Core Insights - Charles River Laboratories (CRL) reported total revenue of $1.03 billion for the quarter ending June 2025, reflecting a 0.6% increase year-over-year [4] International Revenue Performance - Canada generated $135.59 million, accounting for 13.1% of total revenue, exceeding the consensus estimate by 26.56% [5] - Other International markets, including Brazil and Israel, contributed $10.33 million, representing 1% of total revenue, with a surprise of 148.27% compared to expectations [6] - Asia Pacific revenues were $54.5 million, making up 5.3% of total revenue, surpassing projections by 9.44% [7] - Europe accounted for $281.86 million, or 27.3% of total revenue, with a surprise of 9.29% over analyst expectations [8] Future Revenue Forecasts - Analysts predict total revenue of $960.79 million for the current fiscal quarter, a decline of 4.9% year-over-year, with regional contributions expected from Canada (11.8%), Other International (0.5%), Asia Pacific (4.3%), and Europe (25.6%) [9] - For the full year, total revenue is projected at $3.96 billion, indicating a 2.2% decrease from the previous year, with regional shares expected to be Canada (11.6%), Other International (0.9%), Asia Pacific (4.7%), and Europe (25.7%) [10] Market Context - The company's reliance on international markets presents both opportunities and challenges, necessitating close monitoring of international revenue trends to forecast future performance [12] - In the context of increasing global interdependencies and geopolitical tensions, analysts are focused on these trends to refine earnings predictions [13]

Core Insights - Charles River Laboratories International Inc. reported lower stock trading following the release of its second-quarter 2025 earnings, amid ongoing scrutiny regarding animal endangerment allegations [1][2]. Financial Performance - The company reported revenue of $1.03 billion, a marginal increase of 0.6% year-over-year, surpassing the consensus estimate of $984.65 million [5]. - The impact of foreign currency translation increased reported revenue by 1.2%, while organic revenue declined by 0.5% [5]. - Operating margin decreased to 9.7% from 14.8% in the second quarter of 2024, with net income at $52.3 million, or $1.06 per share, down from $90.0 million, or $1.74 per diluted share [5]. - Adjusted operating margin increased to 22.1% from 21.3%, with adjusted earnings at $3.12 per share, up 11.4%, exceeding the consensus estimate of $2.50 [5]. Segment Performance - Revenue for the Research Models and Services (RMS) segment was $213.3 million, an increase of 3.3% year-over-year, with organic revenue up by 2.3% [5]. - Discovery and Safety Assessment (DSA) segment revenue was $618 million, down 1.5%, with organic revenue decreasing by 2.4% due to lower sales volumes [5]. - Manufacturing Solutions revenue reached $200.8 million, up 4.4%, with organic revenue increasing by 2.9% [5]. Outlook and Market Conditions - The company raised its fiscal year 2025 adjusted earnings outlook from $9.30-$9.80 to $9.90-$10.30, compared to the consensus estimate of $9.60 [3]. - The company expects 2025 revenue to decline between (2.5)% and (0.5)%, a revision from the prior range of 5.5%-3.5% [3]. - The effects of government funding reductions have been minimal, and the company anticipates that the loss of commercial CDMO revenue will reduce the growth rate of manufacturing solutions by less than 500 basis points in 2025 [4]. Regulatory and Legal Context - The U.S. Fish and Wildlife Service cleared the company's shipments from late 2022 and early 2023 as legal, and investigations by the U.S. Department of Justice have been closed [2]. - The company faced allegations from PETA regarding misleading investors about its sales and purchases of long-tailed macaques, but recent legal developments have cleared the company of these allegations [1][2]. Market Reaction - Following the earnings report, CRL stock was down 4.82% at $159.42 [6].

Core Insights - Shares of Charles River Laboratories (NYSE: CRL) have declined approximately 25% over the past year, missing out on a broader market recovery [1] - The company is experiencing challenges due to a tougher funding environment impacting its operations [1] Company Performance - The stock has faced significant pressure, indicating potential underlying issues that may affect future performance [1] - The decline in stock value suggests that investor sentiment may be shifting, warranting closer examination of the company's fundamentals [1] Market Environment - The current funding environment is described as more difficult, which could pose challenges for companies in the drug testing sector [1]

Key Takeaways Charles River Laboratories International, Inc. (CRL) reported second-quarter 2025 adjusted earnings per share (EPS) of $3.12, which rose 11.4% year over year. The figure surpassed the Zacks Consensus Estimate by 24.8%. On a GAAP basis, the company reported earnings of $1.06 per share compared with the year-ago quarter's level of $1.74. CRL's Q2 Revenues Revenues totaled $1.03 billion, which beat the Zacks Consensus Estimate by 5%. The top line rose 0.6% from the year-ago quarter's level (down ...

