Group 1 - The core index of the China Securities Internet Medical Theme Index (CS Internet Medical, 930720) opened lower but rose, closing at 2514.46 points with a trading volume of 6.017 billion yuan [1] - Over the past month, the CS Internet Medical Theme Index has decreased by 12.73%, increased by 15.90% over the past three months, and has risen by 5.70% year-to-date [1] - The index reflects the overall performance of representative companies providing hardware, software, or services for medical informationization and intelligence [1] Group 2 - The top ten weighted companies in the CS Internet Medical Theme Index are: Yifeng Pharmacy (6.65%), Daclin (6.44%), Laobaixing (6.21%), Wandong Medical (5.53%), Haier Biomedical (5.48%), Jiuzhoutong (5.44%), Yixintang (5.37%), Aier Eye Hospital (5.33%), Yuyue Medical (5.28%), and Lepu Medical (5.17%) [1] - The market share of the CS Internet Medical Theme Index holdings is 51.03% from the Shenzhen Stock Exchange and 48.97% from the Shanghai Stock Exchange [1] - The industry composition of the index holdings shows that 70.41% is in pharmaceuticals and healthcare, 25.78% in information technology, and 3.81% in communication services [1] Group 3 - The index samples are adjusted quarterly, with adjustments implemented on the next trading day after the second Friday of March, June, September, and December [2] - Weight factors are generally fixed until the next scheduled adjustment, with temporary adjustments made under special circumstances [2] Group 4 - Public funds tracking the CS Internet Medical Index include: Huatai-PineBridge China Securities Internet Medical A and Huatai-PineBridge China Securities Internet Medical C [3]

报名：首届全球眼科大会 | 议程更新 报名：首届全球骨科大会 | 议程更新 报名：首届全球心血管大会 | 奖项申报 合作伙伴征集：2025全球手术机器人大会 心未来 近日， 乐普（北京）医疗器械股份有限公司 （以下简称 " 乐普医疗 "）研发的用于对狭窄血管病变预处 理的" Vessridge® 冠脉棘突球囊扩张导管 "（国械注准 20253030679 ）正式获得国家药品监督管理局 （ NMPA ）的上市批准。 值得一提的是，这是国产 第4款 冠状动脉棘突球囊扩张导管。 棘突球囊 以普通球囊导管为基础，使用尼龙切割件，截面为 类三角形突起物 ，固定于球囊两端，在球囊 充盈扩张时，借助凸出于球囊表面的尼龙切割件将压力聚焦传递给血管内壁，达到切割血管内膜、扩张狭 窄血管的目的，从而更有效扩张狭窄血管，有助于减少血管不规则撕裂、降低夹层发生风险。 因此，棘突球囊的出现改善了复杂病变预处理的效果，能够提高手术即刻成功率及远期预后。 | 国家约品监管管理局 National Medical Products Administration | 2 言数据查询 首页 政务服务门户 | | --- | --- | | 目境 ...

Group 1 - The core viewpoint of the article highlights the significant decline in the stock price of Lepu Medical, which closed at 10.42 yuan, down 11.99%, with a rolling PE ratio of 27.71 times and a total market capitalization of 19.596 billion yuan [1] - The average PE ratio for the medical device industry is 43.33 times, with a median of 27.80 times, placing Lepu Medical at the 73rd position in the industry ranking [1] - As of September 30, 2024, Lepu Medical has 94,003 shareholders, an increase of 11,288 from the previous count, with an average holding value of 352,800 yuan and an average holding quantity of 27,600 shares [1] Group 2 - Lepu Medical's main business includes medical devices, pharmaceuticals, medical services, and health management, with a strong focus on cardiovascular medical devices and leading technology in "interventional without implantation" [1] - The latest financial results for the third quarter of 2024 show that the company achieved an operating income of 4.785 billion yuan, a year-on-year decrease of 23.55%, and a net profit of 803 million yuan, down 40.70%, with a gross profit margin of 62.80% [1]

