Core Viewpoint - The company Zhifei Biological Products Co., Ltd. has received approval from the National Medical Products Administration for clinical trials of its lyophilized varicella inactivated vaccine, aimed at preventing chickenpox caused by varicella-zoster virus infection [1] Group 1 - The clinical trial approval is granted to the company's wholly-owned subsidiary, Anhui Zhifei Longkema Biological Pharmaceutical Co., Ltd. [1] - The vaccine is intended to address infections caused by the varicella-zoster virus, which leads to chickenpox [1]

Core Viewpoint - The announcement indicates that Zhifei Biological's subsidiary has received approval for clinical trials of a freeze-dried varicella inactivated vaccine aimed at preventing varicella-zoster virus infections [1] Group 1 - Zhifei Biological's wholly-owned subsidiary, Anhui Zhifei Longkema Biological Pharmaceutical Co., Ltd., is responsible for the development of the vaccine [1] - The vaccine is intended to prevent infections caused by the varicella-zoster virus, which leads to chickenpox [1] - The approval was granted by the National Medical Products Administration, allowing the company to proceed with clinical trials [1]

证券代码：300122 证券简称：智飞生物 公告编号：2026-09 重庆智飞生物制品股份有限公司 关于冻干水痘灭活疫苗获得临床试验批准通知书的公告 本公司及董事会全体成员保证信息披露内容的真实、准确和完整，没有虚 假记载、误导性陈述或重大遗漏。 重庆智飞生物制品股份有限公司（以下简称"公司"）于近日获悉，由全资 子公司安徽智飞龙科马生物制药有限公司（以下简称"智飞龙科马"）研发的冻 干水痘灭活疫苗获得国家药品监督管理局药物临床试验批准通知书（通知书编号： 2026LP00327），同意开展预防水痘-带状疱疹病毒感染引起的水痘的临床试验。 水痘是由水痘-带状疱疹病毒（varicella-zoster virus，VZV）引起的发热 出疹性疾病，初次感染水痘-带状疱疹病毒后（通常在儿童期）表现为水痘，并 可在神经节潜伏；免疫力低下时，潜伏的病毒可被再次激活（通常在成年或老年 期），表现为带状疱疹。水痘的典型症状包括发热、头痛、全身不适等前驱症状， 随后出现向心性分布的皮疹。皮疹呈红色斑丘疹→疱疹→结痂的演变过程，常伴 有剧烈瘙痒。重症水痘多见于免疫功能低下人群，如婴儿、孕妇、HIV 感染者等， 可能引发出血性皮 ...

机构持仓方面，截止2025年9月30日，智飞生物十大流通股东中，香港中央结算有限公司位居第三大流 通股东，持股3356.08万股，相比上期减少278.88万股。易方达创业板ETF（159915）位居第五大流通股 东，持股2415.90万股，相比上期减少405.65万股。华泰柏瑞沪深300ETF（510300）位居第六大流通股 东，持股2042.08万股，相比上期减少96.46万股。招商国证生物医药指数A（161726）位居第九大流通 股东，持股1615.47万股，相比上期减少274.48万股。易方达沪深300医药ETF（512010）位居第十大流 通股东，持股1499.56万股，相比上期减少470.11万股。 声明：市场有风险，投资需谨慎。本文基于第三方数据库自动发布，不代表新浪财经观点，任何在本文 出现的信息均只作为参考，不构成个人投资建议。如有出入请以实际公告为准。如有疑问，请联系 biz@staff.sina.com.cn。 责任编辑：小浪快报 资料显示，重庆智飞生物制品股份有限公司位于重庆市江北区庆云路1号50层，成立日期1995年7月20 日，上市日期2010年9月28日，公司主营业务涉及疫苗、生物 ...

