Investment Rating - The investment rating for the pharmaceutical and biotechnology industry is "Positive" and the rating has been maintained [1] Core Insights - The pharmaceutical and biotechnology industry index experienced a decline of 2.72%, ranking 23rd among 31 primary industries, underperforming the CSI 300 index which declined by 2.62% [4][16] - The industry valuation as of September 30, 2025, is a PE (TTM overall method, excluding negative values) of 31.23x, down from 31.79x in the previous period, indicating a downward trend and below the average [21] - The top three sub-industries in terms of PE (TTM overall method, excluding negative values) are vaccines (55.74x), medical devices (41.29x), and hospitals (39.51x), with the median at 33.19x, while pharmaceutical circulation has the lowest valuation at 14.34x [21] Industry Review - The report highlights that during the reporting period, 51 listed companies in the pharmaceutical and biotechnology sector had a net reduction in shareholders amounting to 2.435 billion yuan, with 14 companies increasing their holdings by 681 million yuan and 37 companies reducing their holdings by 3.116 billion yuan [4] - The report emphasizes the importance of upcoming clinical data and the strong fundamentals of companies ahead of the ESMO 2025 conference, which is expected to showcase significant clinical research results from various domestic pharmaceutical companies [7][8] Important Industry News - AstraZeneca plans to list on the New York Stock Exchange [6] - The report mentions the approval of a new oral SERD drug by Eli Lilly, marking it as the second such drug approved globally [8][45] - The approval of the first domestic quadrivalent HPV vaccine in China is expected to expand the coverage population and potentially be priced lower than imported versions [8][50][52]

Group 1 - Proprius announced that it will accept investor research from September 15 to September 17, 2025, on September 19, 2025, and from September 24 to September 26, 2025 [1] - The company's board secretary, Lai Xiaolong, will participate in the reception and answer questions from investors during these periods [1]

Company Overview - Proris is a data-driven clinical research service provider focused on patient-centered approaches, creating a comprehensive project management system for clinical trials [1][2]. - The company specializes in Site Management Organization (SMO) services, enhancing the quality and efficiency of clinical trials in China [1]. Financial Performance - In the first half of 2025, the company achieved a revenue of CNY 390.10 million and a net profit of CNY 54.16 million [3]. - The second quarter of 2025 saw a year-on-year revenue growth of 1.82% and a quarter-on-quarter increase of 21.06% [3]. - Net profit for the second quarter increased by 45.17% year-on-year and 528.73% quarter-on-quarter [3]. - The company has handled over 4,000 SMO projects, with 2,428 currently active [3]. Market Demand and Orders - In the first half of 2025, the company signed new contracts worth CNY 600 million, a year-on-year increase of 40.12% [4]. - The total value of existing contracts reached CNY 1.998 billion, reflecting a year-on-year growth of 9.45% [4]. Industry Landscape - The SMO industry in China is entering a new development phase, with leading companies expanding their customer resources and technical capabilities [5]. - Smaller SMO firms are gradually exiting the market, leading to increased industry concentration [5]. Client Composition - The company's clients include multinational pharmaceutical companies, domestic innovative drug firms, and primarily multinational CROs [6]. - Proris collaborates with top global pharmaceutical companies, enhancing its service capabilities in innovative drug projects [6]. Project Execution and Areas of Expertise - The company has a strong competitive advantage in various disease areas, including hematological tumors, solid tumors, and rare diseases [8]. - As of June 2025, Proris has facilitated the launch of 93 new oncology drugs and 17 biosimilars [8]. - The company is involved in cutting-edge research areas such as CGT, ADC, and GLP-1, with numerous projects in these fields [8].

