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How Will Skyrizi and Rinvoq Sales Aid AbbVie's Upcoming Q2 Results?
ZACKS· 2025-07-08 13:31
Core Insights - AbbVie has effectively managed the loss of exclusivity for Humira by launching two new immunology drugs, Skyrizi and Rinvoq, with significant sales expected in the upcoming quarterly report [1][3][8] Group 1: Drug Performance and Sales Expectations - Skyrizi and Rinvoq have been launched across major indications previously covered by Humira, including a new indication for atopic dermatitis, showing strong performance particularly in inflammatory bowel disease (IBD) [2] - AbbVie anticipates combined sales of $6 billion for Skyrizi and Rinvoq in the second quarter, with individual estimates of $4 billion for Skyrizi and $2 billion for Rinvoq [3][8] Group 2: Expansion in Other Therapeutic Areas - AbbVie is also expanding its oncology and neuroscience portfolios, adding new therapies such as Epkinly, Elahere, and Emrelis, bringing its total oncology therapies to five [4] - The neuroscience segment has seen growth driven by increased uptake of migraine treatments, Ubrelvy and Qulipta [4] Group 3: Competitive Landscape - The immunology market is highly competitive, with key players like Johnson & Johnson and Eli Lilly also expanding their portfolios. Johnson & Johnson is focusing on Tremfya after Stelara lost patent exclusivity [5] - Eli Lilly has recently received FDA approval for Omvoh, marking its entry into the IBD market, which enhances its immunology offerings [6] Group 4: Valuation and Market Performance - AbbVie shares have outperformed the industry year to date, trading at a price/earnings (P/E) ratio of 14.21, slightly below the industry average of 15.01 [7][10] - The bottom-line estimate for AbbVie in 2025 remains at $12.28, with a slight increase in the 2026 estimate from $14.05 to $14.06 [11]
2 ETFs To Prepare You For A Potential Recession
Seeking Alpha· 2025-07-07 10:50
Group 1 - The article discusses ongoing recession talks, indicating that these discussions have been prevalent for several years [1] - The author emphasizes a focus on dividend investing in quality blue-chip stocks, BDCs, and REITs, aiming to build investment portfolios for lower and middle-class workers [2] - The author expresses a personal investment strategy of buy-and-hold, with plans to rely on dividends for retirement income in the next 5-7 years [2] Group 2 - The article includes a disclosure of a beneficial long position in SCHD shares, indicating a personal investment interest [3] - It clarifies that the article is not providing financial advice and encourages readers to conduct their own due diligence [2][4] - The article notes that past performance is not indicative of future results, highlighting the uncertainty in investment outcomes [4]
US Large Cap Pharmaceuticals_ Mid-Year State Of Play
2025-07-07 00:51
Summary of US Large Cap Pharmaceuticals: Mid-Year State Of Play Industry Overview - The report focuses on the US Large Cap Pharmaceuticals sector, analyzing key companies such as ABBV, LLY, JNJ, MRK, BMY, and PFE [6][5][32]. Core Insights and Arguments 1. **Revenue Growth and Stability**: Projected revenues from growth/stable products for 2025-2030 are as follows: ABBV at $10.39 billion, LLY at $3.06 billion, JNJ at $1.68 billion, MRK at $1.37 billion, BMY at $0.60 billion, and PFE at $0.54 billion [5]. 2. **Patent Cliff Exposure**: The number of years to the next major patent cliff varies, with ABBV and MRK at 3.5 years, while LLY and JNJ face longer timelines [5]. 3. **Market Sentiment**: The report indicates a "Launch Trade" momentum, with high investor psychology impacting stock performance, particularly for ABBV and GILD as popular longs, while MRK is viewed as a funding underweight [6]. 4. **Macro Environment**: A friendlier US macro backdrop with diminished recession risks and benign inflation data is noted, which could complicate the case for large-cap biopharma relative to other sectors [6]. 5. **Drug Pricing Uncertainty**: Ongoing debates regarding drug pricing and potential implementation of Most Favored Nation (MFN) pricing are highlighted as significant uncertainties affecting investor sentiment [6]. 6. **Key Catalysts for 2H25**: Important upcoming catalysts include LLY's ATTAIN-1 data for an oral obesity pill, BMY's ADEPT-2 Phase 3 data for Alzheimer's treatment, and MRK's CADENCE trial outcomes [6]. Additional Important Considerations 1. **Tariff Implications**: The report discusses potential tariffs on pharmaceuticals, with an expected starting rate of 25% on transfer pricing, potentially dropping to around 10% based on negotiations [6]. 2. **Investor Positioning**: The healthcare sector is experiencing a positioning cleanse, with Medtech favored over large-cap biopharma [6]. 3. **Earnings Setup**: Investor sentiment is more comfortable with ABBV, PFE, and LLY, while concerns are raised regarding BMY's performance [6]. 4. **Government Exposure**: The report notes that government end-market exposure varies significantly among companies, with LLY and MRK having over 35% exposure to Medicare/Medicaid revenues [5]. Conclusion The US Large Cap Pharmaceuticals sector is navigating a complex landscape characterized by macroeconomic factors, regulatory uncertainties, and evolving investor sentiment. Key companies are positioned differently based on their revenue growth potential, patent cliff exposure, and government market dependencies. The upcoming catalysts and tariff implications will be critical in shaping the sector's performance in the second half of 2025.