Financial Data and Key Metrics Changes - The company reported revenue of $1,030 million in Q2 2025, a 0.6% increase year over year, with nearly half of the revenue outperformance driven by foreign exchange [9][10] - Organic revenue declined by 0.5%, primarily due to a low single-digit decline in the DSA segment, partially offset by low single-digit increases in RMS and manufacturing segments [10][12] - The operating margin improved to 22.1%, an increase of 80 basis points year over year, reflecting cost savings from restructuring and better sales volume [10][11] Business Line Data and Key Metrics Changes - DSA segment revenue was $618 million, a 2.4% decrease year over year on an organic basis, driven by lower revenue for discovery services [13] - RMS revenue increased by 2.3% on an organic basis to $213.3 million, primarily driven by the timing of NHP shipments and higher revenue for research model services [21][22] - Manufacturing segment revenue was $200.8 million, a 2.9% increase on an organic basis, driven by growth in microbial solutions [25][26] Market Data and Key Metrics Changes - Revenue for small and mid-sized biotech clients improved slightly for the third consecutive quarter, while revenue for global biopharmaceutical clients remained below last year's level but improved sequentially [10][21] - The demand environment for global biopharmaceutical clients appears to be stabilizing, with proposal activity increasing both year over year and sequentially [15][50] - The academic and government client segments saw revenue increases despite potential NIH budget cuts, with only a minor impact observed [22] Company Strategy and Development Direction - The company is focused on expanding its NAMS portfolio and enhancing scientific capabilities to support biopharmaceutical companies in transitioning to alternative technologies [19][20] - A strategic review is underway to evaluate avenues for value creation, including portfolio and capital allocation strategies [28][29] - The company aims to generate over $175 million in cost savings this year, contributing to improved financial performance [11][44] Management's Comments on Operating Environment and Future Outlook - Management noted that the global biopharmaceutical demand trends appear to have bottomed and are beginning to slowly move upward [7] - The company raised its revenue and non-GAAP earnings per share guidance due to outperformance in Q2, reflecting a more favorable demand environment [12][33] - There is recognition of ongoing uncertainty in the healthcare landscape, but management remains optimistic about stabilization in demand [8][9] Other Important Information - The company experienced a slight decline in DSA backlog to $1.93 billion, with gross and net bookings improving at mid-single-digit rates year over year [14] - The non-GAAP tax rate increased to 22.7%, primarily due to stock-based compensation, but was more favorable than expected [40][41] - Free cash flow for Q2 was strong at $169.3 million, driven by higher earnings and improved working capital [42][43] Q&A Session Summary Question: Current demand environment and pharma's perspective - Management indicated that the demand situation is stabilizing for pharma, with some demand trends having bottomed [48] - Revenue and proposals are up, but cancellations have also increased, particularly for longer-term post-IND work [49][50] Question: Clarification on revenue guidance and book-to-bill ratio - Management stated that the current book-to-bill ratio is expected to remain in the range of 0.8 to 0.93, which does not require improvement to meet guidance [55] Question: CDMO performance and revenue impact - The CDMO revenue headwind is expected to be around $20 million due to the wind-down of a client relationship, with higher margins noted in the first half [62][63] Question: Backlog conversion and revenue support - Management believes the backlog is stable and robust, allowing for continued drawing from it to replace studies that slip or cancel [72][74] Question: Hiring confidence and future growth - Management expressed confidence in hiring to meet current demand, with improvements in the overall demand curve expected to support future growth [78][79] Question: Pricing stability and margin implications - Pricing in DSA remains stable, with mix favorability contributing positively to margins [82][84] Question: Cancellations in longer-term work - Cancellations are not expected to significantly impact margins, as the margin profile for different types of work is often comparable [86]