Group 1 - The core viewpoint of the news is that Prasis (Shanghai) Pharmaceutical Technology Development Co., Ltd. has seen a stock price increase of 5.15%, reaching 48.16 CNY per share, with a total market capitalization of 3.805 billion CNY as of September 30 [1] - The company was established on February 22, 2013, and went public on May 17, 2022, focusing on technology development, transfer, consulting, and services in the pharmaceutical sector, with 100% of its revenue coming from services [1] - The trading volume for Prasis on the reporting date was 75.4268 million CNY, with a turnover rate of 2.13% [1] Group 2 - Among the top ten circulating shareholders of Prasis, a fund under Rongtong Fund has increased its holdings by 100,000 shares to a total of 1 million shares, representing 1.33% of the circulating shares [2] - The Rongtong Health Industry Flexible Allocation Mixed A/B fund (000727) has achieved a year-to-date return of 17.3% and a one-year return of 23.7%, ranking 4996 out of 8167 and 4660 out of 8010 in its category, respectively [2] - The fund was established on December 25, 2014, and has a current size of 2.074 billion CNY, with a cumulative return of 183.4% since inception [2]

Core Viewpoint - The stock price of Prise has shown significant fluctuations, with a year-to-date increase of 74.65% but a recent decline of 1.20% over the last five trading days [2]. Company Overview - Prise (Shanghai) Pharmaceutical Technology Development Co., Ltd. was established on February 22, 2013, and went public on May 17, 2022. The company is located at 500 Guangdong Road, 23rd Floor, World Trade Building, Huangpu District, Shanghai [2]. - The main business involves technology development, transfer, consulting, and services in the pharmaceutical field, with 100% of its revenue coming from services [2]. - The company belongs to the pharmaceutical and biotechnology sector, specifically in medical services and medical research outsourcing [2]. Financial Performance - For the first half of 2025, Prise reported a revenue of 390 million yuan, a year-on-year decrease of 1.08%, and a net profit attributable to shareholders of 54.16 million yuan, down 1.40% year-on-year [2]. - Since its A-share listing, Prise has distributed a total of 40.77 million yuan in dividends [3]. Shareholder Information - As of June 30, 2025, the number of shareholders for Prise was 8,571, a decrease of 1.88% from the previous period, with an average of 8,787 circulating shares per person, an increase of 1.91% [2]. - The top ten circulating shareholders include Tianhong Medical Health A, which holds 1.4287 million shares, a decrease of 17,600 shares from the previous period, and Rongtong Health Industry Flexible Allocation Mixed A/B, which holds 1 million shares, an increase of 100,000 shares [3].

Group 1 - The company announced that it will hold a staff representative meeting on September 26, 2025 [2] - During the meeting, the staff representatives voted to elect Gu Shengnan as the employee representative director for the company's third board of directors [2]

关于选举公司第三届董事会职工代表董事的公告 本公司及董事会全体成员保证信息披露的内容真实、准确、完 整，没有虚假记载、误导性陈述或重大遗漏。 普蕊斯（上海）医药科技开发股份有限公司（以下简称"公司"）根据《中华 人民共和国公司法》《深圳证券交易所创业板股票上市规则》《深圳证券交易所 上市公司自律监管指引第 2 号——创业板上市公司规范运作》等法律法规、规范 性文件及《公司章程》的有关规定，公司董事会设职工代表董事一名。 公司于 2025 年 9 月 26 日召开职工代表大会，经全体与会职工代表审议，通 过投票表决，同意选举顾胜男女士为公司第三届董事会职工代表董事（简历详见 附件）。顾胜男女士将与公司现任的 8 位董事共同组成公司第三届董事会，任期 自本次职工代表大会审议通过之日起至第三届董事会任期届满之日止。 顾胜男女士当选公司职工代表董事后，公司第三届董事会兼任高级管理人员 以及由职工代表担任的董事人数未超过公司董事总数的二分之一，符合相关法律 法规及《公司章程》的规定。 证券代码：301257 证券简称：普蕊斯 公告编号：2025-060 普蕊斯（上海）医药科技开发股份有限公司 特此公告。 普蕊斯（上海） ...

