第六届董事会第六次会议决议公告 本公司及董事会全体成员保证信息披露内容的真实、准确和完整，没有虚 假记载、误导性陈述或重大遗漏。 一、董事会会议召开情况 1、本次董事会于 2025 年 6 月 25 日以电子邮件的方式向董事发出通知。 证券代码：300122 证券简称：智飞生物 公告编号：2025-34 重庆智飞生物制品股份有限公司 2、本次会议于 2025 年 6 月 26 日 10:00 在公司会议室以现场结合通讯方式 召开。 3、本次会议应出席并参加表决的董事 9 人，实际出席并参加表决的董事 9 人。 4、本次会议由公司董事长蒋仁生先生主持，公司监事、高级管理人员列席 了本次会议。 5、本次会议的召集、召开和表决程序符合有关法律、行政法规、部门规章、 规范性文件及公司章程的规定。 二、董事会会议审议情况 经过各位董事认真审议，本次会议形成如下决议： 1、审议通过了《关于发行公司债券预案的议案》 为促进公司稳健发展，加速推动科技创新，拓宽融资渠道，满足生产经营与 投资的资金需求，优化债务结构，经慎重考虑，公司拟通过在境内申请发行公司 债券的方式筹集资金。董事会同意发行公司债券规模合计不超过人民币 60 ...

Core Viewpoint - The 2025 New Fortune 500 Rich List reveals a significant increase in the total market value of listed entrepreneurs, reaching 13.7 trillion yuan, an 11% year-on-year growth, indicating a new wave of wealth creation driven by innovation and overseas expansion [3][14]. Group 1: Wealth Distribution and Rankings - The top ten wealthiest individuals are heavily influenced by AI, with Zhang Yiming of ByteDance topping the list with a holding value of 481.57 billion yuan, marking a 42% increase from the previous year [4][18]. - The list features a notable shift, with four individuals from Hangzhou, Zhejiang, highlighting the region's growing economic prominence [43]. - The average holding value of the 500 entrepreneurs is 273.8 million yuan, with a threshold of 66.2 million yuan to make the list [8]. Group 2: Industry Insights - The TMT (Technology, Media, and Telecommunications), pharmaceutical, and daily consumer goods sectors are the top three wealth-generating industries, contributing 110, 54, and 52 individuals respectively [51]. - The TMT sector saw a significant increase in wealth, with a total of 334.08 billion yuan, a 46% increase from the previous year [51]. - The pharmaceutical sector experienced a decline, with 54 individuals listed, down from 64, indicating ongoing valuation adjustments [51]. Group 3: AI and Technological Advancements - AI has emerged as a key driver of wealth creation, with companies like DeepSeek and ByteDance leading the charge in user engagement and valuation [4][21]. - The rise of AI has also led to a resurgence in the semiconductor industry, with China exporting 2.981 billion chips worth approximately 159.5 billion USD, marking a significant shift in the global market [56]. - The AI sector is still in its nascent stage, with notable entries like Liang Wenfeng of DeepSeek entering the top ten, reflecting the rapid growth and potential of AI applications [60]. Group 4: Regional Wealth Creation - Wealth creation is becoming more balanced across regions, with western provinces like Sichuan, Tibet, and Xinjiang seeing an increase in listed individuals, while traditional economic hubs like Zhejiang and Shanghai continue to grow [5][6]. - The shift from real estate to technology and AI reflects a broader transformation in China's economic landscape, with younger entrepreneurs increasingly dominating the wealth rankings [46][45]. Group 5: Future Outlook - The ongoing evolution of industries, particularly in AI and technology, suggests a promising future for innovation-driven wealth creation in China [60][62]. - The integration of AI into various sectors, including automotive and consumer electronics, is expected to further enhance China's competitive edge in the global market [62][63].

Financial Performance - As of June 20, 2025, Zhifei Biological reported a closing price of 19.02 yuan, with a slight increase of 0.42% [1] - The total operating revenue for the first quarter of 2025 was 2.374 billion yuan, representing a year-on-year decrease of 79.16% [1] - The net profit attributable to shareholders was approximately 305.14 million yuan, down 120.93% year-on-year [1] - The company's current ratio is 2.298, quick ratio is 1.029, and debt-to-asset ratio stands at 36.85% [1] Market Activity - The trading volume was 222,300 hands, with a total transaction amount of 425 million yuan [1] - The net inflow of main funds was 38.55 million yuan, accounting for 9.06% of the transaction amount [1] - Large orders saw a net inflow of 44.10 million yuan, while small orders experienced a net outflow of 42.67 million yuan [1] Company Overview - Zhifei Biological, established in 1995, is located in Chongqing and primarily engages in the pharmaceutical manufacturing industry [2] - The company has a registered capital of approximately 2.39 billion yuan and a paid-in capital of 400 million yuan [1] - Zhifei Biological has made investments in 9 companies and participated in 1,149 bidding projects [2]

