证券日报网讯12月15日，皓元医药在互动平台回答投资者提问时表示，公司始终坚持"产业化、全球 化、品牌化"的发展战略，持续推动三大业务引擎稳健增长。ADC业务的收入目前占后端创新药CDMO 的收入比重较大，公司积极推动ADC业务的发展。目前公司在ADC小分子领域已经形成了较强竞争优 势，随着今年3月份重庆抗体偶联CDMO基地顺利投入运营，标志着上海、马鞍山、重庆"三位一体"的 XDC全方位服务体系已经形成，公司已发展为国内稀缺的一站式ADCCDMO企业，构建了覆盖Payload- Linker开发、抗体发现、偶联工艺优化至商业化生产的全链条闭环服务能力。公司正积极有序推进重庆 皓元的市场推广和项目推进进度，加快新建产能快速爬坡，目前新签订单快速增长中。公司已成立了战 略投资部，不排除会通过收并购和合作的方式加大公司在国际市场的开拓。公司暂无应披露而未披露的 信息，重大投资与并购计划请以相关公告为准。 ...

Group 1: Company Performance Overview - The company achieved double-digit growth in new orders for Q3, with an acceleration compared to the first half of the year [2] - The new business segments, including chemical and biological macromolecule businesses, are showing strong growth, indicating a positive revenue outlook for 2026 [2] Group 2: Capacity and Capital Expenditure - The capital expenditure for 2025 is projected to increase to approximately 1.3-1.4 billion, focusing on new business areas [3] - The small molecule business is experiencing tight capacity, particularly in Tianjin, while the Northeast facility is operating at normal utilization levels [3] - The company is expanding its capacity in the chemical macromolecule sector, with significant growth expected in the peptide and oligonucleotide businesses [3] Group 3: Profitability and Margins - The gross margin for new business segments reached 30.6% in the first three quarters of 2025, an increase of 10.6 percentage points year-on-year [4] - The domestic business revenue is expected to continue increasing, driven by a competitive domestic market and ongoing projects [5] - The company is implementing cost control measures to ensure that expense growth remains below revenue growth [6] Group 4: Market Trends and Future Outlook - The company anticipates a revenue growth of 13%-15% for the full year 2025, with increasing growth rates expected in 2026 and 2027 [4] - The domestic revenue share is expected to rise, supported by the increasing number of projects going overseas [5] - The company is focusing on enhancing its capabilities to capture more collaboration opportunities in the rapidly growing new molecule sector [4] Group 5: Competitive Positioning - The company’s core competencies lie in its delivery capabilities and investment in new technologies aimed at significantly reducing production costs [7] - The revenue structure of the chemical macromolecule business shows over 50% coming from peptide business, with a shift towards overseas markets expected [8]

Core Insights - The report from Cinda Securities indicates a significant recovery in domestic innovative drug financing, with a total of $7.75 billion in financing from January to August 2025, representing a year-on-year increase of approximately 89% [1] - The secondary market financing reached $5.135 billion, showing a remarkable year-on-year growth of about 304% [1] - The CXO industry is experiencing an improvement in supply-demand dynamics, with leading companies expected to re-enter an expansion phase due to recovering market demand [2] Group 1: CXO Industry Overview - The CXO industry operates on a "water seller" business model, closely tied to the financing of the biopharmaceutical sector [1] - Domestic innovative drug financing has begun to recover, aided by a rebound in the Hong Kong stock market and business development (BD) opportunities abroad [1] - The overall supply-demand relationship in the CXO sector is improving, with leading companies like WuXi AppTec and WuXi Biologics planning significant capital expenditures for 2025, indicating confidence in market recovery [2] Group 2: CDMO Sector Insights - CDMO leaders are experiencing marginal improvements in performance since Q4 2024, driven by high overseas revenue and a recovery in overseas investment and financing demand [3] - The unique business model of CDMOs allows for project pipeline expansion, which can sustain performance growth even amid challenges in new project signings [3] - The demand for new molecules such as peptides and ADCs is robust, prompting CDMO leaders to strategically position themselves in these emerging markets [3] Group 3: CRO Sector Insights - The CRO sector shows performance divergence among leading companies, with some beginning to recover, likely due to their specific business characteristics and operational cycles [4] - Most CRO companies are seeing improvements in order volumes, which serve as a leading indicator for future performance [4] - The slight increase in the price of experimental monkeys suggests a potential recovery in preclinical CRO demand, highlighting the importance of companies that control these scarce resources [4] Group 4: Recommended Companies - Key companies to watch include WuXi AppTec, WuXi Biologics, WuXi AppTec's ADC business, and others, with their valuations falling within reasonable ranges based on their business characteristics and market trends [5][6] - Specific highlights include WuXi AppTec's TIDES business, WuXi Biologics' project reserves, and the resilience of Sunlight Nuohuo's CRO business [6]

