PresentationTerence FlynnEquity Analyst Great. Good morning. Thanks for joining us, everybody. I'm Terence Flynn, Morgan Stanley's U.S. Biopharma Analyst. I'm very pleased to be hosting Arcus this morning. Joining us from the company, we have Jennifer Jarrett, the company's COO and Richard Markus, the company's CMO. Thank you both so much for being here. Really looking forward to catching up. Before we get started, for important disclosures, please see the Morgan Stanley research disclosure website at www.m ...

PresentationTerence FlynnEquity Analyst Great. Good morning. Thanks for joining us, everybody. I'm Terence Flynn, Morgan Stanley's U.S. Biopharma Analyst. I'm very pleased to be hosting Arcus this morning. Joining us from the company, we have Jennifer Jarrett, the company's COO and Richard Markus, the company's CMO. Thank you both so much for being here. Really looking forward to catching up. Before we get started, for important disclosures, please see the Morgan Stanley research disclosure website at www.m ...

Arcus Biosciences (NYSE:RCUS) FY Conference September 10, 2025 08:30 AM ET Company ParticipantsRichard Markus - CMOJennifer Jarrett - COOConference Call ParticipantsTerrence Flynn - U.S. Biopharma AnalystTerrence FlynnGreat. Good morning. Thanks for joining us, everybody. I'm Terrence Flynn, Morgan Stanley's U.S. Biopharma Analyst. I'm very pleased to be hosting Arcus this morning. Joining us from the company, we have Jennifer Jarrett, the company's Chief Operating Officer, and Richard Markus, the company's ...

Arcus Biosciences (NYSE:RCUS) FY Conference September 09, 2025 08:00 AM ET Company ParticipantsRichard Markus - CMOPia Eaves - Head of Investor RelationsJennifer Jarrett - COOConference Call ParticipantsEmily Bodnar - AnalystEmily BodnarHi everyone. Good morning and thanks for joining us at the H.C. Wainwright 27th Annual Global Investment Conference. My name is Emily Bodner, and I'm an Equity Research Analyst at H.C. Wainwright. I'm pleased to introduce the team from Arcus Biosciences. We have Jennifer Jar ...

HAYWARD, Calif.--(BUSINESS WIRE)--Arcus Biosciences, Inc. (NYSE:RCUS), a clinical-stage, global biopharmaceutical company focused on developing differentiated molecules and combination therapies for people with cancer, today announced that the Compensation Committee of the Company's Board of Directors granted three new employees options to purchase a total of 19,300 shares of the Company's common stock at an exercise price per share of $12.19, which was the closing price on September 8, 2025, a. ...

Group 1 - The Citi Biopharma Back To School Summit is being held, featuring discussions on recent developments in the biotech sector [1] - Arcus Biosciences is presenting, with key executives including the CEO, COO, and Head of Investor Relations participating [2] - The CEO of Arcus Biosciences highlighted the positive outcomes from the recent ASCO event and mentioned upcoming catalysts related to their product, cas [3]