Core Viewpoint - The performance forecasts for A-share vaccine companies in 2025 reveal significant industry adjustments, with major players like Zhifei Biological, Wantai Biological, and Baike Biological reporting losses, while companies like CanSino and Watson Biologics achieve growth through innovative products and overseas market expansion [1][2]. Industry Overview - The vaccine industry is facing multiple pressures, including price wars, shrinking demand, and product homogenization, which are forcing companies to shift from channel-driven to innovation-driven strategies [1][4]. - The overall profitability of the industry has sharply declined, with Zhifei Biological expecting its first annual loss since its listing, projecting a net loss of 10.698 billion to 13.726 billion yuan, a year-on-year decline of 630% to 780% [1][2]. Company Performance - Zhifei Biological, Wantai Biological, and Baike Biological have all transitioned from profit to loss due to various factors, including price cuts and inventory issues [1][2]. - CanSino has turned a profit in 2025, with a projected net profit of 24.5 million to 29 million yuan, benefiting from the strong sales of its four-valent meningococcal vaccine, which accounts for 90% of its revenue [2][6]. - Watson Biologics has seen a 35% year-on-year increase in overseas vaccine exports, achieving a net profit of 16 million to 19 million yuan, reflecting its ability to counter domestic declines [2][7]. Market Dynamics - The ongoing price war is compressing profit margins, with significant price drops observed in various vaccine categories, such as the HPV vaccine and flu vaccine, leading to reduced gross margins for companies [4][8]. - Demand for vaccines is declining due to a falling birth rate and low vaccination rates among adults, exacerbating the industry's growth challenges [4][5]. Strategic Shifts - Companies are increasingly focusing on innovation and overseas expansion as key strategies to navigate the current market challenges [5][9]. - The inclusion of the HPV vaccine in the national immunization program is expected to stabilize market demand but will also pressure companies to reduce costs and innovate further [8][9]. Future Outlook - 2025 is seen as a pivotal year for the vaccine industry in China, with a shift towards high-quality development and a focus on core competencies and innovation [9]. - The industry is expected to gradually recover as innovative products are launched, overseas markets are expanded, and public awareness of vaccination increases [9].

Core Insights - The performance forecasts for A-share vaccine companies in 2025 reveal significant industry adjustments, with major players like Zhifei Biological, Wantai Biological, and Baike Biological reporting losses, while companies like CanSino and Watson Biologics achieve growth through innovative products and overseas market expansion [1][2][5] Industry Overview - The vaccine industry is facing multiple pressures, including price wars and shrinking demand, leading to a significant contraction in profitability [5][6] - The continuous price competition has compressed profit margins, with HPV vaccines and flu vaccines reaching historical lows in pricing, impacting overall industry profitability [5][6] - The decline in birth rates has reduced the core vaccination population for children's vaccines, while adult vaccine uptake remains low due to vaccine hesitancy [5][6] Company Performance - Zhifei Biological is expected to report its first annual loss since its listing, with a projected net loss of 10.698 billion to 13.726 billion yuan, a year-on-year decline of 630% to 780% [1] - Wantai Biological and Baike Biological also shift from profit to loss, with projected net losses of 330 million to 410 million yuan and 220 million to 280 million yuan, respectively [1] - CanSino is projected to turn a profit with a net income of 24.5 million to 29 million yuan, benefiting from the strong sales of its quadrivalent meningococcal vaccine [2] - Watson Biologics expects a net profit of 160 million to 190 million yuan, driven by a 35% increase in overseas vaccine exports [2] Market Dynamics - The industry is experiencing severe product homogeneity, leading to intensified competition among companies in popular vaccine segments like HPV and shingles [6] - Companies overly reliant on agency models are facing challenges, as seen with Zhifei Biological, which has a high dependency on agency products [6] - Inventory and cash flow pressures are evident, with companies like Zhifei Biological and Wantai Biological facing significant inventory write-downs [6] Innovation and Opportunities - Companies with unique innovative products are achieving performance rebounds, with CanSino's quadrivalent vaccine capturing over 90% market share [7] - The overseas market is becoming a crucial growth point, with Watson Biologics exporting to 24 countries and CanSino's inhaled vaccine gaining market share in Southeast Asia and Latin America [8] - The inclusion of the bivalent HPV vaccine in the national immunization program is expected to stabilize market demand while also compressing profit margins for companies [9] Future Outlook - 2025 is seen as a pivotal year for the vaccine industry to transition towards high-quality development, with a focus on innovation and overseas market expansion [10] - The industry is expected to gradually emerge from the adjustment period as innovative products are launched and vaccination awareness increases among residents [10] - The China Vaccine Industry Association has initiated measures to curb irrational price competition, aiming for a more rational pricing environment in the future [10]