Industry Overview - Vaccines are essential biological products for preventing and controlling infectious diseases, representing a core defense in public health systems [1][5] - The Chinese vaccine industry is experiencing rapid growth, with the market size projected to increase from 306.22 billion yuan in 2015 to 1,762.19 billion yuan in 2024, and expected to exceed 300 billion yuan by 2031 [1][5] Industry Chain - The upstream of the vaccine industry includes raw material supply, such as microcarriers, human serum albumin, and packaging materials [3] - The midstream involves vaccine research and production, with key players including Sinopharm, Sinovac, CanSino, Zhifei, and Watson [3] - The downstream consists of vaccine distribution and consumption, reaching end consumers through health service centers and medical institutions [3] Current Industry Status - As of December 31, 2024, 47 companies in China have received vaccine batch approvals, totaling 543 million doses, with a decrease of 5.6% compared to 2023 [7] - The most approved vaccines in 2024 were influenza and rabies vaccines, each exceeding 80 million doses, accounting for 30% of total approvals [9] Market Competition - The Chinese vaccine market is characterized by a diverse competitive landscape, with local companies like Sinopharm and Zhifei rising against foreign giants like Merck and Pfizer [11] - Zhifei has achieved significant growth in international markets, with a 300% increase in exports of its WHO-precertified 23-valent pneumococcal polysaccharide vaccine [11] - Innovative companies like CanSino and Watson are making breakthroughs in mRNA and recombinant protein vaccines, enhancing their market presence [11][12] Future Trends - Technological innovation is driving the vaccine industry forward, with new platforms like mRNA and gene-engineered vaccines emerging [17] - The adult vaccine market is growing, with a 45% increase in HPV vaccine uptake in 2024, indicating a shift in public health awareness [18] - Chinese vaccine companies are expanding internationally, with over 2.5 billion doses of COVID-19 vaccines supplied abroad, focusing on markets in Africa and Southeast Asia [19]

重庆智飞生物制品股份有限公司（以下简称"公司"）于近日获悉，由全资 子公司北京智飞绿竹生物制药有限公司（以下简称"智飞绿竹"）研发的吸附破 伤风疫苗获得国家药品监督管理局药物临床试验批准通知书（通知书编号： 2025LP01605），同意本品开展用于预防破伤风的的临床试验。公司将根据临床 试验批准通知书的要求，尽快开展相关临床试验工作。 一、研发项目简介 证券代码：300122 证券简称：智飞生物 公告编号：2025-33 重庆智飞生物制品股份有限公司 关于吸附破伤风疫苗获得临床试验批准通知书的公告 本公司及董事会全体成员保证信息披露内容的真实、准确和完整，没有虚 假记载、误导性陈述或重大遗漏。 1、药品研制是非常复杂严谨的科学活动，具有投入大，周期长，风险高的 特点，产品的研发和行政审批主要有以下几个阶段：临床前研究；申请临床试验； 开展临床试验；申请生产文号；上市销售。 2、公司吸附破伤风疫苗临床试验申请获得批准对公司近期业绩不会产生重 大影响，若未来产品研发顺利，将丰富公司产品结构，提升公司的盈利能力与核 心竞争力。 破伤风是由破伤风梭状芽孢杆菌通过皮肤或黏膜的破口侵入人体，引起的以 全身骨骼肌持续强直 ...

1．经公司 2024 年 6 月 18 日召开的 2023 年年度股东大会审议通过的《重庆 智飞生物制品股份有限公司章程》（以下简称"《公司章程》"）； 2024 年年度股东大会的法律意见书 致：重庆智飞生物制品股份有限公司 北京市金杜（重庆）律师事务所（以下简称本所）接受重庆智飞生物制品股份 有限公司（以下简称"公司"）的委托，根据《中华人民共和国证券法》（以下简 称《证券法》）、《中华人民共和国公司法》（以下简称《公司法》）、中国证券 监督管理委员会《上市公司股东会规则》（以下简称"《股东会规则》"）等中华 人民共和国境内（以下简称中国境内，为本法律意见书之目的，不包括中国香港特 别行政区、中国澳门特别行政区和中国台湾省）现行有效的法律、行政法规、规章、 规范性文件和现行有效的公司章程有关规定，指派律师出席了公司于 2025 年 6 月 18 日召开的 2024 年年度股东大会（以下简称"本次股东大会"），并就本次股东 大会相关事项出具本法律意见书。 为出具本法律意见书，本所律师审查了以下文件，包括但不限于： 北京市金杜（重庆）律师事务所 关于重庆智飞生物制品股份有限公司 4．公司 2025 年 4 月 ...