Summary of Arcus Biosciences Conference Call - September 03, 2025 Company Overview - **Company**: Arcus Biosciences (RCUS) - **Focus**: Development of innovative cancer therapies, particularly in the area of HIF-2 alpha inhibitors Key Points and Arguments Product Pipeline and Clinical Trials - **Casdatafan**: - Positioned as a best-in-class HIF-2 alpha inhibitor, with compelling data from 120 patients indicating superior efficacy compared to Merck's belzutafan [6][17] - Total addressable market estimated at $10 billion [7] - Phase 3 studies initiated, including a combination with cabozantinib (cabo) and a collaboration with AstraZeneca for frontline settings [8][10] - Expected rapid enrollment due to investigator enthusiasm [7][11] - **Domzim**: - An anti-TIGIT, anti-PD-1 combination therapy, with data to be presented at ESMO [9][10] - **Quemly**: - A CD73 inhibitor in pancreatic cancer, fully enrolled ahead of schedule, with results expected in the next 12-18 months [12][97] Competitive Landscape - **Comparison with Merck's Belzutafan**: - Casdatafan shows a lower rate of primary progression (15% vs. 35% for belzutafan) and better overall response rates (over 30% vs. just over 20%) [17][18] - Arcus believes their development strategy is superior, focusing on combining with cabo, which is more widely used and easier to manage than Merck's lenvatinib [22][24] Strategic Advantages - **Development Strategy**: - Arcus employs a cleaner statistical analysis plan with a single primary endpoint of progression-free survival (PFS) [30] - Two-to-one randomization in trials to enhance patient enrollment [32] - **Collaboration with AstraZeneca**: - Cost-sharing arrangement for a phase 1b/3 study combining Casdatafan with AstraZeneca's bispecific anti-PD-1/CTLA-4 [40][41] Upcoming Data and Events - **Investor Event**: - Scheduled for October 6, 2025, to present updated data on Casdatafan and other therapies [8] - **Data Readouts**: - Continuous flow of data expected from various studies, including OS data from the Edge Gastric study and the phase 3 study for upper GI cancers [10][66] Market Positioning - **TKI-Sparing Regimen**: - Arcus aims to shift the use of TKIs to later lines of therapy, enhancing patient quality of life by avoiding early toxicities associated with TKIs [49] Other Important Insights - **Safety Profile**: - Casdatafan is expected to have minimal overlapping toxicity with other treatments, which could make it a backbone agent in clear cell renal cell carcinoma (CCRCC) [60] - **Regulatory Landscape**: - No competing phase 3 studies currently exist for Casdatafan, positioning Arcus favorably in the market [35] Conclusion - Arcus Biosciences is in a transformative phase with multiple late-stage clinical trials and a strong competitive position against Merck's belzutafan. The company is focused on delivering innovative therapies with a favorable safety profile and robust efficacy data, aiming to capture significant market share in the oncology space.

On CNBC's "Mad Money Lightning Round," Jim Cramer recommended buying Uranium Energy Corp. UEC, saying, "I like nuclear." Supporting his view, HC Wainwright & Co. analyst Heiko F. Ihle, on Aug. 6, maintained Uranium Energy with a Buy and raised the price target from $12.25 to $12.75. When asked about Arcus Biosciences, Inc. RCUS, he said, "Let this be your speculation. But if you do this, you have to promise me that the other stocks are not going to be speculative. Because it's too risky to just bank it all ...

Group 1 - The article promotes a weekly newsletter focused on stocks in the biotech, pharma, and healthcare industries, highlighting key trends and catalysts that influence market valuations [1] - The newsletter is designed for both novice and experienced biotech investors, offering insights on product sales, forecasts for major pharmaceutical companies, and detailed financial analyses [1] - Edmund Ingham, a biotech consultant with over five years of experience, leads the investing group Haggerston BioHealth and has compiled extensive reports on more than 1,000 companies in the sector [1]

Financial Performance - Arcus Biosciences reported break-even quarterly earnings per share, compared to a Zacks Consensus Estimate of a loss of $1.14, and a loss of $1.02 per share a year ago, indicating an earnings surprise of +100.00% [1] - The company posted revenues of $160 million for the quarter ended June 2025, surpassing the Zacks Consensus Estimate by 593.24%, compared to year-ago revenues of $39 million [2] - Over the last four quarters, Arcus Biosciences has surpassed consensus EPS estimates three times and topped consensus revenue estimates three times [2] Stock Performance - Arcus Biosciences shares have lost about 35.9% since the beginning of the year, while the S&P 500 has gained 7.1% [3] - The current status translates into a Zacks Rank 3 (Hold) for the stock, indicating expected performance in line with the market in the near future [6] Earnings Outlook - The current consensus EPS estimate for the coming quarter is -$1.21 on revenues of $22.96 million, and -$4.59 on revenues of $91.93 million for the current fiscal year [7] - The estimate revisions trend for Arcus Biosciences was mixed ahead of the earnings release, which could change following the recently released earnings report [6] Industry Context - The Medical - Biomedical and Genetics industry, to which Arcus Biosciences belongs, is currently in the bottom 42% of the Zacks industries, indicating potential challenges for stock performance [8] - Empirical research shows a strong correlation between near-term stock movements and trends in earnings estimate revisions, suggesting that industry outlook can materially impact stock performance [5][8]