二、药品其他相关情况 证券代码：003020 证券简称：立方制药 公告编号：2026-001 合肥立方制药股份有限公司 关于全资子公司取得药品注册证书的公告 本公司及董事会全体成员保证信息披露的内容真实、准确、完整，没有虚假记 载、误导性陈述或重大遗漏。 近日，合肥立方制药股份有限公司（以下简称"公司"或"立方制药"）全资 子公司合肥诚志生物制药有限公司（以下简称"诚志生物"）收到国家药品监督管 理局核准签发的洛索洛芬钠口服溶液《药品注册证书》。现将相关情况公告如下： 一、药品注册批准情况 | 药品名称： | 洛索洛芬钠口服溶液 | 申请事项： | 药品注册（境内生产） | | --- | --- | --- | --- | | 剂型： | 口服溶液剂 | 注册分类： | 化学药品3类 | | 规格： | 10ml：60mg（以C15H17 NaO3计） | 药品有效期： | 12个月 | | 药品批准文号： | 国药准字H20263001 | 药品批准文号 有效期： | 至2031年01月04日 | | 上市许可持有人： | | 合肥诚志生物制药有限公司 | | | 生产企业： | | 合肥诚志生物制药有限 ...

Core Insights - The recent developments in ADHD treatment highlight the approval of a new compound medication by Aikobai, which combines two forms of methylphenidate to provide extended symptom control for ADHD patients aged 6 and above [3][4] - The ADHD prevalence among children globally is approximately 7.2%, with a lower rate of 6.26% reported in China, indicating a significant number of untreated cases due to low consultation rates [3][4] Company Developments - Aikobai's compound medication, marketed as Aizhida, has received approval from the National Medical Products Administration, marking its entry into the commercial stage [3] - The compound consists of 30% immediate-release methylphenidate and 70% prodrug, designed for gradual release throughout the day, enhancing treatment adherence [3][4] - Aikobai acquired the rights to this medication for the Greater China region for a total price of $105.5 million [3] Market Dynamics - The market for methylphenidate is dominated by Johnson & Johnson's product, "Zhuanzhuo," which has a significant market share despite being an older drug with expired patents [4][6] - The supply of "Zhuanzhuo" has faced challenges due to increased global demand and production constraints, prompting Johnson & Johnson to shift packaging operations to local facilities to meet market needs [9] - The approval of generic versions of methylphenidate by other companies, such as Liyoujia and Youer Pharmaceutical, indicates a potential shift in market competition dynamics [9][10] Treatment Guidelines - Current treatment guidelines recommend long-acting methylphenidate formulations as first-line medications for ADHD, with alternatives like atomoxetine and alpha-2 adrenergic agonists as second and third-line options [4][10] - The sales of methylphenidate are projected to exceed 500 million yuan in 2024, with Johnson & Johnson's product accounting for nearly the entire market share [4] Regulatory Environment - Methylphenidate and its derivatives are classified as controlled substances in China, requiring qualified practitioners to prescribe them, which may limit accessibility and increase the risk of misuse [10]

Group 1: Event Overview - The 2025 Technology Innovation Sharing Conference hosted by Luo Yonghao was held in Shanghai on December 30, but he arrived over 40 minutes late [1] - Luo announced a full refund for ticket prices ranging from 300 to 1000 yuan and apologized, stating he would write a confession letter [3] Group 2: ADHD and Treatment Insights - Luo Yonghao revealed that his tardiness was related to ADHD, a condition he has suffered from for over a decade [3][7] - According to the 2023 edition of the "Chinese Adult ADHD Diagnosis and Treatment Expert Consensus," the prevalence of ADHD among adults in China is approximately 3% [5] - Current treatments for ADHD include medication, psychological therapy, and behavioral training, with medication being the most effective [5][9] Group 3: Medication Landscape - The primary medication for ADHD in China is methylphenidate, marketed as "Zhuanzhu Da," which is the only approved import for this treatment in the past 20 years [5][9] - The long-acting formulation of methylphenidate has shown significant efficacy and is recommended as a first-line treatment for adult ADHD patients [9] - The market for ADHD medications is expanding, with sales in domestic sample hospitals reaching approximately 350 million yuan in 2023, and further growth to about 430 million yuan in the first three quarters of 2024 [11] Group 4: Market Dynamics and Competition - The introduction of the first generic version of methylphenidate by Lifan Pharmaceutical in September 2023 has broken the 20-year monopoly of "Zhuanzhu Da" [11][12] - Other companies, such as China Resources Double Crane and Suzhou First Pharmaceutical, hold production licenses for regular formulations of methylphenidate, but these are less effective than the sustained-release versions [12] - New drug developments are underway, including a potential first-in-class medication for ADHD currently in clinical trials [12]