Core Viewpoint - The company Sichuan Ruijian Medical Technology Co., Ltd. (referred to as "Ruijian Medical") has submitted its initial public offering (IPO) application to the Beijing Stock Exchange, aiming to raise 482 million yuan, with significant connections to Lepu Medical [1][2]. Group 1: Company Overview - Ruijian Medical, established in August 2013, transitioned to a joint-stock system in 2016 and was listed on the New Third Board before being delisted in 2018. It was acquired by Hong Kong-listed company Puhua Heshun in 2021, which now controls 50.55% of Ruijian Medical [2]. - The actual controllers of Ruijian Medical are Pu Zhongjie and his mother-in-law Yufeng Liu, who is the ultimate controlling shareholder of Puhua Heshun [2]. Group 2: Financial Performance - Ruijian Medical's revenue from 2021 to the first nine months of 2024 was 2.61 billion yuan, 3.45 billion yuan, 4.11 billion yuan, and 3.42 billion yuan, respectively. The net profit for the same periods was 679.32 million yuan, 1.04 billion yuan, 1.46 billion yuan, and 926.27 million yuan [5][6]. - The company reported a revenue increase of 17.63% for 2024, reaching 4.83 billion yuan, but net profit and net profit excluding non-recurring items decreased by 12.63% and 5.88%, respectively, marking the first instance of revenue growth without profit growth in three years [5][6]. Group 3: Related Party Transactions - Ruijian Medical engaged in significant related party transactions, selling goods worth a total of 202 million yuan to related parties from 2021 to the first nine months of 2024, with Lepu Medical being a major customer [3][4]. - The company also had arrangements for salary payments with related parties, with amounts paid on behalf of employees totaling 116.96 million yuan, 131.09 million yuan, 148.55 million yuan, and 53 million yuan over the reporting periods [3][4]. Group 4: Market Dynamics - The implementation of volume-based procurement has led to a noticeable decline in the sales prices of Ruijian Medical's main products, with the average selling price of blood dialysis machines and blood perfusion devices dropping by over 10% from 2021 to the first nine months of 2024 [5][7]. - The sales prices for blood dialysis machines were 31.21 yuan, 30.83 yuan, 30.1 yuan, and 27.37 yuan, while blood perfusion devices were priced at 169.41 yuan, 164.14 yuan, 159.81 yuan, and 147.32 yuan during the same periods, reflecting a decline of approximately 12.3% and 13%, respectively [7]. Group 5: Future Plans - Ruijian Medical plans to issue up to 43 million new shares to raise a total of 482 million yuan, which will be allocated to projects related to high-value consumables for blood purification, new blood purification equipment, and the establishment of an innovative research center [7].

Group 1 - The company issued a total of 16.38 billion yuan in convertible bonds, with 16.38 million bonds at a face value of 100 yuan each [1][2] - The convertible bonds, named "Lepu Convertible Bond 2," began trading on April 19, 2021, and the conversion period started on October 8, 2021 [2][3] - As of March 31, 2025, the total number of remaining convertible bonds is 16,376,686, with a remaining amount of 1,637,668,600 yuan [3][4] Group 2 - The conversion price of the bonds was adjusted from 28.06 yuan per share to 27.92 yuan per share after the implementation of the 2024 semi-annual profit distribution plan [2][3] - During the conversion period from October 8, 2021, to March 31, 2025, the company saw a total of 10,766 shares converted from the bonds [3] - The total share capital of the company is 1,880,611,082 shares, with 85.93% being freely tradable shares [4]

| 证券代码：300003 | 证券简称：乐普医疗 | 公告编号：2025-009 | | --- | --- | --- | | 债券代码：123108 | 债券简称：乐普转 2 | | 乐普（北京）医疗器械股份有限公司 经深交所同意，公司 16.38 亿元可转债于 2021 年 4 月 19 日起在深交所挂 牌交易，债券简称"乐普转 2"，债券代码"123108"。转股期自 2021 年 10 月 8 日至 2026 年 3 月 29 日。 2、转股价格调整情况 关于 2025 年第一季度可转换公司债券转股情况的公告 本公司及董事会全体成员保证信息披露的内容真实、准确、完整，没有虚假 记载、误导性陈述或重大遗漏。 特别提示： 根据《深圳证券交易所创业板股票上市规则》《深圳证券交易所上市公司自 律监管指引第 15 号——可转换公司债券》等有关规定，乐普（北京）医疗器械 股份有限公司（以下简称：公司）现将 2025 年第一季度可转换公司债券乐普转 2（以下简称：可转债）转股及公司股份变动情况公告如下： 一、 可转债发行上市概况 1、发行上市基本情况 经中国证券监督管理委员会出具的《关于同意乐普（北京）医疗器械 ...

