.73 percentage points, with a monthly increase of 10.95% [21][24] 2. Pharmaceutical Sector Trends and Valuation - The pharmaceutical and biotechnology industry index currently has a PE (TTM) of 37.98, above the 5-year historical average of 32.08 [41] 3. Recent Research Achievements - The report highlights various recent research findings, including the positive outlook for the blood products industry and the acceleration of the inhalation drug sector due to policy support [45] 4. Recent Industry Policies and News - The National Healthcare Security Administration has implemented measures to support the high-quality development of innovative drugs, enhancing the support for R&D and clinical applications [46] - Recent news includes significant approvals and collaborations in the pharmaceutical sector, indicating a vibrant market environment [48][49] 5. Key Company Recommendations - The report recommends specific companies based on their potential to benefit from the improving innovation environment and market trends, including CXO firms and those involved in TCE technology [8]

证券代码：002317 公告编号：2025-077 广东众生药业股份有限公司 关于全资子公司获得氯贝酸铝化学原料药 上市申请批准通知书的公告 本公司及董事会全体成员保证信息披露内容的真实、准确和完整，没有虚假 记载、误导性陈述或重大遗漏。 广东众生药业股份有限公司（以下简称"公司"）全资子公司广东先强药业 有限公司于近日收到国家药品监督管理局核准签发的原料药氯贝酸铝《化学原料 药上市申请批准通知书》。现就相关情况公告如下： 一、《化学原料药上市申请批准通知书》的主要内容 登记号：Y20230001298 通知书编号：2025YS00606 化学原料药名称：氯贝酸铝 申请事项：境内生产化学原料药上市申请 生产企业：名称：广东先强药业有限公司，地址：广州市从化经济开发区工 业大道 6 号 审批结论：根据《中华人民共和国药品管理法》及有关规定，经审查，本品 符合药品注册的有关要求，批准注册。 二、药品简介 氯贝酸铝是氯贝丁酸衍生物类血脂调节药，在胃中不分解，对胃无刺激，在 肠道碱性环境中分解为氯贝丁酯而起作用。氯贝酸铝通过降低极低密度脂蛋白的 量，达到降血脂的目的。氯贝酸铝作为有效成分应用于脂降宁片（安络宁片）、 ...

Core Viewpoint - The pharmaceutical industry is undergoing a profound transformation from "following innovation" to "source breakthrough," driven by new quality productivity and technological innovation [2][12]. Company Overview - Guangdong Zhongsheng Pharmaceutical Co., Ltd. was established in 1979 and listed on the Shenzhen Stock Exchange in December 2009, with stock code 002317 [4]. - The company integrates drug research and development, production, and sales, positioning itself as one of China's top 100 pharmaceutical companies [4]. - Zhongsheng Pharmaceutical focuses on high-quality products and services, with a product portfolio covering major disease areas such as cardiovascular, respiratory, ophthalmology, and digestion [4]. Innovation and Product Development - The company has established a development strategy centered on traditional Chinese medicine, innovation, and focusing on specialty areas, with core products including the Compound Thrombus Tong series and Brain Thrombus Tong capsules [4]. - Zhongsheng is the only domestic company with innovative drugs for both COVID-19 and influenza, having successfully launched the first peptide 3CL single-agent antiviral drug for COVID-19 and the first RNA polymerase PB2 protein inhibitor for influenza [4][8]. - The company has invested in innovative drug development, with two new drugs launched recently, including the innovative drug for treating adult influenza, which was approved in May [8]. Digital Transformation - The company is investing 300 million yuan in its subsidiary to create a smart, digital, and intensive traditional Chinese medicine extraction workshop [9]. - Advanced technologies such as cloud computing, big data, artificial intelligence, and IoT are being utilized to enhance the entire pharmaceutical supply chain [7][9]. Sustainable Development Strategy - Zhongsheng emphasizes the coordination between traditional and emerging businesses, proposing a sustainable development structure that includes innovative drugs as the leading force, traditional Chinese medicine as the foundation, and chemical generics as support [10]. - The company has maintained a research and development investment of over 8% of its revenue annually since 2010, with recent years exceeding 10% [12]. Industry Trends - The core of new quality productivity in the biopharmaceutical industry lies in technological innovation and the transformation of results [6]. - The industry is expected to evolve towards innovation-driven and high-quality growth, supported by policy, market changes, and technological advancements [6].

Group 1 - The avian influenza concept sector declined by 0.90%, ranking among the top declines in concept sectors, with leading declines from companies such as Zhijiang Biology, Biological Shares, and Zhongmu Shares [1][2] - Among the 10 stocks that increased in price, Weilan Biology, Lianhuan Pharmaceutical, and Wens Foodstuff were the top gainers, with increases of 1.38%, 0.66%, and 0.53% respectively [1][2] - The avian influenza concept sector experienced a net outflow of 383 million yuan from main funds, with 17 stocks seeing net outflows, and 8 stocks with outflows exceeding 10 million yuan [2][3] Group 2 - The stock with the highest net outflow was Biological Shares, with a net outflow of 128 million yuan, followed by Zhongsheng Pharmaceutical, Taiji Group, and Zhijiang Biology with net outflows of 93.42 million yuan, 35.18 million yuan, and 33.51 million yuan respectively [2][3] - The stocks with the highest net inflows included Wens Foodstuff, Weilan Biology, and Oriental Biology, with net inflows of 16.02 million yuan, 13.06 million yuan, and 7.22 million yuan respectively [2][3] - The avian influenza concept sector's outflow list included Biological Shares, Zhongsheng Pharmaceutical, Taiji Group, and Zhijiang Biology, with respective declines of 5.56%, 0.45%, 0.27%, and 7.07% [2][3]