2025年A股疫苗企业业绩预告悉数出炉，行业调整的阵痛全面显现。 智飞生物、万泰生物、百克生物等头部企业出现亏损，而康希诺、沃森生物凭借创新产品放量与海外市场拓展实现业绩突围，行业马太效应进 一步加剧。 根据目前业绩预告显示，行业盈利面大幅收窄。智飞生物迎来上市以来首次年度亏损，2025年归母净利润预计亏损106.98亿元至137.26亿元， 同比大幅下滑630%—780%。二级市场上，截至2月3日收盘， 智飞生物今年以来股价跌超8%，市值最新为412亿元。 记者丨 唐唯珂 编辑丨季媛媛 康泰生物虽保持盈利，但业绩大幅预减 ，归母净利润预计0.49亿元至0.73亿元，同比下滑63.8%-75.7%，四联苗受免疫程序调整与成本上升拖 累，主业承压明显。 | 17.22 +0.21 +1.23% | | | | | 智飞生物 立即 300122 交易 | | | --- | --- | --- | --- | --- | --- | --- | | SZSE CNY 15:30:54 闭市 查看L2全景 | | | | | | 通融公口+ | | 委比 | 29.15% 委差 | 1771 | Wind ESG评 ...

Core Viewpoint - The pharmaceutical sector is experiencing a mixed performance in 2025, with a significant number of companies forecasting profit increases, while others are facing substantial losses. Group 1: Profit Forecasts - A total of 283 pharmaceutical stocks have disclosed their 2025 earnings forecasts, with 160 companies expecting year-on-year profit growth. Among these, Sino Medical has the highest projected increase, with an expected profit growth of over 32 times [1][4]. - WuXi AppTec is anticipated to achieve a record net profit of 19.15 billion yuan, marking the highest since its listing. This includes nearly 5.6 billion yuan in non-recurring gains from the sale of equity interests [6]. - Sino Medical's projected net profit for 2025 is between 43 million and 50 million yuan, reflecting a year-on-year increase of 2,767% to 3,233%. The growth is attributed to stable revenue from its neuro-interventional business and a 22% increase in its coronary intervention business due to the implementation of a national procurement policy [4][5]. Group 2: Loss Forecasts - Over 120 companies are forecasting profit declines for 2025, with 39 facing their first losses since going public, including companies like Zhifei Biological and Zhenbao Island. Zhifei is expected to report a loss of between 10.698 billion and 13.726 billion yuan, a decline of 630% to 780% compared to the previous year [2][8]. - Zhenbao Island anticipates a net loss of between 1.012 billion and 1.173 billion yuan, attributed to delays in the procurement process and increased cost control measures [8]. - Huiyu Pharmaceutical's losses are primarily due to non-core investment losses, with a fair value loss of 173 million yuan from its investment in Zhejiang Tongyuan Kang Pharmaceutical [9]. Group 3: Innovative Drug Companies - The innovative drug sector is showing signs of recovery, with companies like Nocera and Rongchang Biopharma expected to turn losses into profits. Nocera forecasts a net profit of approximately 633 million yuan, a significant increase from the previous year [3][11]. - Rongchang Biopharma is also expected to achieve profitability with projected revenues of around 3.25 billion yuan, a year-on-year increase of about 89% [11]. - Companies like Junshi Biosciences are reducing their losses significantly, with an expected net loss of around 873 million yuan, a reduction of 408 million yuan compared to the previous year [11][12].