行业周报:艾伯维收购Capstan,加码体内CAR-T-20250706
KAIYUAN SECURITIES· 2025-07-06 13:24
Investment Rating - The industry investment rating is "Positive" (maintained) [2] Core Insights - The report highlights the acquisition of Capstan Therapeutics by AbbVie for up to $2.1 billion, focusing on in vivo CAR-T therapy development [6][15] - The report emphasizes the growing interest and investment in in vivo CAR-T technology, with multiple companies actively pursuing diverse delivery systems [7][26] - The pharmaceutical and biotechnology sector saw a weekly increase of 3.64%, outperforming the CSI 300 index by 2.1 percentage points, ranking 4th among 31 sub-industries [8][31] Summary by Sections 1. AbbVie Acquisition of Capstan - AbbVie announced the acquisition of Capstan Therapeutics for a maximum of $2.1 billion, focusing on in vivo CAR-T therapies [6][15] - Capstan's main asset, CPTX2309, is an RNA delivery candidate for anti-CD19 CAR-T therapy, currently in Phase I clinical trials [15][20] 2. MNC's Active Layout in In Vivo CAR-T Technology - MNC has been actively investing in in vivo CAR-T technology through collaborations and acquisitions, focusing on both lentiviral and lipid nanoparticle delivery systems [7][26] - The report notes that over 20 disclosed mRNA technology projects in in vivo CAR-T are primarily concentrated in the lipid nanoparticle direction [22][30] 3. Weekly Performance of the Pharmaceutical Sector - The pharmaceutical sector increased by 3.64% in the first week of July, outperforming the CSI 300 index [31] - Among sub-sectors, other biological products saw the highest increase of 8.28%, while medical equipment experienced the largest decline of 0.21% [35][36] 4. Recommended Stocks - Recommended stocks include major pharmaceutical and biotechnology companies such as Heng Rui Medicine, East China Medicine, and others [9]
2 Dividend Stocks to Buy for Decades of Passive Income
The Motley Fool· 2025-07-06 12:45
AbbVie - AbbVie is a pharmaceutical leader with a strong portfolio, particularly in immunology with products Skyrizi and Rinvoq, achieving a revenue increase of 8.4% year-over-year to $13.3 billion in Q1, with adjusted earnings per share at $2.46, a 6.5% increase [3][4] - Skyrizi generated $3.4 billion in sales, a 70.5% year-over-year increase, while Rinvoq's revenue was $1.7 billion, up 57.2% year-over-year; management forecasts combined annual sales exceeding $31 billion by 2027, significantly higher than the previous year's $17.7 billion [4][5] - AbbVie has a deep pipeline with approximately 90 products in development, allowing it to navigate patent cliffs and maintain long-term success [5][7] - AbbVie has increased its dividends by 310% since 2013 and has a track record of 53 consecutive years of payout increases, indicating strong potential for sustained passive income [8] Abbott Laboratories - Abbott Laboratories is a leader in the medical device space, with a diversified operation across diagnostics, pharmaceuticals, and nutrition, which helps mitigate challenges in specific segments [9][10] - The diabetes care segment, particularly the FreeStyle Libre continuous glucose monitoring system, has been a significant growth driver, becoming the most successful medical device in history in terms of dollar sales [11][12] - Abbott has increased its dividends by almost 146% over the past decade, reinforcing its reputation as a Dividend King and indicating a strong foundation for long-term dividend growth [13]
Is It Worth Investing in AbbVie (ABBV) Based on Wall Street's Bullish Views?