Group 1 - Shengxin Lithium Energy plans to acquire 30% equity of Qicheng Mining for 2.08 billion yuan, aiming to hold 100% of Qicheng Mining post-transaction [1] - Qicheng Mining holds a 70.97% stake in Huirong Mining, which has confirmed Li2O resources of 989,600 tons with an average grade of 1.62% [1] - The acquisition is part of Shengxin Lithium Energy's strategy to enhance its lithium resource portfolio [1] Group 2 - Zhongju High-tech intends to repurchase shares worth 300 million to 600 million yuan, with a maximum price of 26 yuan per share [2] - Baili Tianheng plans to repurchase shares valued between 100 million to 200 million yuan, with a maximum price of 546 yuan per share [3] Group 3 - China Aluminum's subsidiary plans to acquire 51% of Yun Aluminum Logistics for approximately 264 million yuan [5] - Yilake Co. will be included in the consolidated financial statements of China Aluminum post-acquisition [5] Group 4 - Salt Lake Co. intends to acquire 51% of Wuku Salt Lake for 4.605 billion yuan, aiming to become the controlling shareholder [6] - The acquisition is part of Salt Lake Co.'s strategy to accelerate the development of a world-class salt lake industry base [6] Group 5 - Cobalt Co. plans to invest 1.741 billion yuan in the expansion of a lead-zinc mining project with an annual capacity of 1.65 million tons [7] - The investment aims to enhance the mining capacity of the Cobalt Co.'s subsidiary [7] Group 6 - Tianyuan Co. is investing 1.483 billion yuan in a new chlorination titanium dioxide project with an annual capacity of 100,000 tons [9] - The project is part of Tianyuan Co.'s expansion strategy in the titanium dioxide market [9] Group 7 - Jiangbo Long plans to purchase the remaining 19% equity of its subsidiary Zilia Eletrônicos for approximately 46.08 million USD [26] - The acquisition aims to strengthen Jiangbo Long's position in the storage business and expand its international investment layout [26] Group 8 - China National Airlines intends to purchase 60 Airbus A320NEO series aircraft at a total catalog price of approximately 9.53 billion USD [33] - The aircraft are scheduled for delivery between 2028 and 2032 [33]

Group 1 - Zijin Mining expects a net profit of approximately 51-52 billion yuan for 2025, representing a year-on-year increase of about 59%-62% due to growth in gold, copper, and silver production and sales prices, along with a significant increase in lithium carbonate production [1] - Tianpu Co. has seen its stock price rise by 718.39% from August 22 to December 30, leading to a suspension for stock trading review due to significant deviation from the company's fundamentals [1] - Salt Lake Co. plans to acquire 51% of Wenkang Salt Lake for 4.605 billion yuan, which will enhance its competitive edge in lithium and potassium resource development [1] Group 2 - Mingde Bio intends to acquire 100% of Wuhan Bikaier Rescue Supplies Co. in a cash transaction, which is expected to constitute a major asset restructuring [2] - Jiamei Packaging has announced that it may apply for a trading suspension if its stock price continues to rise abnormally, despite no significant changes in its fundamentals [2] Group 3 - Jinpan Technology signed a contract worth approximately 696 million yuan for an overseas data center project, which is expected to positively impact the company's long-term performance [3] Group 4 - China Pharmaceutical plans to acquire 70% of Zezheng Pharmaceutical for 525 million yuan [4] - Shengxin Lithium Energy intends to acquire 30% of Qicheng Mining for 2.08 billion yuan to increase its control over Huirong Mining [5] - China Aluminum's subsidiary plans to acquire 51% of Yun Aluminum Logistics for 264 million yuan [5]

格隆汇12月30日丨立方制药(003020.SZ)公布，公司拟向鹿灵葵花转让所持有的"美沙拉秦肠溶片（规 格：0.5g）"药品上市许可持有人（简称"持有人"或"MAH"）及相关权益。立方制药合法持有"美沙拉秦 肠溶片（规格：0.5g）"的药品批准文号。经交易双方协商一致，标的产品转让的总费用为3,400.00万元 （含税）。双方确认该金额已充分考虑了标的产品权益的实际价值及市场行情等因素。 ...