Core Viewpoint - The article highlights a significant surge in the innovative drug sector, driven by new policies from the National Healthcare Security Administration aimed at supporting the development of innovative drugs and optimizing procurement processes [1][2]. Summary by Sections Innovative Drug Market Surge - On July 17, there was a notable increase in the stock prices of innovative drug companies, with companies like ShenZhou Cell rising over 15% and KangnuoYa increasing over 14% [1]. - The article mentions that the 11th batch of national drug centralized procurement has been initiated, emphasizing that new drugs will not be included in centralized procurement to protect industry innovation [1]. Policy Support for Innovative Drugs - The "Measures" issued on June 30 by the National Healthcare Security Administration and the National Health Commission aim to support the entire chain of innovative drug development from laboratory to bedside [1]. - The measures include dynamic adjustments to the medical insurance catalog, allowing eligible innovative drugs to be included, and establishing more scientifically reasonable payment standards [1]. Establishment of Commercial Health Insurance Directory - A groundbreaking proposal to establish a "Commercial Health Insurance Innovative Drug Directory" is introduced, which will include innovative drugs with significant clinical value that exceed basic medical insurance coverage [2]. - Drugs in this directory will enjoy special treatment, such as confidential price negotiations and exemption from centralized procurement monitoring, creating new payment channels for high-priced breakthrough therapies [2]. Investment Opportunities - Analysts from Bohai Securities suggest that the introduction of innovative drug policies and the potential establishment of the commercial health insurance directory present investment opportunities in related innovative drug companies and their supply chains [2]. - Xiangcai Securities predicts that by 2025, the domestic innovative drug industry may experience a turning point, shifting from capital-driven to profit-driven trends, leading to dual recovery in performance and valuation [2].

Group 1: Clinical Trial Results - RAY1225 injection shows significant weight loss in obese/overweight participants with a mean percentage change from baseline of -10.05%, -12.98%, and -15.05% for the 3mg, 6mg, and 9mg groups respectively, compared to -3.55% in the placebo group [3] - The percentage of participants achieving weight loss ≥5% was 73.2%, 95.1%, and 95.1% for the 3mg, 6mg, and 9mg groups respectively, while the placebo group had a rate of 51.2% for weight loss ≥10% [4] - In the SHINING-1 trial, the HbA1c levels decreased by -1.68%, -2.06%, and -2.16% for the 3mg, 6mg, and 9mg groups respectively, compared to -0.33% in the placebo group [6] Group 2: Safety and Tolerability - RAY1225 injection demonstrated good safety and tolerability across both REBUILDING-1 and SHINING-1 trials, with a low risk of hypoglycemia and no new safety signals identified [10] - The most common adverse reactions were gastrointestinal, with a lower incidence compared to similar drugs [10] Group 3: Future Development and Market Strategy - The company has received ethical approval for Phase III clinical trials of RAY1225 for obesity and type 2 diabetes, with participant enrollment for REBUILDING-2 initiated in June 2025 [10] - The company plans to enhance its marketing strategy for the newly approved drug, focusing on academic ecosystem construction, data-driven service upgrades, and key project practices [14][15] Group 4: Research and Development Investment - The company has consistently invested over 8% of its annual revenue in R&D, with the last three years exceeding 10% [16] - The focus is on building a diversified R&D matrix that includes traditional Chinese medicine, innovative drugs, and generic drugs, transitioning towards an innovative pharmaceutical enterprise [18] Group 5: International Collaboration and Market Expansion - The company emphasizes the importance of international collaboration for expanding market opportunities and enhancing global R&D capabilities [19] - Plans are in place to explore the commercial potential of innovative drug pipelines and seek international partnerships [19] Group 6: Shareholder and Subsidiary Management - The company redeemed 13.15% of shares from its subsidiary, increasing its ownership from 61.11% to 74.26%, enhancing control and operational efficiency [20] - This move is part of a broader strategy to strengthen the company's position in innovative drug development, particularly in respiratory and metabolic disease areas [20][21]

Group 1 - The company has established a multi-mode positive cycle research and development ecosystem, focusing on self-research as the main approach and collaborative research as an effective supplement [1] - The company primarily targets metabolic diseases and respiratory system diseases [1] - Currently, the company has two innovative drug projects approved for market launch, with multiple innovative drug projects in clinical trial stages [1]

证券代码：002317 公告编号：2025-076 广东众生药业股份有限公司 关于控股子公司获得欧洲专利证书的公告 本公司及董事会全体成员保证信息披露内容的真实、准确和完整，没有虚假 记载、误导性陈述或重大遗漏。 近日，广东众生药业股份有限公司（以下简称"公司"）控股子公司广东众 生睿创生物科技有限公司收到欧洲专利局（European Patent Office）颁发的专利 证书。具体情况如下： 发明名称：ANTI-INFLUENZA VIRUS PYRIMIDINE DERIVATIVE（抗流感 病毒嘧啶衍生物） 专利号：3502112 专利申请日：2017 年 09 月 05 日 专利权人：广东众生睿创生物科技有限公司 该专利是公司自主研发的一类创新药物昂拉地韦项目的化合物专利，属于该 创新药项目的核心专利。昂拉地韦片（商品名：安睿威®）已于 2025 年 5 月获 得国家药品监督管理局批准上市，适用于成人单纯型甲型流感患者的治疗。为方 便特殊人群包括儿童患者以及吞咽困难患者用药，公司研发的昂拉地韦颗粒已获 得 II 期临床试验顶线分析数据，初步结果表明，昂拉地韦颗粒在 2～17 岁单纯 性甲型流感参与者 ...