ZACKS· 2025-07-03 14:30
Core Viewpoint - Analyst recommendations play a significant role in influencing stock prices, but their reliability is questionable due to potential biases from brokerage firms [1][10]. Brokerage Recommendation Summary - AbbVie (ABBV) has an average brokerage recommendation (ABR) of 1.84, indicating a consensus between Strong Buy and Buy, based on 28 brokerage firms [2]. - Out of the 28 recommendations, 15 are Strong Buy (53.6%) and 2 are Buy (7.1%) [2]. Zacks Rank vs. ABR - The Zacks Rank, which is based on earnings estimate revisions, is a more reliable indicator of a stock's near-term price performance compared to the ABR [8][11]. - The Zacks Rank is displayed in whole numbers (1 to 5) and reflects timely changes in earnings estimates, while the ABR may not be up-to-date [9][12]. Current Earnings Estimates for AbbVie - The Zacks Consensus Estimate for AbbVie remains unchanged at $12.28 for the current year, suggesting stable earnings prospects [13]. - AbbVie currently holds a Zacks Rank 3 (Hold), indicating a cautious approach despite the Buy-equivalent ABR [14].
AbbVie Stock At $190: Premium Pricing For A Transformation Story
Forbes· 2025-07-02 14:50
Core Insights - AbbVie has emerged as a top performer in the healthcare sector, with its stock increasing by 6% while the S&P 500 healthcare index declined by 1%, reflecting strong investor confidence in its transformation strategy post-Humira [2] - The company faces significant challenges due to the decline in Humira sales, which dropped 58% from a peak of $21.2 billion in 2022 to $9 billion last year, highlighting a substantial revenue gap [3] - AbbVie has adopted an aggressive acquisition strategy, totaling over $22 billion since the start of 2024, aimed at diversifying its portfolio and securing leadership in high-growth therapeutic areas [5] Acquisition Strategy - The acquisitions include ImmunoGen for $10.1 billion, Cerevel Therapeutics for $8.7 billion, Aliada Therapeutics for $1.4 billion, and Capstan Therapeutics for up to $2.1 billion, among others, indicating a strategic focus on oncology, neuroscience, and Alzheimer's [7] - AbbVie's past success with acquisitions, such as the collaboration with Boehringer Ingelheim that led to Skyrizi, which generated $11.7 billion in sales in 2024, serves as a model for potential future successes [6] Financial Performance - Despite the decline in Humira sales, AbbVie achieved 4% revenue growth last year, demonstrating the resilience of its broader portfolio and the initial benefits of its acquisition strategy [8] - The company anticipates revenue growth accelerating to high single-digits in the coming years, with even greater earnings growth expected as margins improve [8] Valuation and Market Position - AbbVie's stock is currently trading at approximately $190 per share, with a valuation of 18.5 times its trailing adjusted earnings of $10.27 per share, representing a premium compared to its historical average of 14x and other major pharmaceutical competitors [9][10] - The elevated valuation reflects investor confidence in AbbVie's growth strategy and operational capabilities, supported by a robust revenue growth trajectory and ongoing pipeline expansion [11] Balance Sheet Considerations - AbbVie currently holds $70 billion in debt against a market capitalization of $336 billion, resulting in a debt-to-equity ratio of 21.3%, which is moderately above the S&P 500 average [12] - The company's cash position is concerning, with only $5.2 billion in cash and equivalents out of $136 billion in total assets, leading to a low cash-to-assets ratio of 3.8%, which may limit future strategic opportunities [13] Strategic Outlook - AbbVie's transition from reliance on Humira to a diversified pharmaceutical company represents a significant strategic shift, positioning it as a potentially attractive long-term investment for those willing to accept balance sheet risks and a premium valuation [14]
Will AbbVie's Acquisition Spree Aid Pipeline Growth?