Financial Performance and Key Metrics - The company reported revenue of $1,030 million in Q2 2025, a 0.6% increase year over year, with nearly half of the revenue outperformance driven by foreign exchange [10][11] - Organic revenue declined by 0.5%, primarily due to a low single-digit decline in the DSA segment, partially offset by low single-digit increases in RMS and manufacturing segments [11][12] - Operating margin improved to 22.1%, an increase of 80 basis points year over year, reflecting cost savings from restructuring and better sales volume [11][12] - Earnings per share were $3.12, an increase of 11.4% from the previous year, driven by operating margin improvement [12] Business Segment Performance - DSA segment revenue was $618 million, a 2.4% decrease year over year on an organic basis, driven by lower revenue for discovery services [14] - RMS revenue increased by 2.3% on an organic basis to $213.3 million, primarily due to timing of NHP shipments and higher revenue from research model services [22][24] - Manufacturing segment revenue was $200.8 million, a 2.9% increase on an organic basis, driven by microbial solutions and commercial CDMO clients [25][27] Market Trends and Key Indicators - Demand trends in global biopharmaceuticals appear to have stabilized, with mid-sized biotechs performing better than smaller ones, which remain cash constrained [7][11] - DSA backlog was $1,930 million at the end of Q2, a slight decline from the previous quarter, with gross and net bookings improving at mid-single-digit rates year over year [14][15] - The net book to bill ratio dipped to 0.82 times in Q2, reflecting an increase in cancellations and DSA revenue outperformance [7][15] Company Strategy and Industry Competition - The company is focusing on expanding its NAMS portfolio, which generated approximately $200 million in annual DSA revenue, and aims to enhance its capabilities through partnerships and internal development [20][21] - The strategic review is ongoing, evaluating avenues for value creation while balancing the strength of the company's scientifically distinguished portfolio [29] Management Commentary on Operating Environment and Future Outlook - Management noted that the demand environment is stabilizing, with no significant impact from tariffs or drug pricing concerns observed to date [10][11] - The company raised its revenue and non-GAAP earnings per share guidance for 2025, reflecting outperformance in Q2 and favorable foreign exchange rates [12][34] - The outlook for the second half of the year includes expected revenue declines of 2% to 4% year over year, with a focus on maintaining operational efficiency [44][45] Other Important Information - Free cash flow for Q2 was $169.3 million, an increase from $154 million last year, driven by higher earnings and improved working capital [43] - The company expects total net interest expense to be lower than previously anticipated, benefiting from diligent capital planning [40] Q&A Session Summary Question: Current demand environment and pharma's perspective - Management indicated that the demand situation is stabilizing for pharma, with improvements in proposals and bookings, although cancellations have increased for longer-term work [50][51] Question: Clarification on revenue guidance and book to bill - Management clarified that the current book to bill ratio is expected to remain in the range of 0.8 to 0.93, supporting the guidance without needing to return above one [56][57] Question: CDMO performance and impact of NHP supply clearance - Management confirmed that the $20 million revenue from a client will not repeat in the second half, impacting overall CDMO performance, but the clearance of NHP shipments provides operational flexibility [62][63] Question: Dynamics of cancellations and margin implications - Management noted that cancellations are not expected to significantly impact margins, as the nature of work varies and is driven by client prioritization [91][92]

Company Performance - Charles River Laboratories (CRL) reported quarterly earnings of $3.12 per share, exceeding the Zacks Consensus Estimate of $2.50 per share, and up from $2.80 per share a year ago, representing an earnings surprise of +24.80% [1][2] - The company posted revenues of $1.03 billion for the quarter ended June 2025, surpassing the Zacks Consensus Estimate by 5.01%, with year-ago revenues also at $1.03 billion [3] Earnings Outlook - The current consensus EPS estimate for the upcoming quarter is $2.37 on revenues of $958.76 million, and for the current fiscal year, it is $9.62 on revenues of $3.89 billion [8] - The estimate revisions trend for Charles River was favorable ahead of the earnings release, leading to a Zacks Rank 2 (Buy) for the stock, indicating expected outperformance in the near future [7] Industry Context - The Medical Services industry, to which Charles River belongs, is currently in the top 30% of over 250 Zacks industries, suggesting a positive outlook for stocks within this sector [9] - Empirical research indicates a strong correlation between near-term stock movements and trends in earnings estimate revisions, which can be tracked by investors [6]