格隆汇12月30日｜立方制药(003020.SZ)公告称，公司与葵花药业集团佳木斯鹿灵制药有限公司签订 《美沙拉秦肠溶片MAH转让合同》，拟以3400万元转让所持有的美沙拉秦肠溶片药品上市许可持有人 及相关权益。本次交易不构成关联交易，不构成重大资产重组，尚需国家药品监督管理局审批。转让完 成后，公司将在未来两年内继续为受让方提供该产品的委托生产服务。 ...

每经AI快讯，立方制药12月30日晚间发布公告称，公司第六届第三次董事会会议于2025年12月30日在 公司会议室以现场结合通讯表决方式召开。会议审议了《关于签署〈药品上市许可持有人转让合同〉的 议案》等文件。 （记者 王晓波） 每经头条（nbdtoutiao）——2025十大财经新闻出炉！护航、酣战、变局、狂飙分别指向哪些大事件？ ...

证券代码：003020 证券简称：立方制药 公告编号：2025-078 合肥立方制药股份有限公司 关于签署《药品上市许可持有人转让合同》的公告 本公司及董事会全体成员保证信息披露的内容真实、准确、完整，没有虚假 记载、误导性陈述或重大遗漏。 特别提示： 1、本次交易存在药品监管部门审批环节不能获得通过的风险。 2、本次交易不构成关联交易，不构成重大资产重组。 2025 年 12 月 30 日，合肥立方制药股份有限公司（以下称"公司"或"立 方制药"）召开第六届董事会第三次会议，审议通过了《关于签署〈药品上市许 可持有人转让合同〉的议案》。同日，公司与葵花药业集团佳木斯鹿灵制药有限 公司（以下称"鹿灵葵花"）签订了《美沙拉秦肠溶片 MAH 转让合同》，决定 以人民币（下同）3,400.00 万元转让美沙拉秦肠溶片药品的所有权，现将相关情 况公告如下： 一、交易概述 1、基本情况 公司拟向鹿灵葵花转让所持有的"美沙拉秦肠溶片（规格：0.5g）"药品上 市许可持有人（以下简称"持有人"或"MAH"）及相关权益（以下简称"标 的产品"或"合同产品"）。 立方制药合法持有"美沙拉秦肠溶片（规格：0.5g）"的药品批准文 ...

证券代码：003020 证券简称：立方制药 公告编号：2025-077 合肥立方制药股份有限公司 第六届董事会第三次会议决议公告 本公司及董事会全体成员保证信息披露的内容真实、准确、完整，没有虚假 记载、误导性陈述或重大遗漏。 一、董事会会议召开情况 合肥立方制药股份有限公司（以下简称"公司"）第六届董事会第三次会议 于 2025 年 12 月 26 日以电子邮件、电话、短信等方式通知公司全体董事。会议 于 2025 年 12 月 30 日在公司会议室以现场结合通讯表决方式召开，会议应出席 董事 8 人，实际出席董事 8 人，其中董事邓晓娟女士、独立董事杨模荣先生以通 讯方式参会并表决。公司高级管理人员列席了会议。会议由公司董事长季俊虬先 生主持。 本次董事会会议的召集、召开程序符合有关法律、行政法规、部门规章、规 范性文件和《公司章程》的规定。 二、董事会会议审议情况 与会董事经过认真审议并投票表决，审议通过了如下议案： 1、《关于签署〈药品上市许可持有人转让合同〉的议案》 同意公司以 3,400 万元（含税）的价格向葵花药业集团佳木斯鹿灵制药有限 公司转让公司持有的美沙拉秦肠溶片（规格：0.5g）药品上市 ...