特别提示： 1、本次会议采取现场表决与网络投票相结合的方式。 2、本次股东大会不存在否决提案的情况。 3、本次股东大会不涉及变更以往股东大会已通过的决议。 4、本次股东大会表决的提案中，提案 5.00 以提案 1.00 审议通过为前提条件。 证券代码：301257 证券简称：普蕊斯 公告编号：2025-059 普蕊斯（上海）医药科技开发股份有限公司 2025 年第三次临时股东大会决议公告 本公司及董事会全体成员保证信息披露的内容真实、准确、完 整，没有虚假记载、误导性陈述或重大遗漏。 一、会议召开和出席情况 1、召开时间： （1）现场会议召开时间：2025 年 9 月 26 日（星期五）14:45 （2）网络投票时间：通过深交所交易系统进行网络投票的具体时间为：2025 年 9 月 26 日 9:15-9:25，9:30-11:30 和 13:00-15:00；通过深交所互联网投票系统 投票的具体时间为 2025 年 9 月 26 日 9:15-15:00 期间的任意时间。 2、召开地点：上海市黄浦区广东路 500 号世界贸易大厦 23 楼大会议室 3、召开方式：现场表决与网络投票相结合的方式 4、召集人：普 ...

上海市黄浦区中山东二路 600 号 BFC 外滩金融中心 S2 栋 23 层 电话：021-23122000 传真：021-23122100 邮编：200010 北京国枫（上海）律师事务所 关于普蕊斯（上海）医药科技开发股份有限公司 2025 年第三次临时股东大会的法律意见书 对本法律意见书的出具，本所律师特作如下声明： 1. 本所律师仅就本次会议的召集与召开程序、召集人和出席现场会议人员资格、 会议表决程序及表决结果的合法性发表意见，不对本次会议所审议的议案内容及该等 议案所表述的事实或数据的真实性、准确性和完整性发表意见； 2. 本所律师无法对网络投票过程进行见证，参与本次会议网络投票的股东资格、 网络投票结果均由相应的证券交易所交易系统和互联网投票系统予以认证； 3. 本所律师已经按照《股东会规则》的要求，对贵公司本次会议所涉及的相关 事项进行了必要的核查和验证，所发表的结论性意见合法、准确，不存在虚假记载、 误导性陈述或者重大遗漏； 4. 本法律意见书仅供贵公司本次会议之目的使用，不得用作任何其他用途。本 所律师同意将本法律意见书随贵公司本次会议决议一起予以公告。 本所律师根据《公司法》《证券法》《股 ...

Investment Rating - The report maintains a "Positive" investment rating for the pharmaceutical and biotechnology industry [2] Core Insights - The CXO industry is experiencing a recovery in market conditions, driven by improvements in supply-demand dynamics and a rebound in financing activities for innovative drugs [3][4] - The CDMO sector continues to show high growth potential, with leading companies improving their performance and expanding into emerging markets [5][6] - The CRO sector is approaching a turning point, with signs of demand recovery and improved order conditions [6][7] Summary by Sections CXO Industry Overview - The CXO industry operates on a "water seller" business model, closely tied to the financing of the biopharmaceutical sector. In the first eight months of 2025, overseas innovative drug financing reached $22.6 billion, a year-on-year decline of approximately 36%, while domestic innovative drug financing amounted to $7.75 billion, a year-on-year increase of about 89% [3][31] - The leading companies in the CXO sector are expected to enter an expansion phase as demand recovers, while smaller companies may face increased competition and exit the market [4][44] CDMO Sector - CDMO leading companies have begun to see marginal improvements in performance since Q4 2024, attributed to high overseas revenue and a unique business model that supports project pipeline growth [5][46] - The order situation for CDMO companies has improved significantly, with notable increases in backlogged orders for major players like WuXi AppTec and WuXi Biologics [49][50] - The CDMO business model is characterized by strong customer retention and project scalability, allowing for sustained growth despite challenges in new project signings [52] CRO Sector - The CRO sector is witnessing a divergence in performance among leading companies, with some starting to recover. The overall order situation has shown improvement, indicating a potential demand revival [6][22] - The price increase of experimental monkeys suggests a forthcoming recovery in preclinical CRO demand, highlighting the importance of resource availability for leading CRO companies [6][24] - The integration of AI in drug development processes is expected to enhance efficiency and reduce costs, with many domestic CRO leaders already adopting AI technologies [7][18] Recommended Companies - The report suggests focusing on key players in the CXO sector, including WuXi AppTec, WuXi Biologics, WuXi AppTec, and others, which are positioned well for growth based on their business characteristics and market trends [8][10]