Financial Performance & Guidance - Charles River's 2Q25 revenue reached $1032.1 million, a 0.6% increase year-over-year, but experienced a 0.5% organic decline[12, 36] - Non-GAAP EPS for 2Q25 was $3.12, an 11.4% increase year-over-year[14, 36] - The company is raising its revenue guidance by +150 bps to a 1%-3% decrease organically and Non-GAAP EPS by +$0.55 at midpoint to $9.90-$10.30[15] - The updated 2025 organic revenue growth guidance is a decrease of 3.0%-1.0%[16, 37] - Free cash flow for 2Q25 was $169.3 million, with FY 2025 guidance at $430-$470 million[49] Segment Performance - DSA (Discovery and Safety Assessment) revenue for 2Q25 was $618.0 million, a 1.5% decrease year-over-year, with a 2.4% organic decline[17] - RMS (Research Models and Services) revenue for 2Q25 was $213.3 million, a 3.3% increase year-over-year, with a 2.3% organic increase[26] - Manufacturing Solutions revenue for 2Q25 was $200.8 million, a 4.4% increase year-over-year, with a 2.9% organic increase[30] Demand Trends & Outlook - DSA net book-to-bill dipped back below 1x in 2Q25, to 0.82x [10] - The company now expects DSA revenue to decline at a low- to mid-single-digit rate in 2025, an improvement from the prior outlook of a mid-single-digit decline[21] - NAMs (New Approach Methodologies) portfolio generates approximately $200 million in annual DSA revenue[24]

[Executive Summary & Financial Highlights](index=1&type=section&id=Executive%20Summary%20%26%20Financial%20Highlights) Charles River Laboratories' Q2 2025 performance showed mixed results with revenue growth but declining GAAP net income, offset by strong non-GAAP performance [Second-Quarter 2025 Financial Performance](index=1&type=section&id=Second-Quarter%202025%20Financial%20Performance) Charles River Laboratories reported Q2 2025 revenue of $1.0321 billion, a 0.6% increase, with GAAP net income declining but non-GAAP metrics showing strong growth Financial Highlights | Metric | Q2 2025 | Q2 2024 | Change (YoY) | | :-------------------------------- | :------------- | :------------- | :---------- | | **Revenue** | $1,032.1 Million USD | $1,026.1 Million USD | +0.6% | | Organic Revenue Growth | -0.5% | - | - | | **GAAP Operating Margin** | 9.7% | 14.8% | -5.1 pp | | **GAAP Net Income** | $52.3 Million USD | $90.0 Million USD | -41.9% | | **GAAP EPS** | $1.06 | $1.74 | -39.0% | | **Non-GAAP Operating Margin** | 22.1% | 21.3% | +0.8 pp | | **Non-GAAP Net Income** | $154.0 Million USD | $144.9 Million USD | +6.2% | | **Non-GAAP Diluted EPS** | $3.12 | $2.80 | +11.4% | - GAAP performance declined primarily due to increased amortization expenses related to certain CDMO client relationships, company restructuring costs, and third-party legal and consulting fees[3](index=3&type=chunk) - Non-GAAP performance growth was driven by improved operating margins across all three business segments, partially offset by increased unallocated corporate costs, with **reduced diluted shares from the company's share repurchase program** also contributing to non-GAAP EPS growth[4](index=4&type=chunk) [CEO Commentary](index=1&type=section&id=CEO%20Commentary) CEO James C. Foster noted stabilizing biopharmaceutical demand and gradual organic revenue recovery, particularly in the DSA segment, with an improved outlook - Biopharmaceutical demand is stabilizing, and the company is gradually achieving organic revenue growth, primarily driven by **strong performance in the DSA segment**[5](index=5&type=chunk)[6](index=6&type=chunk) - The company is well-positioned for an improving demand environment due to its broad, scientifically differentiated portfolio and leading non-clinical market position[6](index=6&type=chunk) - DSA business and overall non-GAAP financial performance are expected to be **significantly better than the company's initial expectations**[6](index=6&type=chunk) [Segment Results](index=2&type=section&id=Segment%20Results) This section details the Q2 2025 financial performance and operational highlights for the Research Models and Services, Discovery and Safety Assessment, and Manufacturing Solutions segments [Research Models and Services (RMS)](index=2&type=section&id=Research%20Models%20and%20Services%20(RMS)) The RMS segment achieved 3.3% revenue growth in Q2 2025, driven by increased demand for large research models and services, improving both GAAP and non-GAAP operating margins RMS Segment Performance | Metric | Q2 2025 | Q2 2024 | Change (YoY) | | :----------------------- | :------------- | :------------- | :---------- | | **Revenue** | $213.3 Million USD | $206.4 Million USD | +3.3% | | Organic Revenue Growth | +2.3% | - | - | | **GAAP Operating Margin** | 16.8% | 14.5% | +2.3 pp | | **Non-GAAP Operating Margin** | 25.3% | 23.1% | +2.2 pp | - Organic revenue growth was primarily attributable to increased revenue from **large research model products and research model services**, including Genetic Engineering Model Services (GEMS) and Insourcing Solutions businesses[7](index=7&type=chunk) - The increase in GAAP and non-GAAP operating margins was primarily driven by a **favorable revenue mix** related to large research models, operating leverage from increased research model services revenue, and cost savings from the company's restructuring initiatives[8](index=8&type=chunk) [Discovery and Safety Assessment (DSA)](index=2&type=section&id=Discovery%20and%20Safety%20Assessment%20(DSA)) The DSA segment experienced a 1.5% revenue decline in Q2 2025 due to lower service volumes, with GAAP operating margin decreasing but non-GAAP margin slightly improving from cost savings DSA Segment Performance | Metric | Q2 2025 | Q2 2024 | Change (YoY) | | :----------------------- | :------------- | :------------- | :---------- | | **Revenue** | $618.0 Million USD | $627.4 Million USD | -1.5% | | Organic Revenue Growth | -2.4% | - | - | | **GAAP Operating Margin** | 19.9% | 22.1% | -2.2 pp | | **Non-GAAP Operating Margin** | 27.4% | 27.1% | +0.3 pp | - Organic revenue decline was primarily driven by **lower sales volumes in discovery and regulatory safety assessment services**[9](index=9&type=chunk) - The decrease in GAAP operating margin was primarily due to **lower revenue**, increased costs associated with the company's restructuring initiatives, and increased third-party legal costs related to the U.S. government's investigation into the company's NHP supply chain[10](index=10&type=chunk) - The increase in non-GAAP operating margin was primarily driven by **cost savings from the company's restructuring initiatives**, partially offset by lower revenue[10](index=10&type=chunk) [Manufacturing Solutions (Manufacturing)](index=3&type=section&id=Manufacturing%20Solutions%20(Manufacturing)) The Manufacturing segment reported 4.4% revenue growth in Q2 2025, primarily from microbial solutions, with GAAP operating margin significantly impacted by accelerated amortization, while non-GAAP margin rose Manufacturing Segment Performance | Metric | Q2 2025 | Q2 2024 | Change (YoY) | | :----------------------- | :------------- | :------------- | :---------- | | **Revenue** | $200.8 Million USD | $192.3 Million USD | +4.4% | | Organic Revenue Growth | +2.9% | - | - | | **GAAP Operating Margin** | 6.0% | 19.4% | -13.4 pp | | **Non-GAAP Operating Margin** | 32.8% | 26.6% | +6.2 pp | - Organic revenue growth was primarily driven by **increased revenue in the microbial solutions business**, partially offset by lower revenue in the biologics testing business[11](index=11&type=chunk) - The decrease in GAAP operating margin was due to **increased amortization expenses** related to the accelerated amortization of certain CDMO client relationships[12](index=12&type=chunk) - The increase in non-GAAP operating margin was primarily driven by **revenue and payments associated with commercial CDMO clients** and operating leverage from increased revenue in the microbial solutions business[12](index=12&type=chunk) [Key Updates & Outlook](index=3&type=section&id=Key%20Updates%20%26%20Outlook) This section provides updates on the NHP supply chain investigation and revised 2025 financial guidance, reflecting improved Q2 performance and favorable exchange rates [Update on U.S. Department of Justice Investigation into Non-Human Primate Supply Chain](index=3&type=section&id=Update%20on%20U.S.%20Department%20of%20Justice%20Investigation%20into%20Non-Human%20Primate%20Supply%20Chain) The U.S. Department of Justice has closed its federal grand jury and civil investigations into the company's non-human primate supply chain, with past shipments approved - The U.S. Fish and Wildlife Service has approved the **lawful entry into the U.S. of non-human primates (NHPs)** shipped in late 2022 and early 2023[13](index=13&type=chunk) - The U.S. Department of Justice has closed both the **federal grand jury investigation and the parallel civil investigation** related to these NHP shipments[13](index=13&type=chunk) [Updates 2025 Guidance](index=3&type=section&id=Updates%202025%20Guidance) The company has raised its full-year 2025 revenue and non-GAAP EPS outlook, driven by better-than-expected Q2 financial results, particularly in the DSA segment - The company has **raised