Investment Rating - The report maintains a "Positive" investment rating for the pharmaceutical and biotechnology industry [2] Core Insights - The CXO industry is experiencing a recovery in market conditions, driven by improvements in supply-demand dynamics and a rebound in financing activities for innovative drugs [3][4] - The CDMO sector continues to show high growth potential, with leading companies improving their performance and expanding into emerging markets [5][6] - The CRO sector is approaching a turning point, with signs of demand recovery and improved order conditions [6][7] Summary by Sections CXO Industry Overview - The CXO industry operates on a "water seller" business model, closely tied to the financing of the biopharmaceutical sector. In the first eight months of 2025, overseas innovative drug financing reached $22.6 billion, a year-on-year decline of approximately 36%, while domestic innovative drug financing amounted to $7.75 billion, a year-on-year increase of about 89% [3][31] - The leading companies in the CXO sector are expected to enter an expansion phase as demand recovers, while smaller companies may face increased competition and exit the market [4][44] CDMO Sector - CDMO leading companies have begun to see marginal improvements in performance since Q4 2024, attributed to high overseas revenue and a unique business model that supports project pipeline growth [5][46] - The order situation for CDMO companies has improved significantly, with notable increases in backlogged orders for major players like WuXi AppTec and WuXi Biologics [49][50] - The CDMO business model is characterized by strong customer retention and project scalability, allowing for sustained growth despite challenges in new project signings [52] CRO Sector - The CRO sector is witnessing a divergence in performance among leading companies, with some starting to recover. The overall order situation has shown improvement, indicating a potential demand revival [6][22] - The price increase of experimental monkeys suggests a forthcoming recovery in preclinical CRO demand, highlighting the importance of resource availability for leading CRO companies [6][24] - The integration of AI in drug development processes is expected to enhance efficiency and reduce costs, with many domestic CRO leaders already adopting AI technologies [7][18] Recommended Companies - The report suggests focusing on key players in the CXO sector, including WuXi AppTec, WuXi Biologics, WuXi AppTec, and others, which are positioned well for growth based on their business characteristics and market trends [8][10]

Core Insights - In Q1 2025, the company achieved a revenue of 800 million yuan, representing an approximate 18% year-on-year growth, and significantly reduced its net loss to 4.28 million yuan [1] - The overseas market showed strong growth, with revenue from international clients reaching 609 million yuan, a year-on-year increase of about 30%, while domestic revenue declined by approximately 8% to 192 million yuan [1] - The small molecule API business generated 761 million yuan in revenue, up about 20% year-on-year, while new businesses collectively contributed 40.59 million yuan [1] Business Performance - The company's core small molecule API business demonstrated a notable improvement in profitability [1] - New businesses negatively impacted the net profit by approximately 58 million yuan, with specific contributions from small molecule formulations, gene cell therapy, and ADC business reducing net profit by 27 million yuan, 16 million yuan, and 15 million yuan respectively [1] Strategic Focus - The company aims to enhance its management capabilities, strengthen marketing, and improve core business competencies to navigate external uncertainties [2] - The goal is to restore revenue growth and gradually achieve profitability by focusing on "certainty to strengthen and adapt" in response to market volatility [2]