证券代码：300122 证券简称：智飞生物 公告编号：2025-32 重庆智飞生物制品股份有限公司 2024 年年度股东大会决议公告 1、会议召开情况 （1） 时间： 现场会议：2025年6月18日（星期三）10:00； 网络投票：2025年6月18日。其中，通过深圳证券交易所交易系统进行网络投票 的时间为2025年6月18日上午9:15-9:25、9:30-11:30，下午13:00-15:00；通过深圳证券 交易所互联网系统投票的具体时间为：2025年6月18日9:15-15:00； 本公司及董事会全体成员保证信息披露内容的真实、准确和完整，没有虚假记 载、误导性陈述或重大遗漏。 重要提示 1.本次股东大会未出现否决议案的情形； 2.本次股东大会未涉及变更前次股东大会决议。 一、会议召开和出席情况 （2） 现场会议地点：重庆市江北区金源路9号重庆君豪大饭店； （3） 会议方式：本次会议以现场投票与网络投票相结合的方式召开； （6） 本次会议的召集、召开和表决程序符合《中华人民共和国公司法》《中华 人民共和国证券法》《上市公司股东会规则》等有关法律、行政法规、部门规章、 规范性文件及《重庆智飞生物制品股份有 ...

Group 1 - The price of the imported Merck nine-valent HPV vaccine has significantly decreased in several cities, with promotional offers reducing the effective price to around 700 yuan per dose from the original price of 1320 yuan [1][2] - The market for the nine-valent HPV vaccine has shifted dramatically, with the once exclusive Merck vaccine facing competition from domestic manufacturers, leading to a more accessible supply [2][4] - The inventory pressure on Zhifei Biological, the agent for Merck's vaccine, is evident, with a 14.8% year-on-year decline in the batch issuance of the nine-valent vaccine and a staggering 95.49% drop for the four-valent vaccine [3] Group 2 - The approval of the domestic nine-valent HPV vaccine "Xinkening 9" by Wantai Biological has disrupted the market, with a potential price point around 700 yuan, effectively halving the original price of the imported vaccine [4] - Other domestic companies, including Kanglaisheng, Watson Bio, and Shanghai Bowei, are also nearing the launch of their nine-valent HPV vaccines, which is expected to reignite price competition in the market [5] - The anticipated release of more domestic nine-valent vaccines marks the beginning of a trend towards greater affordability and accessibility in the HPV vaccine market [5]

Core Viewpoint - The article discusses the recent price reductions for imported HPV vaccines and shingles vaccines in China, highlighting various promotional campaigns aimed at increasing vaccination rates among different demographics [1][2]. Group 1: Vaccine Price Reductions - Several vaccination sites have launched promotional programs for imported HPV vaccines, including a "buy one, get one free" offer for the two-dose regimen for girls aged 9 to 14 [1]. - For women aged 15 to 45, the two-dose HPV vaccines are offered at significant discounts, with the two-dose regimen for the bivalent HPV vaccine costing only one dose, and the nine-valent vaccine costing two doses for three [1]. - The price per dose for the imported bivalent HPV vaccine is 588 yuan, while the nine-valent vaccine is priced at 1306 yuan, leading to substantial cost reductions for full vaccination [1]. Group 2: Broader Vaccine Promotions - In Dezhou, Shandong Province, promotional activities for imported four-valent and nine-valent HPV vaccines have been introduced, including free third doses for males aged 16 to 26 [2]. - The Jining Health Service Center has also initiated a discount for the imported shingles vaccine, reducing the price from 3260 yuan for two doses to 1652 yuan, a reduction of 1608 yuan [2]. Group 3: Industry Performance Challenges - Despite the price reductions, the performance of vaccine manufacturers has been disappointing, with significant declines in sales for core products like HPV vaccines [3]. - Zhifei Biological Products Co., Ltd. reported a 50.74% decrease in revenue to 26.07 billion yuan in 2024, and a 74.99% drop in net profit to 2.018 billion yuan [4]. - In Q1 2025, the company experienced a 79.16% decline in revenue compared to the previous year, resulting in a net loss of 305 million yuan [4]. Group 4: Company Strategies - The company aims to address operational challenges by focusing on inventory reduction, debt recovery, and lowering liabilities as part of its 2025 strategy [5]. - Efforts include optimizing sales policies, participating in local health promotion projects, and enhancing awareness of HPV vaccination for males [5]. - As of Q1 2025, the company's accounts receivable decreased to 14.6 billion yuan, indicating a focus on managing financial risks [5].

Group 1 - The performance of vaccine manufacturers is not optimistic amid the price reduction of imported HPV and shingles vaccines [1][3] - Various vaccination centers have launched promotional programs for imported HPV vaccines, offering discounts such as "buy one get one free" and "buy three get two free" [1][2] - The price for the imported bivalent HPV vaccine is 588 yuan per dose, while the nine-valent HPV vaccine is priced at 1306 yuan per dose, with significant discounts available [1] Group 2 - Merck, the manufacturer of imported quadrivalent and nine-valent HPV vaccines, plans to adjust the delivery schedule in the Chinese market starting February 2025 based on consumer demand [3] - Zhifei Biological Products Co., Ltd. reported significant declines in sales and financial indicators, with a notable drop in core product sales starting from Q2 2024 [3][4] - In 2024, Zhifei Biological's revenue was 26.07 billion yuan, a decrease of 50.74% year-on-year, and the net profit attributable to shareholders fell by 74.99% [4]