ZACKS· 2025-07-02 13:51
Core Insights - AbbVie is actively enhancing its deal-making efforts to strengthen its pipeline, focusing on immunology while also exploring early-stage deals in oncology and neuroscience [2][4] Group 1: Recent Acquisitions - AbbVie signed a definitive agreement to acquire Capstan Therapeutics for nearly $2.1 billion, expected to close in Q3, which will add a first-in-class CAR-T therapy and proprietary RNA delivery platform to its immunology pipeline [3][11] - The company has completed over 20 early-stage deals since last year, including a long-acting amylin analog for obesity from Gubra, marking its entry into the obesity treatment space [4][11] - Recent larger acquisitions include ImmunoGen, adding the ovarian cancer drug Elahere, and Cerevel Therapeutics, diversifying AbbVie's therapeutic portfolio across multiple modalities [5][11] Group 2: Market Context and Competitors - Broader macroeconomic concerns have impacted deal-making, but major pharmaceutical companies continue to pursue strategic assets in key growth areas [7] - Eli Lilly announced its intent to acquire Verve Therapeutics for up to $1.3 billion, marking its third targeted M&A deal this year, indicating a selective M&A strategy focused on long-term strength across therapeutic areas [8] - Sanofi's $9.5 billion acquisition of Blueprint Medicines aims to strengthen its immunology pipeline and reduce reliance on Dupixent, showcasing ongoing consolidation in the industry [9] Group 3: Financial Performance and Valuation - AbbVie shares have outperformed the industry year to date, trading at a P/E ratio of 14.42, slightly below the industry average of 14.86, but higher than its five-year mean of 12.46 [10][13] - The Zacks Consensus Estimate for AbbVie's 2025 EPS has increased from $12.26 to $12.28, while the estimate for 2026 remains at $14.06 [14]
ABBV to Boost Immunology Pipeline With Capstan Buyout for $2.1B
ZACKS· 2025-07-01 15:05
Core Viewpoint - AbbVie has entered into a definitive agreement to acquire Capstan Therapeutics for up to $2.1 billion in cash, aiming to enhance its immunology pipeline with innovative therapies [1][7]. Acquisition Details - The acquisition will incorporate Capstan's lead asset, CPTX2309, which is a potential first-in-class in vivo tLNP anti-CD19 CAR-T therapy currently in phase I development for treating B-cell-mediated autoimmune diseases [2][3]. - Capstan's proprietary tLNP platform technology, CellSeeker, will also be added, facilitating RNA delivery to engineer specific cell types within the body [2][7]. - The acquisition is subject to customary closing conditions, including regulatory approvals [3]. AbbVie's Acquisition Strategy - AbbVie has been actively pursuing acquisitions to strengthen its pipeline, particularly in the immunology sector, while also exploring early-stage deals in oncology and neuroscience [4]. - Since the beginning of 2024, AbbVie has signed over 20 early-stage deals, focusing on promising technologies that can enhance care standards in immunology, oncology, and neuroscience [4]. Recent Acquisitions - Earlier in 2024, AbbVie acquired rights to develop GUB014295 (ABBV-295), a long-acting amylin analog for obesity treatment, marking its entry into the obesity market [5]. - In January 2025, AbbVie completed the acquisition of Nimble Therapeutics, adding an investigational oral peptide IL23R inhibitor for psoriasis treatment and a proprietary peptide synthesis platform for autoimmune diseases [8].
临床一期、Science两篇、创立三年,这家in vivo CAR-T公司卖了21亿美元
生物世界· 2025-07-01 08:19
Core Viewpoint - AbbVie is making a significant move into the in vivo CAR-T market by acquiring Capstan Therapeutics for $2.1 billion in cash, aiming to integrate a candidate therapy for autoimmune diseases, CPTX2309, which is currently in Phase 1 clinical trials [2][9]. Group 1: Capstan Therapeutics Overview - Capstan Therapeutics, founded in early 2022, focuses on in vivo reprogramming of T cells to address manufacturing and scalability challenges in CAR-T therapies, allowing patients to avoid lymphocyte-depleting chemotherapy prior to treatment [3][9]. - The company has raised $340 million from various pharmaceutical giants and venture capital firms, with a founding team that includes pioneers in CAR-T cell therapy and mRNA technology [9]. Group 2: In Vivo CAR-T Technology - The in vivo CAR-T technology was developed based on a research paper published by researchers at the University of Pennsylvania in January 2022, which introduced a method to generate CAR-T cells in situ using lipid nanoparticles to deliver mRNA [6][12]. - This innovative approach, similar to mRNA vaccines, aims to simplify the CAR-T cell production process, addressing issues such as complexity, time, and high costs associated with traditional methods [7][14]. Group 3: Clinical Development and Applications - Capstan's lead product, CPTX2309, is currently in Phase 1 clinical trials for treating B cell-mediated autoimmune diseases, with promising preclinical results demonstrated in animal models [11][19]. - The therapy utilizes targeted lipid nanoparticles to deliver mRNA encoding CD19 CAR to CD8+ T cells, effectively generating CAR-T cells that can eliminate autoreactive B cells while allowing for the regeneration of healthy B cells [19][20]. Group 4: Market Context and Potential - Since 2017, the FDA has approved six CAR-T therapies for various B cell malignancies, with hundreds more in clinical trials globally, highlighting the growing interest and potential in the CAR-T market despite existing challenges [14][15]. - Recent advancements in CAR-T therapies for autoimmune diseases have shown significant clinical benefits, indicating a promising avenue for future treatments [15].