its full-year 2025 outlook** for revenue and non-GAAP diluted earnings per share[14](index=14&type=chunk) - This increase primarily reflects **better-than-anticipated financial performance in the second quarter**, particularly in the DSA segment, and to a lesser extent, a favorable foreign exchange impact[14](index=14&type=chunk) 2025 Guidance | 2025 Guidance | Current | Previous | | :--------------------------------------- | :---------- | :---------- | | Revenue Growth/(Decline), Reported | (2.5)% – (0.5)% | (5.5)% – (3.5)% | | Favorable/(Unfavorable) Impact of Foreign Exchange | ~(0.5)% | ~1.0% | | Revenue Growth/(Decline), Organic | (3.0)% – (1.0)% | (4.5)% – (2.5)% | | GAAP EPS Estimate | $4.25 – $4.65 | $4.35 – $4.85 | | Non-GAAP EPS Estimate | $9.90 – $10.30 | $9.30 – $9.80 | [Additional Information](index=4&type=section&id=Additional%20Information) This section provides details on the webcast, the use of non-GAAP financial measures, cautionary statements regarding forward-looking information, and an overview of Charles River Laboratories [Webcast and Use of Non-GAAP Financial Measures](index=4&type=section&id=Webcast%20and%20Use%20of%20Non-GAAP%20Financial%20Measures) The company will host a webcast to discuss results and provides non-GAAP financial measures to offer a clearer view of core operational performance by excluding one-time items - The company will host a **webcast on August 6 at 9:00 AM ET** to discuss matters related to this press release and provide a reconciliation of GAAP to non-GAAP financial measures[20](index=20&type=chunk) - Non-GAAP financial measures, such as non-GAAP diluted EPS, non-GAAP operating income, non-GAAP operating margin, and non-GAAP net income, exclude items like **amortization of intangible assets, acquisition and divestiture-related adjustments, restructuring costs, investment gains/losses, and certain legal and consulting fees**[21](index=21&type=chunk)[22](index=22&type=chunk) - The company believes providing supplemental non-GAAP financial measures helps investors meaningfully understand its **core operating performance and future prospects**, unaffected by these often one-time expenses, and aligns with how management measures and forecasts company performance[22](index=22&type=chunk) [Caution Concerning Forward-Looking Statements](index=5&type=section&id=Caution%20Concerning%20Forward-Looking%20Statements) This section warns that forward-looking statements are subject to various unpredictable risks and uncertainties, which could cause actual results to differ materially from projections - Forward-looking statements involve **predictions about future events or trends**, not historical facts, and are based on the company's current expectations and beliefs[23](index=23&type=chunk)[24](index=24&type=chunk) - There are various **unpredictable risks and uncertainties** that could cause actual results to differ materially from forward-looking statements[24](index=24&type=chunk) - Key risks and uncertainties include NHP supply constraints and related investigations, changes in global economic and financial markets, ability to successfully integrate acquisitions, R&D spending trends, regulatory changes, loss of key personnel, interest and foreign exchange rate fluctuations, and geopolitical conflicts[24](index=24&type=chunk) [About Charles River](index=7&type=section&id=About%20Charles%20River) Charles River Laboratories provides essential products and services to accelerate research and drug development for global pharmaceutical, biotech, government, and academic institutions - Charles River provides essential products and services to global pharmaceutical and biotechnology companies, government agencies, and leading academic institutions to **accelerate their research and drug development efforts**[25](index=25&type=chunk) - The company is dedicated to providing what clients need to **improve and expedite the discovery, early-stage development, and safe manufacture of new therapies**[25](index=25&type=chunk) [Financial Statements (Unaudited)](index=8&type=section&id=Financial%20Statements%20(Unaudited)) This section presents the unaudited condensed consolidated financial statements, including income statements, balance sheets, and cash flow statements [Condensed Consolidated Statements of Income (Unaudited)](index=8&type=section&id=Condensed%20Consolidated%20Statements%20of%20Income%20(Unaudited)) This statement provides unaudited income, cost, operating profit, net income, and EPS data for Charles River Laboratories for the three and six months ended June 28, 2025, and June 29, 2024 Condensed Consolidated Statements of Income | Metric (Thousand USD) | Q2 2025 | Q2 2024 | H1 2025 | H1 2024 | | :------------------------------------------------- | :------------- | :------------- | :------------- | :------------- | | **Total Revenue** | 1,032,135 | 1,026,117 | 2,016,303 | 2,037,677 | | Service Revenue | 840,836 | 842,900 | 1,638,759 | 1,659,762 | | Product Revenue | 191,299 | 183,217 | 377,544 | 377,915 | | **Operating Income** | 100,134 | 151,652 | 174,803 | 277,629 | | **Income Before Income Taxes** | 71,418 | 119,653 | 107,396 | 218,664 | | **Net Income** | 52,693 | 94,261 | 78,571 | 168,743 | | **Net Income Attributable to Charles River Laboratories International, Inc. Common Stockholders** | 52,326 | 89,988 | 77,795 | 157,317 | | **Diluted Earnings Per Share** | $1.06 | $1.74 | $1.55 | $3.04 | | **Weighted-Average Diluted Common Shares Outstanding** | 49,316 | 51,846 | 50,089 | 51,810 | [Condensed Consolidated Balance Sheets (Unaudited)](index=9&type=section&id=Condensed%20Consolidated%20Balance%20Sheets%20(Unaudited)) This statement presents the unaudited assets, liabilities, redeemable noncontrolling interests, and stockholders' equity for Charles River Laboratories as of June 28, 2025, and December 28, 2024 Condensed Consolidated Balance Sheets | Metric (Thousand USD) | June 28, 2025 | December 28, 2024 | | :--------------------------------------- | :------------- | :--------------- | | **Total Assets** | 7,560,545 | 7,528,345 | | Cash and Cash Equivalents | 182,824 | 194,606 | | Trade Receivables and Contract Assets, Net | 767,569 | 720,915 | | Inventories | 279,550 | 278,544 | | Goodwill | 2,936,265 | 2,846,608 | | Intangible Assets, Net | 602,452 | 723,400 | | **Total Liabilities** | 4,160,959 | 4,020,267 | | Long-Term Debt, Net and Finance Leases | 2,332,374 | 2,240,205 | | **Total Equity Attributable to Charles River Laboratories International, Inc.** | 3,353,321 | 3,461,503 | | **Total Liabilities, Redeemable Noncontrolling Interests and Equity** | 7,560,545 | 7,528,345 | [Condensed Consolidated Statements of Cash Flows (Unaudited)](index=10&type=section&id=Condensed%20Consolidated%20Statements%20of%20Cash%20Flows%20(Unaudited)) This statement details the unaudited cash flows from operating, investing, and financing activities for Charles River Laboratories for the six months ended June 28, 2025, and June 29, 2024 Condensed Consolidated Statements of Cash Flows | Metric (Thousand USD) | H1 2025 | H1 2024 | | :--------------------------------------- | :------------- | :------------- | | **Net Cash Provided by Operating Activities** | 376,300 | 323,423 | | **Net Cash Used in Investing Activities** | (82,818) | (147,658) | | **Net Cash Used in Financing Activities** | (332,246) | (267,512) | | **Effect of Exchange Rate Changes on Cash, Cash Equivalents, and Restricted Cash** | 17,934 | (11,729) | | **Net Change in Cash, Cash Equivalents, and Restricted Cash** | (20,830) | (103,476) | | **Cash, Cash Equivalents, and Restricted Cash at End of Period** | 184,740 | 181,004 | [Non-GAAP Reconciliations (Unaudited)](index=11&type=section&id=Non-GAAP%20Reconciliations%20(Unaudited)) This section provides unaudited reconciliations of GAAP to non-GAAP financial measures for various segments and overall company performance, detailing specific adjustments [Reconciliation of GAAP to Non-GAAP Selected Business Segment Information (Unaudited)](index=11&type=section&id=Reconciliation%20of%20GAAP%20to%20Non-GAAP%20Selected%20Business%20Segment%20Information%20(Unaudited)) This table reconciles GAAP to non-GAAP operating profit for RMS, DSA, and Manufacturing Solutions segments, detailing adjustments like acquisition-related amortization and restructuring costs GAAP to Non-GAAP Selected Business Segment Information | Metric (Thousand USD) | Q2 2025 (GAAP) | Q2 2025 (Non-GAAP) | Q2 2024 (GAAP) | Q2 2024 (Non-GAAP) | | :--------------------------------------- | :-------------------- | :---------------------- | :-------------------- | :---------------------- | | **RMS Operating Income** | 35,786 | 53,879 | 29,948 | 47,701 | | RMS Operating Margin | 16.8% | 25.3% | 14.5% | 23.1% | | **DSA Operating Income** | 122,781 | 169,173 | 138,376 | 170,141 | | DSA Operating Margin | 19.9% | 27.4% | 22.1% | 27.1% | | **Manufacturing Operating Income** | 12,061 | 65,838 | 37,230 | 51,203 | | Manufacturing Operating Margin | 6.0% | 32.8% | 19.4% | 26.6% | | **Total Operating Income** | 100,134 | 228,194 | 151,652 | 218,555 | | Total Operating Margin | 9.7% | 22.1% | 14.8% | 21.3% | - Non-GAAP adjustments primarily include **acquisition-related amortization** (with Manufacturing Solutions including **$35.5 million of accelerated amortization** in Q2 2025), acquisition, integration, and divestiture-related adjustments, severance, asset impairments, site consolidation costs, and third-party legal and consulting