睿健医疗股东乐普医疗持有公司17.11%股份，其实际控制人为蒲忠杰。Yufeng LIU为蒲忠杰的岳母，参 照《上市公司收购管理办法（2020修正）》的规定，Yufeng LIU与蒲忠杰互为一致行动人。 瑞财经 刘治颖 3月31日，四川睿健医疗科技股份有限公司（以下简称：睿健医疗）北交所IPO获受理， 保荐机构为中国银河证券股份有限公司，保荐代表人为付月芳、夏沛沛，会计师事务所为立信会计师事 务所(特殊普通合伙)。 招股书显示，睿健医疗自成立以来主要从事血液净化产品的研发、生产和销售。报告期内公司销售的主 要产品包括血液透析器、血液灌流器等。2024年公司取得了血液透析机、连续性血液净化设备和连续性 肾脏替代治疗管路（配合公司连续性血液净化设备使用）医疗器械注册证。 业绩方面，2021年至2023年及2024年前9月，睿健医疗营收分别为2.61亿元、3.45亿元、4.11亿元及3.42 亿元，归母净利润分别为6793.18万元、1.04亿元、1.46亿元及9262.67万元，毛利率分别为48.02%、 49.63%、52.98%及51.44%。 | 项目 | 2024年9月30日 | 2023年12月31 | ...

证券代码：300003 证券简称：乐普医疗 公告编号：2025-008 乐普（北京）医疗器械股份有限公司 关于冠脉棘突球囊扩张导管 获得 NMPA 注册批准的提示性公告 本公司及董事会全体成员保证信息披露的内容真实、准确、完整，没有虚假 记载、误导性陈述或重大遗漏。 乐普（北京）医疗器械股份有限公司（以下简称"公司"）于今日获悉，公 司自主研发的冠脉棘突球囊扩张导管获得国家药品监督管理局（NMPA）注册批 准，注册证编号：国械注准 20253030679。 二、对公司影响 冠脉支架置入或药物球囊放置前需采用球囊对病变血管充分预扩张，通过球 囊对血管壁的机械性挤压，从而扩大狭窄的管腔。但对于部分纤维化或者钙化病 变，普通球囊难以达到充分扩张的目的，导致支架或药物球囊无法输送到位、膨 胀不全或贴壁不良，造成患者预后不佳。冠脉棘突球囊扩张导管具有3条呈120° 分布的棘突元件。在球囊扩张时，这些棘突元件能够挤压斑块，形成裂纹，同时 还能防止球囊滑动。这种设计使其特别适合硬度不高的钙化病变，并且降低了动 脉壁受损的风险，有助于更好地控制扩张过程。因此，棘突球囊的出现显著改善 了复杂病变的预处理效果，提高了手术的即刻成 ...

| 证券代码：300003 | 证券简称：乐普医疗 | 公告编号：2025-007 | | --- | --- | --- | | 债券代码：123108 | 债券简称：乐普转 2 | | 乐普（北京）医疗器械股份有限公司 关于 2025 年可转换公司债券付息的公告 本公司及董事会全体成员保证信息披露的内容真实、准确、完整，没有虚假 记载、误导性陈述或重大遗漏。 特别提示： 1、"乐普转 2"（债券代码：123108）将于 2025 年 3 月 31 日按面值支付 第四年利息，每 10 张"乐普转 2"（面值 1,000 元）利息为 15.00 元（含税）。 2、债权登记日：2025 年 3 月 28 日（星期五） 3、付息日：2025 年 3 月 31 日（星期一） 4、除息日：2025 年 3 月 31 日（星期一） 5、本次付息期间及票面利率：计息期间为 2024 年 3 月 30 日至 2025 年 3 月 29 日，票面利率为 1.50%。 6、"乐普转 2"本次付息的债权登记日为 2025 年 3 月 28 日，截至 2025 年 3 月 28 日下午深圳证券交易所收市后，在中国证券登记结算有限责 ...

合作伙伴征集：2025全球手术机器人大会 报名：首届全球眼科大会 | 暂定议程 报名：首届全球心血管大会 | 奖项报名倒计时 报名：首届全球骨科大会 | 奖项报名倒计时 2025年3月15日上午，2025中国医学装备大会在重庆悦来国际会议中心成功召开。相关政府部门领导、知名院士、医疗机构专家，研发生产企业、高校、科 研院所、投融资机构负责人等嘉宾出席大会。 中国医学装备协会理事长 侯岩介绍， 2024年中国医学装备市场规模达到 1.35万亿 元，同比增长 6％ 左右 。据了解，目前我国已形成22个大类1100多个 品类的产品体系，是世界上产品类别和品种最齐全的国家之一，产品广泛服务于临床应用，覆盖卫生健康各个领域。 目前大会已圆满落幕。本届展会中，哪些企业凭借创新亮相引起了行业关注？又有哪些前沿产品和技术成为焦点？思宇将全面回顾展会精彩亮点，供各位读 者参考。 # 美敦力 美敦力在本届大会上展出 近80款 全球创新产品， 包括 全球首发的PulseSelect一次性心脏脉冲场消融导管 ，以及多款前沿技术产品， 其中不乏首次展出及近 期获批的产品和技术。 其中包括中国首款获批的 PulseSelect一次性心脏 ...