Group 1 - Fulin Precision's subsidiary Jiangxi Shenghua invested 270 million yuan to establish a joint venture for a 500,000-ton ferrous oxalate project, with a total investment of 1.5 billion yuan expected to be completed by September 30, 2026 [1] - Xuguang Electronics plans to raise up to 1 billion yuan through a private placement to fund high-voltage vacuum arc extinguishing chamber expansion and other projects [2] - Minexplosion Optoelectronics intends to acquire 100% equity of Xiazhi Precision, with the transaction subject to shareholder and regulatory approvals [3] Group 2 - Shangluo Electronics' controlling shareholder plans to reduce his stake by up to 3% due to personal financial needs [4] - Babi Food reported a 1.3% decline in net profit for 2025, despite an 11.22% increase in revenue [5] - Pengding Holdings' subsidiary acquired industrial land in Huai'an for 66.14 million yuan [6] Group 3 - Zhuoyue New Energy's net profit for 2025 increased by 14.16%, despite a 17.43% decline in revenue [7] - Zhongyuan Media's net profit grew by 30.99% in 2025, with revenue decreasing by 5.13% [8] - Huangshan Tourism plans to invest approximately 530 million yuan in a hotel project with a 24-month construction period [9] Group 4 - *ST Jinling's restructuring plan was approved by the court, which may improve the company's financial situation [11] - Jichuan Pharmaceutical's subsidiary paid 80 million yuan for exclusive commercialization rights of a drug [12] - Pilin Bio's subsidiary received a notice for the acceptance of a drug supplement application [13] Group 5 - Nepe Mining terminated its investment in Swiss Veritas Resources AG due to changes in conditions [14] - Jinhui Wine announced a cash dividend of 0.20 yuan per share for the first three quarters of 2025 [15] - Hualan Biological's clinical trial for a new drug received approval for an additional indication [16] Group 6 - Industrial Fulian reported a total of 247 million yuan spent on share buybacks as of January 31, 2026 [17] - Yitong Century was pre-selected for a 107 million yuan project with China Tower [18] - Wanfeng Co. noted uncertainty in future price changes for disperse dyes [19] Group 7 - Bibet's clinical trial application for a new drug was approved by the National Medical Products Administration [21] - Chengbang Co. signed new project contracts worth 40.03 million yuan in Q4 2025 [22] - *ST Hengji received a court ruling for a performance compensation of 175 million yuan [23] Group 8 - Jihua Group is planning a change in control, leading to continued stock suspension [24] - Ningbo Port expects a container throughput of 5.03 million TEUs in January 2026, a 9.5% increase [25] - Hengli Petrochemical's actual controller increased his stake by 3.3 million shares [26] Group 9 - Hongfuhan signed a sales contract worth 480 million yuan with Guangdong Quanxiang [27] - All New Good's shareholder lifted a judicial freeze on 4.36% of the company's shares [28] - Changchun High-tech's subsidiary's clinical trial application for a new drug was accepted [29] Group 10 - Xingqi Eye Medicine's clinical trial for a new drug entered the first/second phase [31] - Hanma Technology reported a 140.04% increase in new energy heavy truck production in January 2026 [32] - Hengfeng Paper plans to invest 349 million yuan in a new green printing project [33] Group 11 - Zhifei Biological's mRNA vaccine for shingles received clinical trial approval [34] - Yutong Bus reported a 15.35% decrease in production in January 2026 [35] - StarNet Ruijie plans to sign a lease contract with an affiliate for a total rent of up to 110 million yuan [36] Group 12 - Hacheng Bonda's director completed a 0.97% share reduction [37] - Hendi Pharmaceutical's application for a new drug was approved [38] - Xinhua Medical's subsidiary received a medical device registration certificate [40] Group 13 - Yaokang Bio reported a 31.49% increase in net profit for 2025 [41] - Gaotie Electric reported a 14.02% increase in net profit for 2025 [42]

智飞生物2月3日公告，公司全资子公司安徽智飞龙科马生物制药有限公司研发的带状疱疹mRNA疫苗获 得国家药品监督管理局药物临床试验批准通知书，同意开展用于预防带状疱疹的临床试验。公司带状疱 疹mRNA疫苗临床试验申请获得批准对公司近期业绩不会产生重大影响，但有利于公司夯实研发技术， 加强在研管线储备。该项目后续临床试验进度、结果及产品上市情况存在不确定性，公司将根据研发进 展情况及时履行信息披露义务。 ...