fees[31](index=31&type=chunk) [Reconciliation of GAAP Earnings to Non-GAAP Earnings (Unaudited)](index=13&type=section&id=Reconciliation%20of%20GAAP%20Earnings%20to%20Non-GAAP%20Earnings%20(Unaudited)) This table reconciles GAAP net income and EPS to non-GAAP net income and EPS, detailing adjustments for redeemable noncontrolling interests, non-GAAP operating profit, and tax impacts GAAP to Non-GAAP Earnings | Metric (Thousand USD) | Q2 2025 (GAAP) | Q2 2025 (Non-GAAP) | Q2 2024 (GAAP) | Q2 2024 (Non-GAAP) | | :------------------------------------------------- | :-------------------- | :---------------------- | :-------------------- | :---------------------- | | **Net Income Attributable to Charles River Laboratories International, Inc. Common Stockholders** | 52,326 | 153,992 | 89,988 | 144,939 | | **Diluted Earnings Per Share** | $1.06 | $3.12 | $1.74 | $2.80 | | **Weighted-Average Diluted Common Shares Outstanding** | 49,316 | 49,316 | 51,846 | 51,846 | - Non-GAAP adjustments include **redeemable noncontrolling interest adjustments**, incremental dividends to noncontrolling interest holders, non-GAAP operating income adjustments, net gains/losses on venture capital and strategic equity investments, gains/losses on divestitures, and the tax impact of each non-GAAP adjustment[32](index=32&type=chunk) [Reconciliation of GAAP Revenue Growth to Non-GAAP Revenue Growth, Organic (Unaudited)](index=14&type=section&id=Reconciliation%20of%20GAAP%20Revenue%20Growth%20to%20Non-GAAP%20Revenue%20Growth%2C%20Organic%20(Unaudited)) This table reconciles GAAP reported revenue growth to non-GAAP organic revenue growth for the company and its segments by adjusting for foreign exchange and divestiture impacts GAAP to Non-GAAP Revenue Growth, Organic | Metric | Total CRL | RMS Segment | DSA Segment | MS Segment | | :-------------------------------- | :-------- | :-------- | :-------- | :-------- | | **Q2 2025 Revenue Growth, Reported** | 0.6 % | 3.3 % | (1.5) % | 4.4 % | | Foreign Exchange Impact (Increase) Decrease | (1.2) % | (1.0) % | (1.1) % | (1.5) % | | Divestiture Impact | 0.1 % | — % | 0.2 % | — % | | **Q2 2025 Non-GAAP Revenue Growth, Organic** | (0.5)% | 2.3 % | (2.4)% | 2.9 % | | **H1 2025 Revenue Growth, Reported** | (1.0) % | (0.2) % | (1.8) % | 0.5 % | | Foreign Exchange Impact (Increase) Decrease | (0.2) % | — % | (0.2) % | (0.1) % | | Divestiture Impact | 0.1 % | — % | 0.1 % | — % | | **H1 2025 Non-GAAP Revenue Growth, Organic** | (1.1)% | (0.2)% | (1.9)% | 0.4 % | - Organic revenue growth is defined as reported revenue growth adjusted for the impact of completed acquisitions and divestitures, and foreign currency translation[16](index=16&type=chunk)[34](index=34&type=chunk)

Core Insights - Charles River Laboratories International, Inc. (CRL) is expanding its product and service offerings in drug discovery and early-stage development through strategic partnerships and acquisitions [1][6] - The Discovery and Safety Assessment (DSA) segment shows signs of stabilization with improved bookings, although macroeconomic challenges and currency fluctuations present risks [1][8] Financial Performance - Year-to-date, CRL's shares have declined by 16.4%, while the industry has seen a 4.2% decline, and the S&P 500 has increased by 6% [2] - The company has a market capitalization of $7.76 billion and an earnings yield of 6%, outperforming the industry's 4.1% [2] - CRL has consistently beaten earnings estimates over the past four quarters, with an average surprise of 10.9% [2] Growth Drivers - The DSA segment is a potential growth driver, being the largest provider of outsourced drug discovery and non-clinical development services globally [4] - In Q1 2025, DSA's net book-to-bill ratio exceeded 1X for the first time in over two years, indicating improved quarterly bookings and expected incremental revenues in 2025 [5][9] - Strategic partnerships, such as those with Akron Bio, Deciphex, H. Lundbeck A/S, and Autobahn Labs, are enhancing CRL's capabilities in drug development and research [6][7] Challenges - The company faces a cautious spending environment among biopharmaceutical and biotechnology clients, particularly due to reduced research grants from the NIH [8] - Macroeconomic factors, including tariffs on imports from key supplier countries, are impacting CRL's operations [8] - Foreign exchange fluctuations pose significant challenges, as a considerable portion of CRL's revenues is generated outside the U.S., with the strengthening dollar exacerbating these issues [10] Earnings Estimates - The Zacks Consensus Estimate for CRL's 2025 earnings remains at $9.62 per share, while revenues are projected at $3.89 billion, reflecting a 3.9% decrease from the previous year [11]